Angiotensin II activates connective tissue growth factor and induces extracellular matrix changes involving Smad/activation and p38 mitogen-activated protein kinase signalling pathways in human dermal fibroblasts

Experimental Dermatology

Volumn 18, Issue 11, 2009, Pages 947-953

  Zhang, Guo You ^a   Li, Xuan ^b   Yi, Cheng Gang ^c   Pan, Hua ^c   He, Guo Dong ^d   Yu, Qing ^a   Jiang, Liang Fu ^a   Xu, Wei Hua ^a   Li, Zhi Jie ^a   Ding, Jian ^a   Lin, Ding Sheng ^a   Gao, Wei Yang ^a  

^a THE SECOND AFFILIATED HOSPITAL AND YUYING CHILDREN S HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

^b Second People's Hospital of Hefei   (China)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^d THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Angiotensin; Dermal fibroblasts; Fibrosis; Signalling pathway

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; FIBRONECTIN; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROCOLLAGEN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; GROWTH INHIBITION; HORMONE ACTION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SKIN FIBROBLAST;

ANGIOTENSIN II; CONNECTIVE TISSUE GROWTH FACTOR; ENZYME INHIBITORS; EXTRACELLULAR MATRIX; FIBROBLASTS; FIBRONECTINS; FIBROSIS; HUMANS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; SIGNAL TRANSDUCTION; SKIN; SMAD PROTEINS; SMAD7 PROTEIN;

EID: 70350749353     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00880.x     Document Type: Article

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