Tumor necrosis factor-α inhibits collagen α1(I) gene expression and wound healing in a murine model of cachexia

American Journal of Pathology

Volumn 149, Issue 1, 1996, Pages 195-204

  Buck, Martina ^a   Houglum, Karl ^a   Chojkier, Mario ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; HUMAN GROWTH HORMONE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CACHEXIA; CHO CELL; COLLAGEN METABOLISM; COLLAGEN SYNTHESIS; CONTROLLED STUDY; GENE EXPRESSION; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN INJURY; TRANSGENIC MOUSE; WEIGHT REDUCTION; WOUND HEALING;

ANIMALS; CACHEXIA; COLLAGEN; CRICETINAE; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, NUDE; MICE, TRANSGENIC; SKIN; TUMOR NECROSIS FACTOR-ALPHA; WOUND HEALING; WOUNDS AND INJURIES;

EID: 0030011283     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Beutler B: Tumor Necrosis Factors: The Molecules and their Emerging Role in Medicine. Edited by B Beutler, New York, Raven Press, 1992
2. Tracey KJ, Cerami A: Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 1993, 9:317-343
3. Adams SL: Regulation of Collagen Gene Expression. Edited by MA Zern, LM Reid. New York, Extracellular Matrix, 1993, pp 91-119
4. Chojkier M, Spanheimer R, Peterkofsky B: Specifically decreased collagen biosynthesis in scurvy dissociated from an effect on proline hydroxylation and correlated with body weight loss. J Clin Invest 1983, 72:826-835
5. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG, Brenner DA: Different mechanisms decrease hepatic collagen and albumin production in fasted rats. Hepatology 1988, 8:1040-1045
6. Peterkofsky B, Spanheimer RG, Bird TA: Coordinate regulation of cartilage collagen and proteoglycan synthesis in scorbutic guinea pig. Development and Diseases of Cartilage and Bone Matrix. Edited by A Sen, T Phornhill. New York, AR Liss, 1987, pp 33-43
7. Spanheimer RG, Peterkofsky B: A specific decrease in collagen synthesis in acutely fasted, vitamin C-supplemented guinea pigs. J Biol Chem 1984, 260:3955-3962
8. Solis-Herruzo, JA, Brenner DA, Chojkier M: Tumor necrosis factor-α inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. J Biol Chem 1988, 263:5841-5845
9. Armendariz-Borunda J, Katayama K, Seyer JM: Transcriptional mechanisms of type I collagen gene expression are differentially regulated by interleukin-1β, tumor necrosis factor-α, and transforming growth factor-β in Ito cells. J Biol Chem 1992, 267:14316-14321
10. Oliff A, Defeo-Jones D, Boyer M, Martinez D, Kiefer D, Vuocolo G, Wolfe A, Socher SH: Tumors secreting human TNFα/cachectin induce cachexia in mice. Cell 1987, 50:555-563
11. Brenner DA, Buck M, Feitelberg SP, Chojkier M: Tumor necrosis factor-α inhibits albumin gene expression in a murine model of cachexia. J Clin Invest 1990, 85:248-255
12. Chojkier M: Hepatocyte collagen production in vivo in normal rats. J Clin Invest 1986, 78:333-339
13. Laemmli UK: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685
14. Houglum K, Bedossa P, Chojkier M: TGFβ and collagen α1(I) gene expression are increased in hepatic acinar zone 1 of rats with iron overload. Am J Physiol 1994, 267:G908-G913
15. Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M: Prolonged activation of jun and collagenase genes by tumor necrosis factor-α. Nature 1989, 337:661-663
16. Descombes P, Chojkier M, Lichtsteiner S, Falvey E, Schibler U: LAP, a novel member of the C/EBP gene family, encodes a liver-enriched transcriptional activator protein. Genes Dev 1990, 4:1541-1551
17. Slack JL, Liska DJ, Bornstein P: An upstream regulatory region mediates high-level, tissue-specific expression of the human a1(I) collagen gene in transgenic mice. Mol Cell Biol 1991, 11:2066-2074
18. Miller DA, Pelton RW, Derynck R, Moses HL: Transforming growth factor-β: a family of growth regulatory peptides. NY Acad Sci 1990, 953:208-217
19. Parnes JR, Seidman JG: Structure of wild-type and mutant mouse β2-microglobulin genes. Cell 1982, 29: 661-669
20. Liska DJ, Reed MJ, Sage EH, Bornstein P: Cell-specific expression of α1(I) collagen-hGH minigenes in transgenic mice. J Cell Biol 1994, 25:695-704
21. Scuderi P, Lam KS, Ryan KJ, Peterson E, Sterling KE, Finley PR, Ray CG, Slymen DJ, Salmon SE: Raised serum levels of tumor necrosis factor in parasitic infections. Lancet 1986, ii:1364-1365
22. Waage A, Halstensen A, Espevik T: Association between tumor necrosis factor in serum and fatal outcome in patients with meningococcal disease. Lancet 1987, i:355-357
23. Lahdevirta J, Maury CP, Teppo A, Repo H: Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome. Am J Med 1988, 85:289-291
24. Grau GE, Taylor TE, Molyneux ME, Wirima JJ, Vassalli P, Hommel M, Lambert P: Tumor necrosis factor and disease severity in children with Falciparum malaria. N Engl J Med 1989, 320:1586-1591
25. Welch MP, Odland GF, Clark RAF: Temporal relationships of F-actin bundle formation, collagen and fibronectin matrix assembly, and fibronectin receptor expression to wound contraction. J Cell Biol 1990, 110: 133-145
26. Tracey KJ, Wei H, Manogue KR, Fong Y, Hesse DG, Nguyen HT, Kuo GC, Beutler B, Cotran RS, Cerami A, Lowry SF: Cachectin/tumor necrosis factor induced cachexia, anemia, and inflammation. J Exp Med 1988, 167:1211-1227
27. Singer II, Kawka DW, Kazazis DM, Clark RAF: In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of fibronexus at the myofibroblast surface. J Cell Biol 1984, 98:2091-2106
28. Skalli O, Gabbiani G: The biology of the myofibroblast relationship to wound contraction and fibrocontractive diseases. Molecular and Cellular Biology of Wound Repair. Edited by RAF Clark, PM Henson. New York, Plenum, 1988, pp 373-402
29. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, Fauci AS. Transforming growth factor type-β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986, 83:4167-4171
30. 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991, 99:6642-6646
31. Castilla A, Prieto J, Fausto N: Transforming growth factors β and α in chronic liver disease. N Engl J Med 1991, 324:933-940
32. 1 during repair of arterial injury. J Clin Invest 1991, 88: 904-910
33. Mustoe TA, Pierce GF, Thomason A, Gramates P, Sporn MB, Deuel TF: Accelerated healing of incisional wounds in rats induced by transforming growth factor-β. Science 1987, 237:1333-1336
34. Beck LS, DeGuzman L, Lee WP, Xu Y, Siegel MW, Amento EP: One systemic administration of transforming growth factor-β1 reverses age- or glucocorticoid-impaired wound healing. J Clin Invest 1993, 92:2841-2849
35. Quaglino D, Nanney LB, Ditesheim JA, Davidson JM: Transforming growth factor-β stimulates extracellular matrix gene expression in pig skin: incisional wound model. J Invest Dermatol 1991, 97:34-42
36. Sporn MB, Roberts AB: A major advance in the use of growth factors to enhance wound healing. J Clin Invest 1993, 92:2565-2566
37. Kane CJM, Hebda PA, Mansbridge JN, Hanawalt PC: Direct evidence for spatial and temporal regulation of transforming growth factor β1 expression during cutaneous wound healing. J Cell Biol 1991, 148:157-173
38. Levine JH, Moses HL, Gold LI, Nanney LB: Spatial and temporal patterns of immunoreactive transforming growth factor β1, β2, and β3 during excisional wound repair. Am J Pathol 1993, 143:368-380
39. Barbul A: Immune aspects of wound repair. Clin Plast Surg 1990, 17:433-442
40. Leibovich SJ, Polverini PJ, Shepard HM, Wiseman DM, Shively V, Nureddin N: Macrophage-induced angiogenesis is mediated by tumor necrosis factor-α. Nature 1987, 329:630-632
41. Chojkier M, Fierer J: D-Galactosamine hepatotoxicity is associated with endotoxin-sensitivity and mediated by lymphoreticular cells in mice. Gastroenterology 1985, 88:115-121
42. Bettinger DA, Pellicane JV, Tarry WC, Yager DR, Diegelmann RF, Lee R, Cohen IK, DeMaria EJ: The role of inflammatory cytokines in wound healing: accelerated healing in endotoxin-resistant mice. J Trauma 1994, 36:810-814
43. Regan MC, Kirk SJ, Hurson M, Sodeyama M, Wasserkurg HL, Barbul A: Tumor necrosis factor-α inhibits in vivo collagen synthesis. Surgery 1993, 113:173-177
44. Piguet PF, Collart MA, Grau GE, Sappino AP, Vassalli P: Requirement of tumor necrosis factor for development of silica-induced pulmonary fibrosis. Nature 1990, 344: 245-247
45. Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassalli P: Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med 1989, 170:655-663
46. Miyazaki Y, Araki K, Vesin C, Garcia I, Kapanci Y, Whitsett JA, Piguet PF, Vassalli P: Expression of a tumor necrosis factor-α transgene in murine lung causes lymphocytic and fibrosing alveolitis: a mouse model of progressive pulmonary fibrosis. J Clin Invest 1995, 96:250-259
47. Dinarello CA, Cannon JG, Wolff SM, Bernheim HA, Beutler B, Cerami A, Figari IS, Palladino MA Jr, O'Connor JV: Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of IL-1. J Exp Med 1986, 163:1433-1450
48. Akira S, Hirano T, Taga T, Kishimoto T: Biology of multifunctional cytokines: IL-6 and related molecules (IL-1 and TNF). FASEB J 1990, 4:2860-2867
49. Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman G, Fiers W: Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J 1993, 12:3095-3104
50. Postlethwaite AE, Raghow R, Stricklin GP, Poppleton H, Seyer JM, Kang AH: Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 α and β. J Cell Biol 1988, 106:311-318
51. Border WA, Ruoslahti E: Transforming growth factor-β in disease: the dark side of tissue repair. J Clin Invest 1992, 90:1-7
52. Border WA, Noble NA: Transforming growth factor β in tissue fibrosis. N Engl J Med 1994, 331:1286-1292
53. Ignotz R, Endo T, Massagué J: Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-β. J Biol Chem 1987, 262:6443-6446
54. Varga J, Rosenbloom J, Jimenez SA: Transforming growth factor β (TGFβ) causes a persistent increase in steady state amount of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts. Biochem J 1987, 247:597-604
55. Rossi P, Karsenty G, Roberts AB, Roche NS, Sporn MS, de Crombrugghe B: Nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-β. Cell 1988, 52:405-414
56. Ritzenthaler JD, Goldstein RH, Fine A, Lichtler A, Rowe DW, Smith BD: Transforming-growth-factor-β activation elements in the distal promoter regions of the rat α1 type I collagen gene. Biochem J 1991, 280:157-162
57. Kähäri V-M, Chen YZ, Su MW, Ramirez F, Uitto J: Tumor necrosis factor-α and interferon-γ suppress the activation of human type I collagen gene expression by transforming growth factor-β1. J Clin Invest 1990, 86: 1489-1495