Blood BDNF level is gender specific in severe depression

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Kreinin, Anatoly ^a   Lisson, Serah ^b,c   Nesher, Elimelech ^b   Schneider, Jenny ^b   Bergman, Josef ^a   Farhat, Kamal ^c   Farah, Joseph ^c   Lejbkowicz, Flavio ^d,e   Yadid, Gal ^c   Raskin, Leon ^f   Koman, Igor ^b   Pinhasov, Albert ^b  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b ARIEL UNIVERSITY   (Israel)

^c BAR ILAN UNIVERSITY   (Israel)

^d CARMEL MEDICAL CENTER   (Israel)

^e CLALIT HEALTH SERVICES   (Israel)

^f VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ESCITALOPRAM; FLUOXETINE; PAROXETINE; VENLAFAXINE; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN;

ADULT; ARTICLE; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE COURSE; DISEASE SEVERITY; DRUG EFFICACY; DSM-IV; FEMALE; GENOTYPING TECHNIQUE; HAMILTON DEPRESSION RATING SCALE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PATHOGENESIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT DURATION; BLOOD; DEMOGRAPHY; DEPRESSIVE DISORDER, MAJOR; GENETICS; GENOTYPE; MIDDLE AGED; SEXUAL DEVELOPMENT;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; DEMOGRAPHY; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; SEX CHARACTERISTICS;

EID: 84956582573     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127643     Document Type: Article

References (64)

1. Kessler RC, Berglund P, Demler O, Jin R, Koretz D, Merikangas KR, et al. (2003) The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R). JAMA 289:3095-3105. PMID: 12813115
2. Ebmeier KP, Donaghey C, Steele JD (2006) Recent developments and current controversies in depression. Lancet 367:153-167. PMID: 16413879
3. Ferrari AJ, Charlson FJ, Norman RE, Patten SB, Freedman G, Murray CJ, et al. (2013) Burden of depressive disorders by country, sex, age, and year: findings from the global burden of disease study 2010. PLoSMed 10:e1001547. doi: 10.1371/journal.pmed.1001547 PMID: 24223526
4. American Psychiatric Association. (2000) Diagnostic criteria from DSM-IV-TR. Washington, D. C.: American Psychiatric Association. xii, 370 p. p.
5. Lesch KP (2004) Gene-environment interaction and the genetics of depression. J Psychiatry Neurosci 29:174-184. PMID: 15173894
6. Saveanu RV, Nemeroff CB (2012) Etiology of depression: genetic and environmental factors. Psychiatr Clin North Am 35:51-71. doi: 10.1016/j.psc.2011.12.001 PMID: 22370490
7. Subbarao A, Rhee SH, Young SE, Ehringer MA, Corley RP, Hewitt JK (2008) Common genetic and environmental influences on major depressive disorder and conduct disorder. J Abnorm Child Psychol 36:433-444. PMID: 17965930
8. Hamilton M (1960) A rating scale for depression. J Neurol Neurosurg Psychiatry 23:56-62. PMID: 14399272
9. Cusin C, Yang H, Yeung A, Fava M (2010) Rating scales for depression. In: Baer L, Blais MA, editors. Handbook of clinical rating scales and assessment in psychiatry and mental health (Current clinical psychiatry). New York: Humana Press. pp. 7-35.
10. Culpepper L (2011) Understanding the burden of depression. J Clin Psychiatry 72:e19. doi: 10.4088/JCP.10126tx1c PMID: 21733472
11. Mossner R, Mikova O, Koutsilieri E, Saoud M, Ehlis AC, Muller N, et al. (2007) Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J Biol Psychiatry 8:141-174. PMID: 17654407
12. Benton CS, Miller BH, Skwerer S, Suzuki O, Schultz LE, Cameron MD, et al. (2012) Evaluating genetic markers and neurobiochemical analytes forfluoxetine response using a panel of mouse inbred strains. Psychopharmacology (Berl) 221:297-315. doi: 10.1007/s00213-011-2574-z PMID: 22113448
13. Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, et al. (2007) Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression-a potential biomarker? Biol Psychiatry 62:47-54. PMID: 17123470
14. Reichenstein M, Rehavi M, Pinhasov A (2008) Involvement of pituitary adenylate cyclase activating polypeptide (PACAP) and its receptors in the mechanism of antidepressant action. J Mol Neurosci 36:330-338. doi: 10.1007/s12031-008-9116-0 PMID: 18592413
15. Levinson DF (2006) The genetics of depression: a review. Biol Psychiatry 60:84-92. PMID: 16300747
16. Bath KG, Lee FS (2006) Variant BDNF (Val66Met) impact on brain structure and function. Cogn Affect Behav Neurosci 6:79-85. PMID: 16869232
17. Brunoni AR, Lopes M, Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11:1169-1180. doi: 10.1017/S1461145708009309 PMID: 18752720
18. Sen S, Duman R, Sanacora G (2008) Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol Psychiatry 64:527-532. doi: 10.1016/j. biopsych.2008.05.005 PMID: 18571629
19. Gorski JA, Zeiler SR, Tamowski S, Jones KR (2003) Brain-derived neurotrophic factor is required for the maintenance of cortical dendrites. J Neurosci 23:6856-6865. PMID: 12890780
20. Lim JY, Park SI, Oh JH, Kim SM, Jeong CH, Jun. JA, et al. (2008) Brain-derived neurotrophic factor stimulates the neural differentiation of human umbilical cord blood-derived mesenchymal stem cells and survival of differentiated cells through MAPK/ERK and PI3K/Akt-dependent signaling pathways. J Neurosci Res 86:2168-2178. doi: 10.1002/jnr.21669 PMID: 18438930
21. Labelle C, Leclerc N (2000) Exogenous BDNF, NT-3 and NT-4 differentially regulate neurite outgrowth in cultured hippocampal neurons. Brain Res Dev Brain Res 123:1-11. PMID: 11020545
22. Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S (2010) Brain-derived neurotrophic factor and the development of structural neuronal connectivity. DevNeurobiol 70:271-288. doi: 10.1002/dneu.20774 PMID: 20186709
23. Lu B, Nagappan G, Guan X, Nathan PJ, Wren P (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases. Nat Rev Neurosci 14:401-416. doi: 10.1038/nrn3505 PMID: 23674053
24. Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, et al. (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants. Biol Psychiatry 54:70-75. PMID: 12842310
25. Molendijk ML, Bus BA, Spinhoven P, Penninx BW, Kenis G, Prickaerts J, et al. (2011) Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry 16:1088-1095. doi: 10.1038/mp. 2010.98 PMID: 20856249
26. Karlovic D, Serretti A, Jevtovic S, Vrkic N, Seric V, Peles AM (2013) Diagnostic accuracy of serum brain derived neurotrophic factor concentration in antidepressant naive patients with first major depression episode. J Psychiatr Res 47:162-167. doi: 10.1016/j.jpsychires.2012.09.017 PMID: 23102630
27. Ladea M, Bran M (2013) Brain derived neurotrophic factor (BDNF) levels in depressed women treated with open-label escitalopram. Psychiatr Danub 25:128-132. PMID: 23793276
28. Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T, et al. (2012) Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoSOne 7:e42676. doi: 10.1371/journal.pone.0042676 PMID: 22880079
29. Gonul AS, Akdeniz F, Taneli F, Donat O, Eker C, Vahip S (2005) Effect of treatment on serum brain-derived neurotrophic factor levels in depressed patients. Eur Arch Psychiatry Clin Neurosci 255:381-386. PMID: 15809771
30. Karege F, Bondolfi G, Gervasoni N, Schwald M, Aubry JM, Bertschy G (2005) Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry 57:1068-1072. PMID: 15860348
31. Jevtovic S, Karlovic D, Mihaljevic-Peles A, Seric V, Vrkic N, Jaksic N (2011) Serum Brain-derived neurotrophic factor (BDNF): the severity and symptomatic dimensions of depression. Psychiatr Danub 23:363-369. PMID: 22075737
32. Park YM, Lee BH, Um TH, Kim S (2014) Serum BDNF levels in relation to illness severity, suicide attempts, and central serotonin activity in patients with major depressive disorder: a pilot study. PLoS One 9:e91061. doi: 10.1371/journal.pone.0091061 PMID: 24663244
33. Tardito D, Perez J, Tiraboschi E, Musazzi L, Racagni G, Popoli M (2006) Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview. Pharmacol Rev 58:115-134. PMID: 16507885
34. Conti AC, Cryan JF, Dalvi A, Lucki I, Blendy JA (2002) cAMP response element-binding protein is essential for the upregulation of brain-derived neurotrophic factor transcription, but not the behavioral or endocrine responses to antidepressant drugs. J Neurosci 22:3262-3268. PMID: 11943827
35. Aydemir O, Deveci A, Taneli F (2005) The effect of chronic antidepressant treatment on serum brainderived neurotrophic factor levels in depressed patients: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry 29:261-265. PMID: 15694233
36. Cattaneo A, Bocchio-Chiavetto L, Zanardini R, Milanesi E, Placentino A, Gennarelli M (2010) Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment. IntJ Neuropsychopharmacol 13:103-108. doi: 10.1017/S1461145709990812 PMID: 19835669
37. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37:1553-1561. PMID: 9886678
38. Taylor WD, Zuchner S, McQuoid DR, Steffens DC, Speer MC, Krishnan KR (2007) Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression. Am J Geriatr Psychiatry 15:850-857. PMID: 17911362
39. Hwang JP, Tsai SJ, Hong CJ, Yang CH, Lirng JF, Yang YM (2006) The Val66Met polymorphism of the brain-derived neurotrophic-factor gene is associated with geriatric depression. Neurobiol Aging 27:1834-1837. PMID: 16343697
40. Ribeiro L, Busnello JV, Cantor RM, Whelan F, Whittaker P, Deloukas P, et al. (2007) The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans. Neuroreport 18:1291-1293. PMID: 17632285
41. Oswald P, Del-Favero J, Massat I, Souery D, Claes S, Van Broeckhoven C, et al. (2005) No implication of brain-derived neurotrophic factor (BDNF) gene in unipolar affective disorder: evidence from Belgian first and replication patient-control studies. Eur Neuropsychopharmacol 15:491-495. PMID: 16139165
42. Surtees PG, Wainwright NW, Willis-Owen SA, Sandhu MS, Luben R, Day NE, et al. (2007) No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. J PsychiatrRes 41:404-409. PMID: 16497333
43. Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, et al. (2005) Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 58:307-314. PMID: 16005437
44. Hong CJ, Huo SJ, Yen FC, Tung CL, Pan GM, Tsai SJ (2003) Association study of a brain-derived neurotrophic-factor genetic polymorphism and mood disorders, age of onset and suicidal behavior. Neuropsychobiology 48:186-189. PMID: 14673216
45. Czira ME, Wersching H, Baune BT, Berger K (2012) Brain-derived neurotrophic factor gene polymorphisms, neurotransmitter levels, and depressive symptoms in an elderly population. Age (Dordr) 34:1529-1541. doi: 10.1007/s11357-011-9313-6 PMID: 21898033
46. Verhagen M, van der Meij A, van Deurzen PA, Janzing JG, Arias-Vasquez A, Buitelaar JK, et al. (2010) Meta-analysis of the BDNF Val66Met polymorphism in major depressive disorder: effects of gender and ethnicity. Mol Psychiatry 15:260-271. doi: 10.1038/mp. 2008.109 PMID: 18852698
47. Zou YF, Wang Y, Liu P, Feng XL, Wang BY, Zang TH, et al. (2010) Association of brain-derived neurotrophic factor genetic Val66Met polymorphism with severity of depression, efficacy of fluoxetine and its side effects in Chinese major depressive patients. Neuropsychobiology 61:71-78. doi: 10.1159/000265132 PMID: 20016225
48. Shimizu E, Hashimoto K, Iyo M (2004) Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet 126 B: 122-123. PMID: 15048661
49. Choi MJ, Kang RH, Lim SW, Oh KS, Lee MS (2006) Brain-derived neurotrophic factor gene polymorphism (Val66Met) and citalopram response in major depressive disorder. Brain Res 1118:176-182. PMID: 16979146
50. Lang UE, Hellweg R, Sander T, Gallinat J (2009) The Metallele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations. Mol Psychiatry 14:120-122. doi: 10.1038/mp. 2008.80 PMID: 19156154
51. de Azevedo Cardoso T, Mondin TC, Wiener CD, Marques MB, Fucolo Bde A, Pinheiro RT, et al. (2014) Neurotrophic factors, clinical features and gender differences in depression. Neurochem Res 39:1571-1578. doi: 10.1007/s11064-014-1349-4 PMID: 24899094
52. Aydemir C, Yalcin ES, Aksaray S, Kisa C, Yildirim SG, Uzbay T, et al. (2006) Brain-derived neurotrophic factor (BDNF) changes in the serum of depressed women. Prog Neuropsychopharmacol Biol Psychiatry 30:1256-1260. PMID: 16647794
53. Bus BA, Arias-Vasquez A, Franke B, Prickaerts J, de Graaf J, Voshaar RC (2012) Increase in serum brain-derived neurotrophic factor in metallele carriers of the BDNF Val66Met polymorphism is specific to males. Neuropsychobiology 65:183-187. doi: 10.1159/000336997 PMID: 22538247
54. Bijl RV, Ravelli A, van Zessen G (1998) Prevalence of psychiatric disorder in the general population: results of The Netherlands Mental Health Survey and Incidence Study (NEMESIS). Soc Psychiatry Psychiatr Epidemiol 33:587-595. PMID: 9857791
55. Karege F, Perret G, Bondolfi G, Schwald M, Bertschy G, Aubry JM (2002) Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res 109:143-148. PMID: 11927139
56. Dell'Osso L, Del Debbio A, Veltri A, Bianchi C, Roncaglia I, Carlini M, et al. (2010) Associations between brain-derived neurotrophic factor plasma levels and severity of the illness, recurrence and symptoms in depressed patients. Neuropsychobiology 62:207-212. doi: 10.1159/000319946 PMID: 20714169
57. Wolkowitz OM, Wolf J, Shelly W, Rosser R, Burke HM, Lerner GK, et al. (2011) Serum BDNF levels before treatment predict SSRI response in depression. Prog Neuropsychopharmacol Biol Psychiatry 35:1623-1630. doi: 10.1016/j.pnpbp. 2011.06.013 PMID: 21749907
58. Hasin DS, Goodwin RD, Stinson FS, Grant BF (2005) Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry 62:1097-1106. PMID: 16203955
59. Studd J, Panay N (2004) Hormones and depression in women. Climacteric 7:338-346. PMID: 15799605
60. Maier W, Gansicke M, Gater R, Rezaki M, Tiemens B, Urzua RF (1999) Gender differences in the prevalence of depression: a survey in primary care. J Affect Disord 53:241-252. PMID: 10404710
61. Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen MG, Placentino A, et al. (2010) Serum and plasma BDNF levels in major depression: a replication study and meta-analyses. World J Biol Psychiatry 11:763-773. doi: 10.3109/15622971003611319 PMID: 20334574
62. Basterzi AD, Yazici K, Aslan E, Delialioglu N, Tasdelen B, Tot AcarS, et al. (2009) Effects of fluoxetine and venlafaxine on serum brain derived neurotrophic factor levels in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 33:281-285. doi: 10.1016/j.pnpbp. 2008.11.016 PMID: 19110026
63. Lee HY, Kim YK (2008) Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants. Neuropsychobiology 57:194-199. doi: 10.1159/000149817 PMID: 18679038
64. Ristevska-Dimitrovska G, Shishkov R, Gerazova VP, Vujovik V, Stefanovski B, Novotni A, et al. (2013) Different serum BDNF levels in depression: results from BDNF studies in FYR Macedonia and Bulgaria. Psychiatr Danub 25:123-127. PMID: 23793275