Design, synthesis, biological evaluation, and docking study of acetylcholinesterase inhibitors: New acridone-1,2,4-oxadiazole-1,2,3-triazole hybrids

Chemical Biology and Drug Design

Volumn 86, Issue 6, 2015, Pages 1425-1432

  Mohammadi Khanaposhtani, Maryam ^a   Mahdavi, Mohammad ^b   Saeedi, Mina ^a   Sabourian, Reyhaneh ^b   Safavi, Maliheh ^c   Khanavi, Mahnaz ^b   Foroumadi, Alireza ^b   Shafiee, Abbas ^b   Akbarzadeh, Tahmineh ^a,b  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c IRANIAN RESEARCH ORGANIZATION FOR SCIENCE AND TECHNOLOGY IROST   (Iran)

Author keywords

acetylcholinesterase; acridone 1,2,4 oxadiazole 1,2,3 triazole; Alzheimer's disease; docking study

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 1,2,4 OXADIAZOLE DERIVATIVE; 10 ((1 ((3 (4 METHOXYPHENYL) 1,2,4 OXADIAZOL 5 YL)METHYL) 1H 1,2,3 TRIZOL 4 YL)METHYL)ACRIDIN 9(10H) ONE; ACETYLCHOLINESTERASE; ACRIDONE DERIVATIVE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; RIVASTIGMINE; UNCLASSIFIED DRUG; ANTIOXIDANT; SCAVENGER;

ANTIOXIDANT ACTIVITY; ARTICLE; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; IN VITRO STUDY; MOLECULAR DOCKING; OUTCOME ASSESSMENT; PRIORITY JOURNAL; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; HYDROGEN BOND; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ACETYLCHOLINESTERASE; ACRIDONES; ANTIOXIDANTS; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; DRUG DESIGN; FREE RADICAL SCAVENGERS; HUMANS; HYDROGEN BONDING; MOLECULAR DOCKING SIMULATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84956573428     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12609     Document Type: Article

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