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Volumn 81, Issue , 2014, Pages 237-244
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Synthesis and biological evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7- one derivatives as dual binding site acetylcholinesterase inhibitors
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Author keywords
Acetylcholinesterase; Alzheimer's disease; Docking; Inhibitors; Synthesis
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Indexed keywords
1,2,4 TRIAZINE DERIVATIVE;
6 (4 METHOXYBENZYL) 3 [2 [2( DIMETHYLAMINO) 2 OXOETHOXY]PHENYL]THIAZOLO[3,2,B] 1,2,4 TRIAZIN 7 ONE;
6 (4 METHOXYBENZYL) 3 [3 METHYL 4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL]THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
6 (4 METHOXYBENZYL) 3 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL]THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
6 (4 METHOXYBENZYL) 3 [4 [2 (DIETHYLAMINO)ETHOXY]PHENYL]THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
6 (4 METHOXYBENZYL) 3 [4 [2 (DIMETHYLAMINO)2 OXOETHOXY]PHENYL]THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
6 BENZYL 3 [2 (2 MORPHOLINOETHOXY)PHENYL] 7H THIAZOLO [3,2,B] 1,2,4 TRIAZIN 7 ONE;
6 BENZYL 3 [3 METHYL 4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
6 BENZYL 3 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
6 BENZYL 3 [4 [2 (DIMETHYLAMINO) 2 OXOETHOXY]PHENYL]THAIZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE;
7H THIAZOLO[3,2 B] 1,2,4 TRIAZIN 7 ONE DERIVATIVE;
CHOLINESTERASE;
CHOLINESTERASE INHIBITOR;
UNCLASSIFIED DRUG;
7H-THIAZOLO(3,2-B)-1,2,4-TRIAZIN-7-ONE;
ACETYLCHOLINESTERASE;
THIAZOLE DERIVATIVE;
TRIAZINE DERIVATIVE;
ARTICLE;
CATALYSIS;
CHOLINESTERASE INHIBITION;
COLORIMETRY;
DRUG PROTEIN BINDING;
DRUG SYNTHESIS;
IN VITRO STUDY;
MOLECULAR DOCKING;
BINDING SITE;
CHEMICAL STRUCTURE;
CHEMISTRY;
DOSE RESPONSE;
DRUG EFFECTS;
HUMAN;
METABOLISM;
STRUCTURE ACTIVITY RELATION;
SYNTHESIS;
ACETYLCHOLINESTERASE;
BINDING SITES;
CHOLINESTERASE INHIBITORS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
HUMANS;
MODELS, MOLECULAR;
MOLECULAR STRUCTURE;
STRUCTURE-ACTIVITY RELATIONSHIP;
THIAZOLES;
TRIAZINES;
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EID: 84901056032
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2014.05.020 Document Type: Article |
Times cited : (37)
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References (14)
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