메뉴 건너뛰기




Volumn 7, Issue , 2016, Pages

Bcl-xL promotes metastasis independent of its anti-apoptotic activity

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; TRANSFORMING GROWTH FACTOR BETA; PROTEIN BCL X;

EID: 84955609337     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms10384     Document Type: Article
Times cited : (74)

References (57)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011).
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0032877668 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in cancer
    • Reed, J. C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 17, 2941-2953 (1999).
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2941-2953
    • Reed, J.C.1
  • 3
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax
    • Yin, X. M., Oltvai, Z. N. & Korsmeyer, S. J. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369, 321-323 (1994).
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.N.2    Korsmeyer, S.J.3
  • 4
    • 79953719297 scopus 로고    scopus 로고
    • A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
    • Placzek, W. J. et al. A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy. Cell Death Dis. 1, e40 (2010).
    • (2010) Cell Death Dis , vol.1 , pp. e40
    • Placzek, W.J.1
  • 5
    • 84865736998 scopus 로고    scopus 로고
    • Targeting the B-cell lymphoma/leukemia 2 family in cancer
    • Davids, M. S. & Letai, A. Targeting the B-cell lymphoma/leukemia 2 family in cancer. J. Clin. Oncol. 30, 3127-3135 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 3127-3135
    • Davids, M.S.1    Letai, A.2
  • 6
    • 84856879033 scopus 로고    scopus 로고
    • From mitochondrial biology to magic bullet: Navitoclax disarms BCL-2 in chronic lymphocytic leukemia
    • Walensky, L. D. From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia. J. Clin. Oncol. 30, 554-557 (2012).
    • (2012) J. Clin. Oncol. , vol.30 , pp. 554-557
    • Walensky, L.D.1
  • 7
    • 37549048249 scopus 로고    scopus 로고
    • The BCL-2 protein family: Opposing activities that mediate cell death
    • Youle, R. J. & Strasser, A. The BCL-2 protein family: opposing activities that mediate cell death. Nat. Rev. Mol. Cell Biol. 9, 47-59 (2008).
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 47-59
    • Youle, R.J.1    Strasser, A.2
  • 8
    • 65849378710 scopus 로고    scopus 로고
    • Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
    • Cragg, M. S., Harris, C., Strasser, A. & Scott, C. L. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat. Rev. Cancer 9, 321-326 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 321-326
    • Cragg, M.S.1    Harris, C.2    Strasser, A.3    Scott, C.L.4
  • 9
    • 28544443984 scopus 로고    scopus 로고
    • Promoting apoptosis as a strategy for cancer drug discovery
    • Fesik, S. W. Promoting apoptosis as a strategy for cancer drug discovery. Nat. Rev. Cancer 5, 876-885 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 876-885
    • Fesik, S.W.1
  • 10
    • 84875554051 scopus 로고    scopus 로고
    • Functions of BCL-xL at the interface between cell death and metabolism
    • Michels, J. et al. Functions of BCL-xL at the interface between cell death and metabolism. Int. J. Cell Biol. 2013, 705294 (2013).
    • (2013) Int. J. Cell Biol. , vol.2013 , pp. 705294
    • Michels, J.1
  • 12
    • 35648938726 scopus 로고    scopus 로고
    • Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion
    • Du, Y. C., Lewis, B. C., Hanahan, D. & Varmus, H. Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion. PLoS Biol. 5, e276 (2007).
    • (2007) PLoS Biol. , vol.5 , pp. e276
    • Du, Y.C.1    Lewis, B.C.2    Hanahan, D.3    Varmus, H.4
  • 13
    • 84887212503 scopus 로고    scopus 로고
    • Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer
    • Hager, J. H., Ulanet, D. B., Hennighausen, L. & Hanahan, D. Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer. PLoS ONE 4, e4455 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e4455
    • Hager, J.H.1    Ulanet, D.B.2    Hennighausen, L.3    Hanahan, D.4
  • 14
    • 84884854914 scopus 로고    scopus 로고
    • Beyond cell deathãantiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro
    • Koehler, B. C. et al. Beyond cell deathãantiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro. PLoS ONE 8, e76446 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e76446
    • Koehler, B.C.1
  • 15
    • 77954163242 scopus 로고    scopus 로고
    • Bcl-XL and STAT3 mediate malignant actions of gammairradiation in lung cancer cells
    • Ho, J. N. et al. Bcl-XL and STAT3 mediate malignant actions of gammairradiation in lung cancer cells. Cancer Sci. 101, 1417-1423 (2010).
    • (2010) Cancer Sci. , vol.101 , pp. 1417-1423
    • Ho, J.N.1
  • 16
    • 33745197969 scopus 로고    scopus 로고
    • BCL-xL: Time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells
    • Weiler, M. et al. BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells. Cell Death Differ. 13, 1156-1169 (2006).
    • (2006) Cell Death Differ. , vol.13 , pp. 1156-1169
    • Weiler, M.1
  • 17
    • 4544276651 scopus 로고    scopus 로고
    • Overexpression of Bcl-xL in human breast cancer cells enhances organ-selective lymph node metastasis
    • Espana, L. et al. Overexpression of Bcl-xL in human breast cancer cells enhances organ-selective lymph node metastasis. Breast Cancer Res. Treat. 87, 33-44 (2004).
    • (2004) Breast Cancer Res. Treat. , vol.87 , pp. 33-44
    • Espana, L.1
  • 18
    • 0033625203 scopus 로고    scopus 로고
    • Bcl-xL promotes metastasis of breast cancer cells by induction of cytokines resistance
    • Fernandez, Y., Espana, L., Manas, S., Fabra, A. & Sierra, A. Bcl-xL promotes metastasis of breast cancer cells by induction of cytokines resistance. Cell Death Differ. 7, 350-359 (2000).
    • (2000) Cell Death Differ. , vol.7 , pp. 350-359
    • Fernandez, Y.1    Espana, L.2    Manas, S.3    Fabra, A.4    Sierra, A.5
  • 19
    • 3042623408 scopus 로고    scopus 로고
    • A cytoskeleton-based functional genetic screen identifies BclxL as an enhancer of metastasis, but not primary tumor growth
    • Martin, S. S. et al. A cytoskeleton-based functional genetic screen identifies BclxL as an enhancer of metastasis, but not primary tumor growth. Oncogene 23, 4641-4645 (2004).
    • (2004) Oncogene , vol.23 , pp. 4641-4645
    • Martin, S.S.1
  • 20
    • 0035016397 scopus 로고    scopus 로고
    • Metastatic behavior of human breast carcinomas overexpressing the Bcl-x(L) gene: A role in dormancy and organospecificity
    • Rubio, N., Espana, L., Fernandez, Y., Blanco, J. & Sierra, A. Metastatic behavior of human breast carcinomas overexpressing the Bcl-x(L) gene: a role in dormancy and organospecificity. Lab. Invest. 81, 725-734 (2001).
    • (2001) Lab. Invest. , vol.81 , pp. 725-734
    • Rubio, N.1    Espana, L.2    Fernandez, Y.3    Blanco, J.4    Sierra, A.5
  • 21
    • 0030805125 scopus 로고    scopus 로고
    • Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases
    • Olopade, O. I. et al. Overexpression of BCL-x protein in primary breast cancer is associated with high tumor grade and nodal metastases. Cancer J. Sci. Am. 3, 230-237 (1997).
    • (1997) Cancer J. Sci. Am. , vol.3 , pp. 230-237
    • Olopade, O.I.1
  • 22
    • 84920019403 scopus 로고    scopus 로고
    • Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation
    • Keitel, U. et al. Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget 5, 11778-11791 (2014).
    • (2014) Oncotarget , vol.5 , pp. 11778-11791
    • Keitel, U.1
  • 24
    • 0029097470 scopus 로고
    • Multiple Bcl-2 family members demonstrate selective dimerizations with Bax
    • Sedlak, T. W. et al. Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. Proc. Natl Acad. Sci. USA 92, 7834-7838 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 7834-7838
    • Sedlak, T.W.1
  • 25
    • 0032477721 scopus 로고    scopus 로고
    • Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice
    • Holland, E. C. & Varmus, H. E. Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice. Proc. Natl Acad. Sci. USA 95, 1218-1223 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 1218-1223
    • Holland, E.C.1    Varmus, H.E.2
  • 26
    • 77956826481 scopus 로고    scopus 로고
    • Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis
    • Toneff, M. J. et al. Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis. Neoplasia 12, 718-726 (2010).
    • (2010) Neoplasia , vol.12 , pp. 718-726
    • Toneff, M.J.1
  • 27
    • 80053631995 scopus 로고    scopus 로고
    • Receptor for hyaluronanmediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis
    • Du, Y. C., Chou, C. K., Klimstra, D. S. & Varmus, H. Receptor for hyaluronanmediated motility isoform B promotes liver metastasis in a mouse model of multistep tumorigenesis and a tail vein assay for metastasis. Proc. Natl Acad. Sci. USA 108, 16753-16758 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 16753-16758
    • Du, Y.C.1    Chou, C.K.2    Klimstra, D.S.3    Varmus, H.4
  • 28
    • 0025861592 scopus 로고
    • Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth
    • Evers, B. M. et al. Establishment and characterization of a human carcinoid in nude mice and effect of various agents on tumor growth. Gastroenterology 101, 303-311 (1991).
    • (1991) Gastroenterology , vol.101 , pp. 303-311
    • Evers, B.M.1
  • 29
    • 2442562277 scopus 로고    scopus 로고
    • A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging
    • Ponomarev, V. et al. A novel triple-modality reporter gene for whole-body fluorescent, bioluminescent, and nuclear noninvasive imaging. Eur. J. Nucl. Med. Mol. Imaging 31, 740-751 (2004).
    • (2004) Eur. J. Nucl. Med. Mol. Imaging , vol.31 , pp. 740-751
    • Ponomarev, V.1
  • 30
    • 84925310766 scopus 로고    scopus 로고
    • Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies
    • Yasmin, R. et al. Epigenetic regulation of inflammatory cytokines and associated genes in human malignancies. Mediators Inflamm. 2015, 201703 (2015).
    • (2015) Mediators Inflamm. , vol.2015 , pp. 201703
    • Yasmin, R.1
  • 31
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague, J. TGFbeta in cancer. Cell 134, 215-230 (2008).
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 32
    • 33748668261 scopus 로고    scopus 로고
    • Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line
    • Fiebig, A. A., Zhu, W., Hollerbach, C., Leber, B. & Andrews, D. W. Bcl-XL is qualitatively different from and ten times more effective than Bcl-2 when expressed in a breast cancer cell line. BMC Cancer 6, 213 (2006).
    • (2006) BMC Cancer , vol.6 , pp. 213
    • Fiebig, A.A.1    Zhu, W.2    Hollerbach, C.3    Leber, B.4    Andrews, D.W.5
  • 33
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cellsãan integrated concept of malignant tumour progression
    • Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cellsãan integrated concept of malignant tumour progression. Nat. Rev. Cancer 5, 744-749 (2005).
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 34
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak, K. & Weinberg, R. A. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer 9, 265-273 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 35
    • 0037948854 scopus 로고    scopus 로고
    • In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
    • Dontu, G. et al. In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 17, 1253-1270 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1253-1270
    • Dontu, G.1
  • 36
    • 48949119473 scopus 로고    scopus 로고
    • Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
    • Fillmore, C. M. & Kuperwasser, C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 10, R25 (2008).
    • (2008) Breast Cancer Res. , vol.10 , pp. R25
    • Fillmore, C.M.1    Kuperwasser, C.2
  • 37
    • 0027282044 scopus 로고
    • Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death
    • Boise, L. H. et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell 74, 597-608 (1993).
    • (1993) Cell , vol.74 , pp. 597-608
    • Boise, L.H.1
  • 38
    • 33751362668 scopus 로고    scopus 로고
    • Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma
    • Sanchez-Ceja, S. G. et al. Differential expression of STAT5 and Bcl-xL, and high expression of Neu and STAT3 in non-small-cell lung carcinoma. Lung Cancer 54, 163-168 (2006).
    • (2006) Lung Cancer , vol.54 , pp. 163-168
    • Sanchez-Ceja, S.G.1
  • 39
    • 0032758427 scopus 로고    scopus 로고
    • Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma
    • Soini, Y. et al. Apoptosis and expression of apoptosis regulating proteins bcl-2, mcl-1, bcl-X, and bax in malignant mesothelioma. Clin. Cancer Res. 5, 3508-3515 (1999).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3508-3515
    • Soini, Y.1
  • 40
    • 54349126441 scopus 로고    scopus 로고
    • Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells
    • Schulze-Bergkamen, H. et al. Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells. World J. Gastroenterol. 14, 3829-3840 (2008).
    • (2008) World J. Gastroenterol. , vol.14 , pp. 3829-3840
    • Schulze-Bergkamen, H.1
  • 41
    • 80855156718 scopus 로고    scopus 로고
    • Prognostic significance of Bcl-xL gene expression in human colorectal cancer
    • Jin-Song, Y. et al. Prognostic significance of Bcl-xL gene expression in human colorectal cancer. Acta Histochem. 113, 810-814 (2011).
    • (2011) Acta Histochem. , vol.113 , pp. 810-814
    • Jin-Song, Y.1
  • 42
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulators of the cellular life-or-death switch
    • Cory, S. & Adams, J. M. The Bcl2 family: regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2, 647-656 (2002).
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 43
    • 0032471711 scopus 로고    scopus 로고
    • Moderate activation of the apoptosis inhibitor bcl-xL worsens the prognosis in pancreatic cancer
    • Friess, H. et al. Moderate activation of the apoptosis inhibitor bcl-xL worsens the prognosis in pancreatic cancer. Ann. Surg. 228, 780-787 (1998).
    • (1998) Ann. Surg. , vol.228 , pp. 780-787
    • Friess, H.1
  • 44
    • 84857714411 scopus 로고    scopus 로고
    • Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors
    • Yachida, S. et al. Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am. J. Surg. Pathol. 36, 173-184 (2012).
    • (2012) Am. J. Surg. Pathol. , vol.36 , pp. 173-184
    • Yachida, S.1
  • 45
    • 17844403793 scopus 로고    scopus 로고
    • Bcl-XL protein levels determine apoptotic index in pancreatic carcinoma
    • Sharma, J. et al. Bcl-XL protein levels determine apoptotic index in pancreatic carcinoma. Pancreas 30, 337-342 (2005).
    • (2005) Pancreas , vol.30 , pp. 337-342
    • Sharma, J.1
  • 46
    • 20444486559 scopus 로고    scopus 로고
    • An inhibitor of Bcl-2 family proteins induces regression of solid tumours
    • Oltersdorf, T. et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature 435, 677-681 (2005).
    • (2005) Nature , vol.435 , pp. 677-681
    • Oltersdorf, T.1
  • 47
    • 79952291173 scopus 로고    scopus 로고
    • Phase i study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors
    • Gandhi, L. et al. Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors. J. Clin. Oncol. 29, 909-916 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , pp. 909-916
    • Gandhi, L.1
  • 48
    • 84861482216 scopus 로고    scopus 로고
    • Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer
    • Rudin, C. M. et al. Phase II study of single-agent navitoclax (ABT-263) and biomarker correlates in patients with relapsed small cell lung cancer. Clin. Cancer Res. 18, 3163-3169 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 3163-3169
    • Rudin, C.M.1
  • 49
    • 0034508217 scopus 로고    scopus 로고
    • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
    • Lindsten, T. et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389-1399 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 1389-1399
    • Lindsten, T.1
  • 50
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei, M. C. et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730 (2001).
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1
  • 51
    • 84865759481 scopus 로고    scopus 로고
    • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6
    • Tang, L. H. et al. Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. Clin. Cancer Res. 18, 4612-4620 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 4612-4620
    • Tang, L.H.1
  • 52
    • 25444479744 scopus 로고    scopus 로고
    • Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    • Kang, Y. et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl Acad. Sci. USA 102, 13909-13914 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 13909-13914
    • Kang, Y.1
  • 53
    • 70249112640 scopus 로고    scopus 로고
    • Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors
    • Du, Y. C., Klimstra, D. S. & Varmus, H. Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors. PLoS ONE 4, e6932 (2009).
    • (2009) PLoS ONE , vol.4 , pp. e6932
    • Du, Y.C.1    Klimstra, D.S.2    Varmus, H.3
  • 54
  • 55
    • 0029862497 scopus 로고    scopus 로고
    • A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes
    • Ory, D. S., Neugeboren, B. A. & Mulligan, R. C. A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes. Proc. Natl Acad. Sci. USA 93, 11400-11406 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 11400-11406
    • Ory, D.S.1    Neugeboren, B.A.2    Mulligan, R.C.3
  • 56
    • 0033756308 scopus 로고    scopus 로고
    • Chromatin association of human origin recognition complex cdc6, and minichromosome maintenance proteins during the cell cycle: Assembly of prereplication complexes in late mitosis
    • Mendez, J. & Stillman, B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell Biol. 20, 8602-8612 (2000).
    • (2000) Mol. Cell Biol. , vol.20 , pp. 8602-8612
    • Mendez, J.1    Stillman, B.2
  • 57
    • 11144277489 scopus 로고    scopus 로고
    • Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
    • Polo, J. M. et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat. Med. 10, 1329-1335 (2004).
    • (2004) Nat. Med. , vol.10 , pp. 1329-1335
    • Polo, J.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.