메뉴 건너뛰기




Volumn 4, Issue 4, 2014, Pages 153-164

Current challenges towards the development of a blood test for Parkinson's disease

Author keywords

Biomarkers; Blood; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BIOLOGICAL MARKER; DJ 1 PROTEIN; LEUCINE RICH REPEAT KINASE 2; MESSENGER RNA; PROTEIN SNCA; PROTEIN TYROSINE PHOSPHATASE 1B; RNA; UNCLASSIFIED DRUG;

EID: 84955566351     PISSN: None     EISSN: 20754418     Source Type: Journal    
DOI: 10.3390/diagnostics4040153     Document Type: Review
Times cited : (11)

References (58)
  • 1
    • 84911423174 scopus 로고    scopus 로고
    • The prevalence of parkinson's disease: A systematic review and meta-analysis
    • Pringsheim, T.; Jette, N.; Frolkis, A.; Steeves, T.D. The prevalence of parkinson's disease: A systematic review and meta-analysis. Mov. Disord. 2014, doi:10.1002/mds.25945.
    • (2014) Mov. Disord
    • Pringsheim, T.1    Jette, N.2    Frolkis, A.3    Steeves, T.D.4
  • 2
    • 84869109864 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiates parkinson-like neurodegeneration in nontransgenic mice
    • Luk, K.C.; Kehm, V.; Carroll, J.; Zhang, B.; O'Brien, P.; Trojanowski, J.Q.; Lee, V.M. Pathological alpha-synuclein transmission initiates parkinson-like neurodegeneration in nontransgenic mice. Science 2012, 338, 949-953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 3
    • 84873458538 scopus 로고    scopus 로고
    • Parkinson's disease and alpha synuclein: Is parkinson's disease a prion-like disorder? Mov
    • Olanow, C.W.; Brundin, P. Parkinson's disease and alpha synuclein: Is parkinson's disease a prion-like disorder? Mov. Disord. 2013, 28, 31-40.
    • (2013) Disord , vol.28 , pp. 31-40
    • Olanow, C.W.1    Brundin, P.2
  • 4
    • 84906306620 scopus 로고    scopus 로고
    • Slowing of neurodegeneration in parkinson's disease and huntington's disease: Future therapeutic perspectives
    • Schapira, A.H.; Olanow, C.W.; Greenamyre, J.T.; Bezard, E. Slowing of neurodegeneration in parkinson's disease and huntington's disease: Future therapeutic perspectives. Lancet 2014, 384, 545-555.
    • (2014) Lancet , vol.384 , pp. 545-555
    • Schapira, A.H.1    Olanow, C.W.2    Greenamyre, J.T.3    Bezard, E.4
  • 5
    • 84903521521 scopus 로고    scopus 로고
    • Genetics and genomics of parkinson's disease
    • Lin, M.K.; Farrer, M.J. Genetics and genomics of parkinson's disease. Genome Med. 2014, 6, 48.
    • (2014) Genome Med , vol.6 , pp. 48
    • Lin, M.K.1    Farrer, M.J.2
  • 8
    • 82655171636 scopus 로고    scopus 로고
    • Phosphorylated alpha-synuclein can be detected in blood plasma and is potentially a useful biomarker for parkinson's disease
    • Foulds, P.G.; Mitchell, J.D.; Parker, A.; Turner, R.; Green, G.; Diggle, P.; Hasegawa, M.; Taylor, M.; Mann, D.; Allsop, D. Phosphorylated alpha-synuclein can be detected in blood plasma and is potentially a useful biomarker for parkinson's disease. FASEB J. 2011, 25, 4127-4137.
    • (2011) FASEB J , vol.25 , pp. 4127-4137
    • Foulds, P.G.1    Mitchell, J.D.2    Parker, A.3    Turner, R.4    Green, G.5    Diggle, P.6    Hasegawa, M.7    Taylor, M.8    Mann, D.9    Allsop, D.10
  • 13
    • 84880218192 scopus 로고    scopus 로고
    • Measurement of LRRK2 and ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic parkinson's disease patients
    • Dzamko, N.; Chua, G.; Ranola, M.; Rowe, D.B.; Halliday, G.M. Measurement of LRRK2 and ser910/935 phosphorylated LRRK2 in peripheral blood mononuclear cells from idiopathic parkinson's disease patients. J. Parkinsons Dis. 2013, 3, 145-152.
    • (2013) J. Parkinsons Dis. , vol.3 , pp. 145-152
    • Dzamko, N.1    Chua, G.2    Ranola, M.3    Rowe, D.B.4    Halliday, G.M.5
  • 14
    • 84857498641 scopus 로고    scopus 로고
    • Diagnosis of parkinson's disease based on disease-specific autoantibody profiles in human sera
    • Han, M.; Nagele, E.; DeMarshall, C.; Acharya, N.; Nagele, R. Diagnosis of parkinson's disease based on disease-specific autoantibody profiles in human sera. PLoS One 2012, 7, e32383.
    • (2012) PLoS One , vol.7
    • Han, M.1    Nagele, E.2    DeMarshall, C.3    Acharya, N.4    Nagele, R.5
  • 16
    • 0030661630 scopus 로고    scopus 로고
    • High prevalence of vitamin d deficiency and reduced bone mass in parkinson's disease
    • Sato, Y.; Kikuyama, M.; Oizumi, K. High prevalence of vitamin d deficiency and reduced bone mass in parkinson's disease. Neurology 1997, 49, 1273-1278.
    • (1997) Neurology , vol.49 , pp. 1273-1278
    • Sato, Y.1    Kikuyama, M.2    Oizumi, K.3
  • 17
    • 81155162501 scopus 로고    scopus 로고
    • Alterations in glutathione S-transferase pi expression following exposure to mpp+ -induced oxidative stress in the blood of parkinson's disease patients
    • Korff, A.; Pfeiffer, B.; Smeyne, M.; Kocak, M.; Pfeiffer, R.F.; Smeyne, R.J. Alterations in glutathione S-transferase pi expression following exposure to mpp+ -induced oxidative stress in the blood of parkinson's disease patients. Parkinsonism Relat. Disord. 2011, 17, 765-768.
    • (2011) Parkinsonism Relat. Disord. , vol.17 , pp. 765-768
    • Korff, A.1    Pfeiffer, B.2    Smeyne, M.3    Kocak, M.4    Pfeiffer, R.F.5    Smeyne, R.J.6
  • 18
    • 84875243183 scopus 로고    scopus 로고
    • Parkinson's disease in the nuclear age of neuroinflammation
    • Nolan, Y.M.; Sullivan, A.M.; Toulouse, A. Parkinson's disease in the nuclear age of neuroinflammation. Trends Mol. Med. 2013, 19, 187-196.
    • (2013) Trends Mol. Med. , vol.19 , pp. 187-196
    • Nolan, Y.M.1    Sullivan, A.M.2    Toulouse, A.3
  • 19
    • 84904104280 scopus 로고    scopus 로고
    • Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
    • Spielman, L.J.; Little, J.P.; Klegeris, A. Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration. J. Neuroimmunol. 2014, 273, 8-21.
    • (2014) J. Neuroimmunol. , vol.273 , pp. 8-21
    • Spielman, L.J.1    Little, J.P.2    Klegeris, A.3
  • 26
  • 27
    • 84865420939 scopus 로고    scopus 로고
    • Biosignatures for parkinson's disease and atypical parkinsonian disorders patients
    • Potashkin, J.A.; Santiago, J.A.; Ravina, B.M.; Watts, A.; Leontovich, A.A. Biosignatures for parkinson's disease and atypical parkinsonian disorders patients. PLoS One 2012, 7, e43595.
    • (2012) PLoS One , vol.7
    • Potashkin, J.A.1    Santiago, J.A.2    Ravina, B.M.3    Watts, A.4    Leontovich, A.A.5
  • 28
    • 84886389750 scopus 로고    scopus 로고
    • Specific splice variants are associated with parkinson's disease
    • Santiago, J.A.; Scherzer, C.R.; Potashkin, J.A. Specific splice variants are associated with parkinson's disease. Mov. Disord. 2013, 28, 1724-1727.
    • (2013) Mov. Disord. , vol.28 , pp. 1724-1727
    • Santiago, J.A.1    Scherzer, C.R.2    Potashkin, J.A.3
  • 29
    • 84860215577 scopus 로고    scopus 로고
    • Exon arrays reveal alternative splicing aberrations in parkinson's disease leukocytes
    • Soreq, L.; Bergman, H.; Israel, Z.; Soreq, H. Exon arrays reveal alternative splicing aberrations in parkinson's disease leukocytes. Neurodegener. Dis. 2012, 10, 203-206.
    • (2012) Neurodegener. Dis. , vol.10 , pp. 203-206
    • Soreq, L.1    Bergman, H.2    Israel, Z.3    Soreq, H.4
  • 30
    • 84897431152 scopus 로고    scopus 로고
    • Long non-coding rna and alternative splicing modulations in parkinson's leukocytes identified by RNA sequencing
    • Soreq, L.; Guffanti, A.; Salomonis, N.; Simchovitz, A.; Israel, Z.; Bergman, H.; Soreq, H. Long non-coding rna and alternative splicing modulations in parkinson's leukocytes identified by RNA sequencing. PLoS Comput. Biol. 2014, 10, e1003517.
    • (2014) PLoS Comput. Biol. , vol.10
    • Soreq, L.1    Guffanti, A.2    Salomonis, N.3    Simchovitz, A.4    Israel, Z.5    Bergman, H.6    Soreq, H.7
  • 31
    • 84915774442 scopus 로고    scopus 로고
    • A network approach to clinical intervention in neurodegenerative diseases
    • in press
    • Santiago, J.A.; Potashkin, J.A. A network approach to clinical intervention in neurodegenerative diseases. Trends Mol. Med. 2014, in press.
    • (2014) Trends Mol. Med
    • Santiago, J.A.1    Potashkin, J.A.2
  • 32
    • 84898059351 scopus 로고    scopus 로고
    • A network approach to diagnostic biomarkers in progressive supranuclear palsy
    • Santiago, J.A.; Potashkin, J.A. A network approach to diagnostic biomarkers in progressive supranuclear palsy. Mov. Disord. 2014, 29, 550-555.
    • (2014) Mov. Disord. , vol.29 , pp. 550-555
    • Santiago, J.A.1    Potashkin, J.A.2
  • 35
    • 84863625218 scopus 로고    scopus 로고
    • Clinical features of parkinson disease when onset of diabetes came first: A case-control study
    • Cereda, E.; Barichella, M.; Cassani, E.; Caccialanza, R.; Pezzoli, G. Clinical features of parkinson disease when onset of diabetes came first: A case-control study. Neurology 2012, 78, 1507-1511.
    • (2012) Neurology , vol.78 , pp. 1507-1511
    • Cereda, E.1    Barichella, M.2    Cassani, E.3    Caccialanza, R.4    Pezzoli, G.5
  • 37
    • 84862110832 scopus 로고    scopus 로고
    • Risk of parkinson disease onset in patients with diabetes: A 9-year population-based cohort study with age and sex stratifications
    • Sun, Y.; Chang, Y.H.; Chen, H.F.; Su, Y.H.; Su, H.F.; Li, C.Y. Risk of parkinson disease onset in patients with diabetes: A 9-year population-based cohort study with age and sex stratifications. Diabetes Care 2012, 35, 1047-1049.
    • (2012) Diabetes Care , vol.35 , pp. 1047-1049
    • Sun, Y.1    Chang, Y.H.2    Chen, H.F.3    Su, Y.H.4    Su, H.F.5    Li, C.Y.6
  • 38
    • 84875235515 scopus 로고    scopus 로고
    • Shared dysregulated pathways lead to parkinson's disease and diabetes
    • Santiago, J.A.; Potashkin, J.A. Shared dysregulated pathways lead to parkinson's disease and diabetes. Trends Mol. Med. 2013, 19, 176-186.
    • (2013) Trends Mol. Med. , vol.19 , pp. 176-186
    • Santiago, J.A.1    Potashkin, J.A.2
  • 39
    • 84864855869 scopus 로고    scopus 로고
    • Parkinson's disease, insulin resistance and novel agents of neuroprotection
    • Aviles-Olmos, I.; Limousin, P.; Lees, A.; Foltynie, T. Parkinson's disease, insulin resistance and novel agents of neuroprotection. Brain 2013, 136, 374-384.
    • (2013) Brain , vol.136 , pp. 374-384
    • Aviles-Olmos, I.1    Limousin, P.2    Lees, A.3    Foltynie, T.4
  • 40
    • 84909590793 scopus 로고    scopus 로고
    • System-based approaches to decode the molecular links in parkinson's disease and diabetes
    • in press
    • Santiago, J.A.; Potashkin, J.A. System-based approaches to decode the molecular links in parkinson's disease and diabetes. Neurobiol Dis 2014, in press.
    • (2014) Neurobiol Dis
    • Santiago, J.A.1    Potashkin, J.A.2
  • 41
    • 84893511983 scopus 로고    scopus 로고
    • Integrative network analysis unveils convergent molecular pathways in parkinson's disease and diabetes
    • Santiago, J.A.; Potashkin, J.A. Integrative network analysis unveils convergent molecular pathways in parkinson's disease and diabetes. PLoS One 2013, 8, e83940.
    • (2013) PLoS One , vol.8
    • Santiago, J.A.1    Potashkin, J.A.2
  • 42
    • 0035834076 scopus 로고    scopus 로고
    • Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking alzheimer's disease and parkinson's disease
    • Masliah, E.; Rockenstein, E.; Veinbergs, I.; Sagara, Y.; Mallory, M.; Hashimoto, M.; Mucke, L. Beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking alzheimer's disease and parkinson's disease. Proc. Natl. Acad. Sci. USA 2001, 98, 12245-12250.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12245-12250
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3    Sagara, Y.4    Mallory, M.5    Hashimoto, M.6    Mucke, L.7
  • 44
    • 84915744886 scopus 로고    scopus 로고
    • Network analysis identifies SOD2 mRNA as a potential biomarker for parkinson's disease
    • Santiago, J.A.; Scherzer, C.R.; Potashkin, J.A. Network analysis identifies SOD2 mRNA as a potential biomarker for parkinson's disease. PLoS One 2014, 9, e109042.
    • (2014) PLoS One , vol.9
    • Santiago, J.A.1    Scherzer, C.R.2    Potashkin, J.A.3
  • 46
    • 41249098565 scopus 로고    scopus 로고
    • RNA biomarkers of parkinson's disease: Developing tools for novel therapies
    • Hennecke, G.; Scherzer, C.R. RNA biomarkers of parkinson's disease: Developing tools for novel therapies. Biomark. Med. 2008, 2, 41-53.
    • (2008) Biomark. Med. , vol.2 , pp. 41-53
    • Hennecke, G.1    Scherzer, C.R.2
  • 48
    • 85161761871 scopus 로고    scopus 로고
    • Harvard neurodiscovery center, (accessed on 9 September 2014)
    • Harvard neurodiscovery center. Available online: http://www.neurodiscovery.harvard.edu/ research/biomarkers.html (accessed on 9 September 2014).
  • 49
    • 84902205572 scopus 로고    scopus 로고
    • Unrecognized vitamin D3 deficiency is common in parkinson disease: Harvard biomarker study
    • discussion 1666
    • Mehanna, R.; Scherzer, C.R.; Ding, H.; Locascio, J.J. Unrecognized vitamin D3 deficiency is common in parkinson disease: Harvard biomarker study. Neurology 2014, 82, 1666; discussion 1666.
    • (2014) Neurology , vol.82 , pp. 1666
    • Mehanna, R.1    Scherzer, C.R.2    Ding, H.3    Locascio, J.J.4
  • 50
    • 82755161902 scopus 로고    scopus 로고
    • The parkinson progression marker initiative (ppmi)
    • The parkinson progression marker initiative (ppmi). Prog. Neurobiol. 2011, 95, 629-635.
    • (2011) Prog. Neurobiol , vol.95 , pp. 629-635
  • 51
    • 85161740803 scopus 로고    scopus 로고
    • Parkinson's progression markers initiative, (accessed on 9 September 2014)
    • Parkinson's progression markers initiative. Available online: http://www.ppmi-info.org/ (accessed on 9 September 2014)
  • 53
    • 84859846991 scopus 로고    scopus 로고
    • Defining at-risk populations for parkinson's disease: Lessons from ongoing studies
    • Berg, D.; Marek, K.; Ross, G.W.; Poewe, W. Defining at-risk populations for parkinson's disease: Lessons from ongoing studies. Mov. Disord. 2012, 27, 656-665.
    • (2012) Mov. Disord. , vol.27 , pp. 656-665
    • Berg, D.1    Marek, K.2    Ross, G.W.3    Poewe, W.4
  • 54
    • 85161778482 scopus 로고    scopus 로고
    • Parkinson's associated risk study, (accessed on 9 September 2014)
    • Parkinson's associated risk study. Available online: http://www.parsinfosource.com/ (accessed on 9 September 2014).
  • 57
    • 84937965429 scopus 로고    scopus 로고
    • Is exenatide the next big thing in parkinson's disease?
    • Simuni, T.; Brundin, P. Is exenatide the next big thing in parkinson's disease? J. Parkinsons Dis. 2014, 4, 345-347.
    • (2014) J. Parkinsons Dis , vol.4 , pp. 345-347
    • Simuni, T.1    Brundin, P.2
  • 58
    • 84921309888 scopus 로고    scopus 로고
    • Thiazolidinediones under preclinical and early clinical development for the treatment of parkinson's disease
    • Carta, A.R.; Simuni, T. Thiazolidinediones under preclinical and early clinical development for the treatment of parkinson's disease. Expert Opin. Investig. Drugs 2014, doi:10.1517/ 13543784.2015.963195.
    • (2014) Expert Opin. Investig. Drugs
    • Carta, A.R.1    Simuni, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.