-
1
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, van der Brug M, Lopez A, Aparicio S, Gil AM, Khan N, Johnson J, Martinez JR, Nicholl D, Carrera IM, Pena AS, de SilvaR, Lees A, Marti-Masso JF, Perez-Tur J, Wood NW, & Singleton AB (2004) Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44, 595-600.
-
(2004)
Neuron
, vol.44
, pp. 595-600
-
-
Paisan-Ruiz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simon, J.5
Van Der Brug, M.6
Lopez, A.7
Aparicio, S.8
Gil, A.M.9
Khan, N.10
Johnson, J.11
Martinez, J.R.12
Nicholl, D.13
Carrera, I.M.14
Pena, A.S.15
De Silvar Lees, A.16
Marti-Masso, J.F.17
Perez-Tur, J.18
Wood, N.W.19
Singleton, A.B.20
more..
-
2
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, & Gasser T (2004) Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601-607.
-
(2004)
Neuron
, vol.44
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
Stoessl, A.J.11
Pfeiffer, R.F.12
Patenge, N.13
Carbajal, I.C.14
Vieregge, P.15
Asmus, F.16
Muller-Myhsok, B.17
Dickson, D.W.18
Meitinger, T.19
Strom, T.M.20
Wszolek, Z.K.21
Gasser, T.22
more..
-
3
-
-
42049122637
-
Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls
-
Paisan-Ruiz C, Nath P, Washecka N, Gibbs JR, & Singleton AB (2008) Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. Hum Mutat 29, 485-490.
-
(2008)
Hum Mutat
, vol.29
, pp. 485-490
-
-
Paisan-Ruiz, C.1
Nath, P.2
Washecka, N.3
Gibbs, J.R.4
Singleton, A.B.5
-
4
-
-
67749118059
-
LRRK2 gene variation and its contribution to Parkinson disease
-
Paisan-Ruiz C (2009) LRRK2 gene variation and its contribution to Parkinson disease. Hum Mutat 30, 1153-1160.
-
(2009)
Hum Mutat
, vol.30
, pp. 1153-1160
-
-
Paisan-Ruiz, C.1
-
5
-
-
28044460070
-
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
-
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, & Dawson TM (2005) Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad SciUS A 102, 16842-16847.
-
(2005)
Proc Natl Acad SciUS A
, vol.102
, pp. 16842-16847
-
-
West, A.B.1
Moore, D.J.2
Biskup, S.3
Bugayenko, A.4
Smith, W.W.5
Ross, C.A.6
Dawson, V.L.7
Dawson, T.M.8
-
6
-
-
34447118788
-
LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity
-
Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, & Alessi DR (2007) LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity. Biochem J 405, 307-317.
-
(2007)
Biochem J
, vol.405
, pp. 307-317
-
-
Jaleel, M.1
Nichols, R.J.2
Deak, M.3
Campbell, D.G.4
Gillardon, F.5
Knebel, A.6
Alessi, D.R.7
-
7
-
-
79952918505
-
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
-
Deng X, Dzamko N, Prescott A, Davies P, Liu Q, Yang Q, Lee JD, Patricelli MP, Nomanbhoy TK, Alessi DR, & Gray NS (2011) Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol 7, 203-205.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 203-205
-
-
Deng, X.1
Dzamko, N.2
Prescott, A.3
Davies, P.4
Liu, Q.5
Yang, Q.6
Lee, J.D.7
Patricelli, M.P.8
Nomanbhoy, T.K.9
Alessi, D.R.10
Gray, N.S.11
-
8
-
-
80054977424
-
Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate parkinson's disease-related toxicity in human neurons
-
Ramsden N, Perrin J, Ren Z, Lee BD, Zinn N, Dawson VL, Tam D, Bova M, Lang M, Drewes G, Bantscheff M, Bard F, Dawson TM, HopfC(2011) Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson's Disease-Related Toxicity in Human Neurons. ACS Chem Biol 6, 1021-1028.
-
(2011)
ACS Chem Biol
, vol.6
, pp. 1021-1028
-
-
Ramsden, N.1
Perrin, J.2
Ren, Z.3
Lee, B.D.4
Zinn, N.5
Dawson, V.L.6
Tam, D.7
Bova, M.8
Lang, M.9
Drewes, G.10
Bantscheff, M.11
Bard, F.12
Dawson, T.M.13
Hopf, C.14
-
9
-
-
34247468302
-
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
-
Lewis PA, Greggio E, Beilina A, Jain S, Baker A, & Cookson MR (2007) The R1441C mutation of LRRK2 disrupts GTP hydrolysis. Biochem Biophys Res Commun 357, 668-671.
-
(2007)
Biochem Biophys Res Commun
, vol.357
, pp. 668-671
-
-
Lewis, P.A.1
Greggio, E.2
Beilina, A.3
Jain, S.4
Baker, A.5
Cookson, M.R.6
-
10
-
-
34548621385
-
Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
-
Li X, Tan YC, Poulose S, Olanow CW, Huang XY, & Yue Z (2007) Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem 103, 238-247.
-
(2007)
J Neurochem
, vol.103
, pp. 238-247
-
-
Li, X.1
Tan, Y.C.2
Poulose, S.3
Olanow, C.W.4
Huang, X.Y.5
Yue, Z.6
-
11
-
-
78650685500
-
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
-
Daniels V, Vancraenenbroeck R, Law BM, Greggio E, Lobbestael E, Gao F, De Maeyer M, Cookson MR, Harvey K, Baekelandt V, & Taymans JM (2011) Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. J Neurochem 116, 304-315.
-
(2011)
J Neurochem
, vol.116
, pp. 304-315
-
-
Daniels, V.1
Vancraenenbroeck, R.2
Law, B.M.3
Greggio, E.4
Lobbestael, E.5
Gao, F.6
De Maeyer, M.7
Cookson, M.R.8
Harvey, K.9
Baekelandt, V.10
Taymans, J.M.11
-
12
-
-
77956674229
-
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
-
Nichols RJ, Dzamko N,Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, & Alessi DR (2010) 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J 430, 393-404.
-
(2010)
Biochem J
, vol.430
, pp. 393-404
-
-
Nichols, R.J.1
Dzamko, N.2
Morrice, N.A.3
Campbell, D.G.4
Deak, M.5
Ordureau, A.6
MacArtney, T.7
Tong, Y.8
Shen, J.9
Prescott, A.R.10
Alessi, D.R.11
-
13
-
-
79952302007
-
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease
-
Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, & Yue Z (2011) Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS One 6, e17153.
-
(2011)
PLoS One
, vol.6
-
-
Li, X.1
Wang, Q.J.2
Pan, N.3
Lee, S.4
Zhao, Y.5
Chait, B.T.6
Yue, Z.7
-
14
-
-
77956655427
-
Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization
-
Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ (2010) Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization. Biochem J 430, 405-413.
-
(2010)
Biochem J
, vol.430
, pp. 405-413
-
-
Dzamko, N.1
Deak, M.2
Hentati, F.3
Reith, A.D.4
Prescott, A.R.5
Alessi, D.R.6
Nichols, R.J.7
-
15
-
-
77950631558
-
Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2
-
Gloeckner CJ, Boldt K, von Zweydorf F, Helm S, Wiesent L, Sarioglu H, & Ueffing M (2010) Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2. J Proteome Res 9, 1738-1745.
-
(2010)
J Proteome Res
, vol.9
, pp. 1738-1745
-
-
Gloeckner, C.J.1
Boldt, K.2
Von Zweydorf, F.3
Helm, S.4
Wiesent, L.5
Sarioglu, H.6
Ueffing, M.7
-
16
-
-
78149473340
-
LRRK2 is involved in the IFN-gamma response and host response to pathogens
-
Gardet A, Benita Y, Li C, Sands BE, Ballester I, Stevens C, Korzenik JR, Rioux JD, Daly MJ, Xavier RJ, & Podolsky DK (2011) LRRK2 is involved in the IFN-gamma response and host response to pathogens. J Immunol 185, 5577-5585.
-
(2011)
J Immunol
, vol.185
, pp. 5577-5585
-
-
Gardet, A.1
Benita, Y.2
Li, C.3
Sands, B.E.4
Ballester, I.5
Stevens, C.6
Korzenik, J.R.7
Rioux, J.D.8
Daly, M.J.9
Xavier, R.J.10
Podolsky, D.K.11
-
17
-
-
79959575659
-
Regulation of LRRK2 expression points to a functional role in human monocyte maturation
-
Thevenet J, Pescini Gobert R, Hooft van Huijsduijnen R, Wiessner C,&Sagot YJ (2011) Regulation of LRRK2 expression points to a functional role in human monocyte maturation. PLoS One 6, e21519.
-
(2011)
PLoS One
, vol.6
-
-
Thevenet, J.1
Pescini Gobert, R.2
Hooft Van Huijsduijnen, R.3
Wiessner, C.4
Sagot, Y.J.5
-
18
-
-
79956199220
-
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
-
Hakimi M, Selvanantham T, Swinton E, Padmore RF, Tong Y, Kabbach G,Venderova K, Girardin SE, Bulman DE, Scherzer CR, LaVoie MJ, Gris D, Park DS, Angel JB, Shen J, Philpott DJ, & Schlossmacher MG (2011) Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm 118, 795-808.
-
(2011)
J Neural Transm
, vol.118
, pp. 795-808
-
-
Hakimi, M.1
Selvanantham, T.2
Swinton, E.3
Padmore, R.F.4
Tong, Y.5
Kabbach, G.6
Venderova, K.7
Girardin, S.E.8
Bulman, D.E.9
Scherzer, C.R.10
Lavoie, M.J.11
Gris, D.12
Park, D.S.13
Angel, J.B.14
Shen, J.15
Philpott, D.J.16
Schlossmacher, M.G.17
-
19
-
-
46749085399
-
Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism
-
Brodacki B, Staszewski J, Toczylowska B, Kozlowska E, Drela N, Chalimoniuk M, & Stepien A (2008) Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism. Neurosci Lett 441, 158-162.
-
(2008)
Neurosci Lett
, vol.441
, pp. 158-162
-
-
Brodacki, B.1
Staszewski, J.2
Toczylowska, B.3
Kozlowska, E.4
Drela, N.5
Chalimoniuk, M.6
Stepien, A.7
-
20
-
-
33947515418
-
Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons
-
Mount MP, Lira A, Grimes D, Smith PD, Faucher S, Slack R, Anisman H, Hayley S, & Park DS (2007) Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons. J Neurosci 27, 3328-3337.
-
(2007)
J Neurosci
, vol.27
, pp. 3328-3337
-
-
Mount, M.P.1
Lira, A.2
Grimes, D.3
Smith, P.D.4
Faucher, S.5
Slack, R.6
Anisman, H.7
Hayley, S.8
Park, D.S.9
-
21
-
-
84856632181
-
LRRK2 inhibition attenuates microglial inflammatory responses
-
Moehle MS, Webber PJ, Tse T, Sukar N, Standaert DG, DeSilva TM, Cowell RM, &West AB (2012) LRRK2 inhibition attenuates microglial inflammatory responses. J Neurosci 32, 1602-1611.
-
(2012)
J Neurosci
, vol.32
, pp. 1602-1611
-
-
Moehle, M.S.1
Webber, P.J.2
Tse, T.3
Sukar, N.4
Standaert, D.G.5
Desilva, T.M.6
Cowell, R.M.7
West, A.B.8
-
22
-
-
80054933395
-
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
-
Liu Z, Lee J, Krummey S, LuW, Cai H,&Lenardo MJ (2011) The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat Immunol 12, 1063-1070.
-
(2011)
Nat Immunol
, vol.12
, pp. 1063-1070
-
-
Liu, Z.1
Lee, J.2
Krummey, S.3
Lu, W.4
Cai, H.5
Lenardo, M.J.6
-
23
-
-
84862497413
-
The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling
-
Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray NS, Cohen P, Pedrioli P, Clark K, & Alessi DR (2012) The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling. Plos One 7, e39132.
-
(2012)
Plos One
, vol.7
-
-
Dzamko, N.1
Inesta-Vaquera, F.2
Zhang, J.3
Xie, C.4
Cai, H.5
Arthur, S.6
Tan, L.7
Choi, H.8
Gray, N.S.9
Cohen, P.10
Pedrioli, P.11
Clark, K.12
Alessi, D.R.13
-
24
-
-
0014082977
-
Parkinsonism: Onset, progression and mortality
-
Hoehn MM, Yahr MD (1967) Parkinsonism: Onset, progression and mortality. Neurology 17, 427-442.
-
(1967)
Neurology
, vol.17
, pp. 427-442
-
-
Hoehn, M.M.1
Yahr, M.D.2
-
25
-
-
61449165975
-
Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results
-
Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J,Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, & LaPelle N (2008) Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Mov Disord 23, 2129-2170.
-
(2008)
Mov Disord
, vol.23
, pp. 2129-2170
-
-
Goetz, C.G.1
Tilley, B.C.2
Shaftman, S.R.3
Stebbins, G.T.4
Fahn, S.5
Martinez-Martin, P.6
Poewe, W.7
Sampaio, C.8
Stern, M.B.9
Dodel, R.10
Dubois, B.11
Holloway, R.12
Jankovic, J.13
Kulisevsky, J.14
Lang, A.E.15
Lees, A.16
Leurgans, S.17
Lewitt, P.A.18
Nyenhuis, D.19
Olanow, C.W.20
Rascol, O.21
Schrag, A.22
Teresi, J.A.23
Van Hilten, J.J.24
Lapelle, N.25
more..
-
26
-
-
78349261173
-
Systematic review of levodopa dose equivalency reporting in Parkinson's disease
-
Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, & Clarke CE (2010) Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Mov Disord 25, 2649-2653.
-
(2010)
Mov Disord
, vol.25
, pp. 2649-2653
-
-
Tomlinson, C.L.1
Stowe, R.2
Patel, S.3
Rick, C.4
Gray, R.5
Clarke, C.E.6
-
27
-
-
84055190871
-
G2019S mutation of the leucine-rich repeat kinase 2 gene in a cohort of Egyptian patients with Parkinson's disease
-
Hashad DI, Abou-Zeid AA, Achmawy GA, Allah HM, & Saad MA (2011) G2019S mutation of the leucine-rich repeat kinase 2 gene in a cohort of Egyptian patients with Parkinson's disease. Genet Test Mol Biomarkers 15, 861-866.
-
(2011)
Genet Test Mol Biomarkers
, vol.15
, pp. 861-866
-
-
Hashad, D.I.1
Abou-Zeid, A.A.2
Achmawy, G.A.3
Allah, H.M.4
Saad, M.A.5
-
28
-
-
34347253600
-
Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease
-
HuangY, Halliday GM,Vandebona H, Mellick GD, Mastaglia F, Stevens J, Kwok J, Garlepp M, Silburn PA, Horne MK, Kotschet K, Venn A, Rowe DB, Rubio JP, & Sue CM (2007) Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's disease. Mov Disord 22, 982-989.
-
(2007)
Mov Disord
, vol.22
, pp. 982-989
-
-
Huang, Y.1
Halliday, G.M.2
Vandebona, H.3
Mellick, G.D.4
Mastaglia, F.5
Stevens, J.6
Kwok, J.7
Garlepp, M.8
Silburn, P.A.9
Horne, M.K.10
Kotschet, K.11
Venn, A.12
Rowe, D.B.13
Rubio, J.P.14
Sue, C.M.15
-
30
-
-
79952172335
-
LRRK2 mutant iPSC-derivedDAneurons demonstrate increased susceptibility to oxidative stress
-
Nguyen HN, Byers B, Cord B, Shcheglovitov A, Byrne J, Gujar P,KeeK, Schule B, Dolmetsch RE, LangstonW, Palmer TD,&Pera RR (2011) LRRK2 mutant iPSC-derivedDAneurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 8, 267-280.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 267-280
-
-
Nguyen, H.N.1
Byers, B.2
Cord, B.3
Shcheglovitov, A.4
Byrne, J.5
Gujar, P.6
Kee, K.7
Schule, B.8
Dolmetsch, R.E.9
Langston, W.10
Palmer, T.D.11
Pera, R.R.12
-
31
-
-
84863584524
-
Pharmacological rescue of mitochondrial deficits in iPSCderived neural cells from patients with familial Parkinson's disease
-
Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sunberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Tores E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Dalay L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM,Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, & Isacson O (2012) Pharmacological rescue of mitochondrial deficits in iPSCderived neural cells from patients with familial Parkinson's disease. Sci Transl Med 4, 141ra190.
-
(2012)
Sci Transl Med
, vol.4
-
-
Cooper, O.1
Seo, H.2
Andrabi, S.3
Guardia-Laguarta, C.4
Graziotto, J.5
Sunberg, M.6
McLean, J.R.7
Carrillo-Reid, L.8
Xie, Z.9
Osborn, T.10
Hargus, G.11
Deleidi, M.12
Lawson, T.13
Bogetofte, H.14
Perez-Tores, E.15
Clark, L.16
Moskowitz, C.17
Mazzulli, J.18
Chen, L.19
Volpicelli-Dalay, L.20
Romero, N.21
Jiang, H.22
Uitti, R.J.23
Huang, Z.24
Opala, G.25
Scarffe, L.A.26
Dawson, V.L.27
Klein, C.28
Feng, J.29
Ross, O.A.30
Trojanowski, J.Q.31
Lee, V.M.32
Marder, K.33
Surmeier, D.J.34
Wszolek, Z.K.35
Przedborski, S.36
Krainc, D.37
Dawson, T.M.38
Isacson, O.39
more..
-
32
-
-
84869877601
-
Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
-
Liu GH, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J, Esteban CR, Sancho-Martinez I, & Izpisua Belmonte JC (2012) Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 491, 603-607
-
(2012)
Nature
, vol.491
, pp. 603-607
-
-
Liu, G.H.1
Qu, J.2
Suzuki, K.3
Nivet, E.4
Li, M.5
Montserrat, N.6
Yi, F.7
Xu, X.8
Ruiz, S.9
Zhang, W.10
Wagner, U.11
Kim, A.12
Ren, B.13
Li, Y.14
Goebl, A.15
Kim, J.16
Soligalla, R.D.17
Dubova, I.18
Thompson, J.19
Yates, J.20
Esteban, C.R.21
Sancho-Martinez, I.22
Izpisua Belmonte, J.C.23
more..
-
33
-
-
84866384715
-
G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
-
Papkovskaia TD, Chau KY, Inesta-Vaquera F, Papkovsky DB, Healy DG, Nishio K, Staddon J, Duchen MR, Hardy J, Schapira AH, & Cooper JM (2012) G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization. Hum Mol Genet 21, 4201-4213.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 4201-4213
-
-
Papkovskaia, T.D.1
Chau, K.Y.2
Inesta-Vaquera, F.3
Papkovsky, D.B.4
Healy, D.G.5
Nishio, K.6
Staddon, J.7
Duchen, M.R.8
Hardy, J.9
Schapira, A.H.10
Cooper, J.M.11
-
34
-
-
84871581831
-
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
-
Yao C, Johnson WM, Gao Y, Wang W, Zhang J, Deak M, Alessi DR, Zhu X, Mieyal JJ, Roder H,Wilson-Delfosse AL, &Chen SG (2012) Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity. Hum Mol Genet 22, 328-344.
-
(2012)
Hum Mol Genet
, vol.22
, pp. 328-344
-
-
Yao, C.1
Johnson, W.M.2
Gao, Y.3
Wang, W.4
Zhang, J.5
Deak, M.6
Alessi, D.R.7
Zhu, X.8
Mieyal, J.J.9
Roder, H.10
Wilson-Delfosse, A.L.11
Chen, S.G.12
-
35
-
-
80053152848
-
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
-
Liu Z, Hamamichi S, Lee BD, Yang D, Ray A, Caldwell GA, Caldwell KA, Dawson TM, Smith WW, & Dawson VL (2011) Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models. Hum Mol Genet 20, 3933-3942.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3933-3942
-
-
Liu, Z.1
Hamamichi, S.2
Lee, B.D.3
Yang, D.4
Ray, A.5
Caldwell, G.A.6
Caldwell, K.A.7
Dawson, T.M.8
Smith, W.W.9
Dawson, V.L.10
-
36
-
-
33746267531
-
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
-
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, & Cookson MR (2006) Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol Dis 23, 329-341.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 329-341
-
-
Greggio, E.1
Jain, S.2
Kingsbury, A.3
Bandopadhyay, R.4
Lewis, P.5
Kaganovich, A.6
Van Der Brug, M.P.7
Beilina, A.8
Blackinton, J.9
Thomas, K.J.10
Ahmad, R.11
Miller, D.W.12
Kesavapany, S.13
Singleton, A.14
Lees, A.15
Harvey, R.J.16
Harvey, K.17
Cookson, M.R.18
-
37
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, Brant SR, Silverberg MS, Taylor KD, Barmada MM, Bitton A, Dassopoulos T, Datta LW, Green T, Griffiths AM, Kistner EO, Murtha MT, Regueiro MD, Rotter JI, Schumm LP, Steinhart AH, Targan SR, Xavier RJ, Libioulle C, Sandor C, Lathrop M, Belaiche J, Dewit O, Gut I, Heath S, Laukens D, Mni M, Rutgeerts P, Van Gossum A, Zelenika D, Franchimont D, Hugot JP, deVos M,Vermeire S, Louis E, Cardon LR, Anderson CA, Drummond H, Nimmo E, Ahmad T, Prescott NJ, Onnie CM, Fisher SA, Marchini J, Ghori J, Bumpstead S, Gwilliam R, Tremelling M, Deloukas P, Mansfield J, Jewell D, Satsangi J, Mathew CG, Parkes M, Georges M, & Daly MJ (2008) Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 40, 955-962.
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
Rioux, J.D.6
Brant, S.R.7
Silverberg, M.S.8
Taylor, K.D.9
Barmada, M.M.10
Bitton, A.11
Dassopoulos, T.12
Datta, L.W.13
Green, T.14
Griffiths, A.M.15
Kistner, E.O.16
Murtha, M.T.17
Regueiro, M.D.18
Rotter, J.I.19
Schumm, L.P.20
Steinhart, A.H.21
Targan, S.R.22
Xavier, R.J.23
Libioulle, C.24
Sandor, C.25
Lathrop, M.26
Belaiche, J.27
Dewit, O.28
Gut, I.29
Heath, S.30
Laukens, D.31
Mni, M.32
Rutgeerts, P.33
Van Gossum, A.34
Zelenika, D.35
Franchimont, D.36
Hugot, J.P.37
Devos, M.38
Vermeire, S.39
Louis, E.40
Cardon, L.R.41
Anderson, C.A.42
Drummond, H.43
Nimmo, E.44
Ahmad, T.45
Prescott, N.J.46
Onnie, C.M.47
Fisher, S.A.48
Marchini, J.49
Ghori, J.50
Bumpstead, S.51
Gwilliam, R.52
Tremelling, M.53
Deloukas, P.54
Mansfield, J.55
Jewell, D.56
Satsangi, J.57
Mathew, C.G.P.58
Arkes, M.59
Georges, M.60
Daly, M.J.61
more..
-
38
-
-
77952708864
-
Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients
-
Torkvist L, Halfvarson J, Ong RT, Lordal M, Sjoqvist U, Bresso F, Bjork J, Befrits R, Lofberg R, Blom J, Carlson M, Padyukov L, D'Amato, Seielstad M, & Pettersson S (2010) Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. Inflamm Bowel Dis 16, 907-909.
-
(2010)
Inflamm Bowel Dis
, vol.16
, pp. 907-909
-
-
Torkvist, L.1
Halfvarson, J.2
Ong, R.T.3
Lordal, M.4
Sjoqvist, U.5
Bresso, F.6
Bjork, J.7
Befrits, R.8
Lofberg, R.9
Blom, J.10
Carlson, M.11
Padyukov, L.12
D'Amato Seielstad, M.13
Pettersson, S.14
-
39
-
-
0036935553
-
An inflammatory review of Parkinson's disease
-
Orr CF, Rowe DB, & Halliday GM (2002) An inflammatory review of Parkinson's disease. Prog Neurobiol 68, 325-340.
-
(2002)
Prog Neurobiol
, vol.68
, pp. 325-340
-
-
Orr, C.F.1
Rowe, D.B.2
Halliday, G.M.3
-
40
-
-
84859107546
-
Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease
-
Collins LM, Toulouse A, Connor TJ, & Nolan YM (2012) Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease. Neuropharmacology 62, 2154-2168.
-
(2012)
Neuropharmacology
, vol.62
, pp. 2154-2168
-
-
Collins, L.M.1
Toulouse, A.2
Connor, T.J.3
Nolan, Y.M.4
-
41
-
-
67649404131
-
Blood monocytes: Development, heterogeneity, and relationship with dendritic cells
-
Auffray C, SiewekeMH,&Geissmann F (2009) Blood monocytes: Development, heterogeneity, and relationship with dendritic cells. Annu Rev Immunol 27, 669-692.
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 669-692
-
-
Auffray, C.1
Sieweke, M.H.2
Geissmann, F.3
|