Specific splice variants are associated with Parkinson's disease

Movement Disorders

Volumn 28, Issue 12, 2013, Pages 1724-1727

  Santiago, Jose A ^a   Scherzer, Clemens R ^b   Potashkin, Judith A ^a,b   Hyman, Bradley T ^b,c   Ivinson, Adrian J ^b,c   Trisini Lipsanopoulos, Ana ^b,c   Dhima, Kaltra ^b,c   Bayer, Stephen ^b,c   Lockhart, Kaitlin C ^b,c   Yi, Thomas ^b,c   Liao, Zhixiang ^b,c   Hoesing, Ashley N ^b,c   Duong, Karen ^b,c   Roderick, Sarah ^b,c   Sudarsky, Lewis R ^b,d   Hayes, Michael T ^b   Sperling, Reisa ^b,d   Growdon, John H ^b,d   Schwarzschild, Michael A ^b,d   Hung, Albert Y ^b,d   Flaherty, Alice W ^b,d   Blacker, Deborah ^b,d   Wills, Anne Marie ^b,d   Sohur, U Shivraj ^b,d   Unni, Vivek K ^b,d   Mejia, Nicte I ^b,d   Viswanathan, Anand ^b,d   Gomperts, Stephen N ^b,d   Khurana, Vikram ^b,d   Albers, Mark W ^b,d   Rudel, Rebecca K ^b,d   Locascio, Joseph J ^b,d   Selkoe, Dennis J ^b,d   Schlossmacher, Michael G ^b,e   Ascherio, Alberto ^b,f   more..

^a ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c The Harvard Center for Neurodegeneration & Repair   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF OTTAWA   (Canada)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Biomarker; Gene expression; Neurodegeneration; Parkinson's disease; Splicing

Indexed keywords

BIOLOGICAL MARKER;

ADULT; ARTICLE; BLOOD; BLOOD CELL; CLINICAL ARTICLE; FEMALE; GENE EXPRESSION; HUMAN; MALE; PARKINSON DISEASE; POPULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BIOMARKER; GENE EXPRESSION; NEURODEGENERATION; PARKINSON'S DISEASE; SPLICING;

AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; MALE; MIDDLE AGED; PARKINSON DISEASE; PROTEIN ISOFORMS;

EID: 84886389750     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.25635     Document Type: Article

References (12)

1. Scherzer CR, Eklund AC, Morse LJ, Liao Z, Locascio JJ, Fefer D, et al. Molecular markers of early Parkinson's disease based on gene expression in blood. Proc Natl Acad Sci U S A 2007;104:955-960.
2. Molochnikov L, Rabey JM, Dobronevsky E, et al. A molecular signature in blood identifies early Parkinson's disease. Mol Neurodegener 2012;7:26.
3. Soreq L, Bergman H, Israel Z, Soreq H. Exon arrays reveal alternative splicing aberrations in Parkinson's disease leukocytes. Neurodegener Dis 2012;10(1-4):203-206.
4. Potashkin JA, Santiago JA, Ravina BM, Watts A, Leontovich AA. Biosignatures for Parkinson's disease and atypical parkinsonian disorders patients. PloS One 2012;7:e43595.
5. Ding H, Sarokhan AK, Roderick SS, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Mov Disord 2011;26:2283-2286.
6. Warde-Farley D, Donaldson SL, Comes O, et al. The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res 2010;38:W214-W220.
7. Santiago JA, Potashkin JA. Shared dysregulated pathways lead to Parkinson's disease and diabetes. Trends Mol Med 2013;19:176-186.
8. Jaeschke A, Rincon M, Doran B, et al. Disruption of the Jnk2 (Mapk9) gene reduces destructive insulitis and diabetes in a mouse model of type I diabetes. Proc Natl Acad Sci U S A 2005;102:6931-6935.
9. Han MS, Jung DY, Morel C, et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 2013;339:218-222.
10. Chacko BK, Scott DW, Chandler RT, Patel RP. Endothelial surface N-glycans mediate monocyte adhesion and are targets for anti-inflammatory effects of peroxisome proliferator-activated receptor gamma ligands. J Biol Chem 2011;286:38738-38747.
11. Zheng B, Liao Z, Locascio JJ, et al. PGC- 1alpha, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med 2010;2:52ra73.
12. Schintu N, Frau L, Ibba M, et al. PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson's disease. Eur J Neurosci 2009;29:954-963.