Alterations in glutathione S-transferase pi expression following exposure to MPP +-induced oxidative stress in the blood of Parkinson's disease patients

Parkinsonism and Related Disorders

Volumn 17, Issue 10, 2011, Pages 765-768

  Korff, Ane ^a   Pfeiffer, Brenda ^b   Smeyne, Michelle ^a   Kocak, Mehmet ^a   Pfeiffer, Ronald F ^b   Smeyne, Richard Jay ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Biomarker; Glutathione S transferase; MPTP; Oxidative stress

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; AMANTADINE; APOMORPHINE; BIOLOGICAL MARKER; CARBIDOPA PLUS ENTACAPONE PLUS LEVODOPA; CARBIDOPA PLUS LEVODOPA; ENTACAPONE; GLUTATHIONE TRANSFERASE P1; LEVODOPA; PRAMIPEXOLE; RASAGILINE; ROPINIROLE; SELEGILINE; SERTRALINE;

ADULT; AGED; ARTICLE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE; EXPOSURE; FEMALE; HUMAN; HUMAN CELL; LEUKOCYTE; MALE; OXIDATIVE STRESS; PARKINSON DISEASE; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

1-METHYL-4-PHENYLPYRIDINIUM; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTES; FEMALE; GLUTATHIONE S-TRANSFERASE PI; HUMANS; LEUKOCYTES; MALE; MIDDLE AGED; OXIDATIVE STRESS; PARKINSON DISEASE;

EID: 81155162501     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2011.06.026     Document Type: Article

References (12)

1. Zhou C., Huang Y., Przedborski S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann N Y Acad Sci 2008, 1147:93-104.
2. Hayes J.D., Flanagan J.U., Jowsey I.R. Glutathione transferases. Annu Rev Pharmacol Toxicol 2005, 45:51-88.
3. Smeyne M., Boyd J., Raviie Shepherd K., Jiao Y., Pond B.B., Hatler M., et al. GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism. Proc Natl Acad Sci U S A 2007, 104:1977-1982.
4. Shi M., Bradner J., Bammler T.K., Eaton D.L., Zhang J., Ye Z., et al. Identification of glutathione S-transferase pi as a protein involved in Parkinson disease progression. Am J Pathol 2009, 175:54-65.
5. Wang T., Arifoglu P., Ronai Z., Tew K.D. Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus. J Biol Chem 2001, 276:20999-21003.
6. Boyd J.D., Jang H., Shepherd K.R., Faherty C., Slack S., Jiao Y., et al. Response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) differs in mouse strains and reveals a divergence in JNK signaling and COX-2 induction prior to loss of neurons in the substantia nigra pars compacta. Brain Res 2007, 1175:107-116.
7. Werner C.J., Heyny-von Haussen R., Mall G., Wolf S. Proteome analysis of human substantia nigra in Parkinson's disease. Proteome Sci 2008, 6:8.
8. Alberio T., Bossi A.M., Milli A., Parma E., Gariboldi M.B., Tosi G., et al. Proteomic analysis of dopamine and alpha-synuclein interplay in a cellular model of Parkinson's disease pathogenesis. FEBS J 2010, 277:4909-4919.
9. Whitworth A.J., Theodore D.A., Greene J.C., Benes H., Wes P.D., Pallanck L.J. Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease. Proc Natl Acad Sci U S A 2005, 102:8024-8029.
10. Golbe L.I., Di Iorio G., Markopoulou K., Athanassiadou A., Papapetropoulos S., Watts R.L., et al. Glutathione S-transferase polymorphisms and onset age in alpha-synuclein A53T mutant Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet 2007, 144:254-258.
11. Yanamandra K., Gruden M.A., Casaite V., Meskys R., Forsgren L., Morozova-Roche L.A. Alpha-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients. PLoS One 2011, 6. e18513.
12. Josefsson E., Bergquist J., Ekman R., Tarkowski A. Catecholamines are synthesized by mouse lymphocytes and regulate function of these cells by induction of apoptosis. Immunology 1996, 88:140-146.