Single-cell functional analysis of parathyroid adenomas reveals distinct classes of calcium sensing behaviour in primary hyperparathyroidism

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 2, 2016, Pages 351-359

  Koh, James ^a   Hogue, Joyce A ^a   Wang, Yuli ^b   Disalvo, Matthew ^b   Allbritton, Nancy L ^b   Shi, Yuhong ^c   Olson, John A ^c   Sosa, Julie A ^a,d  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d DUKE CLINICAL RESEARCH INSTITUTE   (United States)

Author keywords

Adenoma; Calcium; Hyperparathyroidism; Parathyroid; Single cell analysis

Indexed keywords

CALCIUM SENSING RECEPTOR; PARATHYROID HORMONE; CALCIUM;

ARTICLE; CALCIUM SENSING; CALCIUM TRANSPORT; CELL FUNCTION; CELL VIABILITY; CELLULAR, SUBCELLULAR AND MOLECULAR BIOLOGICAL PHENOMENA AND FUNCTIONS; CONTROLLED STUDY; EC50; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; MICROTECHNOLOGY; PARATHYROID ADENOMA; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; ADENOMA; CALCIUM SIGNALING; CELL LINE; METABOLISM; PARATHYROID TUMOR; PHYSIOLOGY; PROCEDURES; SINGLE CELL ANALYSIS;

ADENOMA; CALCIUM; CALCIUM SIGNALING; CELL LINE; HUMANS; HYPERPARATHYROIDISM, PRIMARY; PARATHYROID NEOPLASMS; RECEPTORS, CALCIUM-SENSING; SINGLE-CELL ANALYSIS;

EID: 84955562498     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12732     Document Type: Article

References (34)

1. Mackenzie-Feder J, Sirrs S, Anderson D, et al. Primary hyperparathyroidism: an overview. Int J Endocrinol. 2011; 2011: 251410.
2. Yeh MW, Ituarte PH, Zhou HC, et al. Incidence and prevalence of primary hyperparathyroidism in a racially mixed population. J Clin Endocrinol Metab. 2013; 98: 1122-9.
3. Wermers RA, Khosla S, Atkinson EJ, et al. Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993-2001: an update on the changing epidemiology of the disease. J Bone Miner Res. 2006; 21: 171-7.
4. Morris LF, Zelada J, Wu B, et al. Parathyroid surgery in the elderly. Oncologist. 2010; 15: 1273-84.
5. Wu B, Haigh PI, Hwang R, et al. Underutilization of parathyroidectomy in elderly patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 2010; 95: 4324-30.
6. Silverberg SJ, Lewiecki EM, Mosekilde L, et al. Presentation of asymptomatic primary hyperparathyroidism: proceedings of the third international workshop. J Clin Endocrinol Metab. 2009; 94: 351-65.
7. DeLellis RA, Mazzaglia P, Mangray S. Primary hyperparathyroidism: a current perspective. Arch Pathol Lab Med. 2008; 132: 1251-62.
8. Brown EM. Role of the calcium-sensing receptor in extracellular calcium homeostasis. Best Pract Res Clin Endocrinol Metab. 2013; 27: 333-43.
9. Brennan SC, Thiem U, Roth S, et al. Calcium sensing receptor signalling in physiology and cancer. Biochim Biophys Acta. 2013; 1833: 1732-44.
10. 2+-sensing receptor in primary and uremic secondary hyperparathyroidism. J Clin Endocrinol Metab. 1996; 81: 1598-606.
11. Farnebo F, Hoog A, Sandelin K, et al. Decreased expression of calcium-sensing receptor messenger ribonucleic acids in parathyroid adenomas. Surgery. 1998; 124: 1094-8; discussion 8-9.
12. Costa-Guda J, Arnold A. Genetic and epigenetic changes in sporadic endocrine tumors: parathyroid tumors. Mol Cell Endocrinol. 2014; 386: 46-54.
13. Cromer MK, Starker LF, Choi M, et al. Identification of somatic mutations in parathyroid tumors using whole-exome sequencing. J Clin Endocrinol Metab. 2012; 97: E1774-81.
14. Newey PJ, Nesbit MA, Rimmer AJ, et al. Whole-exome sequencing studies of nonhereditary (sporadic) parathyroid adenomas. J Clin Endocrinol Metab. 2012; 97: E1995-2005.
15. Koh J, Dar M, Untch BR, et al. Regulator of G-protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. Mol Endocrinol. 2011; 25: 867-76.
16. Silverberg SJ, Bone HG 3rd, Marriott TB, et al. Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism. N Engl J Med. 1997; 337: 1506-10.
17. Goodman WG, Hladik GA, Turner SA, et al. The Calcimimetic agent AMG 073 lowers plasma parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism. J Am Soc Nephrol. 2002; 13: 1017-24.
18. 2+ -sensing receptor. Mol Endocrinol. 2007; 21: 274-80.
19. Nesbit MA, Hannan FM, Howles SA, et al. Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3. Nat Genet. 2013; 45: 93-7.
20. Nesbit MA, Hannan FM, Howles SA, et al. Mutations affecting G-protein subunit alpha11 in hypercalcemia and hypocalcemia. N Engl J Med. 2013; 368: 2476-86.
21. Shi Y, Hogue J, Dixit D, et al. Functional and genetic studies of isolated cells from parathyroid tumors reveal the complex pathogenesis of parathyroid neoplasia. Proc Natl Acad Sci USA. 2014; 111: 3092-7.
22. Gach PC, Wang Y, Phillips C, et al. Isolation and manipulation of living adherent cells by micromolded magnetic rafts. Biomicrofluidics. 2011; 5: 032002-12.
23. Liu X, Ory V, Chapman S, et al. ROCK inhibitor and feeder cells induce the conditional reprogramming of epithelial cells. Am J Pathol. 2012; 180: 599-607.
24. Carneiro DM, Solorzano CC, Nader MC, et al. Comparison of intraoperative iPTH assay (QPTH) criteria in guiding parathyroidectomy: which criterion is the most accurate? Surgery. 2003; 134: 973-9; discussion 9-81.
25. Wang Y, Phillips CN, Herrera GS, et al. Array of biodegradable micro rafts for isolation and implantation of living, adherent cells. RSC Adv. 2013; 3: 9264-72.
26. Gach PC, Wang Y, Phillips C, et al. Isolation and manipulation of living adherent cells by micromolded magnetic rafts. Biomicrofluidics. 2011; 5: 32002-3200212.
27. Wang Y, Phillips C, Xu W, et al. Micromolded arrays for separation of adherent cells. Lab Chip. 2010; 10: 2917-24.
28. Bedard PL, Hansen AR, Ratain MJ, et al. Tumour heterogeneity in the clinic. Nature. 2013; 501: 355-64.
29. McGranahan N, Swanton C. Biological and therapeutic impact of intratumor heterogeneity in cancer evolution. Cancer Cell. 2015; 27: 15-26.
30. Meacham CE, Morrison SJ. Tumour heterogeneity and cancer cell plasticity. Nature. 2013; 501: 328-37.
31. Davey AE, Leach K, Valant C, et al. Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor. Endocrinology. 2012; 153: 1232-41.
32. Brennan SC, Mun HC, Leach K, et al. Receptor expression modulates calcium-sensing receptor mediated intracellular Ca(2+) mobilization. Endocrinology. 2015; 156: 1330-42.
33. Aggarwal A, Prinz-Wohlgenannt M, Tennakoon S, et al. The calcium-sensing receptor: a promising target for prevention of colorectal cancer. Biochim Biophys Acta. 2015; 1853: 2158-67.
34. Singh N, Promkan M, Liu G, et al. Role of calcium sensing receptor (CaSR) in tumorigenesis. Best Pract Res Clin Endocrinol Metab. 2013; 27: 455-63.