Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload

Journal of Molecular and Cellular Cardiology

Volumn 92, Issue , 2016, Pages 1-9

  Fu, Lianwu ^a,c   Wei, Chih Chang ^a,b   Powell, Pamela C ^a   Bradley, Wayne E ^b   Ahmad, Sarfaraz ^d   Ferrario, Carlos M ^d   Collawn, James F ^c   Dell'Italia, Louis J ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Cardiac fibroblast; Chymase; Intracellular procollagen; Volume overload

Indexed keywords

CELL PROTEIN; CHYMASE; DYNAMIN; MESSENGER RNA; PROCOLLAGEN; TYPE II MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTOCAVAL FISTULA; ARTICLE; AUTOPHAGY; CELL ISOLATION; CELL VACUOLE; COLLAGEN DEGRADATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME SYNTHESIS; HEART FIBROBLAST; HEART VENTRICLE OVERLOAD; IMMUNOCYTOCHEMISTRY; INTERNALIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; RNA SYNTHESIS; SHAM PROCEDURE; SPRAGUE DAWLEY RAT; ANIMAL; AORTA; BIOSYNTHESIS; BLOOD VESSEL FISTULA; CARDIAC MUSCLE; EXTRACELLULAR MATRIX; FIBROBLAST; GENETICS; HEART FAILURE; HUMAN; MAST CELL; METABOLISM; PATHOLOGY; PHAGOSOME; PROTEIN DEGRADATION;

ANIMALS; AORTA; ARTERIO-ARTERIAL FISTULA; AUTOPHAGY; CHYMASES; EXTRACELLULAR MATRIX; FIBROBLASTS; HEART FAILURE; HUMANS; MAST CELLS; MYOCARDIUM; PHAGOSOMES; PROCOLLAGEN; PROTEOLYSIS; RATS; RNA, MESSENGER;

EID: 84955514921     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2016.01.019     Document Type: Article

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