Clathrin pit-mediated endocytosis of neutrophil elastase and cathepsin G by cancer cells

Journal of Biological Chemistry

Volumn 287, Issue 42, 2012, Pages 35341-35350

  Gregory, Alyssa D ^a   Hales, Pamela ^a   Perlmutter, David H ^a   Houghton, A McGarry ^a,b,c  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER CELLS; CELL SURFACE RECEPTORS; CELL SURFACES; CHONDROITIN; CLATHRINS; DISSOCIATION CONSTANT; DYNAMIN; ELASTASE; ENDOSOMES; HEPARAN SULFATES; INTRACELLULAR SUBSTRATE; LUNG CANCER CELLS; PROTEOGLYCANS; SERINE PROTEINASE; SUBSTRATE SPECIFICITY; TUMOR CELLS;

AMINO ACIDS; DISSOCIATION; MOLECULAR BIOLOGY; SUBSTRATES; TUMORS;

CELL MEMBRANES;

CATHEPSIN G; CAVEOLIN 1; CELL SURFACE RECEPTOR; CHONDROITIN SULFATE; CLATHRIN; DYNAMIN; EARLY ENDOSOME ANTIGEN 1; FLOTILLIN 1; GLUCAN SYNTHASE; HEPARAN SULFATE; LEUKOCYTE ELASTASE; MYELOBLASTIN;

ARTICLE; BINDING COMPETITION; BINDING SITE; CANCER CELL; CELL PROLIFERATION; CELL SURFACE; CLATHRIN PIT MEDIATED ENDOCYTOSIS; CONTROLLED STUDY; DISSOCIATION CONSTANT; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; LUNG CANCER; PRIORITY JOURNAL;

ANIMALS; CATHEPSIN G; CAVEOLIN 1; CHO CELLS; CHONDROITIN SULFATES; CLATHRIN; COATED PITS, CELL-MEMBRANE; CRICETINAE; CRICETULUS; ENDOCYTOSIS; HUMANS; LEUKOCYTE ELASTASE; LUNG NEOPLASMS; NEOPLASM PROTEINS; PROTEIN BINDING; PROTEIN TRANSPORT;

EID: 84867407206     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.385617     Document Type: Article

References (30)

1. Baugh, R. J., and Travis, J. (1976) Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 15, 836-841
2. Belaaouaj, A., McCarthy, R., Baumann, M., Gao, Z., Ley, T. J., Abraham, S. N., and Shapiro, S. D. (1998) Mice lacking neutrophil elastase reveal impaired host defense against Gram-negative bacterial sepsis. Nat. Med. 4, 615-618 (Pubitemid 28237363)
3. Belaaouaj, A., Kim, K. S., and Shapiro, S. D. (2000) Degradation of outer membrane protein A in Escherichia coli killing by neutrophil elastase. Science 289, 1185-1188
4. Weinrauch, Y., Drujan, D., Shapiro, S. D., Weiss, J., and Zychlinsky, A. (2002) Neutrophil elastase targets virulence factors of enterobacteria. Nature 417, 91-94 (Pubitemid 34498822)
5. Gabay, J. E., Scott, R. W., Campanelli, D., Griffith, J., Wilde, C., Marra, M. N., Seeger, M., and Nathan, C. F. (1989) Antibiotic proteins of human polymorphonuclear leukocytes. Proc. Natl. Acad. Sci. U.S.A. 86, 5610-5614 (Pubitemid 19185594)
6. Lee, W. L., and Downey, G. P. (2001) Leukocyte elastase: physiological functions and role in acute lung injury. Am. J. Respir. Crit. Care Med. 164, 896-904 (Pubitemid 32881931)
7. Hedstrom, L. (2002) Serine protease mechanism and specificity. Chem. Rev. 102, 4501-4524
8. Lane, A. A., and Ley, T. J. (2003) Neutrophil elastase cleaves PML-RARα and is important for the development of acute promyelocytic leukemia in mice. Cell 115, 305-318 (Pubitemid 37487704)
9. Kohri, K., Ueki, I. F., and Nadel, J. A. (2002) Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am. J. Physiol. Lung Cell Mol. Physiol. 283, L531-540
10. Kaynar, A. M., Houghton, A. M., Lum, E. H., Pitt, B. R., and Shapiro, S. D. (2008) Neutrophil elastase is needed for neutrophil emigration into lungs in ventilator-induced lung injury. Am. J. Respir. Cell Mol. Biol. 39, 53-60 (Pubitemid 351883958)
11. Shapiro, S. D., Goldstein, N. M., Houghton, A. M., Kobayashi, D. K., Kelley, D., and Belaaouaj, A. (2003) Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am. J. Pathol. 163, 2329-2335 (Pubitemid 37466476)
12. Senior, R. M., Tegner, H., Kuhn, C., Ohlsson, K., Starcher, B. C., and Pierce, J. A. (1977) The induction of pulmonary emphysema with human leukocyte elastase. Am. Rev. Respir. Dis. 116, 469-475 (Pubitemid 8181304)
13. Liou, T. G., and Campbell, E. J. (1996) Quantum proteolysis resulting from release of single granules by human neutrophils: a novel, nonoxidative mechanism of extracellular proteolytic activity. J. Immunol. 157, 2624-2631 (Pubitemid 126450478)
14. Owen, C. A., Campbell, M. A., Sannes, P. L., Boukedes, S. S., and Campbell, E. J. (1995) Cell surface-bound elastase and cathepsin G on human neutrophils: a novel, nonoxidative mechanism by which neutrophils focus and preserve catalytic activity of serine proteinases. J. Cell Biol. 131, 775-789
15. Campbell, E. J., and Owen, C. A. (2007) The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G. J. Biol. Chem. 282, 14645-14654 (Pubitemid 47100453)
16. Houghton, A. M., Rzymkiewicz, D. M., Ji, H., Gregory, A. D., Egea, E. E., Metz, H. E., Stolz, D. B., Land, S. R., Marconcini, L. A., Kliment, C. R., Jenkins, K. M., Beaulieu, K. A., Mouded, M., Frank, S. J., Wong, K. K., and Shapiro, S. D. (2010) Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth. Nat. Med. 16, 219-223
17. Metz, H. E., and Houghton, A. M. (2011) Insulin receptor substrate regulation of phosphoinositide 3-kinase. Clin. Cancer Res. 17, 206-211
18. Mittendorf, E. A., Alatrash, G., Qiao, N., Wu, Y., Sukhumalchandra, P., St John, L. S., Philips, A. V., Xiao, H., Zhang, M., Ruisaard, K., Clise-Dwyer, K., Lu, S., and Molldrem, J. J. (2012) Breast cancer cell uptake of the inflammatory mediator neutrophil elastase triggers an anticancer adaptive immune response. Cancer Res. 72, 3153-3162
19. Esko, J. D., Stewart, T. E., and Taylor, W. H. (1985) Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc. Natl. Acad. Sci. U.S.A. 82, 3197-3201 (Pubitemid 15029573)
20. Eckhardt, M., Gotza, B., and Gerardy-Schahn, R. (1998) Mutants of the CMP-sialic acid transporter causing the Lec2 phenotype. J. Biol. Chem. 273, 20189-20195 (Pubitemid 28377579)
21. 1- antitrypsinelastase complexes and amyloid-β peptide. J. Clin. Invest. 90, 1150-1154
22. David, G., Bai, X. M., Van der Schueren, B., Cassiman, J. J., and Van den Berghe, H. (1992) Developmental changes in heparan sulfate expression: in situ detection with mAbs. J. Cell Biol. 119, 961-975
23. Rubino, M., Miaczynska, M., Lippé, R., and Zerial, M. (2000) Selective membrane recruitment of EEA-1 suggests a role in directional transport of clathrin-coated vesicles to early endosomes. J. Biol. Chem. 275, 3745-3748 (Pubitemid 30094593)
24. Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., and Kirchhausen, T. (2006) Dynasore, a cell-permeable inhibitor of dynamin. Dev. Cell 10, 839-850 (Pubitemid 43779110)
25. Nabi, I. R., and Le, P. U. (2003) Caveolae/raft-dependent endocytosis. J. Cell Biol. 161, 673-677 (Pubitemid 36648749)
26. McMahon, H. T., and Boucrot, E. (2011) Molecular mechanism and physiological functions of clathrin-mediated endocytosis. Nat. Rev. Mol. Cell Biol. 12, 517-533
27. Glebov, O. O., Bright, N. A., and Nichols, B. J. (2006) Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells. Nat. Cell Biol. 8, 46-54 (Pubitemid 43064796)
28. Buchholz, C. J., Koller, D., Devaux, P., Mumenthaler, C., Schneider-Schaulies, J., Braun, W., Gerlier, D., and Cattaneo, R. (1997) Mapping of the primary binding site of measles virus to its receptor CD46. J. Biol. Chem. 272, 22072-22079 (Pubitemid 27382833)
29. Erlenhoefer, C., Wurzer, W. J., Löffler, S., Schneider-Schaulies, S., ter Meulen, V., and Schneider-Schaulies, J. (2001) CD150 (SLAM) is a receptor for measles virus but is not involved in viral contact-mediated proliferation inhibition. J. Virol. 75, 4499-4505 (Pubitemid 32381492)
30. 1- antitrypsin-protease complexes is mediated by the serpin-enzyme complex (SEC) receptor. J. Biol. Chem. 265, 16713-16716