Polymeric nanoparticles for oral delivery of 5-fluorouracil: Formulation optimization, cytotoxicity assay and pre-clinical pharmacokinetics study

European Journal of Pharmaceutical Sciences

Volumn 84, Issue , 2016, Pages 83-91

  Mattos, Ana Cristina De ^a   Altmeyer, Clescila ^a   Tominaga, Tania Toyomi ^a   Khalil, Najeh Maissar ^b   Mainardes, Rubiana Mara ^b  

^a Universidade Estadual   (Brazil)

^b UNIVERSIDADE ESTADUAL DO CENTRO OESTE   (Brazil)

Author keywords

5 fluorouracil; Bioavailability; Cytotoxicity; Nanoparticles; Poly(lactic acid)

Indexed keywords

FLUOROURACIL; MACROGOL; NANOPARTICLE; POLYLACTIC ACID; ANTINEOPLASTIC ANTIMETABOLITE; DRUG CARRIER; MACROGOL DERIVATIVE; MONOMETHOXYPOLYETHYLENEGLYCOL-POLYLACTIDE BLOCK COPOLYMER; POLYESTER; POLYLACTIDE;

ADULT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DIFFUSION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; EXPERIMENTAL DESIGN; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS OPTIMIZATION; RAT; RELEASE ASSAY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION; TUMOR CELL; VOLUME OF DISTRIBUTION; ANIMAL; BLOOD; CELL SURVIVAL; DRUG EFFECTS; MEDICINAL CHEMISTRY; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; FLUOROURACIL; HUMANS; MALE; NANOPARTICLES; POLYESTERS; POLYETHYLENE GLYCOLS; RATS, WISTAR;

EID: 84955496186     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2016.01.012     Document Type: Article

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