메뉴 건너뛰기




Volumn 7, Issue 4, 1997, Pages 249-259

Mechanisms of action and modulation of fluorouracil

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLORO 2,4 DIHYDROXYPYRIDINE; 5 ETHYNYLURACIL; ANTINEOPLASTIC AGENT; CAPECITABINE; CISPLATIN; DOXIFLURIDINE; FLOXURIDINE; FLUOROURACIL; FOLINIC ACID; METHOTREXATE; OXONIC ACID; TEGAFUR; URACIL;

EID: 0030842931     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1053-4296(97)80023-9     Document Type: Article
Times cited : (37)

References (100)
  • 1
    • 33745464490 scopus 로고
    • Fluorinated pyrimidines: A new class of tumor, inhibitory compounds
    • Heidelberger C Chaudhuari NK Danenberg P Fluorinated pyrimidines: A new class of tumor, inhibitory compounds Nature 179 1957 663 666
    • (1957) Nature , vol.179 , pp. 663-666
    • Heidelberger, C1    Chaudhuari, NK2    Danenberg, P3
  • 2
    • 0002548405 scopus 로고    scopus 로고
    • 5-Fluoropyrimidines
    • Grem JL 5-Fluoropyrimidines Chabner BA Longo DL Cancer Chemotherapy and Biotherapy: Principles and Practice ed 2 1996 Lippincott Philadelphia, PA 149 211
    • (1996) , pp. 149-211
    • Grem, JL1
  • 3
    • 0027268254 scopus 로고
    • Transport of 5-fluorouracil and uracil into human erythrocytes
    • Domin BA Mabony WB Zimmerman TP Transport of 5-fluorouracil and uracil into human erythrocytes Biochem Pharmacol 46 1993 503 510
    • (1993) Biochem Pharmacol , vol.46 , pp. 503-510
    • Domin, BA1    Mabony, WB2    Zimmerman, TP3
  • 4
    • 0023667703 scopus 로고
    • Kinetics and thermodynamics of the interaction of 5-fluouro-2′-deoxy-uridylate and thymidylate synthase
    • Santi DV McHenry CS Raines RT Kinetics and thermodynamics of the interaction of 5-fluouro-2′-deoxy-uridylate and thymidylate synthase Biochemistry 26 1987 8606 8613
    • (1987) Biochemistry , vol.26 , pp. 8606-8613
    • Santi, DV1    McHenry, CS2    Raines, RT3
  • 5
    • 0023462477 scopus 로고
    • An overview of the current status and future directions of clinical trials of 5-fluorouracil and folinic acid
    • Grem JL Hoth D Hamilton MJ An overview of the current status and future directions of clinical trials of 5-fluorouracil and folinic acid Cancer Treat Rep 71 1987 1249 1264
    • (1987) Cancer Treat Rep , vol.71 , pp. 1249-1264
    • Grem, JL1    Hoth, D2    Hamilton, MJ3
  • 6
    • 0026721532 scopus 로고
    • For the Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by, leucovorin in patients with advancel, colorectal cancer: Evidence in terms of response rate
    • Piedbois P Buyse M Rustum Y For the Advanced Colorectal Cancer Meta-Analysis Project: Modulation of fluorouracil by, leucovorin in patients with advancel, colorectal cancer: Evidence in terms of response rate J Clin Oncol 10 1992 896
    • (1992) J Clin Oncol , vol.10 , pp. 896
    • Piedbois, P1    Buyse, M2    Rustum, Y3
  • 7
    • 0019807257 scopus 로고
    • 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity
    • Kufe DW Major PP 5-Fluorouracil incorporation into human breast carcinoma RNA correlates with cytotoxicity J Biol Chem 256 1981 9802 9805
    • (1981) J Biol Chem , vol.256 , pp. 9802-9805
    • Kufe, DW1    Major, PP2
  • 8
    • 0020070256 scopus 로고
    • Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture
    • Glazer RI Lloyd LS Association of cell lethality with incorporation of 5-fluorouracil and 5-fluorouridine into nuclear RNA in human colon carcinoma cells in culture Mol Pharmacol 21 1982 468 473
    • (1982) Mol Pharmacol , vol.21 , pp. 468-473
    • Glazer, RI1    Lloyd, LS2
  • 9
    • 0022618268 scopus 로고
    • The inhbitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro
    • Kanamaru R Kakuta H Sato T The inhbitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro Cancer Chemother Pharmacol 17 1986 43 46
    • (1986) Cancer Chemother Pharmacol , vol.17 , pp. 43-46
    • Kanamaru, R1    Kakuta, H2    Sato, T3
  • 10
    • 0024827539 scopus 로고
    • 5-fluorouracil inhibits dihydrofolate reductase precursor mRNa processing and/or nuclear mRNA stability in methotrexate-resistant KB cells
    • Will CL Dolnick BJ 5-fluorouracil inhibits dihydrofolate reductase precursor mRNa processing and/or nuclear mRNA stability in methotrexate-resistant KB cells J Biol Chem 264 1989 21413 21421
    • (1989) J Biol Chem , vol.264 , pp. 21413-21421
    • Will, CL1    Dolnick, BJ2
  • 11
    • 0022879423 scopus 로고
    • Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism
    • Armstrong RD Lewis M Stern SG Acute effect of 5-fluorouracil on cytoplasmic and nuclear dihydrofolate reductase messenger RNA metabolism J Biol Chem 261 1986 7366 7371
    • (1986) J Biol Chem , vol.261 , pp. 7366-7371
    • Armstrong, RD1    Lewis, M2    Stern, SG3
  • 12
    • 0027501771 scopus 로고
    • Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA
    • Takimoto CH Voeller DB Strong JM Effects of 5-fluorouracil substitution on the RNA conformation and in vitro translation of thymidylate synthase messenger RNA J Biol Chem 28 1993 21438 21442
    • (1993) J Biol Chem , vol.28 , pp. 21438-21442
    • Takimoto, CH1    Voeller, DB2    Strong, JM3
  • 13
    • 0025371661 scopus 로고
    • Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA
    • Danenberg PV Shea LCC Danenberg K Effect of 5-fluorouracil substitution on the self-splicing activity of Tetrahymena ribosomal RNA Cancer Res 50 1990 1757 1763
    • (1990) Cancer Res , vol.50 , pp. 1757-1763
    • Danenberg, PV1    Shea, LCC2    Danenberg, K3
  • 14
    • 0023667711 scopus 로고
    • Catalytic mechanism and inhibition of tRNA (uracil-5)methyltransferase: Evidence for covalent catalysis
    • Santi DV Hardy LW Catalytic mechanism and inhibition of tRNA (uracil-5)methyltransferase: Evidence for covalent catalysis Biochemistry 26 1987 8599 8606
    • (1987) Biochemistry , vol.26 , pp. 8599-8606
    • Santi, DV1    Hardy, LW2
  • 15
    • 0026008878 scopus 로고
    • Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil
    • Samuelsson T Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil Nucleic Acids Res 19 1991 6139 6144
    • (1991) Nucleic Acids Res , vol.19 , pp. 6139-6144
    • Samuelsson, T1
  • 16
    • 0030010220 scopus 로고    scopus 로고
    • 5-Fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells
    • Jin Y Heck DE DeGeorge G 5-Fluorouracil suppresses nitric oxide biosynthesis in colon carcinoma cells Cancer Res 56 1996 1978 1982
    • (1996) Cancer Res , vol.56 , pp. 1978-1982
    • Jin, Y1    Heck, DE2    DeGeorge, G3
  • 17
    • 0023929848 scopus 로고
    • 5-Fluorouracil substitution alters pre-mRNA splicing in vitro
    • Doong SL Dolnick BJ 5-Fluorouracil substitution alters pre-mRNA splicing in vitro J Biol Chem 263 1988 4467 4473
    • (1988) J Biol Chem , vol.263 , pp. 4467-4473
    • Doong, SL1    Dolnick, BJ2
  • 18
    • 0027197954 scopus 로고
    • Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine
    • Patton JR Ribonucleoprotein particle assembly and modification of U2 small nuclear RNA containing 5-fluorouridine Biochemistry 32 1993 8939 8944
    • (1993) Biochemistry , vol.32 , pp. 8939-8944
    • Patton, JR1
  • 19
    • 0027282216 scopus 로고
    • 5-Fluorouracil alters dihydrofolate, reductase pre-mRNA splicing as determined by quantitative polymerase chain reaction
    • Wu XP Dolnick BJ 5-Fluorouracil alters dihydrofolate, reductase pre-mRNA splicing as determined by quantitative polymerase chain reaction Mol Pharmacol 44 1993 22 29
    • (1993) Mol Pharmacol , vol.44 , pp. 22-29
    • Wu, XP1    Dolnick, BJ2
  • 20
    • 0027987215 scopus 로고
    • Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing
    • Lenz H-J Manno DJ Danenberg KD Incorporation of 5-fluorouracil into U2 and U6 snRNA inhibits mRNA precursor splicing J Biol Chem 269 1994 21962 31968
    • (1994) J Biol Chem , vol.269 , pp. 21962-31968
    • Lenz, H-J1    Manno, DJ2    Danenberg, KD3
  • 21
    • 0024532021 scopus 로고
    • Interaction of deoxyuridine with fluorouracid and dipyridamole in a human colon cancer cell line
    • Grem JL Mulcahy RT Miller EM Interaction of deoxyuridine with fluorouracid and dipyridamole in a human colon cancer cell line Biochem Pharmacol 38 1989 51 59
    • (1989) Biochem Pharmacol , vol.38 , pp. 51-59
    • Grem, JL1    Mulcahy, RT2    Miller, EM3
  • 22
    • 0025832444 scopus 로고
    • Mechanism of cell death following thymidylate synthase inhibition: 2′-deoxy-5′-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole
    • Curtin NJ Harris AL Aherne GW Mechanism of cell death following thymidylate synthase inhibition: 2′-deoxy-5′-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole Cancer Res 51 1991 2346 2352
    • (1991) Cancer Res , vol.51 , pp. 2346-2352
    • Curtin, NJ1    Harris, AL2    Aherne, GW3
  • 23
    • 0003267529 scopus 로고    scopus 로고
    • Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition: Effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukemia cells
    • Aherne GW Hardcastle A Raunaud F Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition: Effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukemia cells Biochem Pharmacol 51 1996 1293 1301
    • (1996) Biochem Pharmacol , vol.51 , pp. 1293-1301
    • Aherne, GW1    Hardcastle, A2    Raunaud, F3
  • 24
    • 0019947028 scopus 로고
    • 5-Fluorouracil incorporation in DNA of human breast carcinoma cells
    • Major PP Egan E Herrick D 5-Fluorouracil incorporation in DNA of human breast carcinoma cells Cancer Res 42 1982 3005 3009
    • (1982) Cancer Res , vol.42 , pp. 3005-3009
    • Major, PP1    Egan, E2    Herrick, D3
  • 25
    • 0021331040 scopus 로고
    • 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity
    • Schuetz JD Wallace HJ Diasio RB 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity Cancer Res 44 1984 1358 1363
    • (1984) Cancer Res , vol.44 , pp. 1358-1363
    • Schuetz, JD1    Wallace, HJ2    Diasio, RB3
  • 26
    • 0027482012 scopus 로고
    • Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate
    • Canman CE Lawrence TS Shewach DS Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate Cancer Res 53 1993 5219 5224
    • (1993) Cancer Res , vol.53 , pp. 5219-5224
    • Canman, CE1    Lawrence, TS2    Shewach, DS3
  • 27
    • 0027215502 scopus 로고
    • Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells
    • Mauro DJ De Riel JK Tallarida RJ Mechanisms of excision of 5-fluorouracil by uracil DNA glycosylase in normal human cells Mol Pharmacol 43 1993 854 857
    • (1993) Mol Pharmacol , vol.43 , pp. 854-857
    • Mauro, DJ1    De Riel, JK2    Tallarida, RJ3
  • 28
    • 0028982818 scopus 로고
    • Ratio of 2′-doexyadenosine-5′-triphosphate/thymidine-5′-triphosphate influences the commitment of human colon carcinoma cells to thymineless death
    • Houghton JA Tillman DM Harwood FG Ratio of 2′-doexyadenosine-5′-triphosphate/thymidine-5′-triphosphate influences the commitment of human colon carcinoma cells to thymineless death Clin Cancer Res 1 1995 723 730
    • (1995) Clin Cancer Res , vol.1 , pp. 723-730
    • Houghton, JA1    Tillman, DM2    Harwood, FG3
  • 29
    • 0023655202 scopus 로고
    • Deoxyribonucleoside triphosphate imbalance — fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death
    • Yoshioka A Tanaka S Hiraoka O Deoxyribonucleoside triphosphate imbalance — fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death J Biol Chem 262 1987 8235 8241
    • (1987) J Biol Chem , vol.262 , pp. 8235-8241
    • Yoshioka, A1    Tanaka, S2    Hiraoka, O3
  • 30
    • 0026081558 scopus 로고
    • Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: Relevance to cell growth inhibition
    • Yin M Rustum YM Comparative DNA strand breakage induced by FUra and FdUrd in human ileocecal adenocarcinoma (HCT-8) cells: Relevance to cell growth inhibition Cancer Commun 3 1991 45 51
    • (1991) Cancer Commun , vol.3 , pp. 45-51
    • Yin, M1    Rustum, YM2
  • 31
    • 0028051772 scopus 로고
    • The effect of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral clution
    • Jones S Willmore F Durkaca BW The effect of 5-fluoropyrimidines on nascent DNA synthesis in Chinese hamster ovary cells monitored by pH-step alkaline and neutral clution Carcinogenesis 15 1994 2435
    • (1994) Carcinogenesis , vol.15 , pp. 2435
    • Jones, S1    Willmore, F2    Durkaca, BW3
  • 32
    • 0028657658 scopus 로고
    • Enhanced cytotoxicity with interleuin-1α and 5-fluorouracil in HCT116 colon cancer cells
    • Geoffroy FJ Allegra CJ Sinha B Enhanced cytotoxicity with interleuin-1α and 5-fluorouracil in HCT116 colon cancer cells Oncol Res 6 1994 581 591
    • (1994) Oncol Res , vol.6 , pp. 581-591
    • Geoffroy, FJ1    Allegra, CJ2    Sinha, B3
  • 33
    • 0023678551 scopus 로고
    • A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells
    • Ayusawa D Arai H Wataya Y A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells Mutat Res 200 1988 221 230
    • (1988) Mutat Res , vol.200 , pp. 221-230
    • Ayusawa, D1    Arai, H2    Wataya, Y3
  • 34
    • 0026483281 scopus 로고
    • Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: Implications for mechanisms of resistance and cytotoxicity
    • Canman CE Tang H-Y Normolle DP Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: Implications for mechanisms of resistance and cytotoxicity Proc Natl Acad Sci USA 89 1992 10474 10478
    • (1992) , pp. 10474-10478
    • Canman, CE1    Tang, H-Y2    Normolle, DP3
  • 35
    • 0028064989 scopus 로고
    • Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine
    • Li Z-R Yin M-B Arredendo MA Down-regulation of c-myc gene expression with induction of high molecular weight DNA fragments by fluorodeoxyuridine Biochem Pharmacol 48 1994 327 334
    • (1994) Biochem Pharmacol , vol.48 , pp. 327-334
    • Li, Z-R1    Yin, M-B2    Arredendo, MA3
  • 36
    • 0027817576 scopus 로고
    • Locus of the interaction among 5-fluorouracil, leucovorin, and interferonα2a in colon carcinoma cells
    • Houghton JA Morton CL Adkins DA Locus of the interaction among 5-fluorouracil, leucovorin, and interferonα2a in colon carcinoma cells Cancer Res 53 1993 4243 4250
    • (1993) Cancer Res , vol.53 , pp. 4243-4250
    • Houghton, JA1    Morton, CL2    Adkins, DA3
  • 37
    • 0027451668 scopus 로고
    • p53-Dependent apoptosis modulates the cytotoxicity of anticancèr agents
    • Lowe SW Ruley HE Jacks T p53-Dependent apoptosis modulates the cytotoxicity of anticancèr agents Cell 74 1993 957 967
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, SW1    Ruley, HE2    Jacks, T3
  • 38
    • 0027279128 scopus 로고
    • Bcl-2 modulation, of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways
    • Fisher TC Milner AE Gregory CD Bcl-2 modulation, of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways Cancer Res 53 1993 3321 3326
    • (1993) Cancer Res , vol.53 , pp. 3321-3326
    • Fisher, TC1    Milner, AE2    Gregory, CD3
  • 39
    • 0029589690 scopus 로고
    • Differences in resistance to 5-fluorouracil as a function of cell cycle delay and not apoptosis
    • Pickard M Dive C Kinsella AR Differences in resistance to 5-fluorouracil as a function of cell cycle delay and not apoptosis Br J Cancer 72 1995 1389 1396
    • (1995) Br J Cancer , vol.72 , pp. 1389-1396
    • Pickard, M1    Dive, C2    Kinsella, AR3
  • 40
    • 0026637845 scopus 로고
    • Novel mechanisms of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules
    • Aschele C Sobrero A Faderan MA Novel mechanisms of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules Cancer Res 52 1992 1855 1864
    • (1992) Cancer Res , vol.52 , pp. 1855-1864
    • Aschele, C1    Sobrero, A2    Faderan, MA3
  • 41
    • 0031015454 scopus 로고    scopus 로고
    • Fluorouracil in colorectal cancer—a tale of two drugs: Implications for biochemical modulation
    • Sobrero AF Aschele C Bertino JB Fluorouracil in colorectal cancer—a tale of two drugs: Implications for biochemical modulation J Clin Oncol 15 1997 368 381
    • (1997) J Clin Oncol , vol.15 , pp. 368-381
    • Sobrero, AF1    Aschele, C2    Bertino, JB3
  • 42
    • 0029095796 scopus 로고
    • Quantitation of intratumoral thymidylate synthase expression predicts for response to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial
    • Leichman L Lenz H-J Leichman CG Quantitation of intratumoral thymidylate synthase expression predicts for response to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial Eur J Cancer 31A 1995 1306 1309
    • (1995) Eur J Cancer , vol.31A , pp. 1306-1309
    • Leichman, L1    Lenz, H-J2    Leichman, CG3
  • 43
    • 0001849087 scopus 로고
    • Thymidylate synthase protein expression: Association with response to neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma
    • Alexander HR Grem JL aiHamilton^JH Thymidylate synthase protein expression: Association with response to neoadjuvant chemotherapy and resection for locally advanced gastric and gastroesophageal adenocarcinoma Cancer J Sci Am 1 1995 49 54
    • (1995) Cancer J Sci Am , vol.1 , pp. 49-54
    • Alexander, HR1    Grem, JL aiHamilton^JH2
  • 44
    • 9044250848 scopus 로고    scopus 로고
    • Thymidylate synthase mRNA levels in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival
    • Lenz H-J Leichman CG Danenberg K Thymidylate synthase mRNA levels in adenocarcinoma of the stomach: A predictor for primary tumor response and overall survival J Clin Oncol 14 1996 176 182
    • (1996) J Clin Oncol , vol.14 , pp. 176-182
    • Lenz, H-J1    Leichman, CG2    Danenberg, K3
  • 45
    • 9044245305 scopus 로고    scopus 로고
    • ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer
    • Zalcberg J Cunningham D Van Cutsem E ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer J Clin Oncol 14 1996 716 721
    • (1996) J Clin Oncol , vol.14 , pp. 716-721
    • Zalcberg, J1    Cunningham, D2    Van Cutsem, E3
  • 46
    • 0025076221 scopus 로고
    • Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA
    • Chu E Lai G-M Zinn S Resistance of a human ovarian cancer line to 5-fluorouracil associated with decreased levels of 5-fluorouracil in DNA Mol Pharmacol 38 1990 410 417
    • (1990) Mol Pharmacol , vol.38 , pp. 410-417
    • Chu, E1    Lai, G-M2    Zinn, S3
  • 47
    • 0024578676 scopus 로고
    • Effect of polyglutamylation of 5,10-methylentetrahydrofolate on the binding of 5-fluoro-2-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft
    • Radparvar S Houghton PJ Houghton JA Effect of polyglutamylation of 5,10-methylentetrahydrofolate on the binding of 5-fluoro-2-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft Biochem Pharmacol 38 1989 335 342
    • (1989) Biochem Pharmacol , vol.38 , pp. 335-342
    • Radparvar, S1    Houghton, PJ2    Houghton, JA3
  • 48
    • 0027317751 scopus 로고
    • Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance
    • Wang F-S Aschele C Sobrero A Decreased folylpolyglutamate synthetase expression: A novel mechanism of fluorouracil resistance Cancer Res 53 1993 3677 3680
    • (1993) Cancer Res , vol.53 , pp. 3677-3680
    • Wang, F-S1    Aschele, C2    Sobrero, A3
  • 49
    • 0025307988 scopus 로고
    • Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase
    • Barbour KW Berger SH Berger FG Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase Mol Pharmacol 37 1990 515 518
    • (1990) Mol Pharmacol , vol.37 , pp. 515-518
    • Barbour, KW1    Berger, SH2    Berger, FG3
  • 50
    • 0022344622 scopus 로고
    • Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
    • Berger SH Jenh C-H Johnson LF Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells Mol Pharmacol 28 1985 461 467
    • (1985) Mol Pharmacol , vol.28 , pp. 461-467
    • Berger, SH1    Jenh, C-H2    Johnson, LF3
  • 51
    • 0026030052 scopus 로고
    • Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines
    • Chu E Drake JC Koeller DM Induction of thymidylate synthase associated with multidrug resistance in human breast and colon cancer cell lines Mol Pharmacol 139 1991 136 143
    • (1991) Mol Pharmacol , vol.139 , pp. 136-143
    • Chu, E1    Drake, JC2    Koeller, DM3
  • 52
    • 0025990937 scopus 로고
    • Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
    • Chu E Koeller DM Casey JL Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase Proc Natl Acad Sci USA 88 1991 8977 8981
    • (1991) , pp. 8977-8981
    • Chu, E1    Koeller, DM2    Casey, JL3
  • 53
    • 0024413739 scopus 로고
    • Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
    • Swain SM Lippman ME Chabner BA Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer J Clin Oncol 7 1989 890 899
    • (1989) J Clin Oncol , vol.7 , pp. 890-899
    • Swain, SM1    Lippman, ME2    Chabner, BA3
  • 54
    • 0023187085 scopus 로고
    • Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile
    • Heggie GD Sommadossi J-P Cross DS Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine, and bile Cancer Res 47 1987 2203 2206
    • (1987) Cancer Res , vol.47 , pp. 2203-2206
    • Heggie, GD1    Sommadossi, J-P2    Cross, DS3
  • 55
    • 0024262909 scopus 로고
    • Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule
    • Van Groenigen CJ Pinedo HM Heddes J Pharmacokinetics of 5-fluorouracil assessed with a sensitive mass spectrometric method in patients on a dose escalation schedule Cancer Res 48 1988 6956 6961
    • (1988) Cancer Res , vol.48 , pp. 6956-6961
    • Van Groenigen, CJ1    Pinedo, HM2    Heddes, J3
  • 56
    • 0025949491 scopus 로고
    • A pilot study of interferon alfa-2a in combination with 5-fluorouracil and plus high-dose leucovorin in metastatic gastrointestinal carcinoma
    • Grem JL McAtee N Steinberg S A pilot study of interferon alfa-2a in combination with 5-fluorouracil and plus high-dose leucovorin in metastatic gastrointestinal carcinoma J Clin Oncol 9 1991 1811 1820
    • (1991) J Clin Oncol , vol.9 , pp. 1811-1820
    • Grem, JL1    McAtee, N2    Steinberg, S3
  • 57
    • 0028217482 scopus 로고
    • Phase I and pharmacokinetic study of recombinant human granulocytemacrophage colony-stimulating factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal adenocarcinoma
    • Grem JL McAtee N Murphy RF Phase I and pharmacokinetic study of recombinant human granulocytemacrophage colony-stimulating factor given in combination with fluorouracil plus calcium leucovorin in metastatic gastrointestinal adenocarcinoma J Clin Oncol 12 1994 560 568
    • (1994) J Clin Oncol , vol.12 , pp. 560-568
    • Grem, JL1    McAtee, N2    Murphy, RF3
  • 58
    • 0026793052 scopus 로고
    • Purification and characterization of dihydropyrimidine dehydrogenase from human liver
    • Lu Z Zhang R Diasio RB Purification and characterization of dihydropyrimidine dehydrogenase from human liver J Biol Chem 267 1992 17102 17109
    • (1992) J Biol Chem , vol.267 , pp. 17102-17109
    • Lu, Z1    Zhang, R2    Diasio, RB3
  • 59
    • 0026526790 scopus 로고
    • Pharmacokinetics and tissue distribution of 2-fluoro-β-alanine in rats: Potential relevance to toxicity pattern of 5-fluorouracil
    • Zhang R Soong S-J Liu T Pharmacokinetics and tissue distribution of 2-fluoro-β-alanine in rats: Potential relevance to toxicity pattern of 5-fluorouracil Drug Metal Dispos 20 1992 113 119
    • (1992) Drug Metal Dispos , vol.20 , pp. 113-119
    • Zhang, R1    Soong, S-J2    Liu, T3
  • 60
    • 0023902287 scopus 로고
    • Familial deficiency of dihydropyrimidine dehydrogenase: Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity
    • Diasio RB Beavers TL Carpenter T Familial deficiency of dihydropyrimidine dehydrogenase: Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity J Clin Invest 81 1988 47 51
    • (1988) J Clin Invest , vol.81 , pp. 47-51
    • Diasio, RB1    Beavers, TL2    Carpenter, T3
  • 61
    • 0027426408 scopus 로고
    • Dihydropyrimidine, dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy
    • Lu A Zhang R Diasio RB Dihydropyrimidine, dehydrogenase activity in human peripheral blood mononuclear cells and liver: Population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy Cancer Res 53 1993 5433 5438
    • (1993) Cancer Res , vol.53 , pp. 5433-5438
    • Lu, A1    Zhang, R2    Diasio, RB3
  • 62
    • 0025058867 scopus 로고
    • Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion
    • Harris BE Song R Soong S-J Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion Cancer Res 50 1990 197 201
    • (1990) Cancer Res , vol.50 , pp. 197-201
    • Harris, BE1    Song, R2    Soong, S-J3
  • 63
    • 0027279538 scopus 로고
    • A Phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma
    • Grem JL McAtee N Balis F A Phase II study of continuous infusion 5-fluorouracil and leucovorin with weekly cisplatin in metastatic colorectal carcinoma Cancer 72 1993 663 668
    • (1993) Cancer , vol.72 , pp. 663-668
    • Grem, JL1    McAtee, N2    Balis, F3
  • 64
    • 0026699408 scopus 로고
    • Gas chromatographic-mass, spectrometric method for routine monitoring of 5-fluorouracil in plasma of patients receiving low-level protracted infusions
    • Anderson LW Parker RJ Collins JM Gas chromatographic-mass, spectrometric method for routine monitoring of 5-fluorouracil in plasma of patients receiving low-level protracted infusions J Chromatogr 581 1992 195 201
    • (1992) J Chromatogr , vol.581 , pp. 195-201
    • Anderson, LW1    Parker, RJ2    Collins, JM3
  • 65
    • 0025171495 scopus 로고
    • Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer
    • Yoshida T Araki E Iigo M Clinical significance of monitoring serum levels of 5-fluorouracil by continuous infusion in patients with advanced colonic cancer Cancer Chemother Pharmacol 26 1990 352 354
    • (1990) Cancer Chemother Pharmacol , vol.26 , pp. 352-354
    • Yoshida, T1    Araki, E2    Iigo, M3
  • 66
    • 0022630996 scopus 로고
    • Clinical pharmacokinetic study of 5-FU in continuous, 5-day infusions for head and neck cancer
    • Thyss A Milano G Renee N Clinical pharmacokinetic study of 5-FU in continuous, 5-day infusions for head and neck cancer Cancer Chemother Pharmacol 16 1986 64 66
    • (1986) Cancer Chemother Pharmacol , vol.16 , pp. 64-66
    • Thyss, A1    Milano, G2    Renee, N3
  • 67
    • 0024512054 scopus 로고
    • 5-FU therapeutic monitoring with dose adjustment, leads to an improved therapeutic index in head and neck cancer
    • Santini J Milano G Thyss A 5-FU therapeutic monitoring with dose adjustment, leads to an improved therapeutic index in head and neck cancer Br J Cancer 59 1989 287 290
    • (1989) Br J Cancer , vol.59 , pp. 287-290
    • Santini, J1    Milano, G2    Thyss, A3
  • 68
    • 0022520957 scopus 로고
    • Plasma pharmacokinetics of 5-FU given by continuous infusion with allopurinol
    • Erlichman C Fine S Elhakin T Plasma pharmacokinetics of 5-FU given by continuous infusion with allopurinol Cancer Treat Rep 70 1986 903 904
    • (1986) Cancer Treat Rep , vol.70 , pp. 903-904
    • Erlichman, C1    Fine, S2    Elhakin, T3
  • 69
    • 0026079516 scopus 로고
    • Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole
    • Trump DL Egorin MJ Forrest A Pharmacokinetic and pharmacodynamic analysis of fluorouracil during 72-hour continuous infusion with and without dipyridamole J Clin Oncol 9 1991 2027 2035
    • (1991) J Clin Oncol , vol.9 , pp. 2027-2035
    • Trump, DL1    Egorin, MJ2    Forrest, A3
  • 70
    • 0023876379 scopus 로고
    • Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients
    • Petit E Milano G Levi F Circadian rhythm-varying plasma concentration of 5-fluorouracil during a five-day continuous venous infusion at a constant rate in cancer patients Cancer Res 48 1988 1976 1980
    • (1988) Cancer Res , vol.48 , pp. 1976-1980
    • Petit, E1    Milano, G2    Levi, F3
  • 71
    • 0025356873 scopus 로고
    • Phase I trial of 5-fluorouracil and dipyridamole administered by 72-hour concurrent continuous infusions
    • Remick SC Grem JL Fischer PH Phase I trial of 5-fluorouracil and dipyridamole administered by 72-hour concurrent continuous infusions Cancer Res 50 1990 2667 2672
    • (1990) Cancer Res , vol.50 , pp. 2667-2672
    • Remick, SC1    Grem, JL2    Fischer, PH3
  • 72
    • 0027423480 scopus 로고
    • A Phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N-(phosphonacetyl)-l-aspartate in metastatic gastrointestinal adenocarcinoma
    • Grem JL McAtee N Steinberg SM A Phase I study of continuous infusion 5-fluorouracil plus calcium leucovorin in combination with N -(phosphonacetyl)- l -aspartate in metastatic gastrointestinal adenocarcinoma Cancer Res 53 1993 4828 4836
    • (1993) Cancer Res , vol.53 , pp. 4828-4836
    • Grem, JL1    McAtee, N2    Steinberg, SM3
  • 73
    • 0028819243 scopus 로고
    • Phase I study of phosphonacetyl-l-aspartate, 5-fluorouracil, and leucovorin in patients with advanced cancer
    • Hageboutrous A Rogatko A Newman EM Phase I study of phosphonacetyl- l -aspartate, 5-fluorouracil, and leucovorin in patients with advanced cancer Cancer Chemother Pharmacol 35 1995 205 212
    • (1995) Cancer Chemother Pharmacol , vol.35 , pp. 205-212
    • Hageboutrous, A1    Rogatko, A2    Newman, EM3
  • 74
    • 0026100241 scopus 로고
    • The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer
    • Marsh JC Bertino JR Katz KH The influence of drug interval on the effect of methotrexate and fluorouracil in the treatment of advanced colorectal cancer J Clin Oncol 9 1991 371 380
    • (1991) J Clin Oncol , vol.9 , pp. 371-380
    • Marsh, JC1    Bertino, JR2    Katz, KH3
  • 75
    • 0028219974 scopus 로고
    • Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer
    • Piedbois P Buyse M Blijham G Advanced Colorectal Cancer Meta-Analysis Project Meta-analysis of randomized trials testing the biochemical modulation of fluorouracil by methotrexate in metastatic colorectal cancer J Clin Oncol 12 1994 960 969
    • (1994) J Clin Oncol , vol.12 , pp. 960-969
    • Piedbois, P1    Buyse, M2    Blijham, G3    Advanced Colorectal Cancer Meta-Analysis Project4
  • 76
    • 0028136295 scopus 로고
    • Improving adjuvant, therapy for rectal cancer by combining protracted infusion fluorouracil with radiation therapy after curative surgery
    • O'Connell MJ Martenson JA Wieand HS Improving adjuvant, therapy for rectal cancer by combining protracted infusion fluorouracil with radiation therapy after curative surgery N Engl J Med 331 1994 502 507
    • (1994) N Engl J Med , vol.331 , pp. 502-507
    • O'Connell, MJ1    Martenson, JA2    Wieand, HS3
  • 77
    • 0029012118 scopus 로고
    • Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group Study
    • Leichman CG Fleming TR Muggia FM Phase II study of fluorouracil and its modulation in advanced colorectal cancer: A Southwest Oncology Group Study J Clin Oncol 131 1995 1303 1312
    • (1995) J Clin Oncol , vol.131 , pp. 1303-1312
    • Leichman, CG1    Fleming, TR2    Muggia, FM3
  • 78
    • 0016768026 scopus 로고
    • Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma
    • Seifert P Baker L Reed ML Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma Cancer 36 1975 123 128
    • (1975) Cancer , vol.36 , pp. 123-128
    • Seifert, P1    Baker, L2    Reed, ML3
  • 79
    • 0024539308 scopus 로고
    • A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program Study
    • Lokich JJ Ahlgren JD Gullo JJ A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: A Mid-Atlantic Oncology Program Study J Clin Oncol 7 1989 425 432
    • (1989) J Clin Oncol , vol.7 , pp. 425-432
    • Lokich, JJ1    Ahlgren, JD2    Gullo, JJ3
  • 80
    • 0018216763 scopus 로고
    • Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil
    • Fuji S Ikenaka K Fukushima M Effect of uracil and its derivatives on antitumor activity of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil Jpn J Cancer Res 69 1979 763 772
    • (1979) Jpn J Cancer Res , vol.69 , pp. 763-772
    • Fuji, S1    Ikenaka, K2    Fukushima, M3
  • 81
    • 0026465480 scopus 로고
    • Clinical pharmacology of combined oral uracil and ftorafur
    • Ho DH Cobington WP Pazdur R Clinical pharmacology of combined oral uracil and ftorafur Drug Metab Disp 20 1992 936 940
    • (1992) Drug Metab Disp , vol.20 , pp. 936-940
    • Ho, DH1    Cobington, WP2    Pazdur, R3
  • 82
    • 0030223052 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil
    • Muggia FM Wu X Spicer DM Phase I and pharmacokinetic study of oral UFT, a combination of the 5-fluorouracil prodrug tegafur and uracil Clin Cancer Res 2 1996 1461 1467
    • (1996) Clin Cancer Res , vol.2 , pp. 1461-1467
    • Muggia, FM1    Wu, X2    Spicer, DM3
  • 83
    • 0023726563 scopus 로고
    • Report on nationwide pooled data and cohort investigation, in UFT phase II study
    • Ota K Taguchi T Kimura K Report on nationwide pooled data and cohort investigation, in UFT phase II study Cancer Chemother Pharmacol 22 1988 333 338
    • (1988) Cancer Chemother Pharmacol , vol.22 , pp. 333-338
    • Ota, K1    Taguchi, T2    Kimura, K3
  • 84
    • 0028820944 scopus 로고
    • A fixed ratio combination of uracil and ftorafur (UFT) with low dose leucovorin
    • Saltz LB Leichman CT Young CW A fixed ratio combination of uracil and ftorafur (UFT) with low dose leucovorin Cancer (Phila) 75 1995 782 785
    • (1995) Cancer (Phila) , vol.75 , pp. 782-785
    • Saltz, LB1    Leichman, CT2    Young, CW3
  • 85
    • 0028099423 scopus 로고
    • Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma
    • Pazdur R Lassere Y Rhodes V Phase II trial of uracil and tegafur plus oral leucovorin: An effective oral regimen in the treatment of metastatic colorectal carcinoma J Clin Oncol 12 1994 2296 2300
    • (1994) J Clin Oncol , vol.12 , pp. 2296-2300
    • Pazdur, R1    Lassere, Y2    Rhodes, V3
  • 86
    • 9344248389 scopus 로고    scopus 로고
    • Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypridine-1 M, potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats
    • Shirasaka T Nakano K Takechi T Antitumor activity of 1 M tegafur-0.4 M 5-chloro-2,4-dihydroxypridine-1 M, potassium oxonate (S-1) against human colon carcinoma orthotopically implanted into nude rats Cancer Res 56 1996 2602 2606
    • (1996) Cancer Res , vol.56 , pp. 2602-2606
    • Shirasaka, T1    Nakano, K2    Takechi, T3
  • 87
    • 0000636054 scopus 로고    scopus 로고
    • S-1 new oral fluoropyprimidine is very active in patients with advanced gastric cancer
    • (abstr 466) Horikoshi N Mitachi Y Sakata Y S-1 new oral fluoropyprimidine is very active in patients with advanced gastric cancer Proc Am Soc Clin Oncol 15 1996 206
    • (1996) , pp. 206
    • Horikoshi, N1    Mitachi, Y2    Sakata, Y3
  • 88
    • 0010267929 scopus 로고    scopus 로고
    • New oral anticancer agent: S-1
    • (abst 223) Taguchi T Shirasaka T New oral anticancer agent: S-1 Annals Oncol 7 suppl 1 1996 66
    • (1996) Annals Oncol , vol.7 , Issue.suppl 1 , pp. 66
    • Taguchi, T1    Shirasaka, T2
  • 89
    • 85119466699 scopus 로고    scopus 로고
    • Early Phase II study of S-1 in patients with advanced breast cancer
    • (abstr 151) Taguchi T Horikoshi N Kinoshita H Early Phase II study of S-1 in patients with advanced breast cancer Proc Am Soc Clin Oncol 15 1996 121
    • (1996) , pp. 121
    • Taguchi, T1    Horikoshi, N2    Kinoshita, H3
  • 90
    • 0027135995 scopus 로고
    • 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo
    • Spector T Harrington JA Porter DJT 5-Ethynyluracil (776C85): Inactivation of dihydropyrimidine dehydrogenase in vivo Biochem Pharmacol 46 1993 2243
    • (1993) Biochem Pharmacol , vol.46 , pp. 2243
    • Spector, T1    Harrington, JA2    Porter, DJT3
  • 91
    • 0027489763 scopus 로고
    • 5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil
    • Baccanari DP Davis ST Knick V 5-Ethynyluracil (776C85): A potent modulator of the pharmacokinetics and antitumor efficacy of 5-fluorouracil Proc Natl Acad Sci USA 90 1993 11064 11068
    • (1993) , pp. 11064-11068
    • Baccanari, DP1    Davis, ST2    Knick, V3
  • 92
    • 0028281781 scopus 로고
    • 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma
    • Cao S Rustum YM Spector T 5-Ethynyluracil (776C85): Modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma Cancer Res 54 1994 1507 1510
    • (1994) Cancer Res , vol.54 , pp. 1507-1510
    • Cao, S1    Rustum, YM2    Spector, T3
  • 93
    • 0028920324 scopus 로고
    • Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dyhydrouracil
    • Spector T Cao S Rustum YM Attenuation of the antitumor activity of 5-fluorouracil by (R)-5-fluoro-5,6-dyhydrouracil Cancer Res 55 1995 1239 1241
    • (1995) Cancer Res , vol.55 , pp. 1239-1241
    • Spector, T1    Cao, S2    Rustum, YM3
  • 94
    • 10544243363 scopus 로고    scopus 로고
    • Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase
    • Baker SD Khor SP Adjei AA Pharmacokinetic, oral bioavailability, and safety study of fluorouracil in patients treated with 776C85, an inactivator of dihydropyrimidine dehydrogenase J Clin Oncol 14 1996 3085 3096
    • (1996) J Clin Oncol , vol.14 , pp. 3085-3096
    • Baker, SD1    Khor, SP2    Adjei, AA3
  • 95
    • 0027306127 scopus 로고
    • Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases Implications for chemotherapy with 5-fluoropyrimidines
    • el Khouni MH el Kouni MM Naguib NM Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases Implications for chemotherapy with 5-fluoropyrimidines Cancer Res 53 1993 3687 3693
    • (1993) Cancer Res , vol.53 , pp. 3687-3693
    • el Khouni, MH1    el Kouni, MM2    Naguib, NM3
  • 96
    • 0020530463 scopus 로고
    • Activation of 5′-deoxyfluorouridine by thymidine phosphorylase in human tumors
    • Kono A Hara Y Sugata S Activation of 5′-deoxyfluorouridine by thymidine phosphorylase in human tumors Chem Pharm Bull 31 1983 175 178
    • (1983) Chem Pharm Bull , vol.31 , pp. 175-178
    • Kono, A1    Hara, Y2    Sugata, S3
  • 97
    • 0020596799 scopus 로고
    • 5′-deoxyfluorouridine selective toxicity for human tumor cells compared to human bone marrow
    • Armstrong RD Cadman E 5′-deoxyfluorouridine selective toxicity for human tumor cells compared to human bone marrow Cancer Res 43 1983 2525 2528
    • (1983) Cancer Res , vol.43 , pp. 2525-2528
    • Armstrong, RD1    Cadman, E2
  • 98
    • 0029092369 scopus 로고
    • Doxifluridine and leucovorin: An oral treatment combination in advanced colorectal cancer
    • Bajetta E Colleoni M Di Bartolomeo M Doxifluridine and leucovorin: An oral treatment combination in advanced colorectal cancer J Clin Oncol 13 1995 2613 2619
    • (1995) J Clin Oncol , vol.13 , pp. 2613-2619
    • Bajetta, E1    Colleoni, M2    Di Bartolomeo, M3
  • 99
    • 85119465958 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of capecitabine in two phase I studies
    • (abstr 1509) Twelves C Budman DR Creaven PJ Pharmacokinetics and pharmacodynamics of capecitabine in two phase I studies Proc Am Soc Clin Oncol 15 1996 476
    • (1996) , pp. 476
    • Twelves, C1    Budman, DR2    Creaven, PJ3
  • 100
    • 0002407449 scopus 로고    scopus 로고
    • A Phase I study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic solid cancer
    • (abst 297) Hughes M Planting A Twelves C A Phase I study of intermittent twice daily oral therapy with capecitabine in patients with advanced and/or metastatic solid cancer Ann Oncol 7 suppl 1 1996 87
    • (1996) Ann Oncol , vol.7 , Issue.suppl 1 , pp. 87
    • Hughes, M1    Planting, A2    Twelves, C3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.