SCOPUS 정보 검색 플랫폼

Materials Science and Engineering C

Volumn 60, Issue , 2016, Pages 135-142

Tamoxifen-loaded poly(L-lactide) nanoparticles: Development, characterization and in vitro evaluation of cytotoxicity

(4) Altmeyer, Clescila a Karam, Thaysa Ksiaskiewcz a Khalil, Najeh Maissar a Mainardes, Rubiana Mara a

a UNIVERSIDADE ESTADUAL DO CENTRO OESTE (Brazil)

Author keywords

Cytotoxicity; Hemolysis; Nanoparticles; Poly(L lactide); Tamoxifen

Indexed keywords

BLOOD; CYTOTOXICITY; DRUG PRODUCTS; EMULSIFICATION; ENCAPSULATION; NANOPARTICLES; PARTICLE SIZE; SURFACE ACTIVE AGENTS; TARGETED DRUG DELIVERY; THULIUM COMPOUNDS; TUMORS;

CONTROLLED DELIVERY; DIFFUSION CONTROLLED; ENCAPSULATION EFFICIENCY; HEMOLYSIS; IN-VITRO EVALUATION; POLY (L-LACTIDE); POLY (L-LACTIDE) (PLA); TAMOXIFEN;

CONTROLLED DRUG DELIVERY;

DRUG CARRIER; NANOPARTICLE; POLYESTER; POLYLACTIDE; TAMOXIFEN;

CHEMISTRY; DRUG EFFECTS; HEMOLYSIS; HUMAN;

DRUG CARRIERS; HEMOLYSIS; HUMANS; NANOPARTICLES; POLYESTERS; TAMOXIFEN;

EID: 84947086840 PISSN: 09284931 EISSN: None Source Type: Journal
DOI: 10.1016/j.msec.2015.11.019 Document Type: Article

Times cited : (49)

References (66)

1
- 0036668995
- M. Clemons, S. Danson, and A. Howell Cancer Treat. Rev. 28 2002 165
- (2002) Cancer Treat. Rev. , vol.28 , pp. 165
- Clemons, M.¹ Danson, S.² Howell, A.³

2
- 0033549344
- B. Fisher, J. Dignam, N. Wolmark, D.L. Wickerham, E.R. Fisher, E. Mamounas, R. Smith, M. Begovic, N.V. Dimitrov, R.G. Margolese, C.G. Kardinal, M.T. Kavanah, L. Fehrenbacher, and R.H. Oishi Lancet 353 1999 1993
- (1999) Lancet , vol.353 , pp. 1993
- Fisher, B.¹ Dignam, J.² Wolmark, N.³ Wickerham, D.L.⁴ Fisher, E.R.⁵ Mamounas, E.⁶ Smith, R.⁷ Begovic, M.⁸ Dimitrov, N.V.⁹ Margolese, R.G.¹⁰ Kardinal, C.G.¹¹ Kavanah, M.T.¹² Fehrenbacher, L.¹³ Oishi, R.H.¹⁴

3
- 37549006389
- M.P. Goetz, A. Kamal, and M.M. Ames Clin. Pharmacol. Ther. 83 2008 160
- (2008) Clin. Pharmacol. Ther. , vol.83 , pp. 160
- Goetz, M.P.¹ Kamal, A.² Ames, M.M.³

4
- 0141676399
- S.S. Feng, and S. Chien Chem. Eng. Sci. 58 2003 4087
- (2003) Chem. Eng. Sci. , vol.58 , pp. 4087
- Feng, S.S.¹ Chien, S.²

5
- 84872967522
- R. Siegel, D. Naishadham, and A. Jemal CA Cancer J. Clin. 63 2013 11
- (2013) CA Cancer J. Clin. , vol.63 , pp. 11
- Siegel, R.¹ Naishadham, D.² Jemal, A.³

6
- 34548023883
- M.C. Gamberini, C. Baraldi, A. Tinti, F. Palazzoli, and V. Ferioli J. Mol. Struct. 840 2007 29
- (2007) J. Mol. Struct. , vol.840 , pp. 29
- Gamberini, M.C.¹ Baraldi, C.² Tinti, A.³ Palazzoli, F.⁴ Ferioli, V.⁵

7
- 3342932419
- M.D. Johnson, H. Zuo, K.H. Lee, J.P. Trebley, J.M. Rae, R.V. Weatherman, Z. Desta, D.A. Flockhart, and T.C. Skaar Breast Cancer Res. Treat. 85 2004 151
- (2004) Breast Cancer Res. Treat. , vol.85 , pp. 151
- Johnson, M.D.¹ Zuo, H.² Lee, K.H.³ Trebley, J.P.⁴ Rae, J.M.⁵ Weatherman, R.V.⁶ Desta, Z.⁷ Flockhart, D.A.⁸ Skaar, T.C.⁹

8
- 3543134228
- E.V. Mocanu, and R.F. Harrison Rev. Gynaecol. Pract. 4 2004 37
- (2004) Rev. Gynaecol. Pract. , vol.4 , pp. 37
- Mocanu, E.V.¹ Harrison, R.F.²

9
- 78650509559
- M.H. Lee, J.W. Kim, J.H. Kim, K.S. Kang, G. Kong, and M.O. Lee Toxicol. Lett. 199 2010 416
- (2010) Toxicol. Lett. , vol.199 , pp. 416
- Lee, M.H.¹ Kim, J.W.² Kim, J.H.³ Kang, K.S.⁴ Kong, G.⁵ Lee, M.O.⁶

10
- 0035964474
- L.A. Stanley, P. Carthew, R. Davies, F. Higginson, E. Martin, and J.A. Styles Cancer Lett. 171 2001 27
- (2001) Cancer Lett. , vol.171 , pp. 27
- Stanley, L.A.¹ Carthew, P.² Davies, R.³ Higginson, F.⁴ Martin, E.⁵ Styles, J.A.⁶

11
- 3543100346
- Cohen Gynecol. Oncol. 94 2004 256
- (2004) Gynecol. Oncol. , vol.94 , pp. 256
- Cohen¹

12
- 0033966237
- M.M.C. Silva, V.M.C. Madeira, L.M. Almeida, and J.B. Custódio Biochim. Biophys. Acta 1464 2000 49
- (2000) Biochim. Biophys. Acta , vol.1464 , pp. 49
- Silva, M.M.C.¹ Madeira, V.M.C.² Almeida, L.M.³ Custódio, J.B.⁴

13
- 84868033910
- P.P. Desai, A.A. Date, and V.B. Patravale Drug Discov. Today 9 2012 87
- (2012) Drug Discov. Today , vol.9 , pp. 87
- Desai, P.P.¹ Date, A.A.² Patravale, V.B.³

14
- 84864565220
- N.M. Khalil, T.C. Do Nascimento, D.M. Casa, L.F. Dalmolin, A.C. De Mattos, I. Hoss, M.A. Romano, and R.M. Mainardes Colloids Surf. B: Biointerfaces 101 2013 353
- (2013) Colloids Surf. B: Biointerfaces , vol.101 , pp. 353
- Khalil, N.M.¹ Do Nascimento, T.C.² Casa, D.M.³ Dalmolin, L.F.⁴ De Mattos, A.C.⁵ Hoss, I.⁶ Romano, M.A.⁷ Mainardes, R.M.⁸

15
- 84871857463
- R.M. Mainardes, and M.P. Gremião J. Nanosci. Nanotechnol. 12 2012 8513
- (2012) J. Nanosci. Nanotechnol. , vol.12 , pp. 8513
- Mainardes, R.M.¹ Gremião, M.P.²

16
- 79955974608
- Plapied, N. Duhem, A. Rieux, and V. Préat Curr. Opin. Colloid Interface Sci. 16 2011 228
- (2011) Curr. Opin. Colloid Interface Sci. , vol.16 , pp. 228
- Plapied¹ Duhem, N.² Rieux, A.³ Préat, V.⁴

17
- 84878296177
- K. Thanki, R.P. Gangwal, A.T. Sangamwar, and S. Jain J. Control. Release 170 2013 15
- (2013) J. Control. Release , vol.170 , pp. 15
- Thanki, K.¹ Gangwal, R.P.² Sangamwar, A.T.³ Jain, S.⁴

18
- 78649315943
- F. Danhier, O. Feron, and V. préat J. Control. Release 148 2010 135
- (2010) J. Control. Release , vol.148 , pp. 135
- Danhier, F.¹ Feron, O.² Préat, V.³

19
- 84869209158
- T. Asai Biol. Pharm. Bull. 35 2012 1855
- (2012) Biol. Pharm. Bull. , vol.35 , pp. 1855
- Asai, T.¹

20
- 84938399519
- L. Sun, Q. Wu, F. Peng, L. Liu, and C. Gong Colloids Surf. B: Biointerfaces 135 2015 56
- (2015) Colloids Surf. B: Biointerfaces , vol.135 , pp. 56
- Sun, L.¹ Wu, Q.² Peng, F.³ Liu, L.⁴ Gong, C.⁵

21
- 0037027882
- J.S. Chawla, and M.M. Amiji Int. J. Pharm. 249 2002 127
- (2002) Int. J. Pharm. , vol.249 , pp. 127
- Chawla, J.S.¹ Amiji, M.M.²

22
- 15044348714
- D.B. Shenoy, and M.M. Amiji Int. J. Pharm. 293 2005 261
- (2005) Int. J. Pharm. , vol.293 , pp. 261
- Shenoy, D.B.¹ Amiji, M.M.²

23
- 79959585871
- J.K. Sarmah, R. Mahanta, S.K. Bhattacharjee, R. Mahanta, and A. Biswas Int. J. Biol. Macromol. 49 2011 390
- (2011) Int. J. Biol. Macromol. , vol.49 , pp. 390
- Sarmah, J.K.¹ Mahanta, R.² Bhattacharjee, S.K.³ Mahanta, R.⁴ Biswas, A.⁵

24
- 78449233395
- A.K. Jain, N.K. Swarnakar, C. Godugu, R.P. Singh, and S. Jain Biomaterials 32 2011 503
- (2011) Biomaterials , vol.32 , pp. 503
- Jain, A.K.¹ Swarnakar, N.K.² Godugu, C.³ Singh, R.P.⁴ Jain, S.⁵

25
- 84865807489
- A.N. Frone, S. Berlioz, J.-F. Chailan, and D.M. Panaitescu Carbohydr. Polym. 91 2013 377
- (2013) Carbohydr. Polym. , vol.91 , pp. 377
- Frone, A.N.¹ Berlioz, S.² Chailan, J.-F.³ Panaitescu, D.M.⁴

26
- 84857633381
- N. Najafi, M.C. Heuzey, P.J. Carreau, and P.M. Wood-Adams Polym. Degrad. Stab. 97 2012 554
- (2012) Polym. Degrad. Stab. , vol.97 , pp. 554
- Najafi, N.¹ Heuzey, M.C.² Carreau, P.J.³ Wood-Adams, P.M.⁴

27
- 84907485397
- K. Pandey, S. Ghosh, P. Maiti, and C. Haldar Int. J. Biol. Macromol. 72 2015 309
- (2015) Int. J. Biol. Macromol. , vol.72 , pp. 309
- Pandey, K.¹ Ghosh, S.² Maiti, P.³ Haldar, C.⁴

28
- 84920545747
- D.M. Casa, T.C.M.M. Carraro, L.E.A. Camargo, L.F. Dalmolin, N.M. Khalil, and R.M. Mainardes J. Nanosci. Nanotechnol. 15 2015 848
- (2015) J. Nanosci. Nanotechnol. , vol.15 , pp. 848
- Casa, D.M.¹ Carraro, T.C.M.M.² Camargo, L.E.A.³ Dalmolin, L.F.⁴ Khalil, N.M.⁵ Mainardes, R.M.⁶

29
- 0035844738
- J. Siepmann, and N.A. Peppas Adv. Drug Deliv. Rev. 48 2001 139
- (2001) Adv. Drug Deliv. Rev. , vol.48 , pp. 139
- Siepmann, J.¹ Peppas, N.A.²

30
- 33744979960
- S.K. Jain, J. Rains, and K. Jones Free Radic. Biol. Med. 41 2006 92
- (2006) Free Radic. Biol. Med. , vol.41 , pp. 92
- Jain, S.K.¹ Rains, J.² Jones, K.³

31
- 84947066667
- Cambridge University Press New York
- M.A. Harrison, and I.F. Rae Handbooks in Pratical Animal Cell Biology vol. 13 1997 Cambridge University Press New York 162
- (1997) Handbooks in Pratical Animal Cell Biology , vol.13 , pp. 162
- Harrison, M.A.¹ Rae, I.F.²

32
- 34247205833
- S. Shafiq-Un-Nabi, F. Shakeel, S. Talegaonkar, J. Ali, S. Baboota, A. Ahuja, R.K. Khar, and M. Ali AAPS PharmSciTech 8 2007 1
- (2007) AAPS PharmSciTech , vol.8 , pp. 1
- Shafiq-Un-Nabi, S.¹ Shakeel, F.² Talegaonkar, S.³ Ali, J.⁴ Baboota, S.⁵ Ahuja, A.⁶ Khar, R.K.⁷ Ali, M.⁸

33
- 0030575715
- D. Quintanar-Guerrero, H. Fessi, E. Allémann, and E. Doelker Int. J. Pharm. 143 1996 133
- (1996) Int. J. Pharm. , vol.143 , pp. 133
- Quintanar-Guerrero, D.¹ Fessi, H.² Allémann, E.³ Doelker, E.⁴

34
- 0000080480
- W.C. Griffin J. Soc. Cosmet. Chem. 1 1949 311
- (1949) J. Soc. Cosmet. Chem. , vol.1 , pp. 311
- Griffin, W.C.¹

35
- 78649445972
- T. Schmidts, D. Dobler, A.C. Guldan, N. Paulus, and F. Runkel Colloids Surf. A Physicochem. Eng. Asp. 372 2010 48
- (2010) Colloids Surf. A Physicochem. Eng. Asp. , vol.372 , pp. 48
- Schmidts, T.¹ Dobler, D.² Guldan, A.C.³ Paulus, N.⁴ Runkel, F.⁵

36
- 3242721638
- K. Bouchemal, S. Briançon, E. Perrier, and H. Fessi Int. J. Pharm. 280 2004 241
- (2004) Int. J. Pharm. , vol.280 , pp. 241
- Bouchemal, K.¹ Briançon, S.² Perrier, E.³ Fessi, H.⁴

37
- 0001205413
- W.C. Griffin J. Soc. Cosmet. Chem. 5 1954 249
- (1954) J. Soc. Cosmet. Chem. , vol.5 , pp. 249
- Griffin, W.C.¹

38
- 84878710099
- N. Guerrouani, B. Couturaud, A. Mas, F. Schué, and J.J. Robin Eur. Polym. J. 49 2013 1621
- (2013) Eur. Polym. J. , vol.49 , pp. 1621
- Guerrouani, N.¹ Couturaud, B.² Mas, A.³ Schué, F.⁴ Robin, J.J.⁵

39
- 84902388054
- N. Phromviyo, E. Swatsitang, and A. Chompoosor Vacuum 107 2014 208
- (2014) Vacuum , vol.107 , pp. 208
- Phromviyo, N.¹ Swatsitang, E.² Chompoosor, A.³

40
- 33644820138
- K.C. Song, H.S. Lee, Y. Choung, K. Cho, Y. Ahn, and E.J. Choi Colloids Surf. A Physicochem. Eng. Asp. 276 2006 162
- (2006) Colloids Surf. A Physicochem. Eng. Asp. , vol.276 , pp. 162
- Song, K.C.¹ Lee, H.S.² Choung, Y.³ Cho, K.⁴ Ahn, Y.⁵ Choi, E.J.⁶

41
- 84939832977
- J. Bilea, M.A. Bolzingera, C. Vignea, O. Boyronb, J.P. Valoura, H. Fessia, and Y. Chevalier Int. J. Pharm. 494 2015 152
- (2015) Int. J. Pharm. , vol.494 , pp. 152
- Bilea, J.¹ Bolzingera, M.A.² Vignea, C.³ Boyronb, O.⁴ Valoura, J.P.⁵ Fessia, H.⁶ Chevalier, Y.⁷

42
- 77955334511
- J. Kuntsche, M.H.J. Koch, F. Steiniger, and H. Bunjes J. Colloid Interface Sci. 350 2010 229
- (2010) J. Colloid Interface Sci. , vol.350 , pp. 229
- Kuntsche, J.¹ Koch, M.H.J.² Steiniger, F.³ Bunjes, H.⁴

43
- 0033800221
- V.P. Torchilin Eur. J. Pharm. Sci. 11 2000 81
- (2000) Eur. J. Pharm. Sci. , vol.11 , pp. 81
- Torchilin, V.P.¹

44
- 67349179610
- R. Singh, and J.W. Lillard Jr. Exp. Mol. Pathol. 86 2009 215
- (2009) Exp. Mol. Pathol. , vol.86 , pp. 215
- Singh, R.¹ Lillard, J.W.²

45
- 0037072566
- I. Brigger, C. Dubernet, and P. Couvreur Adv. Drug Deliv. Rev. 54 2002 631
- (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 631
- Brigger, I.¹ Dubernet, C.² Couvreur, P.³

46
- 0032516078
- S.K. Hobbs, W.L. Monsky, F. Yuan, W.G. Roberts, L. Griffith, V.P. Torchilin, and R.K. Jain Proc. Natl. Acad. Sci. U. S. A. 95 1998 4607
- (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 4607
- Hobbs, S.K.¹ Monsky, W.L.² Yuan, F.³ Roberts, W.G.⁴ Griffith, L.⁵ Torchilin, V.P.⁶ Jain, R.K.⁷

47
- 0029150245
- F. Yuan, and et al. Cancer Res. 55 1995 3752
- (1995) Cancer Res. , vol.55 , pp. 3752
- Yuan, F.¹

48
- 33745605771
- P. Couvreur, and C. Vauthier Pharm. Res. 23 2006 1417
- (2006) Pharm. Res. , vol.23 , pp. 1417
- Couvreur, P.¹ Vauthier, C.²

49
- 85041127588
- C.A. Ober, and R.B. Gupta Concyteg 6 2011 714
- (2011) Concyteg , vol.6 , pp. 714
- Ober, C.A.¹ Gupta, R.B.²

50
- 0028386640
- T.M. Allen Adv. Drug Deliv. Rev. 13 1994 285
- (1994) Adv. Drug Deliv. Rev. , vol.13 , pp. 285
- Allen, T.M.¹

51
- 0038309868
- B. Heurtault, P. Saulnier, B. Pech, J.E. Proust, and J.P. Benoit Biomaterials 24 2003 4283
- (2003) Biomaterials , vol.24 , pp. 4283
- Heurtault, B.¹ Saulnier, P.² Pech, B.³ Proust, J.E.⁴ Benoit, J.P.⁵

52
- 3042601972
- J. Panyam, D. Williams, A. Dash, D. Leslie-Pelecky, and V. Labhasetwar J. Pharm. Sci. 93 2004 1804
- (2004) J. Pharm. Sci. , vol.93 , pp. 1804
- Panyam, J.¹ Williams, D.² Dash, A.³ Leslie-Pelecky, D.⁴ Labhasetwar, V.⁵

53
- 4243404947
- LTC Rio de Janeiro
- M.R. Silverstein, F.X. Webster, and D.J. Kiemle Identificação Espectrométrica de Compostos Orgânicos vol. X 2007 LTC Rio de Janeiro (p. X)
- (2007) Identificação Espectrométrica de Compostos Orgânicos , vol.10 , pp. X
- Silverstein, M.R.¹ Webster, F.X.² Kiemle, D.J.³

54
- 59649086627
- H.K. Stulzer, M.P. Tagliari, A.L. Parize, M.A.S. Silva, and M.C.M. Laranjeira Mater. Sci. Eng., C 29 2009 387
- (2009) Mater. Sci. Eng., C , vol.29 , pp. 387
- Stulzer, H.K.¹ Tagliari, M.P.² Parize, A.L.³ Silva, M.A.S.⁴ Laranjeira, M.C.M.⁵

55
- 79956144564
- M.K. Riekes, F.M. Barboza, D.D. Vecchia, M. Bohatch Jr., P.V. Farago, D. Fernandes, M.A.S. Silva, and H.K. Stulzer Mater. Sci. Eng., C 31 2011 962
- (2011) Mater. Sci. Eng., C , vol.31 , pp. 962
- Riekes, M.K.¹ Barboza, F.M.² Vecchia, D.D.³ Bohatch, M.⁴ Farago, P.V.⁵ Fernandes, D.⁶ Silva, M.A.S.⁷ Stulzer, H.K.⁸

56
- 33645275717
- L. Cruz, L.U. Soares, T.D. Costa, G. Mezzalira, N.P. Silveira, S.S. Guterres, and A.R. Pohlmann Int. J. Pharm. 313 2006 198
- (2006) Int. J. Pharm. , vol.313 , pp. 198
- Cruz, L.¹ Soares, L.U.² Costa, T.D.³ Mezzalira, G.⁴ Silveira, N.P.⁵ Guterres, S.S.⁶ Pohlmann, A.R.⁷

57
- 33748422799
- M.R. Pereira, L. Cruz, M.I. Ré, and S.S. Guterres Acta Farm. Bonaer. 25 2006 198
- (2006) Acta Farm. Bonaer. , vol.25 , pp. 198
- Pereira, M.R.¹ Cruz, L.² Ré, M.I.³ Guterres, S.S.⁴

58
- 75749121776
- H. Peng, H. Xiong, J. Li, M. Xie, Y. Liu, C. Bai, and L. Chen Food Chem. 121 2010 23
- (2010) Food Chem. , vol.121 , pp. 23
- Peng, H.¹ Xiong, H.² Li, J.³ Xie, M.⁴ Liu, Y.⁵ Bai, C.⁶ Chen, L.⁷

59
- 0034754864
- M.M.C. Silva, V.M.C. Madeira, L.M. Almeida, and J.B. Custódio Toxicol. in Vitro 15 2001 615
- (2001) Toxicol. in Vitro , vol.15 , pp. 615
- Silva, M.M.C.¹ Madeira, V.M.C.² Almeida, L.M.³ Custódio, J.B.⁴

60
- 0036707316
- M.L. Hans, and A.M. Lowman Curr. Opin. Solid State Mater. Sci. 6 2002 319
- (2002) Curr. Opin. Solid State Mater. Sci. , vol.6 , pp. 319
- Hans, M.L.¹ Lowman, A.M.²

61
- 84884249914
- C.D. Rodrigues, D.M. Casa, L.F. Dalmolin, L.E.A. Camargo, N.M. Khalil, and R.M. Mainardes Curr. Nanosci. 9 2013 594
- (2013) Curr. Nanosci. , vol.9 , pp. 594
- Rodrigues, C.D.¹ Casa, D.M.² Dalmolin, L.F.³ Camargo, L.E.A.⁴ Khalil, N.M.⁵ Mainardes, R.M.⁶

62
- 49649122787
- M. Nahar, D. Mishra, V. Dubey, and N.K. Jain Nanomedicine 4 2008 252
- (2008) Nanomedicine , vol.4 , pp. 252
- Nahar, M.¹ Mishra, D.² Dubey, V.³ Jain, N.K.⁴

63
- 19444365656
- A.M. Bilensoy, I. Vural, A. Bochot, J.M. Renoir, D. Duchene, and A.A. Hincal J. Control. Release 104 2005 489
- (2005) J. Control. Release , vol.104 , pp. 489
- Bilensoy, A.M.¹ Vural, I.² Bochot, A.³ Renoir, J.M.⁴ Duchene, D.⁵ Hincal, A.A.⁶

64
- 84887110369
- S. Khurana, N.K. Jain, and P.M.S. Bedi Life Sci. 93 2013 763
- (2013) Life Sci. , vol.93 , pp. 763
- Khurana, S.¹ Jain, N.K.² Bedi, P.M.S.³

65
- 84883637612
- T.R. Arunraj, N.S. Rejinold, N.A. Kumar, and R. Jayakumar Int. J. Biol. Macromol. 62 2013 35
- (2013) Int. J. Biol. Macromol. , vol.62 , pp. 35
- Arunraj, T.R.¹ Rejinold, N.S.² Kumar, N.A.³ Jayakumar, R.⁴

66
- 84956698601
- D.M. Casa, T.K. Karam, A.C.S. Alves, A.A. Zgoda, N.M. Khalil, and R.M. Mainardes J. Nanosci. Nanotechnol. 15 2015 10183
- (2015) J. Nanosci. Nanotechnol. , vol.15
- Casa, D.M.¹ Karam, T.K.² Alves, A.C.S.³ Zgoda, A.A.⁴ Khalil, N.M.⁵ Mainardes, R.M.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.