메뉴 건너뛰기




Volumn 22, Issue , 2016, Pages 226-233

Differentiation of bone marrow mesenchymal stem cells in osteoblasts and adipocytes and its role in treatment of osteoporosis

Author keywords

Cell transplantation; Osteoblasts; Osteoporosis; Stem cell research

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; CALCITRIOL; CHEMOKINE RECEPTOR CXCR4; ESTROGEN; FIBROBLAST GROWTH FACTOR 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; STROMAL CELL DERIVED FACTOR 1;

EID: 84955482974     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.897044     Document Type: Article
Times cited : (155)

References (83)
  • 1
    • 31044432767 scopus 로고    scopus 로고
    • Pathogenesis of osteoporosis: Concepts, conflicts, and prospects
    • Raisz LG: Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest, 2005; 115: 3318-25.
    • (2005) J Clin Invest , vol.115 , pp. 3318-3325
    • Raisz, L.G.1
  • 3
    • 84555189311 scopus 로고    scopus 로고
    • Rapidly increasing rates of hip fracture in Beijing, China
    • Xia WB, He SL, Xu L et al: Rapidly increasing rates of hip fracture in Beijing, China. J Bone Miner Res, 2012; 27: 125-29.
    • (2012) J Bone Miner Res , vol.27 , pp. 125-129
    • Xia, W.B.1    He, S.L.2    Xu, L.3
  • 5
    • 77952744612 scopus 로고    scopus 로고
    • Treatment of osteoporosis with denosumab
    • Lewiecki EM: Treatment of osteoporosis with denosumab. Maturitas, 2010; 66: 182-86.
    • (2010) Maturitas , vol.66 , pp. 182-186
    • Lewiecki, E.M.1
  • 6
    • 84946487969 scopus 로고    scopus 로고
    • Management of bisphos- phonate-related osteonecrosis of the jaw: A literature review
    • Spanou A, Lyritis GP, Chronopoulos E, Tournis S: Management of bisphos- phonate-related osteonecrosis of the jaw: A literature review. Oral Dis, 2015; 21(8): 927-36.
    • (2015) Oral Dis , vol.21 , Issue.8 , pp. 927-936
    • Spanou, A.1    Lyritis, G.P.2    Chronopoulos, E.3    Tournis, S.4
  • 7
    • 70849133991 scopus 로고    scopus 로고
    • Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients
    • Coipeau P, Rosset P, Langonne A et al: Impaired differentiation potential of human trabecular bone mesenchymal stromal cells from elderly patients. Cytotherapy, 2009; 11: 584-94.
    • (2009) Cytotherapy , vol.11 , pp. 584-594
    • Coipeau, P.1    Rosset, P.2    Langonne, A.3
  • 8
    • 84929395618 scopus 로고    scopus 로고
    • Proliferation and differentiation of rat osteoporosis mesenchymal stem cells (MSCs) after telomerase reverse transcriptase (TERT) transfection
    • Li C, Wei G, Gu Q et al: Proliferation and differentiation of rat osteoporosis mesenchymal stem cells (MSCs) after telomerase reverse transcriptase (TERT) transfection. Med Sci Monit, 2015; 21: 845-54.
    • (2015) Med Sci Monit , vol.21 , pp. 845-854
    • Li, C.1    Wei, G.2    Gu, Q.3
  • 9
    • 0029913741 scopus 로고    scopus 로고
    • Age-related changes in osteogenic stem cells in mice
    • Bergman RJ, Gazit D, Kahn AJ et al: Age-related changes in osteogenic stem cells in mice. J Bone Miner Res, 1996; 11: 568-77.
    • (1996) J Bone Miner Res , vol.11 , pp. 568-577
    • Bergman, R.J.1    Gazit, D.2    Kahn, A.J.3
  • 10
    • 0030690556 scopus 로고    scopus 로고
    • The missing bone
    • Rodan GA, Harada S: The missing bone. Cell, 1997; 89: 677-80.
    • (1997) Cell , vol.89 , pp. 677-680
    • Rodan, G.A.1    Harada, S.2
  • 12
    • 0038780881 scopus 로고    scopus 로고
    • Transcription and immunolocaliza- tion of Runx2/Cbfa1/Pebp2alphaA in developing rodent and human craniofacial tissues: Further evidence suggesting osteoclasts phagocytose os- teocytes
    • Bronckers AL, Sasaguri K, Engelse MA: Transcription and immunolocaliza- tion of Runx2/Cbfa1/Pebp2alphaA in developing rodent and human craniofacial tissues: Further evidence suggesting osteoclasts phagocytose os- teocytes. Microsc Res Tech, 2003; 61: 540-48.
    • (2003) Microsc Res Tech , vol.61 , pp. 540-548
    • Bronckers, A.L.1    Sasaguri, K.2    Engelse, M.A.3
  • 13
    • 0033035286 scopus 로고    scopus 로고
    • Cbfa1 as a regulator of osteoblast differentiation and function
    • Karsenty G, Ducy P, Starbuck M et al: Cbfa1 as a regulator of osteoblast differentiation and function. Bone, 1999; 25: 107-8.
    • (1999) Bone , vol.25 , pp. 107-108
    • Karsenty, G.1    Ducy, P.2    Starbuck, M.3
  • 14
    • 0344131893 scopus 로고    scopus 로고
    • Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics
    • Rodriguez JP, Garat S, Gajardo H et al: Abnormal osteogenesis in osteoporotic patients is reflected by altered mesenchymal stem cells dynamics. J Cell Biochem, 1999; 75: 414-23.
    • (1999) J Cell Biochem , vol.75 , pp. 414-423
    • Rodriguez, J.P.1    Garat, S.2    Gajardo, H.3
  • 15
    • 0033785920 scopus 로고    scopus 로고
    • Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation
    • Rodriguez JP, Montecinos L, Rios S et al: Mesenchymal stem cells from osteoporotic patients produce a type I collagen-deficient extracellular matrix favoring adipogenic differentiation. J Cell Biochem, 2000; 79: 557-65.
    • (2000) J Cell Biochem , vol.79 , pp. 557-565
    • Rodriguez, J.P.1    Montecinos, L.2    Rios, S.3
  • 16
    • 67749090903 scopus 로고    scopus 로고
    • Osteogenic potential and responsiveness to leptin of mesenchymal stem cells between postmenopausal women with osteoarthritis and osteoporosis
    • Zhang ZM, Jiang LS, Jiang SD, Dai LY: Osteogenic potential and responsiveness to leptin of mesenchymal stem cells between postmenopausal women with osteoarthritis and osteoporosis. J Orthop Res, 2009; 27: 1067-73.
    • (2009) J Orthop Res , vol.27 , pp. 1067-1073
    • Zhang, Z.M.1    Jiang, L.S.2    Jiang, S.D.3    Dai, L.Y.4
  • 17
    • 0033926146 scopus 로고    scopus 로고
    • Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis?
    • Nuttall ME, Gimble JM: Is there a therapeutic opportunity to either prevent or treat osteopenic disorders by inhibiting marrow adipogenesis? Bone, 2000; 27: 177-84.
    • (2000) Bone , vol.27 , pp. 177-184
    • Nuttall, M.E.1    Gimble, J.M.2
  • 18
    • 0026718865 scopus 로고
    • Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures
    • Beresford JN, Bennett JH, Devlin C et al: Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci, 1992; 102 (Pt 2): 341-51.
    • (1992) J Cell Sci , vol.102 , pp. 341-351
    • Beresford, J.N.1    Bennett, J.H.2    Devlin, C.3
  • 20
    • 77953559069 scopus 로고    scopus 로고
    • The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts
    • Boufker H, Lagneaux L, Najar M et al: The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts. BMC Cancer, 2010; 10: 298.
    • (2010) BMC Cancer , vol.10 , pp. 298
    • Boufker, H.1    Lagneaux, L.2    Najar, M.3
  • 21
    • 84930652075 scopus 로고    scopus 로고
    • MiR-133 is involved in estrogen deficiency-induced osteoporosis through modulating osteogenic differentiation of mesenchymal stem cells
    • Lv H, Sun Y, Zhang Y: MiR-133 is involved in estrogen deficiency-induced osteoporosis through modulating osteogenic differentiation of mesenchymal stem cells. Med Sci Monit, 2015; 21: 1527-34.
    • (2015) Med Sci Monit , vol.21 , pp. 1527-1534
    • Lv, H.1    Sun, Y.2    Zhang, Y.3
  • 22
    • 84923876146 scopus 로고    scopus 로고
    • Leonurine hydrochloride inhibits osteoclas- togenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-kappaB and PI3K/Akt signaling pathways
    • Yuan FL, Xu RS, Jiang DL et al: Leonurine hydrochloride inhibits osteoclas- togenesis and prevents osteoporosis associated with estrogen deficiency by inhibiting the NF-kappaB and PI3K/Akt signaling pathways. Bone, 2015; 75: 128-37.
    • (2015) Bone , vol.75 , pp. 128-137
    • Yuan, F.L.1    Xu, R.S.2    Jiang, D.L.3
  • 23
    • 0023413256 scopus 로고
    • 17 beta-estradiol acts directly on the clonal osteoblastic cell line UMR106
    • Gray TK, Flynn TC, Gray KM, Nabell LM: 17 beta-estradiol acts directly on the clonal osteoblastic cell line UMR106. Proc Natl Acad Sci USA, 1987; 84: 6267-71.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 6267-6271
    • Gray, T.K.1    Flynn, T.C.2    Gray, K.M.3    Nabell, L.M.4
  • 24
    • 0023914660 scopus 로고
    • Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells
    • Komm BS, Terpening CM, Benz DJ et al: Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells. Science, 1988; 241: 81-84.
    • (1988) Science , vol.241 , pp. 81-84
    • Komm, B.S.1    Terpening, C.M.2    Benz, D.J.3
  • 25
    • 58049204438 scopus 로고    scopus 로고
    • Potential new drug targets for osteoporosis
    • Deal C: Potential new drug targets for osteoporosis. Nat Clin Pract Rheumatol, 2009; 5: 20-27.
    • (2009) Nat Clin Pract Rheumatol , vol.5 , pp. 20-27
    • Deal, C.1
  • 26
    • 84923932220 scopus 로고    scopus 로고
    • Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association
    • Martin A, Xiong J, Koromila T et al: Estrogens antagonize RUNX2-mediated osteoblast-driven osteoclastogenesis through regulating RANKL membrane association. Bone, 2015; 75: 96-104.
    • (2015) Bone , vol.75 , pp. 96-104
    • Martin, A.1    Xiong, J.2    Koromila, T.3
  • 27
    • 52749090092 scopus 로고    scopus 로고
    • Involvement of adipogenic potential of human bone marrow mesenchymal stem cells (MSCs) in osteoporosis
    • Rodriguez JP, Astudillo P, Rios S, Pino AM: Involvement of adipogenic potential of human bone marrow mesenchymal stem cells (MSCs) in osteoporosis. Curr Stem Cell Res Ther, 2008; 3: 208-18.
    • (2008) Curr Stem Cell Res Ther , vol.3 , pp. 208-218
    • Rodriguez, J.P.1    Astudillo, P.2    Rios, S.3    Pino, A.M.4
  • 28
    • 84936851886 scopus 로고    scopus 로고
    • Estrogen modulates BMP-induced sclerostin expression via the Wnt signaling pathway
    • Kim RY, Yang HJ, Song YM et al: Estrogen modulates BMP-induced sclerostin expression via the Wnt signaling pathway. Tissue Eng Part A, 2015; 21(13- 14): 2076-88.
    • (2015) Tissue Eng Part A , vol.21 , Issue.13-14 , pp. 2076-2088
    • Kim, R.Y.1    Yang, H.J.2    Song, Y.M.3
  • 29
    • 84902033384 scopus 로고    scopus 로고
    • Role of mechanical strain and estrogen in modulating osteogenic differentiation of mesenchymal stem cells (MSCs) from normal and ovariectomized rats
    • Li L, Yao XL, He XL et al: Role of mechanical strain and estrogen in modulating osteogenic differentiation of mesenchymal stem cells (MSCs) from normal and ovariectomized rats. Cell Mol Biol, 2013; Suppl.59: OL1889-93.
    • (2013) Cell Mol Biol , pp. 1889-1893
    • Li, L.1    Yao, X.L.2    He, X.L.3
  • 30
    • 33645409010 scopus 로고    scopus 로고
    • Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages
    • Gopalakrishnan V, Vignesh RC, Arunakaran J et al: Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages. Biochem Cell Biol, 2006; 84(1): 93-101.
    • (2006) Biochem Cell Biol , vol.84 , Issue.1 , pp. 93-101
    • Gopalakrishnan, V.1    Vignesh, R.C.2    Arunakaran, J.3
  • 31
    • 44949109953 scopus 로고    scopus 로고
    • Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells
    • Post S, Abdallah BM, Bentzon JF, Kassem M: Demonstration of the presence of independent pre-osteoblastic and pre-adipocytic cell populations in bone marrow-derived mesenchymal stem cells. Bone, 2008; 43: 32-39.
    • (2008) Bone , vol.43 , pp. 32-39
    • Post, S.1    Abdallah, B.M.2    Bentzon, J.F.3    Kassem, M.4
  • 32
    • 0036090574 scopus 로고    scopus 로고
    • Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta
    • Okazaki R, Inoue D, Shibata M et al: Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or beta. Endocrinology, 2002; 143: 2349-56.
    • (2002) Endocrinology , vol.143 , pp. 2349-2356
    • Okazaki, R.1    Inoue, D.2    Shibata, M.3
  • 33
    • 0035286397 scopus 로고    scopus 로고
    • Pulsed electromagnetic fields increase growth factor release by nonunion cells
    • Guerkov HH, Lohmann CH, Liu Y et al: Pulsed electromagnetic fields increase growth factor release by nonunion cells. Clin Orthop Relat Res, 2001; (384): 265-79.
    • (2001) Clin Orthop Relat Res , Issue.384 , pp. 265-279
    • Guerkov, H.H.1    Lohmann, C.H.2    Liu, Y.3
  • 34
    • 84906083004 scopus 로고    scopus 로고
    • Pulsed electromagnetic fields stimulate osteogenic differentiation in human bone marrow and adipose tissue derived mesenchymal stem cells
    • Ongaro A, Pellati A, Bagheri L et al: Pulsed electromagnetic fields stimulate osteogenic differentiation in human bone marrow and adipose tissue derived mesenchymal stem cells. Bioelectromagnetics, 2014; 35: 426-36.
    • (2014) Bioelectromagnetics , vol.35 , pp. 426-436
    • Ongaro, A.1    Pellati, A.2    Bagheri, L.3
  • 35
    • 68849083242 scopus 로고    scopus 로고
    • Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation
    • Tsai MT, Li WJ, Tuan RS, Chang WH: Modulation of osteogenesis in human mesenchymal stem cells by specific pulsed electromagnetic field stimulation. J Orthop Res, 2009; 27: 1169-74.
    • (2009) J Orthop Res , vol.27 , pp. 1169-1174
    • Tsai, M.T.1    Li, W.J.2    Tuan, R.S.3    Chang, W.H.4
  • 36
    • 1542317009 scopus 로고    scopus 로고
    • Pseudarthrosis after lumbar spine fusion: Nonoperative salvage with pulsed electromagnetic fields
    • Simmons JW Jr., Mooney V, Thacker I: Pseudarthrosis after lumbar spine fusion: nonoperative salvage with pulsed electromagnetic fields. Am J Orthop, 2004; 33: 27-30.
    • (2004) Am J Orthop , vol.33 , pp. 27-30
    • Simmons, J.W.1    Mooney, V.2    Thacker, I.3
  • 37
    • 84898412073 scopus 로고    scopus 로고
    • A novel single pulsed electromagnetic field stimulates osteogenesis of bone marrow mesenchymal stem cells and bone repair
    • Fu YC, Lin CC, Chang JK et al: A novel single pulsed electromagnetic field stimulates osteogenesis of bone marrow mesenchymal stem cells and bone repair. PloS One, 2014; 9: e91581.
    • (2014) Plos One , vol.9 , pp. e91581
    • Fu, Y.C.1    Lin, C.C.2    Chang, J.K.3
  • 38
    • 77952015323 scopus 로고    scopus 로고
    • Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation
    • Sun LY, Hsieh DK, Lin PC et al: Pulsed electromagnetic fields accelerate proliferation and osteogenic gene expression in human bone marrow mesenchymal stem cells during osteogenic differentiation. Bioelectromagnetics, 2010; 31: 209-19.
    • (2010) Bioelectromagnetics , vol.31 , pp. 209-219
    • Sun, L.Y.1    Hsieh, D.K.2    Lin, P.C.3
  • 39
    • 84906086206 scopus 로고    scopus 로고
    • Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture
    • Androjna C, Fort B, Zborowski M, Midura RJ: Pulsed electromagnetic field treatment enhances healing callus biomechanical properties in an animal model of osteoporotic fracture. Bioelectromagnetics, 2014; 35: 396-405.
    • (2014) Bioelectromagnetics , vol.35 , pp. 396-405
    • Androjna, C.1    Fort, B.2    Zborowski, M.3    Midura, R.J.4
  • 40
    • 75649094153 scopus 로고    scopus 로고
    • Pulsed electromagnetic fields stimulation affects BMD and local factor production of rats with disuse osteoporosis
    • Shen WW, Zhao JH: Pulsed electromagnetic fields stimulation affects BMD and local factor production of rats with disuse osteoporosis. Bioelectromagnetics, 2010; 31: 113-19.
    • (2010) Bioelectromagnetics , vol.31 , pp. 113-119
    • Shen, W.W.1    Zhao, J.H.2
  • 41
    • 0025453337 scopus 로고
    • Effect of a pulsing electromagnetic field on metabolically derived osteoporosis in rats: A pilot study
    • Takayama K, Nomura H, Tanaka J et al: Effect of a pulsing electromagnetic field on metabolically derived osteoporosis in rats: A pilot study. ASAIO Trans, 1990; 36: M426-28.
    • (1990) ASAIO Trans , vol.36 , pp. M426-M428
    • Takayama, K.1    Nomura, H.2    Tanaka, J.3
  • 42
    • 0033289173 scopus 로고    scopus 로고
    • The effect of pulsed electromagnetic fields on osteoporosis at the knee in individuals with spinal cord injury
    • Garland DE, Adkins RH, Matsuno NN, Stewart CA: The effect of pulsed electromagnetic fields on osteoporosis at the knee in individuals with spinal cord injury. J Spinal Cord Med, 1999; 22: 239-45.
    • (1999) J Spinal Cord Med , vol.22 , pp. 239-245
    • Garland, D.E.1    Adkins, R.H.2    Matsuno, N.N.3    Stewart, C.A.4
  • 43
    • 0025327598 scopus 로고
    • Bone density changes in osteoporosis-prone women exposed to pulsed electromagnetic fields (PEMFs)
    • Tabrah F, Hoffmeier M, Gilbert F Jr. et al: Bone density changes in osteoporosis-prone women exposed to pulsed electromagnetic fields (PEMFs). J Bone Minre Res, 1990; 5: 437-42.
    • (1990) J Bone Minre Res , vol.5 , pp. 437-442
    • Tabrah, F.1    Hoffmeier, M.2    Gilbert, F.3
  • 44
    • 22944489618 scopus 로고    scopus 로고
    • Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study
    • Yeung DK, Griffith JF, Antonio GE et al: Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: A proton MR spectroscopy study. J Magn Reson Imaging, 2005; 22: 279-85.
    • (2005) J Magn Reson Imaging , vol.22 , pp. 279-285
    • Yeung, D.K.1    Griffith, J.F.2    Antonio, G.E.3
  • 45
    • 2342613539 scopus 로고    scopus 로고
    • Controlling the balance between osteoblastogen- esis and adipogenesis and the consequent therapeutic implications
    • Nuttall ME, Gimble JM: Controlling the balance between osteoblastogen- esis and adipogenesis and the consequent therapeutic implications. Curr Opinion Pharmacol, 2004; 4: 290-94.
    • (2004) Curr Opinion Pharmacol , vol.4 , pp. 290-294
    • Nuttall, M.E.1    Gimble, J.M.2
  • 46
    • 0031891040 scopus 로고    scopus 로고
    • The derivation and characterization of stromal cell lines from the bone marrow of p53-/- mice: New insights into osteoblast and adipocyte differentiation
    • Thompson DL, Lum KD, Nygaard SC et al: The derivation and characterization of stromal cell lines from the bone marrow of p53-/- mice: new insights into osteoblast and adipocyte differentiation. J Bone Miner Res, 1998; 13: 195-204.
    • (1998) J Bone Miner Res , vol.13 , pp. 195-204
    • Thompson, D.L.1    Lum, K.D.2    Nygaard, S.C.3
  • 47
    • 0036724870 scopus 로고    scopus 로고
    • Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis
    • Verma S, Rajaratnam JH, Denton J et al: Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol, 2002; 55: 693-98.
    • (2002) J Clin Pathol , vol.55 , pp. 693-698
    • Verma, S.1    Rajaratnam, J.H.2    Denton, J.3
  • 48
    • 77954217361 scopus 로고    scopus 로고
    • Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes
    • Clabaut A, Delplace S, Chauveau C et al: Human osteoblasts derived from mesenchymal stem cells express adipogenic markers upon coculture with bone marrow adipocytes. Differentiation, 2010; 80: 40-45.
    • (2010) Differentiation , vol.80 , pp. 40-45
    • Clabaut, A.1    Delplace, S.2    Chauveau, C.3
  • 49
    • 79958134224 scopus 로고    scopus 로고
    • Differentiation of human mesenchymal stem cells: The potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation
    • Zhao JW, Gao ZL, Mei H et al: Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation. Am J Med Sci, 2011; 341: 460-68.
    • (2011) Am J Med Sci , vol.341 , pp. 460-468
    • Zhao, J.W.1    Gao, Z.L.2    Mei, H.3
  • 50
    • 0642303149 scopus 로고    scopus 로고
    • Breast cancer and hormonal replacement therapy
    • Vassilopoulou-Sellin R: Breast cancer and hormonal replacement therapy. Ann NY Acad Sci, 2003; 997: 341-50.
    • (2003) Ann NY Acad Sci , vol.997 , pp. 341-350
    • Vassilopoulou-Sellin, R.1
  • 51
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women’s Health Initiative randomized controlled trial
    • Rossouw JE, Anderson GL, Prentice RL et al: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. JAMA, 2002; 288: 321-33.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Erson, G.L.2    Prentice, R.L.3
  • 52
    • 84862650710 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteonecrosis
    • Weinstein RS: Glucocorticoid-induced osteonecrosis. Endocrine, 2012; 41: 183-90.
    • (2012) Endocrine , vol.41 , pp. 183-190
    • Weinstein, R.S.1
  • 53
    • 84948132172 scopus 로고    scopus 로고
    • Molecular mechanisms of PPAR-gamma governing MSC osteogenic and adipogenic differentiation
    • Epub ahead of print
    • Zhuang H, Zhang X, Zhu C et al: Molecular mechanisms of PPAR-gamma governing MSC osteogenic and adipogenic differentiation. Curr Stem Cell Res Ther, 2015 [Epub ahead of print].
    • (2015) Curr Stem Cell Res Ther
    • Zhuang, H.1    Zhang, X.2    Zhu, C.3
  • 54
    • 0031763342 scopus 로고    scopus 로고
    • 1,25-Dihydroxy vitamin D3 inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures
    • Kelly KA, Gimble JM: 1,25-Dihydroxy vitamin D3 inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures. Endocrinology, 1998; 139: 2622-28.
    • (1998) Endocrinology , vol.139 , pp. 2622-2628
    • Kelly, K.A.1    Gimble, J.M.2
  • 55
    • 1342265406 scopus 로고    scopus 로고
    • 1,25(OH)2D3 inhibits bone marrow adipo- genesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2)
    • Duque G, Macoritto M, Kremer R: 1,25(OH)2D3 inhibits bone marrow adipo- genesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARgamma2). Exp Gerontol, 2004; 39: 333-38.
    • (2004) Exp Gerontol , vol.39 , pp. 333-338
    • Duque, G.1    Macoritto, M.2    Kremer, R.3
  • 57
    • 84929104954 scopus 로고    scopus 로고
    • Hypoxic culture of bone marrow-derived mesenchymal stromal stem cells differentially enhances in vitro chondrogenesis within cell-seeded collagen and hyaluronic acid porous scaffolds
    • Bornes TD, Jomha NM, Mulet-Sierra A, Adesida AB: Hypoxic culture of bone marrow-derived mesenchymal stromal stem cells differentially enhances in vitro chondrogenesis within cell-seeded collagen and hyaluronic acid porous scaffolds. Stem Cell Res Ther, 2015; 6: 84.
    • (2015) Stem Cell Res Ther , vol.6 , pp. 84
    • Bornes, T.D.1    Jomha, N.M.2    Mulet-Sierra, A.3    Adesida, A.B.4
  • 58
    • 0036455114 scopus 로고    scopus 로고
    • Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells
    • Ichioka N, Inaba M, Kushida T et al: Prevention of senile osteoporosis in SAMP6 mice by intrabone marrow injection of allogeneic bone marrow cells. Stem Cells, 2002; 20: 542-51.
    • (2002) Stem Cells , vol.20 , pp. 542-551
    • Ichioka, N.1    Inaba, M.2    Kushida, T.3
  • 59
    • 0035488958 scopus 로고    scopus 로고
    • [Mesenchymal stem cells. Potential use in cell and gene therapy of bone loss caused by aging and osteoporosis]
    • [in Danish]
    • Justesen J, Stenderup K, Kassem MS: [Mesenchymal stem cells. Potential use in cell and gene therapy of bone loss caused by aging and osteoporosis]. Ugeskr Laeger, 2001; 163(40): 5491-95 [in Danish].
    • (2001) Ugeskr Laeger , vol.163 , Issue.40 , pp. 5491-5495
    • Justesen, J.1    Stenderup, K.2    Kassem, M.S.3
  • 60
    • 78049427750 scopus 로고    scopus 로고
    • Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats
    • Ocarino Nde M, Boeloni JN, Jorgetti V et al: Intra-bone marrow injection of mesenchymal stem cells improves the femur bone mass of osteoporotic female rats. Connect Tiss Res, 2010; 51: 426-33.
    • (2010) Connect Tiss Res , vol.51 , pp. 426-433
    • Ocarino Nde, M.1    Boeloni, J.N.2    Jorgetti, V.3
  • 61
    • 33746736852 scopus 로고    scopus 로고
    • Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model
    • Wang Z, Goh J, Das De S et al: Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model. Tissue Eng, 2006; 12:1753-61.
    • (2006) Tissue Eng , vol.12 , pp. 1753-1761
    • Wang, Z.1    Goh, J.2    Das De, S.3
  • 62
    • 79958851787 scopus 로고    scopus 로고
    • An experimental study of bone healing around the titanium screw implants in ovariectomized rats: Enhancement of bone healing by bone marrow stromal cells transplantation
    • Okamoto Y, Tateishi H, Kinoshita K et al: An experimental study of bone healing around the titanium screw implants in ovariectomized rats: Enhancement of bone healing by bone marrow stromal cells transplantation. Implant Dent, 2011; 20: 236-45.
    • (2011) Implant Dent , vol.20 , pp. 236-245
    • Okamoto, Y.1    Tateishi, H.2    Kinoshita, K.3
  • 63
    • 84946542812 scopus 로고    scopus 로고
    • Vascular endothelial growth factor/bone morphogenetic protein-2 bone marrow combined modification of the mesenchymal stem cells to repair the avascular necrosis of the femoral head
    • Ma XW, Cui DP, Zhao DW: Vascular endothelial growth factor/bone morphogenetic protein-2 bone marrow combined modification of the mesenchymal stem cells to repair the avascular necrosis of the femoral head. Int J Clin Exp Med, 2015; 8: 15528-34.
    • (2015) Int J Clin Exp Med , vol.8 , pp. 15528-15534
    • Ma, X.W.1    Cui, D.P.2    Zhao, D.W.3
  • 64
    • 84955482514 scopus 로고    scopus 로고
    • BMP-2 delivered via sucrose acetate iso- butyrate (SAIB) improves bone repair in a rat open fracture model
    • Epub ahead of print
    • Cheng TL, Schindeler A, Little DG: BMP-2 delivered via sucrose acetate iso- butyrate (SAIB) improves bone repair in a rat open fracture model. J Orthop Res, 2015 [Epub ahead of print].
    • (2015) J Orthop Res
    • Cheng, T.L.1    Schindeler, A.2    Little, D.G.3
  • 65
    • 2942655267 scopus 로고    scopus 로고
    • RhBMP-2 significantly enhances guided bone regeneration
    • Wikesjo UM, Qahash M, Thomson RC et al: rhBMP-2 significantly enhances guided bone regeneration. Clin Oral Implant Res, 2004; 15: 194-204.
    • (2004) Clin Oral Implant Res , vol.15 , pp. 194-204
    • Wikesjo, U.M.1    Qahash, M.2    Thomson, R.C.3
  • 66
    • 66149093343 scopus 로고    scopus 로고
    • Stem cell homing and angiomyogene- sis in transplanted hearts are enhanced by combined intramyocardial SDF- 1alpha delivery and endogenous cytokine signaling
    • Zhao T, Zhang D, Millard RW et al: Stem cell homing and angiomyogene- sis in transplanted hearts are enhanced by combined intramyocardial SDF- 1alpha delivery and endogenous cytokine signaling. Am J Physiol Heart Circ Physiol, 2009; 296(4): H976-86.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , Issue.4 , pp. H976-H986
    • Zhao, T.1    Zhang, D.2    Millard, R.W.3
  • 67
    • 73649094083 scopus 로고    scopus 로고
    • Controlled release of stromal-cell-derived factor-1 from gelatin hydrogels enhances angiogenesis
    • Kimura Y, Tabata Y: Controlled release of stromal-cell-derived factor-1 from gelatin hydrogels enhances angiogenesis. J Biomater Sci Polym Ed, 2010; 21(1): 37-51.
    • (2010) J Biomater Sci Polym Ed , vol.21 , Issue.1 , pp. 37-51
    • Kimura, Y.1    Tabata, Y.2
  • 68
    • 38349073636 scopus 로고    scopus 로고
    • Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/ stromal cell-derived factor-1 pathway
    • Otsuru S, Tamai K, Yamazaki T et al: Circulating bone marrow-derived osteoblast progenitor cells are recruited to the bone-forming site by the CXCR4/ stromal cell-derived factor-1 pathway. Stem Cells, 2008; 26: 223-34.
    • (2008) Stem Cells , vol.26 , pp. 223-234
    • Otsuru, S.1    Tamai, K.2    Yamazaki, T.3
  • 69
    • 18544379954 scopus 로고    scopus 로고
    • Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells
    • Kortesidis A, Zannettino A, Isenmann S et al: Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood, 2005; 105: 3793-801.
    • (2005) Blood , vol.105 , pp. 3793-3801
    • Kortesidis, A.1    Zannettino, A.2    Isenmann, S.3
  • 71
    • 67349251499 scopus 로고    scopus 로고
    • Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration
    • Yuan Q, Kubo T, Doi K et al: Effect of combined application of bFGF and inorganic polyphosphate on bioactivities of osteoblasts and initial bone regeneration. Acta Biomater, 2009; 5: 1716-24.
    • (2009) Acta Biomater , vol.5 , pp. 1716-1724
    • Yuan, Q.1    Kubo, T.2    Doi, K.3
  • 72
    • 0030885841 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow
    • Martin I, Muraglia A, Campanile G et al: Fibroblast growth factor-2 supports ex vivo expansion and maintenance of osteogenic precursors from human bone marrow. Endocrinology, 1997; 138: 4456-62.
    • (1997) Endocrinology , vol.138 , pp. 4456-4462
    • Martin, I.1    Muraglia, A.2    Campanile, G.3
  • 73
    • 1642568739 scopus 로고    scopus 로고
    • Gene therapy: Principles and clinical applications in orthopedics
    • Parikh SN: Gene therapy: Principles and clinical applications in orthopedics. Orthopedics, 2004; 27: 294-303, 304-5.
    • (2004) Orthopedics , vol.27
    • Parikh, S.N.1
  • 74
    • 0036049359 scopus 로고    scopus 로고
    • Mesenchymal stem cells for bone gene therapy and tissue engineering
    • Pelled G G T, Aslan H. et al.: Mesenchymal stem cells for bone gene therapy and tissue engineering. Curr Pharm Des, 2002; 8: 1917-28.
    • (2002) Curr Pharm Des , vol.8 , pp. 1917-1928
    • Pelled, G.1    Aslan, H.2
  • 75
    • 46949103497 scopus 로고    scopus 로고
    • Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells
    • Centeno CJ, Busse D, Kisiday J et al: Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician, 2008; 11: 343-53.
    • (2008) Pain Physician , vol.11 , pp. 343-353
    • Centeno, C.J.1    Busse, D.2    Kisiday, J.3
  • 76
    • 11144221286 scopus 로고    scopus 로고
    • Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy
    • Kumar S, Mahendra G, Nagy TR, Ponnazhagan S: Osteogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy. Hum Gene Ther, 2004; 15: 1197-206.
    • (2004) Hum Gene Ther , vol.15 , pp. 1197-1206
    • Kumar, S.1    Mahendra, G.2    Nagy, T.R.3    Ponnazhagan, S.4
  • 77
    • 0035700511 scopus 로고    scopus 로고
    • Gene therapy for osteoporosis: Evaluation in a murine ovariectomy model
    • Baltzer AW, Whalen JD, Wooley P et al: Gene therapy for osteoporosis: evaluation in a murine ovariectomy model. Gene Ther, 2001; 8: 1770-76.
    • (2001) Gene Ther , vol.8 , pp. 1770-1776
    • Baltzer, A.W.1    Whalen, J.D.2    Wooley, P.3
  • 78
    • 65949116788 scopus 로고    scopus 로고
    • Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells
    • Lien CY, Chih-Yuan Ho K, Lee OK et al: Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and cbfa-1 co-expressing mesenchymal stem cells. J Bone Miner Res, 2009; 24: 837-48.
    • (2009) J Bone Miner Res , vol.24 , pp. 837-848
    • Lien, C.Y.1    Chih-Yuan Ho, K.2    Lee, O.K.3
  • 79
    • 33644702007 scopus 로고    scopus 로고
    • Stem cells and cancer: Evidence for bone marrow stem cells in epithelial cancers
    • Li HC, Stoicov C, Rogers AB, Houghton J: Stem cells and cancer: evidence for bone marrow stem cells in epithelial cancers. World J Gastroenterol, 2006; 12: 363-71.
    • (2006) World J Gastroenterol , vol.12 , pp. 363-371
    • Li, H.C.1    Stoicov, C.2    Rogers, A.B.3    Houghton, J.4
  • 80
    • 60149083711 scopus 로고    scopus 로고
    • Characterization of human embryonic stem cells with features of neoplastic progression
    • Werbowetski-Ogilvie TE, Bosse M, Stewart M et al: Characterization of human embryonic stem cells with features of neoplastic progression. Nat Biotechnol, 2009; 27: 91-97.
    • (2009) Nat Biotechnol , vol.27 , pp. 91-97
    • Werbowetski-Ogilvie, T.E.1    Bosse, M.2    Stewart, M.3
  • 81
    • 0033956271 scopus 로고    scopus 로고
    • The short-term changes of bone mineral metabolism following bone marrow transplantation
    • Kang MI, Lee WY, Oh KW et al: The short-term changes of bone mineral metabolism following bone marrow transplantation. Bone, 2000; 26: 275-79.
    • (2000) Bone , vol.26 , pp. 275-279
    • Kang, M.I.1    Lee, W.Y.2    Oh, K.W.3
  • 82
    • 33847122012 scopus 로고    scopus 로고
    • Cyclic mechanical strain increases production of regulators of bone healing in cultured murine osteoblasts
    • Singh SP, Chang EI, Gossain AK et al: Cyclic mechanical strain increases production of regulators of bone healing in cultured murine osteoblasts. J Am Coll Surg, 2007; 204: 426-34.
    • (2007) J am Coll Surg , vol.204 , pp. 426-434
    • Singh, S.P.1    Chang, E.I.2    Gossain, A.K.3
  • 83
    • 40249109986 scopus 로고    scopus 로고
    • Compressive forces induce osteogenic gene expression in calvarial osteoblasts
    • Rath B, Nam J, Knobloch TJ et al: Compressive forces induce osteogenic gene expression in calvarial osteoblasts. J Biomech, 2008; 41: 1095-103.
    • (2008) J Biomech , vol.41 , pp. 1095-1103
    • Rath, B.1    Nam, J.2    Knobloch, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.