1,25(OH)2D3 inhibits bone marrow adipogenesis in senescence accelerated mice (SAM-P/6) by decreasing the expression of peroxisome proliferator-activated receptor gamma 2 (PPARγ2)

Experimental Gerontology

Volumn 39, Issue 3, 2004, Pages 333-338

  Duque, Gustavo ^a,b,c   Macoritto, Michael ^c   Kremer, Richard ^c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Adipogenesis; MAD cells; Osteoblastogenesis; PPAR 2; SAM P 6; Senile osteoporosis; Vitamin D

Indexed keywords

CALCITRIOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL COUNT; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; IMMUNOFLUORESCENCE; MALE; MESENCHYME CELL; MOUSE; NONHUMAN; OSTEOBLAST; PHYSICAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; SENILE OSTEOPOROSIS; STEM CELL;

EID: 1342265406     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2003.11.008     Document Type: Article

References (23)

1. Bianco P., Gehron Robey P. Marrow stromal stem cells. J. Clin. Invest. 105:2000;1663-1668.
2. Chan G.K., Duque G. Age-related bone loss: old bone, new facts. Gerontology. 48:2002;62-71.
3. Clarke S.L., Robinson C.E., Gimble J.M. CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter. Biochem. Biophys. Res. Commun. 240:1997;99-103.
4. Duque G. Anabolic agents to treat osteoporosis in older people: is there still place for fluoride? Fluoride for treating postmenopausal osteoporosis. J. Am. Geriatr. Soc. 49:2001;1387-1389.
5. Duque G. Will reducing adipogenesis in bone increase bone mass?: PPAR gamma 2 as a key target in the treatment of age related bone loss. Drug News Perspectives. 16:2003;1-6.
6. Duque, G., Prestwood, K.M., 2003. Osteoporosis. In: Hazzard, W.R., Blass, J.R., Halter, J.B., Ouslander, J.G., Tinetti, M.E., (Eds.), Principles of Geriatric Medicine and Gerontology, McGraw-Hill, New York, pp. 973 - 986.
7. Duque G., El-Abdaimi K.E., Macoritto M., Miller M.M., Kremer R. Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivation. Biochem. Biophys. Res. Commun. 299:2002;446-454.
8. El Abdaimi K., Dion N., Papavasiliou V., Cardinal P.E., Binderup L., Goltzman D., Ste-Marie L.G., Kremer R. The vitamin D analogue EB 1089 prevents skeletal metastasis and prolongs survival time in nude mice transplanted with human breast cancer cells. Cancer Res. 60:2000;4412-4418.
9. Garcia-Palacios V., Morita I., Murota S. Expression of adipogenesis markers in a murine stromal cell line treated with 15-deoxy Delta(12,14)- prostaglandin J2, interleukin-11, 9-cis retinoic acid and vitamin K2. Prostaglandins Leukot. Essent. Fatty Acids. 65:2001;215-221.
10. Halloran B.P., Ferguson V.L., Simske S.J., Burghardt A., Venton L.L., Majumdar S. Changes in bone structure and mass with advancing age in the male C57BL/6J mouse. J. Bone Miner. Res. 17:2002;1044-1050.
11. Hida Y., Kawada T., Kayahashi S., Ishihara T., Fushiki T. Counteraction of retinoic acid and 1,25-dihydroxyvitamin D3 on up-regulation of adipocyte differentiation with PPARgamma ligand, an antidiabetic thiazolidinedione, in 3T3-L1 cells. Life Sci. 62:1998;PL205-PL211.
12. Justesen J., Stenderup K., Ebbesen E.N., Mosekilde L., Steiniche T., Kassem M. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology. 2:2001;165-171.
13. Kajkenova O., Lecka-Czernik B., Gubrij I., Hauser S.P., Takahashi K., Parfitt A.M., Jilka R.L., Manolagas S.C., Lipschitz D.A. Increased adipogenesis and myelopoiesis in the bone marrow of SAMP6, a murine model of defective osteoblastogenesis and low turnover osteopenia. J. Bone Miner. Res. 12:1997;1772-1779.
14. Kelly K.A., Gimble J.M. 1,25-Dihydroxy vitamin D3 inhibits adipocyte differentiation and gene expression in murine bone marrow stromal cell clones and primary cultures. Endocrinology. 139:1998;2622-2628.
15. Kirkland J.L., Dobson D.E. Preadipocyte function and aging: links between age-related changes in cell dynamics and altered fat tissue function. J. Am. Geriatr. Soc. 45:1997;959-967.
16. Kirkland J.L., Tchkonia T., Pirtskhalava T., Han J., Karagiannides I. Adipogenesis and aging: does aging make fat go MAD? Exp. Gerontol. 37:2002;757-767.
17. Lecka-Czernik B., Moerman E.J., Grant D.F., Lehmann J.M., Manolagas S.C., Jilka R.L. Divergent effects of selective peroxisome proliferator-activated receptor-gamma 2 ligands on adipocyte versus osteoblast differentiation. Endocrinology. 143:2002;2376-2384.
18. Moore S.G., Dawson K.L. Red and yellow marrow in the femur: age related changes in appearance at MR imaging. Radiology. 175:1990;219-223.
19. Ren Y., Behre E., Ren Z., Zhang J., Wang Q., Fondell J.D. Specific structural motifs determine TRAP220 interactions with nuclear hormone receptors. Mol. Cell Biol. 20:2000;5433-5446.
20. Spiteller G. Lipid peroxidation in aging and age-dependent diseases. Exp. Gerontol. 36:2001;1425-1457.
21. Suda T., Ueno Y., Fujii K., Shinki T. Vitamin D and bone. J. Cell. Biochem. 88:2003;259-266.
22. Takeda T., Hosokawa M., Higuchi K. Senescence-accelerated mouse (SAM): a novel murine model of senescence. Exp. Gerontol. 32:1997;105-109.
23. Tomkinson A., Gevers E.F., Wit J.M., Reeve J., Noble B.S. The role of estrogen in the control of rat osteocyte apoptosis. J. Bone Miner. Res. 13:1998;1243-1250.