메뉴 건너뛰기




Volumn 24, Issue 5, 2009, Pages 837-848

Restoration of bone mass and strength in glucocorticoid-treated mice by systemic transplantation of CXCR4 and Cbfa-1 Co-Expressing Mesenchymal Stem Cells

Author keywords

Bone marrow homing; Cbfa 1; CXCR4; Mesenchymal stem cells; Osteoporosis

Indexed keywords

ADENOVIRUS VECTOR; CHEMOKINE RECEPTOR CXCR4; GLUCOCORTICOID; OSTEOCALCIN; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR RUNX2;

EID: 65949116788     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.081257     Document Type: Article
Times cited : (88)

References (61)
  • 1
    • 34247194211 scopus 로고    scopus 로고
    • Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025
    • Burge R, Dawson-Hughes B. Solomon DH, Wong JB, King A, Tosteson A 2007 Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res 22:465-475.
    • (2007) J Bone Miner Res , vol.22 , pp. 465-475
    • Burge, R.1    Dawson-Hughes, B.2    Solomon, D.H.3    Wong, J.B.4    King, A.5    Tosteson, A.6
  • 3
    • 0036678488 scopus 로고    scopus 로고
    • Meta-analyses of therapies for postmenopausal osteoporosis. III Meta-analysis of risedronate for the treatment of postmenopausal osteoporosis
    • Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
    • Cranney A, Tugwell P, Adachi J, Weaver B, Zytaruk N, Papaioannou A, Robinson V, Shea B, Wells G, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. III Meta-analysis of risedronate for the treatment of postmenopausal osteoporosis. Endocr Rev 23:517-523.
    • (2002) Endocr Rev , vol.23 , pp. 517-523
    • Cranney, A.1    Tugwell, P.2    Adachi, J.3    Weaver, B.4    Zytaruk, N.5    Papaioannou, A.6    Robinson, V.7    Shea, B.8    Wells, G.9    Guyatt, G.10
  • 4
    • 0036677983 scopus 로고    scopus 로고
    • Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women
    • Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group
    • Cranney A, Wells G, Willan A, Griffith L, Zytaruk N, Robinson V, Black D, Adachi J, Shea B, Tugwell P, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women. Endocr Rev 23:508-516.
    • (2002) Endocr Rev , vol.23 , pp. 508-516
    • Cranney, A.1    Wells, G.2    Willan, A.3    Griffith, L.4    Zytaruk, N.5    Robinson, V.6    Black, D.7    Adachi, J.8    Shea, B.9    Tugwell, P.10    Guyatt, G.11
  • 5
    • 0035854025 scopus 로고    scopus 로고
    • Hormone replacement therapy and prevention of nonvertebral fractures: A meta-analysis of randomized trials
    • Torgerson DJ, Bell-Syer SE 2001 Hormone replacement therapy and prevention of nonvertebral fractures: A meta-analysis of randomized trials. JAMA 285:2891-2897.
    • (2001) JAMA , vol.285 , pp. 2891-2897
    • Torgerson, D.J.1    Bell-Syer, S.E.2
  • 6
    • 0036679350 scopus 로고    scopus 로고
    • Cranney A, Tugwell P, Zytaruk N, Robinson V, Weaver B, Adachi J, Wells G. Shea B, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. IV. Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis. Endocr Rev 23:524-528.
    • Cranney A, Tugwell P, Zytaruk N, Robinson V, Weaver B, Adachi J, Wells G. Shea B, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. IV. Meta-analysis of raloxifene for the prevention and treatment of postmenopausal osteoporosis. Endocr Rev 23:524-528.
  • 7
    • 0036679570 scopus 로고    scopus 로고
    • Cranney A, Tugwell P. Zytaruk N, Robinson V, Weaver B, Shea B, Wells G, Adachi J, Waldegger L, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. VI. Meta-analysis of calcitonin for the treatment of postmenopausal osteoporosis. Endocr Rev 23:540-551.
    • Cranney A, Tugwell P. Zytaruk N, Robinson V, Weaver B, Shea B, Wells G, Adachi J, Waldegger L, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. VI. Meta-analysis of calcitonin for the treatment of postmenopausal osteoporosis. Endocr Rev 23:540-551.
  • 8
    • 0036679437 scopus 로고    scopus 로고
    • Papadimitropoulos E, Wells G, Shea B, Gillespie W, Weaver B, Zytaruk N. Cranney A, Adachi J, Tugwell P. Josse R. Greenwood C, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev 23:560-569.
    • Papadimitropoulos E, Wells G, Shea B, Gillespie W, Weaver B, Zytaruk N. Cranney A, Adachi J, Tugwell P. Josse R. Greenwood C, Guyatt G, Osteoporosis Methodology Group and The Osteoporosis Research Advisory Group 2002 Meta-analyses of therapies for postmenopausal osteoporosis. VIII: Meta-analysis of the efficacy of vitamin D treatment in preventing osteoporosis in postmenopausal women. Endocr Rev 23:560-569.
  • 9
    • 2942744520 scopus 로고    scopus 로고
    • Shea B, Wells G, Cranney A, Zytaruk N, Robinson V, Griffith L, Hamel C, Ortiz Z, Peterson J, Adachi J, Tugwell P, Guyatt G, Osteoporosis Methodology Group; Osteoporosis Research Advisory Group 2004 Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev CD004526.
    • Shea B, Wells G, Cranney A, Zytaruk N, Robinson V, Griffith L, Hamel C, Ortiz Z, Peterson J, Adachi J, Tugwell P, Guyatt G, Osteoporosis Methodology Group; Osteoporosis Research Advisory Group 2004 Calcium supplementation on bone loss in postmenopausal women. Cochrane Database Syst Rev CD004526.
  • 11
    • 34548306408 scopus 로고    scopus 로고
    • Mechanisms of anabolic therapies for osteoporosis
    • Canalis E, Giustina A. Bilezikian JP 2007 Mechanisms of anabolic therapies for osteoporosis. N Engl J Med 357:905-916.
    • (2007) N Engl J Med , vol.357 , pp. 905-916
    • Canalis, E.1    Giustina, A.2    Bilezikian, J.P.3
  • 12
    • 0026228558 scopus 로고
    • Mesenchymal stem cells
    • Caplan AI 1991 Mesenchymal stem cells. J Orthop Res 9:641-650.
    • (1991) J Orthop Res , vol.9 , pp. 641-650
    • Caplan, A.I.1
  • 13
    • 0033022341 scopus 로고    scopus 로고
    • Mesenchymal stem cells: No longer second class marrow citizens
    • Gerson SL 1999 Mesenchymal stem cells: No longer second class marrow citizens. Nat Med 5:262-264.
    • (1999) Nat Med , vol.5 , pp. 262-264
    • Gerson, S.L.1
  • 14
    • 28744443617 scopus 로고    scopus 로고
    • Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells
    • Lee OK, Ko YC, Kuo TK, Chou SH, Li HJ, Chen WM, Chen TH, Su Y 2004 Fluvastatin and lovastatin but not pravastatin induce neuroglial differentiation in human mesenchymal stem cells. J Cell Biochem 93:917-928.
    • (2004) J Cell Biochem , vol.93 , pp. 917-928
    • Lee, O.K.1    Ko, Y.C.2    Kuo, T.K.3    Chou, S.H.4    Li, H.J.5    Chen, W.M.6    Chen, T.H.7    Su, Y.8
  • 15
    • 0348129237 scopus 로고    scopus 로고
    • Neuronal generation from somatic stem cells: Current knowledge and perspectives on the treatment of acquired and degenerative central nervous system disorders
    • Corti S, Locatelli F, Strazzer S, Guglieri M, Comi GP 2003 Neuronal generation from somatic stem cells: Current knowledge and perspectives on the treatment of acquired and degenerative central nervous system disorders. Curr Gene Ther 3:247-272.
    • (2003) Curr Gene Ther , vol.3 , pp. 247-272
    • Corti, S.1    Locatelli, F.2    Strazzer, S.3    Guglieri, M.4    Comi, G.P.5
  • 19
    • 0027973996 scopus 로고
    • Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy
    • Bruder SP, Fink DJ, Caplan AI 1994 Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 56:283-294.
    • (1994) J Cell Biochem , vol.56 , pp. 283-294
    • Bruder, S.P.1    Fink, D.J.2    Caplan, A.I.3
  • 20
    • 28444490061 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Lineage, plasticity, and skeletal therapeutic potential
    • Oreffo RO, Cooper C, Mason C, Clements M 2005 Mesenchymal stem cells: Lineage, plasticity, and skeletal therapeutic potential. Stem Cell Rev 1:169-178.
    • (2005) Stem Cell Rev , vol.1 , pp. 169-178
    • Oreffo, R.O.1    Cooper, C.2    Mason, C.3    Clements, M.4
  • 23
    • 0032877812 scopus 로고    scopus 로고
    • Ding L, Lu S, Batchu R, III RS, Munshi N 1999 Bone marrow stromal cells as a vehicle for gene transfer. Gene Ther 6:1611-1616.
    • Ding L, Lu S, Batchu R, III RS, Munshi N 1999 Bone marrow stromal cells as a vehicle for gene transfer. Gene Ther 6:1611-1616.
  • 28
    • 0037173116 scopus 로고    scopus 로고
    • Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone
    • Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, Muul L, Hofmann T 2002 Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone. Proc Natl Acad Sci USA 99:8932-8937.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8932-8937
    • Horwitz, E.M.1    Gordon, P.L.2    Koo, W.K.3    Marx, J.C.4    Neel, M.D.5    McNall, R.Y.6    Muul, L.7    Hofmann, T.8
  • 30
    • 0037623459 scopus 로고    scopus 로고
    • Bone marrow homing: The players, the playfield, and their evolving roles
    • Papayannopoulou T 2003 Bone marrow homing: The players, the playfield, and their evolving roles. Curr Opin Hcmatol 10:214-219.
    • (2003) Curr Opin Hcmatol , vol.10 , pp. 214-219
    • Papayannopoulou, T.1
  • 31
    • 0036800296 scopus 로고    scopus 로고
    • The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice
    • Lapidot T, Kollet O 2002 The essential roles of the chemokine SDF-1 and its receptor CXCR4 in human stem cell homing and repopulation of transplanted immune-deficient NOD/SCID and NOD/SCID/B2m(null) mice. Leukemia 16:1992-2003.
    • (2002) Leukemia , vol.16 , pp. 1992-2003
    • Lapidot, T.1    Kollet, O.2
  • 33
    • 23244435467 scopus 로고    scopus 로고
    • How do stem cells find their way home?
    • Lapidot T, Dar A, Kollet O 2005 How do stem cells find their way home? Blood 106:1901-1910.
    • (2005) Blood , vol.106 , pp. 1901-1910
    • Lapidot, T.1    Dar, A.2    Kollet, O.3
  • 34
    • 0036464597 scopus 로고    scopus 로고
    • Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice
    • Cashman J, Clark-Lewis I, Eaves A, Eaves C 2002 Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood 99:792-799.
    • (2002) Blood , vol.99 , pp. 792-799
    • Cashman, J.1    Clark-Lewis, I.2    Eaves, A.3    Eaves, C.4
  • 35
    • 0037020855 scopus 로고    scopus 로고
    • Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors
    • Cashman J, Dykstra B, Clark-Lewis I, Eaves A, Eaves C 2002 Changes in the proliferative activity of human hematopoietic stem cells in NOD/SCID mice and enhancement of their transplantability after in vivo treatment with cell cycle inhibitors. J Exp Med 196:1141-1149.
    • (2002) J Exp Med , vol.196 , pp. 1141-1149
    • Cashman, J.1    Dykstra, B.2    Clark-Lewis, I.3    Eaves, A.4    Eaves, C.5
  • 36
    • 7244224904 scopus 로고    scopus 로고
    • A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow
    • Wynn RF, Hart CA, Corradi-Perini C, O'Neill L, Evans CA, Wraith JE, Fairbairn LJ, Bellantuono I 2004 A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow. Blood 104:2643-2645.
    • (2004) Blood , vol.104 , pp. 2643-2645
    • Wynn, R.F.1    Hart, C.A.2    Corradi-Perini, C.3    O'Neill, L.4    Evans, C.A.5    Wraith, J.E.6    Fairbairn, L.J.7    Bellantuono, I.8
  • 37
    • 2942555661 scopus 로고    scopus 로고
    • Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury
    • Ji JF, He BP, Dheen ST, Tay SS 2004 Interactions of chemokines and chemokine receptors mediate the migration of mesenchymal stem cells to the impaired site in the brain after hypoglossal nerve injury. Stem Cells 22:415-427.
    • (2004) Stem Cells , vol.22 , pp. 415-427
    • Ji, J.F.1    He, B.P.2    Dheen, S.T.3    Tay, S.S.4
  • 38
    • 33749078198 scopus 로고    scopus 로고
    • Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases
    • Son BR, Marquez-Curtis LA, Kucia M, Wysoczynski M, Turner AR, Ratajczak J, Ratajczak MZ, Janowska-Wieczorek A 2006 Migration of bone marrow and cord blood mesenchymal stem cells in vitro is regulated by stromal-derived factor-1-CXCR4 and hepatocyte growth factor-c-met axes and involves matrix metalloproteinases. Stem Cells 24:1254-1264.
    • (2006) Stem Cells , vol.24 , pp. 1254-1264
    • Son, B.R.1    Marquez-Curtis, L.A.2    Kucia, M.3    Wysoczynski, M.4    Turner, A.R.5    Ratajczak, J.6    Ratajczak, M.Z.7    Janowska-Wieczorek, A.8
  • 39
    • 0036352427 scopus 로고    scopus 로고
    • Runx2, a multifunctional transcription factor in skeletal development
    • Komori T 2002 Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem 87:1-8.
    • (2002) J Cell Biochem , vol.87 , pp. 1-8
    • Komori, T.1
  • 41
    • 0030131155 scopus 로고    scopus 로고
    • Mechanical validation of whole bone composite femur models
    • Cristofolini L, Viceconti M, Cappello A, Toni A 1996 Mechanical validation of whole bone composite femur models. J Biomech 29:525-535.
    • (1996) J Biomech , vol.29 , pp. 525-535
    • Cristofolini, L.1    Viceconti, M.2    Cappello, A.3    Toni, A.4
  • 42
    • 34547597670 scopus 로고    scopus 로고
    • Clinical perspectives on bone quality in osteoporosis: Effects of drug therapy
    • Licata AA 2007 Clinical perspectives on bone quality in osteoporosis: Effects of drug therapy. Drugs Aging 24:529-535.
    • (2007) Drugs Aging , vol.24 , pp. 529-535
    • Licata, A.A.1
  • 43
    • 33845369453 scopus 로고    scopus 로고
    • Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk-a meta-analysis
    • Vestergaard P, Jorgensen NR, Mosekilde L, Schwarz P 2007 Effects of parathyroid hormone alone or in combination with antiresorptive therapy on bone mineral density and fracture risk-a meta-analysis. Osteoporos Int 18:45-57.
    • (2007) Osteoporos Int , vol.18 , pp. 45-57
    • Vestergaard, P.1    Jorgensen, N.R.2    Mosekilde, L.3    Schwarz, P.4
  • 44
    • 11144221286 scopus 로고    scopus 로고
    • Os-teogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy
    • Kumar S, Mahendra G, Nagy TR, Ponnazhagan S 2004 Os-teogenic differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy. Hum Gene Ther 15:1197-1206.
    • (2004) Hum Gene Ther , vol.15 , pp. 1197-1206
    • Kumar, S.1    Mahendra, G.2    Nagy, T.R.3    Ponnazhagan, S.4
  • 45
    • 20444454865 scopus 로고    scopus 로고
    • Role of adult mesenchymal stem cells in bone tissue engineering applications: Current status and future prospects
    • Mauney JR, Volloch V, Kaplan DL 2005 Role of adult mesenchymal stem cells in bone tissue engineering applications: Current status and future prospects. Tissue Eng 11:787-802.
    • (2005) Tissue Eng , vol.11 , pp. 787-802
    • Mauney, J.R.1    Volloch, V.2    Kaplan, D.L.3
  • 46
    • 33746736852 scopus 로고    scopus 로고
    • Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model
    • Wang Z, Goh J, Das De S, Gc Z, Ouyang H. Chong JS, Low SL, Lee EH 2006 Efficacy of bone marrow-derived stem cells in strengthening osteoporotic bone in a rabbit model. Tissue Eng 12:1753.
    • (2006) Tissue Eng , vol.12 , pp. 1753
    • Wang, Z.1    Goh, J.2    Das, D.S.3    Gc, Z.4    Ouyang, H.5    Chong, J.S.6    Low, S.L.7    Lee, E.H.8
  • 49
    • 33644842257 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid action in bone
    • Canalis E 2005 Mechanisms of glucocorticoid action in bone. Curr Osteoporos Rep 3:98-102.
    • (2005) Curr Osteoporos Rep , vol.3 , pp. 98-102
    • Canalis, E.1
  • 51
    • 33748159590 scopus 로고    scopus 로고
    • Soluble glucocorticoid-induced tumor necrosis factor receptor stimulates osteoclastogenesis by down-regulation of osteoprote-gerin in bone marrow stromal cells
    • Shin HH, Kim SJ, Kang SY, Lee DS, Choi HS 2006 Soluble glucocorticoid-induced tumor necrosis factor receptor stimulates osteoclastogenesis by down-regulation of osteoprote-gerin in bone marrow stromal cells. Bone 39:716-723.
    • (2006) Bone , vol.39 , pp. 716-723
    • Shin, H.H.1    Kim, S.J.2    Kang, S.Y.3    Lee, D.S.4    Choi, H.S.5
  • 52
    • 33745138231 scopus 로고    scopus 로고
    • Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones
    • Swanson C, Lorentzon M, Conaway HH, Lerner UH 2006 Glucocorticoid regulation of osteoclast differentiation and expression of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand, osteoprotegerin, and receptor activator of NF-kappaB in mouse calvarial bones. Endocrinology 147:3613-3622.
    • (2006) Endocrinology , vol.147 , pp. 3613-3622
    • Swanson, C.1    Lorentzon, M.2    Conaway, H.H.3    Lerner, U.H.4
  • 53
    • 34547114271 scopus 로고    scopus 로고
    • A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells
    • Zhu W, Boachie-Adjei O, Rawlins BA, Frenkel B, Boskey AL, Ivashkiv LB, Blobel CP 2007 A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells. J Biol Chem 282:18676-18685.
    • (2007) J Biol Chem , vol.282 , pp. 18676-18685
    • Zhu, W.1    Boachie-Adjei, O.2    Rawlins, B.A.3    Frenkel, B.4    Boskey, A.L.5    Ivashkiv, L.B.6    Blobel, C.P.7
  • 54
    • 2342613539 scopus 로고    scopus 로고
    • Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications
    • Nuttall ME, Gimble JM 2004 Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4:290-294.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 290-294
    • Nuttall, M.E.1    Gimble, J.M.2
  • 55
    • 31544457103 scopus 로고    scopus 로고
    • Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract
    • Rosen CJ, Bouxsein ML 2006 Mechanisms of disease: Is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2:35-43.
    • (2006) Rheumatol , vol.2 , pp. 35-43
    • Rosen, C.J.1    Bouxsein, M.L.2
  • 56
    • 26944492288 scopus 로고    scopus 로고
    • Treatment strategies for proximal femur fractures in osteo-porotic patients
    • Bonnaire F, Zenker H, Lill C, Weber AT, Linke B 2005 Treatment strategies for proximal femur fractures in osteo-porotic patients. Osteoporos Int 16(Suppl 2):S93-S102.
    • (2005) Osteoporos Int , vol.16 , Issue.SUPPL. 2
    • Bonnaire, F.1    Zenker, H.2    Lill, C.3    Weber, A.T.4    Linke, B.5
  • 58
    • 35348852485 scopus 로고    scopus 로고
    • Osterix overexpression in mesenchymal stem cells stimulates healing of critical-sized defects in murine calvarial bone
    • Tu Q, Valverde P, Li S, Zhang J, Yang P, Chen J 2007 Osterix overexpression in mesenchymal stem cells stimulates healing of critical-sized defects in murine calvarial bone. Tissue Eng 13:2431-2440.
    • (2007) Tissue Eng , vol.13 , pp. 2431-2440
    • Tu, Q.1    Valverde, P.2    Li, S.3    Zhang, J.4    Yang, P.5    Chen, J.6
  • 59
    • 11144238386 scopus 로고    scopus 로고
    • Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization
    • Byers BA, Guldberg RE, García AJ 2004 Synergy between genetic and tissue engineering: Runx2 overexpression and in vitro construct development enhance in vivo mineralization. Tissue Eng 10:1757-1766.
    • (2004) Tissue Eng , vol.10 , pp. 1757-1766
    • Byers, B.A.1    Guldberg, R.E.2    García, A.J.3
  • 60
    • 34547131038 scopus 로고    scopus 로고
    • Cbfb enhances the osteognic differentiation of both human and mouse mesenchymal stem cells induced by Cbfa-1 via reducing its ubiquitination-mediated degradation
    • Lien CY, Lee OK, Su Y 2007 Cbfb enhances the osteognic differentiation of both human and mouse mesenchymal stem cells induced by Cbfa-1 via reducing its ubiquitination-mediated degradation. Stem Cells 25:1462.
    • (2007) Stem Cells , vol.25 , pp. 1462
    • Lien, C.Y.1    Lee, O.K.2    Su, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.