Angiographic features of transgenic mice with increased expression of human serine protease htra1 in retinal pigment epithelium

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 6, 2014, Pages 3842-3850

  Kumar, Sandeep ^a   Berriochoa, Zachary ^a   Ambati, Balamurali K ^a   Fu, Yingbin ^a  

^a UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

HTRA1; Indocyanine green angiography; Late geographic hyperfluorescence; Pigment epithelial detachment; Polypoidal choroidal vasculopathy

Indexed keywords

SERINE PROTEASE HTRA1; SERINE PROTEINASE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE ANGIOGRAPHY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDOCYANINE GREEN ANGIOGRAPHY; MALE; MOUSE; NONHUMAN; OPHTHALMOSCOPY; PHENOTYPE; PIGMENT EPITHELIUM; POLYPOIDAL CHOROIDAL VASCULOPATHY; PRIORITY JOURNAL; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; TRANSGENIC MOUSE; WESTERN BLOTTING;

HTRA1; INDOCYANINE GREEN ANGIOGRAPHY; LATE GEOGRAPHIC HYPERFLUORESCENCE; PIGMENT EPITHELIAL DETACHMENT; POLYPOIDAL CHOROIDAL VASCULOPATHY;

AGED; ANIMALS; BLOTTING, WESTERN; CHOROIDAL NEOVASCULARIZATION; COLORING AGENTS; DISEASE MODELS, ANIMAL; FEMALE; FLUORESCEIN ANGIOGRAPHY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; INDOCYANINE GREEN; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MIDDLE AGED; PHENOTYPE; POLYPS; RETINAL PIGMENT EPITHELIUM; SERINE ENDOPEPTIDASES; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84902659796     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13111     Document Type: Article

References (40)

1. Imamura Y, Engelbert M, Iida T, Freund KB, Yannuzzi LA. Polypoidal choroidal vasculopathy: a review. Surv Ophthalmol. 2010;55:501-515.
2. Spaide RF, Yannuzzi LA, Slakter JS, Sorenson J, Orlach DA. Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy. Retina. 1995;15:100-110.
3. Ciardella AP, Donsoff IM, Yannuzzi LA. Polypoidal choroidal vasculopathy. Ophthalmol Clin North Am. 2002;15:537-554.
4. Yannuzzi LA. Indocyanine green angiography: a perspective on use in the clinical setting. Am J Ophthalmol. 2011;151:745-751.e1.
5. Koh AH, Chen LJ, Chen SJ, et al; Expert PCV Panel. Polypoidal choroidal vasculopathy: evidence-based guidelines for clinical diagnosis and treatment. Retina. 2013;33:686-716.
6. Kim YT, Kang SW, Chung SE, Kong MG, Kim JH. Development of polypoidal choroidal vasculopathy in unaffected fellow eyes. Br J Ophthalmol. 2012;96:1217-1221.
7. Kang SW, Chung SE, Shin WJ, Lee JH. Polypoidal choroidal vasculopathy and late geographic hyperfluorescence on indocyanine green angiography. Br J Ophthalmol. 2009;93: 759-764.
8. Gomi F, Sawa M, Mitarai K, Tsujikawa M, Tano Y. Angiographic lesion of polypoidal choroidal vasculopathy on indocyanine green and fluorescein angiography. Graefes Arch Clin Exp Ophthalmol. 2007;245:1421-1427.
9. Coscas G. OCT in AMD: Optical Coherence Tomography in Age-Related Macular Degeneration. Heidelberg: Springer; 2009.
10. Lafaut BA, Leys AM, Snyers B, Rasquin F, De Laey JJ. Polypoidal choroidal vasculopathy in Caucasians. Graefes Arch Clin Exp Ophthalmol. 2000;238:752-759.
11. Coppens G, Spielberg L, Leys A. Polypoidal choroidal vasculopathy, diagnosis and management. Bull Soc Belge Ophtalmol. 2011;317:39-44.
12. Tsujikawa A, Sasahara M, Otani A, et al. Pigment epithelial detachment in polypoidal choroidal vasculopathy. Am J Ophthalmol. 2007;143:102-111.
13. Laude A, Cackett PD, Vithana EN, et al. Polypoidal choroidal vasculopathy and neovascular age-related macular degeneration: same or different disease? Prog Retin Eye Res. 2010;29: 19-29.
14. Gomi F, Sawa M, Sakaguchi H, et al. Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy. Br J Ophthalmol. 2008;92:70-73.
15. Lai TY, Chan WM, Liu DT, Luk FO, Lam DS. Intravitreal bevacizumab (Avastin) with or without photodynamic therapy for the treatment of polypoidal choroidal vasculopathy. Br J Ophthalmol. 2008;92:661-666.
16. Cho M, Barbazetto IA, Freund KB. Refractory neovascular agerelated macular degeneration secondary to polypoidal choroidal vasculopathy. Am J Ophthalmol. 2009;148:70-78.e1.
17. Stangos AN, Gandhi JS, Nair-Sahni J, Heimann H, Pournaras CJ, Harding SP. Polypoidal choroidal vasculopathy masquerading as neovascular age-related macular degeneration refractory to ranibizumab. Am J Ophthalmol. 2010;150:666-673.
18. Kokame GT, Yeung L, Lai JC. Continuous anti-VEGF treatment with ranibizumab for polypoidal choroidal vasculopathy: 6- month results. Br J Ophthalmol. 2010;94:297-301.
19. Jones A, Kumar S, Zhang N, et al. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A. 2011;108:14578-14583.
20. Znoiko SL, Crouch RK, Moiseyev G, Ma JX. Identification of the RPE65 protein in mammalian cone photoreceptors. Invest Ophthalmol Vis Sci. 2002;43:1604-1609.
21. Huber G, Beck SC, Grimm C, et al. Spectral domain optical coherence tomography in mouse models of retinal degeneration. Invest Ophthalmol Vis Sci. 2009;50:5888-5895.
22. Alex AF, Heiduschka P, Eter N. Retinal fundus imaging in mouse models of retinal diseases. Methods Mol Biol. 2013; 935:41-67.
23. Esumi N, Oshima Y, Li Y, Campochiaro PA, Zack DJ. Analysis of the VMD2 promoter and implication of E-box binding factors in its regulation. J Biol Chem. 2004;279:19064-19073.
24. Janssen A, Hoellenriegel J, Fogarasi M, et al. Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3. Invest Ophthalmol Vis Sci. 2008;49:2812-2822.
25. Kumar S, Berriochoa Z, Jones AD, Fu Y. Detecting abnormalities in choroidal vasculature in a mouse model of age-related macular degeneration by time-course indocyanine green angiography. J Vis Exp. 2014;84:e51061.
26. Cackett P, Wong D, Yeo I. A classification system for polypoidal choroidal vasculopathy. Retina. 2009;29:187-191.
27. Uyama M, Wada M, Nagai Y, et al. Polypoidal choroidal vasculopathy: natural history. Am J Ophthalmol. 2002;133: 639-648.
28. Khan S, Engelbert M, Imamura Y, Freund KB. Polypoidal choroidal vasculopathy: simultaneous indocyanine green angiography and eye-tracked spectral domain optical coherence tomography findings. Retina. 2012;32:1057-1068.
29. Elliot SJ, Catanuto P, Espinosa-Heidmann DG, et al. Estrogen receptor beta protects against in vivo injury in RPE cells. Exp Eye Res. 2010;90:10-16.
30. Grau S, Richards PJ, Kerr B, et al. The role of human HtrA1 in arthritic disease. J Biol Chem. 2006;281:6124-6129.
31. Vierkotten S, Muether PS, Fauser S. Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components. PLoS One. 2011;6:e22959.
32. Tiaden AN, Klawitter M, Lux V, et al. Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem. 2012;287:21335-21345.
33. An E, Sen S, Park SK, Gordish-Dressman H, Hathout Y. Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome. Invest Ophthalmol Vis Sci. 2010;51:3379-3386.
34. Kang HM, Koh HJ, Lee CS, Lee SC. Combined photodynamic therapy with intravitreal bevacizumab injections for polypoidal choroidal vasculopathy: long-term visual outcome. Am J Ophthalmol. 2014;157:598-606.e1.
35. Kang HM, Koh HJ. Long-term visual outcome and prognostic factors after intravitreal ranibizumab injections for polypoidal choroidal vasculopathy. Am J Ophthalmol. 2013;156:652-660.
36. Marcus DM, Singh H, Lott MN, Singh J, Marcus MD. Intravitreal ranibizumab for polypoidal choroidal vasculopathy in non- Asian patients. Retina. 2013;33:35-47.
37. Sonoda S, Sakamoto T, Otsuka H, et al. Responsiveness of eyes with polypoidal choroidal vasculopathy with choroidal hyperpermeability to intravitreal ranibizumab. BMC Ophthalmol. 2013;13:43.
38. Kurihara T, Westenskow PD, Bravo S, Aguilar E, Friedlander M. Targeted deletion of Vegfa in adult mice induces vision loss. J Clin Invest. 2012;122:4213-4217.
39. Saint-Geniez M, Kurihara T, Sekiyama E, Maldonado AE, D'Amore PA. An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris. Proc Natl Acad Sci U S A. 2009;106:18751-18756.
40. Spaide RF, Curcio CA. Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model. Retina. 2011;31:1609-1619.