Cardiac sodium channel mutation associated with epinephrine-induced QT prolongation and sinus node dysfunction

Heart Rhythm

Volumn 13, Issue 1, 2016, Pages 289-298

  Chen, Jiarong ^a   Makiyama, Takeru ^a   Wuriyanghai, Yimin ^a,b   Ohno, Seiko ^a,b   Sasaki, Kenichi ^a   Hayano, Mamoru ^a   Harita, Takeshi ^a   Nishiuchi, Suguru ^a   Yuta Yamamoto, ^a   Ueyama, Takeshi ^c   Shimizu, Akihiko ^c   Horie, Minoru ^b   Kimura, Takeshi ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^c YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenergic stimulation; Epinephrine; Long QT syndrome; Protein kinase A; Protein kinase C; SCN5A

Indexed keywords

ADRENALIN; AMINO ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C; SODIUM CHANNEL; ADRENERGIC RECEPTOR STIMULATING AGENT; EPINEPHRINE; SODIUM CHANNEL NAV1.5;

ADULT; ARTICLE; CASE REPORT; CLINICAL FEATURE; CONTROLLED STUDY; EXERCISE TEST; GENE; GENE MUTATION; GENETIC SCREENING; HEART ELECTROPHYSIOLOGY; HETEROLOGOUS EXPRESSION; HETEROZYGOSITY; HUMAN; HUMAN CELL; JAPANESE (PEOPLE); LONG QT SYNDROME 3; LOSS OF FUNCTION MUTATION; MALE; MISSENSE MUTATION; PHENOTYPE; PRIORITY JOURNAL; QT PROLONGATION; SCN5A GENE; SINUS NODE DISEASE; SODIUM CURRENT; YOUNG ADULT; ADVERSE EFFECTS; COMPLICATION; GENETIC PREDISPOSITION; GENETICS; LONG QT SYNDROME; PATHOPHYSIOLOGY; PROCEDURES; SICK SINUS SYNDROME; SYNCOPE;

EPINEPHRINE; EXERCISE TEST; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONG QT SYNDROME; MALE; MUTATION, MISSENSE; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; SICK SINUS SYNDROME; SYMPATHOMIMETICS; SYNCOPE; YOUNG ADULT;

EID: 84955474796     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2015.08.021     Document Type: Article

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