In vitro and in vivo anticancer activity of pardaxin against proliferation and growth of oral squamous cell carcinoma

Marine Drugs

Volumn 14, Issue 1, 2016, Pages

  Han, Yifan ^a   Cui, Zhibin ^b   Li, Yen Hsing ^c   Hsu, Wei Hsuan ^d   Lee, Bao Hong ^e  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b PURDUE UNIVERSITY   (United States)

^c PURDUE UNIVERSITY   (United States)

^d INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

7,12 dimethylbenz a anthracene (DMBA); Antimicrobial peptide (AMP); Oral cancer; Oral squamous cell carcinoma (OSCC) cells; Pardaxin

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; CASPASE 3; CYCLIN B; FLUOROURACIL; PARDAXIN; PROSTAGLANDIN E2; PROTEIN P53; ANTINEOPLASTIC AGENT; FISH VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER ADJUVANT THERAPY; CANCER INHIBITION; CANCER MODEL; CARCINOMA CELL LINE; CELL VIABILITY; COLONY FORMATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUTH SQUAMOUS CELL CARCINOMA; NONHUMAN; PROTEIN CLEAVAGE; SCC 4 CELL LINE; SYRIAN HAMSTER; TUMOR VOLUME; ANIMAL; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; HAMSTER; MOUSE; MOUTH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CRICETINAE; DISEASE MODELS, ANIMAL; FISH VENOMS; HUMANS; IN VITRO TECHNIQUES; MICE; MOUTH NEOPLASMS;

EID: 84955473828     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md14010002     Document Type: Article

References (33)

1. Hsu, W.H.; Lee, B.H.; Pan, T.M. Protection of Monascus-fermented dioscorea against DMBA-induced oral injury in hamster by anti-inflammatory and antioxidative potentials. J. Agric. Food Chem. 2010, 58, 6715-6720. [PubMed]
2. Chen, Y.J.; Chang, J.T.; Liao, C.T.; Wang, H.M.; Yen, T.C.; Chiu, C.C.; Lu, Y.C.; Li, H.F.; Cheng, A.J. Head and neck cancer in the betel quid chewing area: Recent advances in molecular carcinogenesis. Cancer Sci. 2008, 99, 1507-1514. [CrossRef] [PubMed]
3. Hsu, W.H.; Lee, B.H.; Pan, T.M. Effects of red mold dioscorea on oral carcinogenesis in DMBA-induced hamster animal model. Food Chem. Toxicol. 2011, 49, 1292-1297. [CrossRef] [PubMed]
4. Rajapakse, N.; Jung, W.K.; Mendis, E.; Moon, S.H.; Kim, S.K. A novel anticoagulant purified from fish protein hydrolysate inhibits factor XIIa and platelet aggregation. Life Sci. 2005, 76, 2607-2619. [CrossRef] [PubMed]
5. Wang, G.; Mishra, B.; Epand, R.F.; Epand, R.M. High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments. Biochim. Biophys. Acta. 2014, 1838, 2160-2172. [CrossRef] [PubMed]
6. Huang, H.N.; Rajanbabu, V.; Pan, C.Y.; Chan, Y.L.; Chen, J.Y.; Wu, C.J. Enhanced control of bladder-associated tumors using shrimp anti-lipopolysaccharide factor (SALF) antimicrobial peptide as a cancer vaccine adjuvant in mice. Mar. Drugs 2015, 13, 3241-3258. [CrossRef] [PubMed]
7. Huang, T.C.; Lee, J.F.; Chen, J.Y. Pardaxin, an antimicrobial peptide, triggers caspase-dependent and ROS-mediated apoptosis in HT1080 cells. Mar. Drugs 2011, 9, 1995-2009. [CrossRef] [PubMed]
8. Chan, D.I.; Prenner, E.J.; Vogel, H.J. Tryptophan- and arginine-rich antimicrobial peptides: Structures and mechanisms of action. Biochim. Biophys. Acta 2006, 1758, 1184-1202. [CrossRef] [PubMed]
9. Zasloff, M. Antimicrobial peptides of multicellular organisms. Nature 2002, 415, 389-395. [CrossRef] [PubMed]
10. Schweizer, F. Cationic amphiphilic peptides with cancer-selective toxicity. Eur. J. Pharmacol. 2009, 625, 190-194. [CrossRef] [PubMed]
11. Mader, J.S.; Hoskin, D.W. Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment. Expert Opin. Ivestig. Drugs 2006, 15, 933-946. [CrossRef] [PubMed]
12. Pan, C.Y.; Lin, C.N.; Chiou, M.T.; Yu, C.Y.; Chen, J.Y.; Chien, C.H. The antimicrobial peptide pardaxin exerts potent anti-tumor activity against canine perianal gland adenoma. Oncotarget 2014, 6, 2290-2301. [CrossRef] [PubMed]
13. Huang, H.N.; Rajanbabu, V.; Pan, C.Y.; Chan, Y.L.; Wu, C.J.; Chen, J.Y. A cancer vaccine based on the marine antimicrobial peptide pardaxin (GE33) for control of bladder-associated tumors. Biomaterials 2013, 34, 10151-10159. [CrossRef] [PubMed]
14. Wu, S.P.; Huang, T.C.; Lin, C.C.; Hui, C.F.; Lin, C.H.; Chen, J.Y. Pardaxin, a fish antimicrobial peptide, exhibits antitumor activity toward murine fibrosarcoma in vitro and in vivo. Mar. Drugs 2012, 10, 1852-1872. [CrossRef] [PubMed]
15. Posner, M.R.; Hershock, D.M.; Blajman, C.R. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N. Engl. J. Med. 2007, 357, 1705-1715. [CrossRef] [PubMed]
16. Takacsi-Nagy, Z.; Hitre, E.; Remenar, E.; Oberna, F.; Polgar, C.; Major, T.; Godeny, M.; Fodor, J.; Kasler, M. Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage III-IV unresectable head and neck cancer. Strahlenther. Onkol. 2015, 191, 635-641. [CrossRef] [PubMed]
17. Udenigwe, C.C.; Aluko, R.E. Food protein-derived bioactive peptides: Production, processing, and potential health benefits. J. Food Sci. 2012, 77, 11-24. [CrossRef] [PubMed]
18. Zheng, L.H.; Wang, Y.J.; Sheng, J.; Wang, F.; Zheng, Y.; Lin, X.K.; Sun, M. Antitumor peptides from marine organisms. Mar.Drugs 2011, 9, 1840-1859. [CrossRef] [PubMed]
19. Lin, X.; Liu, M.; Hu, C.; Liao, D.J. Targeting cellular proapoptotic molecules for developing anticancer agents from marine sources. Curr. Drug Targets 2010, 11, 708-715. [CrossRef] [PubMed]
20. Ceron, J.M.; Contreras-Moreno, J.; Puertollano, E.; de Cienfuegos, G.A.; Puertollano, M.A.; de Pablo, M.A. The antimicrobial peptide cecropin A induces caspase-independent cell death in human promyelocytic leukemia cells. Peptides 2010, 31, 1494-1503. [CrossRef] [PubMed]
21. Chang, W.T.; Pan, C.Y.; Rajanbabu, V.; Cheng, C.W.; Chen, J.Y. Tilapia (Oreochromis mossambicus) antimicrobial peptide, hepcidin 1-5, shows antitumor activity in cancer cells. Peptides 2011, 32, 342-352. [CrossRef] [PubMed]
22. Huang, T.C.; Chen, J.Y. Proteomic analysis reveals that pardaxin triggers apoptotic signaling pathways in human cervical carcinoma HeLa cells: Cross talk among the UPR, c-Jun and ROS. Carcinogenesis 2013, 34, 1833-1842. [CrossRef] [PubMed]
23. Hsu, J.C.; Lin, L.C.; Tzen, J.T.C.; Chen, J.Y. Pardaxin-indueced apoptosis enhances antitumor activity in HeLa cells. Peptides 2011, 32, 1110-1116. [CrossRef] [PubMed]
24. Ashkenazi, A.; Dixit, V.M. Death receptors: Signaling and modulation. Science 1998, 281, 1305-1308. [CrossRef] [PubMed]
25. Meek, D.W. Regulation of the p53 response and its relationship to cancer. Biochem. J. 2015, 469, 325-346. [CrossRef] [PubMed]
26. Marnett, L.J.; DuBois, R.N. COX-2: A target for colon cancer prevention. Annu. Rev. Pharmacol. Toxicol. 2002, 42, 55-80. [CrossRef] [PubMed]
27. Pace, E.; Siena, L.; Ferraro, M.; Profita, M.; Mondello, P.; Chiappara, G.; Montalbano, A.M.; Giarratano, A.; Bonsignore, G.; Gjomarkaj, M. Role of prostaglandin E2 in the invasiveness, growth and protection of cancer cells in malignant pleuritis. Eur. J. Cancer 2006, 42, 2382-2389. [CrossRef] [PubMed]
28. Nakagawa, Y.; Nakayama, H.; Nagata, M.; Yoshida, R.; Kawahara, K.; Hirosue, A.; Tanaka, T.; Yuno, A.; Matsuoka, Y.; Kojima, T.; et al. Overexpression of fibronectin confers cell adhesion-mediated drug resistance (CAM-DR) against 5-FU in oral squamous cell carcinoma cells. Int. J. Oncol. 2014, 44, 1376-1384. [PubMed]
29. Greenhough, A.; Smartt, H.J.; Moore, A.E.; Roberts, H.R.; Williams, A.C.; Paraskeva, C.; Kaidi, A. The COX-2/PGE2 pathway: Key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis 2009, 30, 377-386. [CrossRef] [PubMed]
30. Wang, D.; DuBois, R.N. An inflammatory mediator, prostaglandin E2 , in colorectal cancer. Cancer J. 2013, 19, 502-510. [CrossRef] [PubMed]
31. Moraitis, D.; Du, B.; de Lorenzo, M.S.; Boyle, J.O.; Weksler, B.B.; Cohen, E.G.; Carew, J.F.; Altorki, N.K.; Kopelovich, L.; Subbaramaiah, K.; et al. Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: Evidence for the role of epidermal growth factor receptor and its ligands. Cancer Res. 2005, 65, 664-670. [PubMed]
32. Cebola, I.; Peinado, M.A. Epigenetic deregulation of the COX pathway in cancer. Prog. Lipid Res. 2012, 51, 301-313. [CrossRef] [PubMed]
33. Hsu, W.H.; Lee, B.H.; Pan, T.M. Red mold dioscorea-indueced G2/M arrest and apoptosis in human oral cancer cells. J. Sci. Food Agric. 2010, 90, 2709-2715. [CrossRef] [PubMed]