Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine

Neuropharmacology

Volumn 105, Issue , 2016, Pages 215-227

  Zadina, James E ^a   Nilges, Mark R ^a   Morgenweck, Jenny ^a   Zhang, Xing ^a   Hackler, Laszlo ^a   Fasold, Melita B ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Addiction; Glia; Immunohistochemistry; Opioid; Pain; Reward

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; DELTA OPIATE RECEPTOR; ENDORPHIN DERIVATIVE; KAPPA OPIATE RECEPTOR; MORPHINE SULFATE; MU OPIATE RECEPTOR; PURINERGIC P2X7 RECEPTOR; SYNAPTOPHYSIN; TYROSINE CYCLIZED (DEXTRO GLUTAMYLPHENYLALANYLPHENYLALANYLLYSINE)AMIDE; TYROSINE CYCLIZED (DEXTRO LYSYLTRYPTOPHYLPHENYLALANYLASPARTIC ACID)AMIDE; TYROSINE CYCLIZED (DEXTRO LYSYLTRYPTOPHYLPHENYLALANYLGLUTAMIC ACID)GLYCINAMIDE; TYROSINE CYCLIZED (DEXTRO LYSYLTRYPTOPHYLPHENYLALANYLGLUTAMIC ACID)GLYCINE AMIDE; TYROSINE CYCLIZED(DEXTRO LYSYLTRYPTOPHYLPHENYLALANYLGLUTAMIC ACID)AMIDE; UNCLASSIFIED DRUG; MORPHINE; NARCOTIC ANALGESIC AGENT; OPRM1 PROTEIN, RAT;

ABUSE LIABILITY; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CONDITIONED PLACE PREFERENCE TEST; CONTROLLED STUDY; DRUG ABUSE; DRUG BINDING; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG TOLERANCE; GLIA CELL; GOLD STANDARD; HYPERALGESIA; IN VITRO STUDY; MALE; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; PAIN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; RAT; RESPIRATION DEPRESSION; ROTAROD TEST; SELF ADMINISTRATION TEST; SIGNAL TRANSDUCTION; TAIL FLICK TEST; ANIMAL; BLOOD BRAIN BARRIER; CHEMICALLY INDUCED; DRUG DEPENDENCE; DRUG EFFECTS; DYSKINESIA; INSTRUMENTAL CONDITIONING; MACROPHAGE ACTIVATION; METABOLISM; MICROGLIA; PAIN MEASUREMENT; PATHOPHYSIOLOGY; PSYCHOLOGY; RESPIRATORY FAILURE; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANIMALS; BLOOD-BRAIN BARRIER; CONDITIONING, OPERANT; DRUG TOLERANCE; DYSKINESIA, DRUG-INDUCED; HYPERALGESIA; MACROPHAGE ACTIVATION; MALE; MICE; MICROGLIA; MORPHINE; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; RESPIRATORY INSUFFICIENCY; SUBSTANCE-RELATED DISORDERS;

EID: 84955446711     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2015.12.024     Document Type: Article

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