Codon influence on protein expression in E. coli correlates with mRNA levels

Nature

Volumn 529, Issue 7586, 2016, Pages 358-363

  Boël, Grégory ^a,b   Letso, Reka ^a   Neely, Helen ^a   Price, W Nicholson ^a,f   Wong, Kam Ho ^a   Su, Min ^a   Luff, Jon D ^a   Valecha, Mayank ^a   Everett, John K ^c   Acton, Thomas B ^c   Xiao, Rong ^c   Montelione, Gaetano T ^c,d   Aalberts, Daniel P ^e   Hunt, John F ^a  

^a Columbia University ^*  (United States)

^b INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^c RUTGERS UNIVERSITY   (United States)

^d RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^e WILLIAMS COLLEGE   (United States)

^f Franklin Pierce Law Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; MESSENGER RNA; BACTERIOPHAGE T7 RNA POLYMERASE; CODON; DNA DIRECTED RNA POLYMERASE; ESCHERICHIA COLI PROTEIN; SYNTHETIC DNA; VIRAL PROTEIN;

BACTERIOPHAGE; COLIFORM BACTERIUM; CONCENTRATION (COMPOSITION); ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ANALYSIS; PHYSIOLOGICAL RESPONSE; PROTEIN;

ARTICLE; CODON; CODON USAGE; CONTROLLED STUDY; ENTEROBACTERIA PHAGE T7; ESCHERICHIA COLI; IN VITRO STUDY; IN VIVO STUDY; MESSENGER RNA SYNTHESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA DEGRADATION; RNA TRANSLATION; BIOLOGICAL MODEL; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HALF LIFE TIME; KINETICS; METABOLISM; MOLECULAR GENETICS; ODDS RATIO; PROTEIN SYNTHESIS; RNA FOLDING; RNA STABILITY; STATISTICAL MODEL; TRANSLATION ELONGATION;

ESCHERICHIA COLI;

CODON; DNA-DIRECTED RNA POLYMERASES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; GENES, SYNTHETIC; HALF-LIFE; KINETICS; LOGISTIC MODELS; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; ODDS RATIO; PEPTIDE CHAIN ELONGATION, TRANSLATIONAL; PROTEIN BIOSYNTHESIS; RNA FOLDING; RNA STABILITY; RNA, BACTERIAL; RNA, MESSENGER; TRANSCRIPTION, GENETIC; VIRAL PROTEINS;

EID: 84955442598     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16509     Document Type: Article

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