Investigation of platelet function and platelet disorders using flow cytometry

Platelets

Volumn 27, Issue 1, 2016, Pages 66-74

  Rubak, Peter ^a   Nissen, Peter H ^a   Kristensen, Steen D ^a   Hvas, Anne Mette ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Flow cytometry; platelet disorders; platelet function; platelets; thrombocytopenia

Indexed keywords

ADENOSINE DIPHOSPHATE; ALPHA2 INTEGRIN; ARACHIDONIC ACID; CD63 ANTIGEN; FIBRINOGEN; GLYCOPROTEIN; GLYCOPROTEIN IB; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; GLYCOPROTEIN IX; PADGEM PROTEIN; RISTOCETIN; SODIUM; THROMBIN RECEPTOR ACTIVATING PEPTIDE 6; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BERNARD SOULIER DISEASE; CELL SIZE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FLOW CYTOMETRY; GLANZMANN DISEASE; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THROMBOCYTE COUNT; THROMBOCYTE DISORDER; THROMBOCYTE FUNCTION; VALIDATION STUDY; BLOOD; BLOOD CLOTTING PARAMETERS; CASE CONTROL STUDY; CYTOLOGY; FEMALE; MALE; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; PROCEDURES; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA; YOUNG ADULT;

ADULT; BLOOD PLATELET DISORDERS; BLOOD PLATELETS; CASE-CONTROL STUDIES; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET FUNCTION TESTS; THROMBOCYTOPENIA; YOUNG ADULT;

EID: 84955376538     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2015.1032919     Document Type: Article

References (34)

1. George JN. Platelets. Lancet 2000; 355: 1531-1539
2. Page LK, Psaila B, Provan D, Michael Hamilton J, Jenkins JM, Elish AS, Lesser ML, Bussel JB. The immune thrombocytopenic purpura (ITP) bleeding score: Assessment of bleeding in patients with ITP. Br J Haematol 2007; 138: 245-248
3. Seyfert UT, Haubelt H, Vogt A, Hellstern P. Variables influencing Multiplate(TM) whole blood impedance platelet aggregometry and turbidimetric platelet aggregation in healthy individuals. Platelets 2007; 18: 199-206
4. Wurtz M, Hvas AM, Kristensen SD, Grove EL. Platelet aggregation is dependent on platelet count in patients with coronary artery disease. Thromb Res 2012; 129: 56-61
5. Hanke AA, Roberg K, Monaca E, Sellmann T, Weber CF, Rahe-Meyer N, Gorlinger K. Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate). Eur J Med Res 2010; 15: 214-219
6. Schmitz G, Rothe G, Ruf A, Barlage S, Tschope D, Clemetson KJ, Goodall AH, Michelson AD, Nurden AT, Shankey TV. European Working Group on clinical cell analysis: Consensus protocol for the flow cytometric characterisation of platelet function. Thromb Haemost 1998; 79: 885-896
7. Hickerson DH, Bode AP. Flow cytometry of platelets for clinical analysis. Hematol Oncol Clin North Am 2002; 16: 421-454
8. Michelson AD. Evaluation of platelet function by flow cytometry. Pathophysiol Haemost Thromb 2006; 35: 67-82
9. Tomer A, Scharf RE, McMillan R, Ruggeri ZM, Harker LA. Bernard-Soulier syndrome: Quantitative characterization of megakaryocytes and platelets by flow cytometric and platelet kinetic measurements. Eur J Haematol 1994; 52: 193-200
10. Althaus K, Greinacher A. MYH9-related platelet disorders. Semin Thromb Hemost 2009; 35: 189-203
11. George JN, Caen JP, Nurden AT. Glanzmann's thrombasthenia: The spectrum of clinical disease. Blood 1990; 75: 1383-1395
12. Noris P, Guidetti GF, Conti V, Ceresa IF, Di Pumpo M, Pecci A, Torti M, Savoia A, Balduini CL. Autosomal dominant thrombocytopenias with reduced expression of glycoprotein IA. Thromb Haemost 2006; 95: 483-489
13. Nurden AT, Nurden P. Inherited defects of platelet function. Rev Clin Exp Hematol 2001; 5: 314-334; quiz following 431
14. Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, Machin S. Guidelines for the laboratory investigation of heritable disorders of platelet function. Br J Haematol 2011; 155: 30-44
15. Podda G, Femia EA, Pugliano M, Cattaneo M. Congenital defects of platelet function. Platelets 2012; 23: 552-563
16. Hayward CP. Inherited disorders of platelet alpha-granules. Platelets 1997; 8: 197-209
17. van Velzen JF, Laros-van Gorkom BA, Pop GA, van Heerde WL. Multicolor flow cytometry for evaluation of platelet surface antigens and activation markers. Thromb Res 2012; 130: 92-98
18. Nieuwenhuis HK, van Oosterhout JJ, Rozemuller E, van Iwaarden F, Sixma JJ. Studies with a monoclonal antibody against activated platelets: Evidence that a secreted 53,000-molecular weight lysosome-like granule protein is exposed on the surface of activated platelets in the circulation. Blood 1987; 70: 838-845
19. Shalev A, Michaud G, Israels SJ, McNicol A, Singhroy S, McMillan EM, White JG, Witkop CJ, Nichols WL, Greenberg AH, et al. Quantification of a novel dense granule protein (granulophysin) in platelets of patients with dense granule storage pool deficiency. Blood 1992; 80: 1231-1237
20. Gralnick HR, Williams SB, McKeown L, Shafer B, Connaghan GD, Hansmann K, Vail M, Magruder L. Endogenous platelet fibrinogen: Its modulation after surface expression is related to size-selective access to and conformational changes in the bound fibrinogen. Br J Haematol 1992; 80: 347-357
21. Lindahl TL, Festin R, Larsson A. Studies of fibrinogen binding to platelets by flow cytometry: An improved method for studies of platelet activation. Thromb Haemost 1992; 68: 221-225
22. Barnes MJ, Knight CG, Farndale RW. The use of collagen-based model peptides to investigate platelet-reactive sequences in collagen. Biopolymers 1996; 40: 383-397
23. Maecker HT, Trotter J. Flow cytometry controls, instrument setup, and the determination of positivity. Cytometry A 2006; 69: 1037-1042
24. Hulspas R, O'Gorman MR, Wood BL, Gratama JW, Sutherland DR. Considerations for the control of background fluorescence in clinical flow cytometry. Cytometry B 2009; 76: 355-364
25. Rukoyatkina N, Mindukshev I, Walter U, Gambaryan S. Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists. Cell Death Dis 2013; 4: e931
26. Kodama T, Takehara T, Hikita H, Shimizu S, Shigekawa M, Li W, Miyagi T, Hosui A, Tatsumi T, Ishida H, et al. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: Molecular requisites for the mitochondrial pathway to apoptosis in platelets. J Biol Chem 2011; 286: 13905-13913
27. De Marco L, Girolami A, Zimmerman TS, Ruggeri ZM. Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation. Proc Natl Acad Sci USA 1985; 82: 7424-7428
28. Li S, Wang Z, Liao Y, Zhang W, Shi Q, Yan R, Ruan C, Dai K. The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis. J Thromb Haemost 2010; 8: 341-350
29. Song S, Mody M, Freedman J, Ellis J, Lazarus AH. von Willebrand factor (VWF)-dependent human platelet activation: Porcine VWF utilizes different transmembrane signaling pathways than does thrombin to activate platelets, but both require protein phosphatase function. J Thromb Haemost 2003; 1: 337-346
30. Kehrel B, Wierwille S, Clemetson KJ, Anders O, Steiner M, Knight CG, Farndale RW, Okuma M, Barnes MJ. Glycoprotein VI is a major collagen receptor for platelet activation: It recognizes the platelet-activating quaternary structure of collagen, whereas CD36, glycoprotein IIb/IIIa, and von Willebrand factor do not. Blood 1998; 91: 491-499
31. Michelson AD, Barnard MR, Krueger LA, Frelinger AL III, Furman MI. Evaluation of platelet function by flow cytometry. Methods 2000; 21: 259-270
32. Krueger LA, Barnard MR, Frelinger AL, III, Furman MI, Michelson AD. Immunophenotypic analysis of platelets. Curr Protoc Cytom 2002;Chapter 6:Unit 6 10
33. Michelson AD. Platelet activation by thrombin can be directly measured in whole blood through the use of the peptide GPRP and flow cytometry: Methods and clinical applications. Blood Coagul Fibrinolysis 1994; 5: 121-131
34. Vretenbrant K, Ramstrom S, Bjerke M, Lindahl TL. Platelet activation via PAR4 is involved in the initiation of thrombin generation and in clot elasticity development. Thromb Haemost 2007; 97: 417-424