Guidelines for the laboratory investigation of heritable disorders of platelet function

British Journal of Haematology

Volumn 155, Issue 1, 2011, Pages 30-44

  Harrison, Paul ^a   Mackie, Ian ^b   Mumford, Andrew ^c   Briggs, Carol ^d   Liesner, Ri ^e   Winter, Mark ^f   Machin, Sam ^b  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c BRISTOL HAEMATOLOGY AND ONCOLOGY CENTRE   (United Kingdom)

^d UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^e GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^f KENT AND CANTERBURY HOSPITAL   (United Kingdom)

Author keywords

Platelet disorders; Platelet function; Platelets

Indexed keywords

ADENINE NUCLEOTIDE; CITRATE TRISODIUM; GENOMIC DNA;

ANALYTICAL EQUIPMENT; ARTICLE; BERNARD SOULIER DISEASE; BLEEDING TIME; BLOOD ANALYSIS; BLOOD CLOTTING PARAMETERS; BLOOD SAMPLING; CELL SIZE; CHILDHOOD; CONSENSUS DEVELOPMENT; ENZYME LINKED IMMUNOSORBENT ASSAY; EVIDENCE BASED MEDICINE; FLOW CYTOMETRY; GLANZMANN DISEASE; HEMOSTASIS; HUMAN; INFANCY; LABORATORY TEST; LIGHT TRANSMISSION AGGREGOMETRY; MEDICAL EXPERT; MEDICAL SOCIETY; MEDLINE; MOLECULAR GENETICS; NUCLEIC ACID ANALYSIS; NUCLEOTIDE METABOLISM; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RADIOIMMUNOASSAY; SENSITIVITY AND SPECIFICITY; SHEAR STRESS; SYSTEMATIC REVIEW; THROMBOCYTE COUNT; THROMBOCYTE DISORDER; THROMBOCYTE FUNCTION; THROMBOCYTE RICH PLASMA; THROMBOCYTE STRUCTURE; UNITED KINGDOM; VALIDATION PROCESS; VEIN PUNCTURE; WESTERN BLOTTING; WHOLE BLOOD AGGREGOMETRY;

BLOOD COAGULATION DISORDERS, INHERITED; BLOOD PLATELET DISORDERS; BLOOD SPECIMEN COLLECTION; CHILD, PRESCHOOL; HUMANS; INFANT; PLATELET AGGREGATION; PLATELET COUNT; PLATELET FUNCTION TESTS;

EID: 80052574167     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08793.x     Document Type: Article

References (94)

1. Acharya, S., Barraclough, J., Ibrahim, M.S., Oxby, C., Jones, S.E., Parapia, L. & O'donovan, P. (2008) The usefulness of the platelet function analyser (PFA-100) in screening for underlying bleeding disorders in women with menorrhagia. Journal of Obstetrics and Gynecology, 28, 310-314.
2. Althaus, K. & Greinacher, A. (2009) MYH9-related platelet disorders. Seminars in Thrombosis and Hemostasis, 35, 189-203.
3. Bolton-Maggs, P.H., Perry, D.J., Chalmers, E.A., Parapia, L.A., Wilde, J.T., Williams, M.D., Collins, P.W., Kitchen, S., Dolan, G. & Mumford, A.D. (2004) The rare coagulation disorders - review with guidelines for management from the United Kingdom haemophilia centre doctors' organisation. Haemophilia, 10, 593-628.
4. Bolton-Maggs, P.H., Chalmers, E.A., Collins, P.W., Harrison, P., Kitchen, S., Liesner, R.J., Minford, A., Mumford, A.D., Parapia, L.A., Perry, D.J., Watson, S.P., Wilde, J.T. & Williams, M.D. (2006) A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO. British Journal of Haematology, 135, 603-633.
5. Bonduel, M., Frontroth, J.P., Hepner, M., Sciuccati, G. & Feliu-Torres, A. (2007) Platelet aggregation and adenosine triphosphate release values in children and adults. Journal of Thrombosis and Haemostasis, 5, 1782-1787.
6. Briggs, C., Harrison, P. & Machin, S.J. (2007) Platelet counting. In: Platelets (ed. by A.D. Michelson), pp. 475-483. Academic Press, San Diego.
7. Cardinal, D.C. & Flower, R.J. (1980) The electronic aggregometer: a novel device for assessing platelet behavior in blood. Journal of Pharmacological Methods, 3, 135-158.
8. Cattaneo, M. (2003) Inherited platelet-based bleeding disorders. Journal of Thrombosis and Haemostasis, 1, 1628-1636.
9. Cattaneo, M. (2004) Are the bleeding time and PFA-100 useful in the initial screening of patients with mucocutaneous bleedings of hereditary nature? Journal of Thrombosis and Haemostasis, 2, 890-891.
10. Cattaneo, M. (2009) Light transmission aggregometry and ATP release for the diagnostic assessment of platelet function. Seminars in Thrombosis and Hemostasis, 35, 158-167.
11. Cattaneo, M., Federici, A.B., Lecchi, A., Agati, B., Lombardi, R., Stabile, F. & Bucciarelli, P. (1999) Evaluation of the PFA-100 system in the diagnosis and therapeutic monitoring of patients with von Willebrand disease. Thrombosis and Haemostasis, 82, 35-39.
12. Cattaneo, M., Lecchi, A., Zighetti, M.L. & Lussana, F. (2007) Platelet aggregation studies: autologous platelet-poor plasma inhibits platelet aggregation when added to platelet-rich plasma to normalize platelet count. Haematologica, 92, 694-697.
13. Cattaneo, M., Hayward, C.P., Moffat, K.A., Pugliano, M.T., Liu, Y. & Michelson, A.D. (2009) Results of a worldwide survey on the assessment of platelet function by light transmission aggregometry: a report from the platelet physiology subcommittee of the SSC of the ISTH. Journal of Thrombosis and Haemostasis, 7, 1029.
14. Chanarin, I. (1989) Platelet function tests. In: Laboratory Haematology (ed. by I. Chanarin), pp. 371-399. Churchill Livingstone, Edinburgh.
15. Christie, D.J., Avari, T., Carrington, L.R., Cohen, E., DeBiase, B., Harrison, P., Kickler, T., Kottke-Marchant, K., Ledford-Kraemer, M.R., Rand, M.L., Schmaier, A.H. & McCabe White, M. (2008) Platelet function testing by aggregometry: approved guideline. Wayne PA: Clinical and Laboratory Standards Institute, 28, 1-45.
16. Clauser, S. & Cramer-Borde, E. (2009) Role of platelet electron microscopy in the diagnosis of platelet disorders. Seminars in Thrombosis and Hemostasis, 35, 213-223.
17. Daly, M.E., Dawood, B.B., Lester, W.A., Peake, I.R., Rodeghiero, F., Goodeve, A.C., Makris, M., Wilde, J.T., Mumford, A.D., Watson, S.P. & Mundell, S.J. (2009) Identification and characterization of a novel P2Y 12 variant in a patient diagnosed with type 1 von Willebrand disease in the European MCMDM-1VWD study. Blood, 113, 4110-4113.
18. Dawood, B.B., Wilde, J. & Watson, S.P. (2007) Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. Platelets, 18, 329-345.
19. Duke, W.W. (1910) The relation of blood platelets to hemorrhagic disease. Description of a method for determining the bleeding time and the coagulation time and report of three cases of hemorrahagic disease relieved by blood transfusion. JAMA, 55, 1185-1192.
20. Favaloro, E.J. (2006) The utility of the PFA-100 in the identification of von Willebrand disease: a concise review. Seminars in Thrombosis and Hemostasis, 32, 537-545.
21. Favaloro, E.J. (2008) Clinical utility of the PFA-100. Seminars in Thrombosis and Hemostasis, 34, 709-733.
22. Favaloro, E.J. (2009) Internal quality control and external quality assurance of platelet function tests. Seminars in Thrombosis and Hemostasis, 35, 139-149.
23. Favaloro, E.J., Kershaw, G., Bukuya, M., Hertzberg, M. & Koutts, J. (2001) Laboratory diagnosis of von Willebrand disorder (vWD) and monitoring of DDAVP therapy: efficacy of the PFA-100 and vWF:CBA as combined diagnostic strategies. Haemophilia, 7, 180-189.
24. Favaloro, E.J., Lippi, G. & Adcock, D.M. (2008) Preanalytical and postanalytical variables: the leading causes of diagnostic error in hemostasis? Seminars in Thrombosis and Hemostasis, 34, 612-634.
25. Franchini, M. (2005) The platelet function analyzer (PFA-100): an update on its clinical use. Clinical Laboratory, 51, 367-372.
26. Franchini, M., Gandini, G., Manzato, F. & Lippi, G. (2002) Evaluation of the PFA-100 system for monitoring desmopressin therapy in patients with type 1 von Willebrand's disease. Haematologica, 87, 670.
27. Fritsma, G.A. (2007) Platelet function testing: aggregometry and lumiaggregometry. Clinical Laboratory Science, 20, 32-37.
28. George, J.N. & Shattil, S.J. (1991) The clinical importance of acquired abnormalities of platelet function. New England Journal of Medicine, 324, 27-39.
29. Goodall, A.H. & Appleby, J. (2004) Flow-cytometric analysis of platelet-membrane glycoprotein expression and platelet activation. Methods and Molecular Biology, 272, 225-253.
30. Gordon, N., Thom, J., Cole, C. & Baker, R. (1995) Rapid detection of hereditary and acquired platelet storage pool deficiency by flow cytometry. British Journal of Haematology, 89, 117-123.
31. Greaves, M. & Preston, F.E. (1985) The laboratory investigation of acquired and platelet disorders. In: Blood Coagulation and Haemostasis: A Practical Guide (ed. by J.M. Thomson), pp. 56-134. Churchill Livingstone, Edinburgh.
32. Harrison, P. (2004) In vitro measurement of high-shear platelet adhesion and aggregation by the PFA-100. Methods and Molecular Biology, 272, 215-223.
33. Harrison, P. (2005) The role of PFA-100 testing in the investigation and management of haemostatic defects in children and adults. British Journal of Haematology, 130, 3-10.
34. Harrison, P. & Mumford, A. (2009) Screening tests of platelet function: update on their appropriate uses for diagnostic testing. Seminars in Thrombosis and Hemostasis, 35, 150-157.
35. Harrison, P., Robinson, M.S., Mackie, I.J., Joseph, J., McDonald, S.J., Liesner, R., Savidge, G.F., Pasi, J. & Machin, S.J. (1999) Performance of the platelet function analyser PFA-100 in testing abnormalities of primary haemostasis. Blood Coagulation and Fibrinolysis, 10, 25-31.
36. Harrison, P., Horton, A., Grant, D., Briggs, C. & Machin, S. (2000) Immunoplatelet counting: a proposed new reference procedure. British Journal of Haematology, 108, 228-235.
37. Harrison, P., Robinson, M., Liesner, R., Khair, K., Cohen, H., Mackie, I. & Machin, S. (2002) The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction. Clinical and Laboratory Haematology, 24, 225-232.
38. Harrison, P., Segal, H., Furtado, C., Verjee, S., Sukhu, K. & Murphy, M.F. (2004) High incidence of defective high-shear platelet function among platelet donors. Transfusion, 44, 764-770.
39. Harrison, P., Frelinger, III, A.L., Furman, M.I. & Michelson, A.D. (2007) Measuring antiplatelet drug effects in the laboratory. Thrombosis Research, 120, 323-336.
40. Hayward, C.P. (2008) Diagnostic approach to platelet function disorders. Transfusion and Apheresis Science, 38, 65-76.
41. Hayward, C.P. & Eikelboom, J. (2007) Platelet function testing: quality assurance. Seminars in Thrombosis and Hemostasis, 33, 273-282.
42. Hayward, C.P. & Favaloro, E.J. (2009) Diagnostic evaluation of platelet disorders: the past, the present, and the future. Seminars in Thrombosis and Hemostasis, 35, 127-130.
43. Hayward, C.P., Harrison, P., Cattaneo, M., Ortel, T.L. & Rao, A.K. (2006) Platelet function analyser (PFA-100) closure time in the evaluation of platelet disorders and platelet function. Journal of Thrombosis and Haemostasis, 4, 1-8.
44. Hayward, C.P., Moffat, K.A., Pai, M., Liu, Y., Seecharan, J., McKay, H., Webert, K.E., Cook, R.J. & Heddle, N.M. (2008) An evaluation of methods for determining reference intervals for light transmission platelet aggregation tests on samples with normal or reduced platelet counts. Thrombosis and Haemostasis, 100, 134-145.
45. Hayward, C.P., Pai, M., Liu, Y., Moffat, K.A., Seecharan, J., Webert, K.E., Cook, R.J. & Heddle, N.M. (2009a) Diagnostic utility of light transmission platelet aggregometry: results from a prospective study of individuals referred for bleeding disorder assessments. Journal of Thrombosis and Haemostasis, 7, 676-684.
46. Hayward, C.P., Moffat, K.A., Spitzer, E., Timleck, M., Plumhoff, E., Israels, S.J. & White, J. (2009b) Results of an external proficiency testing exercise on platelet dense-granule deficiency testing by whole mount electron microscopy. American Journal of Clinical Pathology, 131, 671-675.
47. Hayward, C.P., Moffat, K.A., Raby, A., Israels, S., Plumhoff, E., Flynn, G. & Zehnder, J.L. (2010) Development of North American consensus guidelines for medical laboratories that perform and interpret platelet function testing using light transmission aggregometry. American Journal of Clinical Pathology, 134, 955-963.
48. Heilmann, E.J., Kundu, S.K., Sio, R., Garcia, C., Gomez, R. & Christie, D.J. (1997) Comparison of four commercial citrate blood collection systems for platelet function analysis by the PFA-100 system. Thrombosis Research, 87, 159-164.
49. Ingerman-Wojenski, C., Smith, J.B. & Silver, M.J. (1983) Evaluation of electrical aggregometry: comparison with optical aggregometry, secretion of ATP, and accumulation of radiolabeled platelets. Journal of Laboratory and Clinical Medicine, 101, 44-52.
50. Israels, S.J., McNicol, A., Robertson, C. & Gerrard, J.M. (1990) Platelet storage pool deficiency: diagnosis in patients with prolonged bleeding times and normal platelet aggregation. British Journal of Haematology, 75, 118-121.
51. Israels, S.J., Kahr, W.H.A., Blanchette, V.S., Luban, N.L.C., Rivard, G.E. & Rand, M.L. (2011) Platelet disorders in children a diagnostic approach. Pediatric Blood & Cancer, 56, 975-983.
52. James, A.H., Lukes, A.S., Brancazio, L.R., Thames, E. & Ortel, T.L. (2004) Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia. American Journal of Obstetrics and Gynecology, 191, 449-455.
53. Jennings, I., Woods, T.A., Kitchen, S. & Walker, I.D. (2008) Platelet function testing: practice among UK national external quality assessment scheme for blood coagulation participants, 2006. Journal of Clinical Pathology, 61, 950-954.
54. Jilma, B. (2001) Platelet function analyzer (PFA-100): a tool to quantify congenital or acquired platelet dysfunction. Journal of Laboratory and Clinical Medicine, 138, 152-163.
55. Kahr, W.H., Zheng, S., Sheth, P.M., Pai, M., Cowie, A., Bouchard, M., Podor, T.J., Rivard, G.E. & Hayward, C.P. (2001) Platelets from patients with the Quebec platelet disorder contain and secrete abnormal amounts of urokinase-type plasminogen activator. Blood, 98, 257-265.
56. Karger, R., Donner-Banzhoff, N., Muller, H.H., Kretschmer, V. & Hunink, M. (2007) Diagnostic performance of the platelet function analyzer (PFA-100) for the detection of disorders of primary haemostasis in patients with a bleeding history-a systematic review and meta-analysis. Platelets, 18, 249-260.
57. Kerenyi, A., Schlammadinger, A., Ajzner, E., Szegedi, I., Kiss, C., Pap, Z., Boda, Z. & Muszbek, L. (1999) Comparison of PFA-100 closure time and template bleeding time of patients with inherited disorders causing defective platelet function. Thrombosis Research, 96, 487-492.
58. Knofler, R., Weissbach, G. & Kuhlisch, E. (1998) Platelet function tests in childhood. Measuring aggregation and release reaction in whole blood. Seminars in Thrombosis and Hemostasis, 24, 513-521.
59. Kottke-Marchant, K. & Corcoran, G. (2002) The laboratory diagnosis of platelet disorders. Archives of Pathology & Laboratory Medicine, 126, 133-146.
60. Kratzer, M.A. & Born, G.V. (1985) Simulation of primary haemostasis in vitro. Haemostasis, 15, 357-362.
61. Kundu, S.K., Heilmann, E.J., Sio, R., Garcia, C., Davidson, R.M. & Ostgaard, R.A. (1995) Description of an in vitro platelet function analyzer - PFA-100. Seminars in Thrombosis and Hemostasis, 21(Suppl. 2), 106-112.
62. Kunicki, T.J., Williams, S.A., Salomon, D.R., Harrison, P., Crisler, P., Nakagawa, P., Mondala, T.S., Head, S.R. & Nugent, D.J. (2009) Genetics of platelet reactivity in normal, healthy individuals. Journal of Thrombosis and Haemostasis, 7, 2116-2122.
63. Laffan, M., Brown, S.A., Collins, P.W., Cumming, A.M., Hill, F.G., Keeling, D., Peake, I.R. & Pasi, K.J. (2004) The diagnosis of von Willebrand disease: a guideline from the UK haemophilia centre doctors' organization. Haemophilia, 10, 199-217.
64. Linnemann, B., Schwonberg, J., Mani, H., Prochnow, S. & Lindhoff-Last, E. (2008) Standardization of light transmittance aggregometry for monitoring antiplatelet therapy: an adjustment for platelet count is not necessary. Journal of Thrombosis and Haemostasis, 6, 677-683.
65. Lippi, G., Franchini, M., Brocco, G. & Manzato, F. (2001) Influence of the ABO blood type on the platelet function analyzer PFA-100. Thrombosis and Haemostasis, 85, 369-370.
66. Ludlam, C.A., Pasi, K.J., Bolton-Maggs, P., Collins, P.W., Cumming, A.M., Dolan, G., Fryer, A., Harrington, C., Hill, F.G., Peake, I.R., Perry, D.J., Skirton, H. & Smith, M. (2005) UK haemophilia centre doctors' organisation. A framework for genetic service provision for haemophilia and other inherited bleeding disorders. Haemophilia, 2, 145-163.
67. Mackie, I.J., Jones, R. & Machin, S.J. (1984) Platelet impedance aggregation in whole blood and its inhibition by antiplatelet drugs. Journal of Clinical Pathology, 37, 874-878.
68. Mammen, E.F., Comp, P.C., Gosselin, R., Greenberg, C., Hoots, W.K., Kessler, C.M., Larkin, E.C., Liles, D. & Nugent, D.J. (1998) PFA-100 system: a new method for assessment of platelet dysfunction. Seminars in Thrombosis and Hemostasis, 24, 195-202.
69. Michelson, A.D., Linden, M., Barnard, M.R., Furman, M.I. & Frelinger, A.L. (2007) Flow cytometry. In: Platelets (ed. by A.D. Michelson), pp. 545-563. Academic Press, Boston.
70. Moeller, A., Weippert-Kretschmer, M., Prinz, H. & Kretschmer, V. (2001) Influence of ABO blood groups on primary hemostasis. Transfusion, 41, 56-60.
71. Moffat, K.A., Ledford-Kraemer, M.R., Nichols, W.L. & Hayward, C.P. (2005) Variability in clinical laboratory practice in testing for disorders of platelet function: results of two surveys of the North American specialized coagulation laboratory association. Thrombosis and Haemostasis, 93, 549-553.
72. Nieuwenhuis, H.K., Akkerman, J.W. & Sixma, J.J. (1987) Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients. Blood, 70, 620-623.
73. Nurden, P. & Nurden, A. (2009) Diagnostic assessment of platelet function. In: Quality in Laboratory Hemostasis and Thrombosis (ed. by S. Kitchen, J.D. Olson & F.E. Preston), pp. 115. Wiley-Blackwell, Oxford, UK.
74. Nurden, A.T., Fiore, M., Pillois, X. & Nurden, P. (2009) Genetic testing in the diagnostic evaluation of inherited platelet disorders. Seminars in Thrombosis and Hemostasis, 35, 204-212.
75. Pai, M. & Hayward, C.P. (2009) Diagnostic assessment of platelet disorders: what are the challenges to standardization? Seminars in Thrombosis and Hemostasis, 35, 131-138.
76. Perry, D.J., Fitzmaurice, D.A., Kitchen, S., Mackie, I.J. & Mallet, S. (2010) Point of care testing in haemostasis. British Journal of Haematology, 150, 501-514.
77. Peterson, P., Hayes, T.E., Arkin, C.F., Bovill, E.G., Fairweather, R.B., Rock, Jr, W.A., Triplett, D.A. & Brandt, J.T. (1998) The preoperative bleeding time test lacks clinical benefit: college of American pathologists' and American society of clinical pathologists' position article. Archives of Surgery, 133, 134-139.
78. Philipp, C.S., Miller, C.H., Faiz, A., Dilley, A., Michaels, L.A., Ayers, C., Bachmann, G., Dowling, N. & Saidi, P. (2005) Screening women with menorrhagia for underlying bleeding disorders: the utility of the platelet function analyser and bleeding time. Haemophilia, 11, 497-503.
79. Podda, G.M., Bucciarelli, P., Lussana, F., Lecchi, A. & Cattaneo, M. (2007) Usefulness of PFA-100 testing in the diagnostic screening of patients with suspected abnormalities of hemostasis: comparison with the bleeding time. Journal of Thrombosis and Haemostasis, 5, 2393-2398.
80. Posan, E., McBane, R.D., Grill, D.E., Motsko, C.L. & Nichols, W.L. (2003) Comparison of PFA-100 testing and bleeding time for detecting platelet hypofunction and von Willebrand disease in clinical practice. Thrombosis and Haemostasis, 90, 483-490.
81. Quiroga, T., Goycoolea, M., Munoz, B., Morales, M., Aranda, E., Panes, O., Pereira, J. & Mezzano, D. (2004) Template bleeding time and PFA-100 have low sensitivity to screen patients with hereditary mucocutaneous hemorrhages: comparative study in 148 patients. Journal of Thrombosis and Haemostasis, 2, 892-898.
82. Quiroga, T., Goycoolea, M., Panes, O., Aranda, E., Martinez, C., Belmont, S., Munoz, B., Zuniga, P., Pereira, J. & Mezzano, D. (2007) High prevalence of bleeders of unknown cause among patients with inherited mucocutaneous bleeding. A prospective study of 280 patients and 299 controls. Haematologica, 92, 357-365.
83. Rodgers, R.P. & Levin, J. (1990) A critical reappraisal of the bleeding time. Seminars in Thrombosis and Hemostasis, 16, 1-20.
84. Schmitz, G., Rothe, G., Ruf, A., Barlage, S., Tschope, D., Clemetson, K.J., Goodall, A.H., Michelson, A.D., Nurden, A.T. & Shankey, T.V. (1998) European working group on clinical cell analysis: consensus protocol for the flow cytometric characterisation of platelet function. Thrombosis and Haemostasis, 79, 885-896.
85. Summerfield, G.P., Keenan, J.P., Brodie, N.J. & Bellingham, A.J. (1981) Bioluminescent assay of adenine nucleotides: rapid analysis of ATP and ADP in red cells and platelets using the LKB luminometer. Clinical and laboratory haematology, 3, 257-271.
86. Swart, S.S., Pearson, D., Wood, J.K. & Barnett, D.B. (1984) Effects of adrenaline and alpha adrenergic antagonists on platelet aggregation in whole blood: evaluation of electrical impedance aggregometry. Thrombosis Research, 36, 411-418.
87. Sweeney, J.D., Hoernig, L.A., Michnik, A. & Fitzpatrick, J.E. (1989) Whole blood aggregometry. Influence of sample collection and delay in study performance on test results. American Journal of Clinical Pathology, 92, 676-679.
88. The British Society for Haematology BCSH Haemostasis and Thrombosis Task Force (1988) Guidelines on platelet function testing. Journal of Clinical Pathology, 41, 1322-1330.
89. Toth, O., Calatzis, A., Losonczy, H. & Siess, W. (2006) Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood. Thrombosis and Haemostasis, 96, 781-788.
90. van Vliet, H.H., Kappers-Klunne, M.C., Leebeek, F.W. & Michiels, J.J. (2008) PFA-100 monitoring of von Willebrand factor (VWF) responses to desmopressin (DDAVP) and factor VIII/VWF concentrate substitution in von Willebrand disease type 1 and 2. Thrombosis and Haemostasis, 100, 462-468.
91. Wall, J.E., Buijs-Wilts, M., Arnold, J.T., Wang, W., White, M.M., Jennings, L.K. & Jackson, C.W. (1995) A flow cytometric assay using mepacrine for study of uptake and release of platelet dense granule contents. British Journal of Haematology, 89, 380-385.
92. Watson, S., Daly, M., Dawood, B., Gissen, P., Makris, M., Mundell, S., Wilde, J. & Mumford, A. (2010) Phenotypic approaches to gene mapping in platelet function disorrders. Hamostaseologie, 30, 29-38.
93. Zeidan, A.M., Kouides, P.A., Tara, M.A. & Fricke, W.A. (2007) Platelet function testing: state of the art. Expert Review of Cardiovascular Therapy, 5, 955-967.
94. Zhou, L. & Schmaier, A.H. (2005) Platelet aggregation testing in platelet-rich plasma: description of procedures with the aim to develop standards in the field. American Journal of Clinical Pathology, 123, 172-183.