Platelet aggregation is dependent on platelet count in patients with coronary artery disease

Thrombosis Research

Volumn 129, Issue 1, 2012, Pages 56-61

  Würtz, Morten ^a   Hvas, Anne Mette ^a   Kristensen, Steen Dalby ^a   Grove, Erik Lerkevang ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Antiplatelet drugs; Erythrocytes; Leukocytes; Platelet count; Platelet function tests

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; COLLAGEN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORONARY ARTERY DISEASE; ERYTHROCYTE; FEMALE; HEMATOCRIT; HEMATOLOGICAL PARAMETERS; HUMAN; LEUKOCYTE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ADULT; AGED; ARACHIDONIC ACID; ASPIRIN; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; COLLAGEN; CORONARY ANGIOGRAPHY; CORONARY ARTERY DISEASE; DENMARK; ERYTHROCYTE COUNT; FEMALE; HEMATOCRIT; HUMANS; LEUKOCYTE COUNT; LINEAR MODELS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PLATELET COUNT; PLATELET FUNCTION TESTS; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84655167209     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.08.019     Document Type: Article

References (30)

1. M. Cattaneo Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection J Thromb Haemost 5 Suppl 1 2007 230 237 (Pubitemid 46958838)
2. E.L. Grove, and S.D. Kristensen Update on oral antiplatelet therapy: principles, problems and promises Future Cardiol 5 3 2009 247 258
3. E.L. Grove, M. Wurtz, A.M. Hvas, and S.D. Kristensen Increased platelet turnover in patients with previous definite stent thrombosis J Thromb Haemost 9 7 2011 1418 1419
4. E.L. Grove, A.M. Hvas, H.L. Johnsen, S.S. Hedegaard, S.B. Pedersen, and J. Mortensen A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery disease Thromb Haemost 103 6 2010 1245 1253
5. N.J. Breet, J.W. van Werkum, H.J. Bouman, J.C. Kelder, H.J. Ruven, and E.T. Bal Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation JAMA 303 8 2010 754 762
6. D. Sibbing, S. Braun, T. Morath, J. Mehilli, W. Vogt, and A. Schomig Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis J Am Coll Cardiol 53 10 2009 849 856
7. U.T. Seyfert, H. Haubelt, A. Vogt, and P. Hellstern Variables influencing Multiplate(TM) whole blood impedance platelet aggregometry and turbidimetric platelet aggregation in healthy individuals Platelets 18 3 2007 199 206 (Pubitemid 46744118)
8. E.L. Grove, A.M. Hvas, S.B. Mortensen, S.B. Larsen, and S.D. Kristensen Effect of platelet turnover on whole blood platelet aggregation in patients with coronary artery disease J Thromb Haemost 9 1 2011 185 191
9. T. Stissing, N.P. Dridi, S.R. Ostrowski, L. Bochsen, and P.I. Johansson The influence of low platelet count on whole blood aggregometry assessed by multiplate Clin Appl Thromb Hemost 2011 doi: 10.1177/1076029610397183
10. L. Bochsen, P.I. Johansson, A.T. Kristensen, G. Daugaard, and S.R. Ostrowski The influence of platelets, plasma and red blood cells on functional haemostatic assays Blood Coagul Fibrinolysis 22 3 2011 167 175
11. A.A. Hanke, K. Roberg, E. Monaca, T. Sellmann, C.F. Weber, and N. Rahe-Meyer Impact of platelet count on results obtained from multiple electrode platelet aggregometry (Multiplate) Eur J Med Res 15 5 2010 214 219
12. I.J. Mackie, R. Jones, and S.J. Machin Platelet impedance aggregation in whole blood and its inhibition by antiplatelet drugs J Clin Pathol 37 8 1984 874 878 (Pubitemid 14065060)
13. M.R. Muller, A. Salat, S. Pulaki, P. Stangl, E. Ergun, and W. Schreiner Influence of hematocrit and platelet count on impedance and reactivity of whole blood for electrical aggregometry J Pharmacol Toxicol Methods 34 1 1995 17 22
14. M. Wurtz, E.L. Grove, S.D. Kristensen, and A.M. Hvas The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease Heart 96 5 2010 368 371
15. S.B. Mortensen, S.B. Larsen, E.L. Grove, S.D. Kristensen, and A.M. Hvas Reduced platelet response to aspirin in patients with coronary artery disease and type 2 diabetes mellitus Thromb Res 126 4 2010 318 322
16. O. Toth, A. Calatzis, S. Penz, H. Losonczy, and W. Siess Multiple electrode aggregometry: a new device to measure platelet aggregation in whole blood Thromb Haemost 96 6 2006 781 788 (Pubitemid 44883819)
17. S.B. Pedersen, E.L. Grove, H.L. Nielsen, J. Mortensen, S.D. Kristensen, and A.M. Hvas Evaluation of aspirin response by Multiplate® whole blood aggregometry and light transmission aggregometry Platelets 20 6 2009 415 420
18. H.L. Nielsen, S.D. Kristensen, S.S. Thygesen, J. Mortensen, S.B. Pedersen, and E.L. Grove Aspirin response evaluated by the VerifyNowtrade mark Aspirin System and Light Transmission Aggregometry Thromb Res 123 2008 267 273
19. M. Cattaneo Laboratory detection of 'aspirin resistance': what test should we use (if any)? Eur Heart J 28 14 2007 1673 1675 (Pubitemid 47227105)
20. C. Patrono, G. Ciabattoni, E. Pinca, F. Pugliese, G. Castrucci, and S.A. De Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects Thromb Res 17 3-4 1980 317 327 (Pubitemid 10129020)
21. S.S. Hedegaard, A.M. Hvas, E.L. Grove, J. Refsgaard, B. Rocca, and G. Davi Optical platelet aggregation versus thromboxane metabolites in healthy individuals and patients with stable coronary artery disease after low-dose aspirin administration Thromb Res 124 1 2009 96 100
22. C. Patrono, and B. Rocca Drug insight: aspirin resistance-fact or fashion? Nat Clin Pract Cardiovasc Med 4 1 2007 42 50 (Pubitemid 44971071)
23. A.M. Mengistu, J. Mayer, J. Boldt, and K.D. Rohm Whole-blood aggregometry: are there any limits with regard to platelet counts? Acta Anaesthesiol Scand 53 1 2009 72 76
24. J.D. Snoep, M.M. Hovens, J.C. Eikenboom, J.G. van der Bom, and M.V. Huisman Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: a systematic review and meta-analysis Arch Intern Med 167 15 2007 1593 1599 (Pubitemid 47280339)
25. G. Krasopoulos, S.J. Brister, W.S. Beattie, and M.R. Buchanan Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysis BMJ 336 7637 2008 195 198 (Pubitemid 351212675)
26. M.J. Price, P.B. Berger, P.S. Teirstein, J.F. Tanguay, D.J. Angiolillo, and D. Spriggs Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial JAMA 305 11 2011 1097 1105
27. L. Bonello, L. Camoin-Jau, S. Armero, O. Com, S. Arques, and C. Burignat-Bonello Tailored clopidogrel loading dose according to platelet reactivity monitoring to prevent acute and subacute stent thrombosis Am J Cardiol 103 1 2009 5 10
28. N.P. Stafford, A.E. Pink, A.E. White, J.R. Glenn, and S. Heptinstall Mechanisms involved in adenosine triphosphate-induced platelet aggregation in whole blood Arterioscler Thromb Vasc Biol 23 10 2003 1928 1933 (Pubitemid 37254886)
29. D. Pratico, L. Iuliano, C. Alessandri, C. Camastra, and F. Violi Polymorphonuclear leukocyte-derived O2-reactive species activate primed platelets in human whole blood Am J Physiol 264 5 Pt 2 1993 H1582 H1587
30. P. Renesto, and M. Chignard Enhancement of cathepsin G-induced platelet activation by leukocyte elastase: consequence for the neutrophil-mediated platelet activation Blood 82 1 1993 139 144 (Pubitemid 23188757)