Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation

Biomaterials

Volumn 79, Issue , 2016, Pages 88-100

  Wang, Ce ^a   Li, Ping ^a   Liu, Lanlan ^a   Pan, Hong ^a   Li, Hongchang ^a   Cai, Lintao ^a   Ma, Yifan ^a  

^a SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY   (China)

Author keywords

Lysosomal rupture; MHC I antigen presentation; PH sensitive; Proteasome activity; ROS

Indexed keywords

DEXTRAN; DISEASES; NANOPARTICLES; NANOSTRUCTURED MATERIALS; OPHTHALMOLOGY; PH SENSORS; VACCINES;

ANTIGEN PRESENTATION; LYSOSOMAL RUPTURE; PH SENSITIVE; PROTEASOMES; ROS;

ANTIGENS;

CANCER VACCINE; DELAYED RELEASE FORMULATION; HLA ANTIGEN CLASS 1; NANOCAPSULE; REACTIVE OXYGEN METABOLITE;

ADJUVANT CHEMOTHERAPY; ADMINISTRATION AND DOSAGE; ANIMAL; C57BL MOUSE; CELL CULTURE; CHEMISTRY; DELAYED RELEASE FORMULATION; DENDRITIC CELL; DRUG EFFECTS; IMMUNOLOGY; IMMUNOTHERAPY; LYSOSOME; MOUSE; NEOPLASMS, EXPERIMENTAL; PH; PROCEDURES; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

ANIMALS; CANCER VACCINES; CELLS, CULTURED; CHEMOTHERAPY, ADJUVANT; DELAYED-ACTION PREPARATIONS; DENDRITIC CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HYDROGEN-ION CONCENTRATION; IMMUNOTHERAPY; LYSOSOMES; MICE; MICE, INBRED C57BL; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; REACTIVE OXYGEN SPECIES; TISSUE DISTRIBUTION; TREATMENT OUTCOME;

EID: 84955286178     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.11.040     Document Type: Article

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