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Volumn 40, Issue 4, 2016, Pages 654-661

DNA methylation and gene expression patterns in adipose tissue differ significantly within young adult monozygotic BMI-discordant twin pairs

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; C REACTIVE PROTEIN; DNA; FIBROBLAST GROWTH FACTOR RECEPTOR 1; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRANSCRIPTION FACTOR E2F5; TRIACYLGLYCEROL; INTERLEUKIN 6 RECEPTOR; TNF PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

EID: 84955268594     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2015.221     Document Type: Article
Times cited : (51)

References (40)
  • 2
    • 84887391597 scopus 로고    scopus 로고
    • Restricted adipogenesis in hypertrophic obesity: The role of WISP2, WNT, and BMP4
    • Gustafson B, Hammarstedt A, Hedjazifar S, Smith U. Restricted adipogenesis in hypertrophic obesity: the role of WISP2, WNT, and BMP4. Diabetes 2013; 62: 2997-3004.
    • (2013) Diabetes , vol.62 , pp. 2997-3004
    • Gustafson, B.1    Hammarstedt, A.2    Hedjazifar, S.3    Smith, U.4
  • 4
    • 84884266650 scopus 로고    scopus 로고
    • Adipose tissue angiogenesis in obesity
    • Lemoine AY, Ledoux S, Larger E. Adipose tissue angiogenesis in obesity. Thromb Haemost 2013; 110: 661-668.
    • (2013) Thromb Haemost , vol.110 , pp. 661-668
    • Lemoine, A.Y.1    Ledoux, S.2    Larger, E.3
  • 7
    • 84936777834 scopus 로고    scopus 로고
    • Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood
    • Ronn T, Volkov P, Gillberg L, Kokosar M, Perfilyev A, Jacobsen AL et al. Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood. Hum Mol Genet 2015; 24: 3792-3813.
    • (2015) Hum Mol Genet , vol.24 , pp. 3792-3813
    • Ronn, T.1    Volkov, P.2    Gillberg, L.3    Kokosar, M.4    Perfilyev, A.5    Jacobsen, A.L.6
  • 8
    • 84870923467 scopus 로고    scopus 로고
    • Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes
    • Ribel-Madsen R, Fraga MF, Jacobsen S, Bork-Jensen J, Lara E, Calvanese V et al. Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. PLoS One 2012; 7: e51302.
    • (2012) PLoS One , vol.7 , pp. e51302
    • Ribel-Madsen, R.1    Fraga, M.F.2    Jacobsen, S.3    Bork-Jensen, J.4    Lara, E.5    Calvanese, V.6
  • 9
    • 84906707442 scopus 로고    scopus 로고
    • Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes
    • Nilsson E, Jansson PA, Perfilyev A, Volkov P, Pedersen M, Svensson MK et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes 2014; 63: 2962-2976.
    • (2014) Diabetes , vol.63 , pp. 2962-2976
    • Nilsson, E.1    Jansson, P.A.2    Perfilyev, A.3    Volkov, P.4    Pedersen, M.5    Svensson, M.K.6
  • 10
    • 84900826502 scopus 로고    scopus 로고
    • Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances
    • Guenard F, Tchernof A, Deshaies Y, Perusse L, Biron S, Lescelleur O et al. Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances. Physiol Genomics 2014; 46: 216-222.
    • (2014) Physiol Genomics , vol.46 , pp. 216-222
    • Guenard, F.1    Tchernof, A.2    Deshaies, Y.3    Perusse, L.4    Biron, S.5    Lescelleur, O.6
  • 11
    • 84890172667 scopus 로고    scopus 로고
    • Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-Associated variants in distal regulatory elements
    • Grundberg E, Meduri E, Sandling JK, Hedman AK, Keildson S, Buil A et al. Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-Associated variants in distal regulatory elements. Am J Hum Genet 2013; 93: 876-890.
    • (2013) Am J Hum Genet , vol.93 , pp. 876-890
    • Grundberg, E.1    Meduri, E.2    Sandling, J.K.3    Hedman, A.K.4    Keildson, S.5    Buil, A.6
  • 12
    • 84923171580 scopus 로고    scopus 로고
    • Genetic studies of body mass index yield new insights for obesity biology
    • Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015; 518: 197-206.
    • (2015) Nature , vol.518 , pp. 197-206
    • Locke, A.E.1    Kahali, B.2    Berndt, S.I.3    Justice, A.E.4    Pers, T.H.5    Day, F.R.6
  • 13
    • 84873911989 scopus 로고    scopus 로고
    • The Finnish Twin Cohort Study: An update
    • Kaprio J. The Finnish Twin Cohort Study: an update. Twin Res Hum Genet 2013; 16: 157-162.
    • (2013) Twin Res Hum Genet , vol.16 , pp. 157-162
    • Kaprio, J.1
  • 14
    • 84914179053 scopus 로고    scopus 로고
    • R Core Team. R Foundation for Statistical Computing: Vienna, Austria,. Available from
    • R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria, 2013. Available from https://www.R-project.org/.
    • (2013) R: A Language and Environment for Statistical Computing
  • 16
    • 84983084981 scopus 로고    scopus 로고
    • Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat
    • eCollection 2015
    • Ollikainen M, Ismail K, Gervin K, Kyllonen A, Hakkarainen A, Lundbom J et al. Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat. Clin Epigenetics 2015; 739, eCollection 2015.
    • (2015) Clin Epigenetics , vol.739
    • Ollikainen, M.1    Ismail, K.2    Gervin, K.3    Kyllonen, A.4    Hakkarainen, A.5    Lundbom, J.6
  • 17
    • 84872564830 scopus 로고    scopus 로고
    • A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data
    • Teschendorff AE, Marabita F, Lechner M, Bartlett T, Tegner J, Gomez-Cabrero D et al. A beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data. Bioinformatics 2013; 29: 189-196.
    • (2013) Bioinformatics , vol.29 , pp. 189-196
    • Teschendorff, A.E.1    Marabita, F.2    Lechner, M.3    Bartlett, T.4    Tegner, J.5    Gomez-Cabrero, D.6
  • 18
    • 77957220857 scopus 로고    scopus 로고
    • Comparative epigenomic analysis of murine and human adipogenesis
    • Mikkelsen TS, Xu Z, Zhang X, Wang L, Gimble JM, Lander ES et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell 2010; 143: 156-169.
    • (2010) Cell , vol.143 , pp. 156-169
    • Mikkelsen, T.S.1    Xu, Z.2    Zhang, X.3    Wang, L.4    Gimble, J.M.5    Lander, E.S.6
  • 19
    • 0035287009 scopus 로고    scopus 로고
    • ABC transporters and cholesterol metabolism
    • Schmitz G, Kaminski WE. ABC transporters and cholesterol metabolism. Front Biosci 2001; 6: D505-D514.
    • (2001) Front Biosci , vol.6 , pp. D505-D514
    • Schmitz, G.1    Kaminski, W.E.2
  • 20
    • 46249083328 scopus 로고    scopus 로고
    • Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity
    • R14-2008-9-1-r14
    • Henegar C, Tordjman J, Achard V, Lacasa D, Cremer I, Guerre-Millo M et al. Adipose tissue transcriptomic signature highlights the pathological relevance of extracellular matrix in human obesity. Genome Biol 2008; 9: R14-2008-9-1-r14.
    • (2008) Genome Biol , vol.9
    • Henegar, C.1    Tordjman, J.2    Achard, V.3    Lacasa, D.4    Cremer, I.5    Guerre-Millo, M.6
  • 22
    • 84864705801 scopus 로고    scopus 로고
    • Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity
    • Lodhi IJ, Yin L, Jensen-Urstad AP, Funai K, Coleman T, Baird JH et al. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARgamma activation to decrease diet-induced obesity. Cell Metab 2012; 16: 189-201.
    • (2012) Cell Metab , vol.16 , pp. 189-201
    • Lodhi, I.J.1    Yin, L.2    Jensen-Urstad, A.P.3    Funai, K.4    Coleman, T.5    Baird, J.H.6
  • 24
    • 84871053603 scopus 로고    scopus 로고
    • Role of extracellular matrix remodelling in adipose tissue pathophysiology: Relevance in the development of obesity
    • Catalan V, Gomez-Ambrosi J, Rodriguez A, Fruhbeck G. Role of extracellular matrix remodelling in adipose tissue pathophysiology: relevance in the development of obesity. Histol Histopathol 2012; 27: 1515-1528.
    • (2012) Histol Histopathol , vol.27 , pp. 1515-1528
    • Catalan, V.1    Gomez-Ambrosi, J.2    Rodriguez, A.3    Fruhbeck, G.4
  • 27
    • 77955665767 scopus 로고    scopus 로고
    • Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: A follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study
    • Lehtovirta M, Pietilainen KH, Levalahti E, Heikkila K, Groop L, Silventoinen K et al. Evidence that BMI and type 2 diabetes share only a minor fraction of genetic variance: a follow-up study of 23,585 monozygotic and dizygotic twins from the Finnish Twin Cohort Study. Diabetologia 2010; 53: 1314-1321.
    • (2010) Diabetologia , vol.53 , pp. 1314-1321
    • Lehtovirta, M.1    Pietilainen, K.H.2    Levalahti, E.3    Heikkila, K.4    Groop, L.5    Silventoinen, K.6
  • 28
    • 84900510820 scopus 로고    scopus 로고
    • Epigenetic variation in monozygotic twins: A genome-wide analysis of DNA methylation in buccal cells
    • van Dongen J, Ehli EA, Slieker RC, Bartels M, Weber ZM, Davies GE et al. Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells. Genes (Basel) 2014; 5: 347-365.
    • (2014) Genes (Basel) , vol.5 , pp. 347-365
    • Van Dongen, J.1    Ehli, E.A.2    Slieker, R.C.3    Bartels, M.4    Weber, Z.M.5    Davies, G.E.6
  • 29
    • 84864610761 scopus 로고    scopus 로고
    • Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence
    • Gordon L, Joo JE, Powell JE, Ollikainen M, Novakovic B, Li X et al. Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence. Genome Res 2012; 22: 1395-1406.
    • (2012) Genome Res , vol.22 , pp. 1395-1406
    • Gordon, L.1    Joo, J.E.2    Powell, J.E.3    Ollikainen, M.4    Novakovic, B.5    Li, X.6
  • 30
    • 84860572791 scopus 로고    scopus 로고
    • Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population
    • Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D et al. Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet 2012; 8: e1002629.
    • (2012) PLoS Genet , vol.8 , pp. e1002629
    • Bell, J.T.1    Tsai, P.C.2    Yang, T.P.3    Pidsley, R.4    Nisbet, J.5    Glass, D.6
  • 32
    • 84919932178 scopus 로고    scopus 로고
    • Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis
    • Keller M, Kralisch S, Rohde K, Schleinitz D, Dietrich A, Schon MR et al. Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis. Diabetologia 2014; 57: 2374-2383.
    • (2014) Diabetologia , vol.57 , pp. 2374-2383
    • Keller, M.1    Kralisch, S.2    Rohde, K.3    Schleinitz, D.4    Dietrich, A.5    Schon, M.R.6
  • 33
    • 84897489039 scopus 로고    scopus 로고
    • The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
    • Wagner JR, Busche S, Ge B, Kwan T, Pastinen T, Blanchette M. The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts. Genome Biol 2014; 15: R37.
    • (2014) Genome Biol , vol.15 , pp. R37
    • Wagner, J.R.1    Busche, S.2    Ge, B.3    Kwan, T.4    Pastinen, T.5    Blanchette, M.6
  • 35
    • 84885027922 scopus 로고    scopus 로고
    • Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1
    • Amann R, Trueb B. Evidence that the novel receptor FGFRL1 signals indirectly via FGFR1. Int J Mol Med 2013; 32: 983-988.
    • (2013) Int J Mol Med , vol.32 , pp. 983-988
    • Amann, R.1    Trueb, B.2
  • 36
    • 84876095303 scopus 로고    scopus 로고
    • Adipose tissue expandability, lipotoxicity and the metabolic syndrome
    • Vidal-Puig A. Adipose tissue expandability, lipotoxicity and the metabolic syndrome. Endocrinol Nutr 2013; 60(Suppl 1): 39-43.
    • (2013) Endocrinol Nutr , vol.60 , pp. 39-43
    • Vidal-Puig, A.1
  • 37
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, Faloia E et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005; 46: 2347-2355.
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3    Murano, I.4    Ceresi, E.5    Faloia, E.6
  • 38
  • 39
    • 11144346107 scopus 로고    scopus 로고
    • Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome
    • Salmenniemi U, Ruotsalainen E, Pihlajamaki J, Vauhkonen I, Kainulainen S, Punnonen K et al. Multiple abnormalities in glucose and energy metabolism and coordinated changes in levels of adiponectin, cytokines, and adhesion molecules in subjects with metabolic syndrome. Circulation 2004; 110: 3842-3848.
    • (2004) Circulation , vol.110 , pp. 3842-3848
    • Salmenniemi, U.1    Ruotsalainen, E.2    Pihlajamaki, J.3    Vauhkonen, I.4    Kainulainen, S.5    Punnonen, K.6
  • 40
    • 84891942143 scopus 로고    scopus 로고
    • Epigenetic regulation of depot-specific gene expression in adipose tissue
    • Gehrke S, Brueckner B, Schepky A, Klein J, Iwen A, Bosch TC et al. Epigenetic regulation of depot-specific gene expression in adipose tissue. PLoS One 2013; 8: e82516.
    • (2013) PLoS One , vol.8 , pp. e82516
    • Gehrke, S.1    Brueckner, B.2    Schepky, A.3    Klein, J.4    Iwen, A.5    Bosch, T.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.