Uninterrupted sedentary behavior downregulates BRCA1 gene expression

Cancer Prevention Research

Volumn 9, Issue 1, 2016, Pages 83-88

  Pettapiece Phillips, Rachael ^a,b   Kotlyar, Max ^c   Chehade, Rania ^a   Salmena, Leonardo ^b,c   Narod, Steven A ^a,b   Akbari, Mohammad ^a,b   Jurisica, Igor ^c,d   Kotsopoulos, Joanne ^a,b  

^a WOMEN S COLLEGE HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c PRINCESS MARGARET HOSPITAL   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; MESSENGER RNA; BRCA1 PROTEIN, HUMAN;

ACCELEROMETER; ADULT; ANALYTICAL EQUIPMENT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENE MUTATION; HETEROZYGOTE; HUMAN; HUMAN CELL; METABOLIC EQUIVALENT; PERIPHERAL LYMPHOCYTE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; SEDENTARY LIFESTYLE; TASK PERFORMANCE; TUMOR SUPPRESSOR GENE; ACCELEROMETRY; ACTIMETRY; ADOLESCENT; BODY MASS; BREAST TUMOR; GENETICS; LIFESTYLE; LYMPHOCYTE; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ACCELEROMETRY; ACTIGRAPHY; ADOLESCENT; ADULT; BODY MASS INDEX; BRCA1 PROTEIN; BREAST NEOPLASMS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROZYGOTE; HUMANS; LIFE STYLE; LYMPHOCYTES; MIDDLE AGED; RNA, MESSENGER; SEDENTARY LIFESTYLE; YOUNG ADULT;

EID: 84955254147     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-15-0291     Document Type: Article

References (57)

1. Antoniou A, Pharoah PD, Narod S, Risch HA, Eyfjord JE, Hopper JL, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003;72: 1117-30.
2. Lubinski J, Huzarski T, Byrski T, Lynch HT, Cybulski C, Ghadirian P, et al. The risk of breast cancer in women with a BRCA1 mutation from North America and Poland. Int J Cancer 2012;131:229-34.
3. MavaddatN, Peock S, Frost D, Ellis S, Platte R, Fineberg E, et al. Cancer risks for BRCA1 and BRCA2 mutation carriers: results from prospective analysis of EMBRACE. J Natl Cancer Inst 2013;105:812-22.
4. Kotsopoulos J, Narod SA. Towards a dietary prevention of hereditary breast cancer. Cancer Causes Control 2005;16:125-38.
5. Friedenreich CM, Cust AE. Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 2008;42:636-47.
6. Wu Y, Zhang D, Kang S. Physical activity and risk of breast cancer: a metaanalysis of prospective studies. Breast Cancer Res Treat 2013;137:869-82.
7. Lynch BM, Neilson HK, Friedenreich CM. Physical activity and breast cancer prevention. Recent Results Cancer Res 2011;186:13-42.
8. Biswas A, Oh PI, Faulkner GE, Bajaj RR, Silver MA, Mitchell MS, et al. Sedentary time and its associationwith risk for disease incidence, mortality, and hospitalization in adults: a systematic review and meta-analysis. Ann Intern Med 2015;162:123-32.
9. Lynch BM, Healy GN, Dunstan DW, Owen N. Sedentary versus inactive: distinctions for disease prevention. Nat Rev Cardiol 2010;7.
10. Pettapiece-Phillips R, Narod SA, Kotsopoulos J. The role of body size and physical activity on the risk of breast cancer in BRCA mutation carriers. Cancer Causes Control 2015;26:333-44.
11. King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003;302:643-6.
12. Kotsopoulos J, Olopado OI, Ghadirian P, Lubinski J, Lynch HT, Isaacs C, et al. Changes in body weight and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res 2005;7:R833-43.
13. Pijpe A, Manders P, Brohet RM, Collee JM, Verhoef S, Vasen HF, et al. Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers. Breast Cancer Res Treat 2010;120:235-44.
14. Neilson HK, Conroy SM, Friedenreich CM. The influence of energetic factors on biomarkers of postmenopausal breast cancer risk. Curr Nutr Rep 2014;3:22-34.
15. Liu D, Sartor MA, Nader GA, Gutmann L, Treutelaar MK, Pistilli EE, et al. Skeletal muscle gene expression in response to resistance exercise: sex specific regulation. BMC Genomics 2010;11:659.
16. Radom-Aizik S, Zaldivar F Jr, Leu SY, Cooper DM. A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early-and late-pubertal females. J Appl Physiol 2009; 107:168-75.
17. Radom-Aizik S, Zaldivar F Jr., Leu SY, Galassetti P, Cooper DM. Effects of 30 min of aerobic exercise on gene expression in human neutrophils. J Appl Physiol 2008;104:236-43.
18. Catoire M, Mensink M, Boekschoten MV, Hangelbroek R, Muller M, Schrauwen P, et al. Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle. PLoS One 2012;7:e51066.
19. Ronn T, Volkov P, Davegardh C, Dayeh T, Hall E, Olsson AH, et al. A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue. PLoS Genet 2013;9:e1003572.
20. GjevestadGO, Holven KB, Ulven SM. Effects of exercise on gene expression of inflammatory markers in human peripheral blood cells: a systematic review. Curr Cardiovasc Risk Rep 2015;9:34.
21. Salmena L, Narod S. BRCA1 haploinsufficiency: consequences for breast cancer. Women's Health 2012;8:127-9.
22. Wang M, Yu B, Westerlind K, Strange R, Khan G, Patil D, et al. Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Breast Cancer Res Treat 2009;115:213-20.
23. Corder K, Brage S, Ekelund U. Accelerometers and pedometers: methodology and clinical application. Curr Opin Clin Nutr Metab Care 2007;10: 597-603.
24. Vanhelst J, Mikulovic J, Bui-Xuan G, Dieu O, Blondeau T, Fardy P, et al. Comparison of two ActiGraph accelerometer generations in the assessment of physical activity in free living conditions. BMC Res Notes 2012;5:187.
25. Troiano RP, Berrigan D, Dodd KW, Masse LC, Tilert T, McDowell M. Physical activity in the United States measured by accelerometer. Med Sci Sports Exerc 2008;40:181-8.
26. Swartz AM, Strath SJ, Bassett DR Jr, O'Brien WL, King GA, Ainsworth BE. Estimation of energy expenditure usingCSA accelerometers at hip and wrist sites. Med Sci Sports Exerc 2000;32(9 Suppl):S450-6.
27. Ainsworth BE, HaskellWL, Whitt MC, IrwinML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 2000;32(9 Suppl):S498-504.
28. Bayatti N, Cooper-Knock J, Bury JJ, Wyles M, Heath PR, Kirby J, et al. Comparison of blood RNA extraction methods used for gene expression profiling in amyotrophic lateral sclerosis. PLoS One 2014;9:e87508.
29. Geiss GK, Bumgarner RE, Birditt B, Dahl T, Dowidar N, Dunaway DL, et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 2008;26:317-25.
30. Schroeder A, Mueller O, Stocker S, Salowsky R, Leiber M, Gassmann M, et al. The RIN: an RNA integrity number for assigning integrity values to RNA measurements. BMC Mol Biol 2006;7:3.
31. Fleige S, Pfaffl MW. RNA integrity and the effect on the real-time qRT-PCR performance. Mol Aspects Med 2006;27:126-39.
32. Nanostring Technologies I. nCounter expression data analysis guide. [cited 2014 May 20]. Available from: http://www.nanostring.com/media/pdf/MAN-nCounter-Gene-Expression-Data-Analysis-Guidelines.pdf%3E, 2012.
33. Rahmati S, Abovsky M, Pastrello C, Chorlton S, Sheahan N, KotlyarM, et al. pathDIP: A comprehensive resource for known and predicted human genepathway associations. (http://ophid.utoronto.ca/navigator/).
34. Kamburov A, Stelzl U, Lehrach H, Herwig R. The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res 2013;41(Database issue):D793-800.
35. Brown KR, Jurisica I. Unequal evolutionary conservation of human protein interactions in interologous networks. Genome Biol 2007;8:R95.
36. Kotlyar M, Pastrello C, Pivetta F, Lo Sardo A, Cumbaa C, Li H, et al. In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods 2015;12:79-84.
37. Shen D, Mao W, Liu T, Lin Q, Lu X, Wang Q, et al. Sedentary behavior and incident cancer: a meta-analysis of prospective studies. PLoS One 2014;9: e105709.
38. Schmid D, Leitzmann MF. Television viewing and time spent sedentary in relation to cancer risk: a meta-analysis. J Natl Cancer Inst 2014;106.
39. Janssen I. Health care costs of physical inactivity in Canadian adults. Appl Physiol Nutr Metab 2012;37:803-6.
40. World Health Organization. Global Strategy on Diet, Physical Activity and Health. Physical Activity and Adults. Available from: http://www.who.int/dietphysicalactivity/factsheet-adults/en/.
41. Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol 2010;11:138-48.
42. Narod SA, Foulkes WD. BRCA1 and BRCA2: 1994 and beyond. Nat Rev Cancer 2004;4:665-76.
43. Kotsopoulos J, Zhang S, Akbari M, Salmena L, Llacuachaqui M, Zeligs M, et al. BRCA1mRNA levels following a 4-6-week interventionwith oral 3,30-diindolylmethane. Br J Cancer 2014;111:1269-74.
44. Magbanua MJ, Richman EL, Sosa EV, Jones LW, Simko J, Shinohara K, et al. Physical activity and prostate gene expression inmen with low-risk prostate cancer. Cancer Causes Control 2014;25:515-23.
45. Nkondjock A, Robidoux A, Paredes Y, Narod SA, Ghadirian P. Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. Breast Cancer Res Treat 2006;98:285-94.
46. Kohl HW 3rd, Craig CL, Lambert EV, Inoue S, Alkandari JR, Leetongin G, et al. The pandemic of physical inactivity: global action for public health. Lancet 2012;380:294-305.
47. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579-91.
48. Healy GN, Dunstan DW, Salmon J, Cerin E, Shaw JE, Zimmet PZ, et al. Breaks in sedentary time: beneficial associations with metabolic risk. Diabetes Care 2008;31:661-6.
49. Healy GN, Matthews CE, Dunstan DW, Winkler EA, Owen N. Sedentary time and cardio-metabolic biomarkers in US adults: NHANES 2003-06. Eur Heart J 2011;32:590-7.
50. Lynch BM, Friedenreich CM, Winkler EA, Healy GN, Vallance JK, Eakin EG, et al. Associations of objectively assessed physical activity and sedentary time with biomarkers of breast cancer risk in postmenopausal women: findings from NHANES (2003-2006). Breast Cancer Res Treat 2011;130:183-94.
51. Magnard C, Bachelier R, Vincent A, JaquinodM, Kieffer S, Lenoir GM, et al. BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. Oncogene 2002;21:6729-39.
52. Jackson KC, Gidlund EK, Norrbom J, Valencia AP, Thomson DM, Schuh RA, et al. BRCA1 is a novel regulator of metabolic function in skeletal muscle. J Lipid Res 2014;55:668-80.
53. Shephard RJ. Limits to the measurement of habitual physical activity by questionnaires. Br J Sports Med 2003;37:197-206.
54. Prince SA, Adamo KB, Hamel ME, Hardt J, Connor Gorber S, Tremblay M. A comparison of direct versus self-report measures for assessing physical activity in adults: a systematic review. Int J Behav Nutr Phys Act 2008;5:56.
55. Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci U S A 2003;100:1896-901.
56. Cabanes A, Wang M, Olivo S, DeAssis S, Gustafsson JA, Khan G, et al. Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis. Carcinogenesis 2004;25:741-8.
57. Perrin-Vidoz L, SinilnikovaOM,Stoppa-Lyonnet D, Lenoir GM,Mazoyer S. The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codons. Hum Mol Genet 2002;11:2805-14.