A brief bout of exercise alters gene expression and distinct gene pathways in peripheral blood mononuclear cells of early- and late-pubertal females

Journal of Applied Physiology

Volumn 107, Issue 1, 2009, Pages 168-175

  Radom Aizik, Shlomit ^a   Zaldivar Jr , Frank ^a   Leu, Szu Yun ^a   Cooper, Dan M ^a  

^a CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

Author keywords

Gender; Immune system; Leukocytes; Microarrays; Puberty

Indexed keywords

B LYMPHOCYTE RECEPTOR; BRUTON TYROSINE KINASE; CASPASE 10; CASPASE 3; CD19 ANTIGEN; CD22 ANTIGEN; CD72 ANTIGEN; CD79A ANTIGEN; FAS LIGAND; GRANZYME B; HEAT SHOCK PROTEIN 70; HLA F ANTIGEN; INTERFERON; INTERFERON RECEPTOR 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; LACTIC ACID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE 1; PERFORIN; PERFORIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE ZAP 70; PROTEIN PIK3CG; RNA; SOS PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC2; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ADOLESCENT; ANTHROPOMETRIC PARAMETERS; ANTIGEN PRESENTATION; APOPTOSIS; ARTICLE; BICYCLE ERGOMETRY; CELL GROWTH; CHILD; CONTROLLED STUDY; CYTOTOXICITY; EXERCISE; EXERCISE INTENSITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN EXPERIMENT; LEUKOCYTE; MICROARRAY ANALYSIS; MONOCYTE; NATURAL KILLER CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PUBERTY; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION;

ADOLESCENT; BODY SIZE; CHILD; EXERCISE; EXERCISE TEST; FEMALE; HUMANS; LEUKOCYTES, MONONUCLEAR; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PUBERTY, DELAYED; PUBERTY, PRECOCIOUS; RNA, MESSENGER;

EID: 67650092768     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00121.2009     Document Type: Article

References (32)

1. Bailey RC, Olson J, Pepper SL, Barstow TJ, Porszsasz J, Cooper DM. The level and tempo of children's physical activities: an observational study. Med Sci Sports Exerc 27: 1033-1041, 1995.
2. Buttner P, Mosig S, Lechtermann A, Funke H, Mooren FC. Exercise affects the gene expression profiles of human white blood cells. J Appl Physiol 102: 26-36, 2007.
3. Calderwood SK, Mambula SS, Gray PJ Jr. Extracellular heat shock proteins in cell signaling and immunity. Ann NY Acad Sci 1113: 28-39, 2007.
4. Connolly PH, Caiozzo VJ, Zaldivar F, Nemet D, Larson J, Hung SP, Heck JD, Hatfield GW, Cooper DM. Effects of exercise on gene expression in human peripheral blood mononuclear cells. J Appl Physiol 97: 1461-1469, 2004.
5. Cooper DM, Weiler-Ravell D, Whipp BJ, Wasserman K. Aerobic parameters of exercise as a function of body size during growth in children. J Appl Physiol 56: 628-634, 1984.
6. Cooper DM, Weiler-Ravell D, Whipp BJ, Wasserman K. Aerobic parameters of exercise as a function of body size during growth in children. J Appl Physiol 56: 628-634, 1984.
7. Cooper DM, Radom-Aizik S, Schwindt CD, Zaldivar F. Dangerous exercise - lessons learned from dysregulated inflammatory responses to physical activity. J Appl Physiol 103: 700-709, 2007.
8. Fehrenbach E, Niess AM, Veith R, Dickhuth HH, Northoff H. Changes of HSP72-expression in leukocytes are associated with adaptation to exercise under conditions of high environmental temperature. J Leukoc Biol 69: 747-754, 2001.
9. Fehrenbach E. Multifarious microarray-based gene expression patterns in response to exercise. J Appl Physiol 102: 7-8, 2007.
10. Gleeson M. Immune function in sport and exercise. J Appl Physiol 103: 693-699, 2007.
11. Gourdy P, Araujo LM, Zhu R, Garmy-Susini B, Diem S, Laurell H, Leite-de-Moraes M, Dy M, Arnal JF, Bayard F, Herbelin A. Relevance of sexual dimorphism to regulatory T cells: estradiol promotes IFNgamma production by invariant natural killer T cells. Blood 105: 2415-2420, 2005.
12. Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I, Gazit R, Yutkin V, Benharroch D, Porgador A, Keshet E, Yagel S, Mandelboim O. Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med 12: 1065-1074, 2006.
13. Jarvis JN, Petty HR, Tang Y, Frank MB, Tessier PA, Dozmorov I, Jiang K, Kindzelski A, Chen Y, Cadwell C, Turner M, Szodoray P, McGhee JL, Centola M. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther 8: R154, 2006.
14. Lamason R, Zhao P, Rawat R, Davis A, Hall JC, Chae JJ, Agarwal R, Cohen P, Rosen A, Hoffman EP, Nagaraju K. Sexual dimorphism in immune response genes as a function of puberty. BMC Immunol 7: 2, 2006.
15. Matzinger P. Friendly and dangerous signals: is the tissue in control? Nat Immunol 8: 11-13, 2007.
16. Mori S, Jewett A, Murakami-Mori K, Cavalcanti M, Bonavida B. The participation of the Fas-mediated cytotoxic pathway by natural killer cells is tumor-cell-dependent. Cancer Immunol Immunother 44: 282-290, 1997.
17. Moxley G, Posthuma D, Carlson P, Estrada E, Han J, Benson LL, Neale MC. Sexual dimorphism in innate immunity. Arthritis Rheum 46: 250-258, 2002.
18. Moyna NM, Acker GR, Fulton JR, Weber K, Goss FL, Robertson RJ, Tollerud DJ, Rabin BS. Lymphocyte function and cytokine production during incremental exercise in active and sedentary males and females. Int J Sports Med 17: 585-591, 1996.
19. Nieman DC, Miller AR, Henson DA, Warren BJ, Gusewitch G, Johnson RL, Davis JM, Butterworth DE, Nehlsen-Cannarella SL. Effects of high- vs. moderate-intensity exercise on natural killer cell activity. Med Sci Sports Exerc 25: 1126-1134, 1993.
20. Noble EG, Milne KJ, Melling CW. Heat shock proteins and exercise: a primer. Appl Physiol Nutr Metab 33: 1050-1065, 2008.
21. Osterloh A, Breloer M. Heat shock proteins: linking danger and pathogen recognition. Med Microbiol Immunol 197: 1-8, 2008.
22. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol 515: 287-291, 1999.
23. Petersen AC, Crockett L, Richards M, Boxer A. Self-report measure of pubertal status-reliability, vailidity, and initial norms. J Youth Adolescence 17: 117-133, 1988.
24. Radom-Aizik S, Zaldivar F Jr, Leu SY, Cooper DM. Brief bout of exercise alters gene expression in peripheral blood mononuclear cells of early- and late-pubertal males. Pediatr Res 65: 447-452, 2009.
25. Radom-Aizik S, Zaldivar F Jr, Leu SY, Galassetti P, Cooper DM. Effects of 30 min of aerobic exercise on gene expression in human neutrophils. J Appl Physiol 104: 236-243, 2008.
26. Robertson EB, Skinner ML, Love MM, Elder GH, Conger RD, Dubas JS, Petersen AC. The Pubertal Development Scale: a rural and suburban comparison. J Early Adolescence 12: 174-186, 1992.
27. Sabroe I, Whyte MK. Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease. Biochem Soc Trans 35: 1492-1495, 2007.
28. Schneider CP, Schwacha MG, Chaudry IH. Influence of gender and age on T-cell responses in a murine model of trauma-hemorrhage: differences between circulating and tissue-fixed cells. J Appl Physiol 100: 826-833, 2006.
29. Schwindt CD, Zaldivar F, Wilson L, Leu SY, Wang-Rodriguez J, Mills PJ, Cooper DM. Do circulating leucocytes and lymphocyte subtypes increase in response to brief exercise in children with and without asthma? Br J Sports Med 41: 34-40, 2007.
30. Simon RM, Korn EL, McShane LM, Radmacher MD, Wright GW, Zhao Class Prediction Y. In: Design and Analysis of DNA Microarray Investigations. New York: Springer, 2003, p. 65-94.
31. Tidball JG, Wehling-Henricks M. Macrophages promote muscle membrane repair and muscle fibre growth and regeneration during modified muscle loading in mice in vivo. J Physiol Online 578: 327-336, 2007.
32. Tirakitsoontorn P, Nussbaum E, Moser C, Hill M, Cooper DM. Fitness, acute exercise, and anabolic and catabolic mediators in cystic fibrosis. Am J Respir Crit Care Med 164: 1432-1437, 2001.