Roflumilast inhibits leukocyte-platelet interactions and prevents the prothrombotic functions of polymorphonuclear leukocytes and monocytes

Journal of Thrombosis and Haemostasis

Volumn 14, Issue 1, 2016, Pages 191-204

  Totani, L ^a   Amore, C ^a   Di Santo, A ^a   Dell'Elba, G ^a   Piccoli, A ^a   Martelli, N ^a   Tenor, H ^b   Beume, R ^b   Evangelista, V ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b Takeda Pharmaceuticals International GmbH   (Switzerland)

Author keywords

Blood platelets; Leukocytes; Pharmacology; Signal transduction; Thrombosis

Indexed keywords

CD11B ANTIGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; FIBRINOGEN; FOCAL ADHESION KINASE 2; FORMOTEROL; PADGEM PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; ROFLUMILAST; SERINE; THROMBOPLASTIN; TYROSINE; AMINOPYRIDINE DERIVATIVE; BENZAMIDE DERIVATIVE; CYCLOPROPANE DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST N-OXIDE;

ANIMAL CELL; ANTICOAGULATION; ARTICLE; BLOOD; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRACELLULAR TRAP; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IN VITRO STUDY; LEUKOCYTE; LEUKOCYTE PLATELET INTERACTION; MONOCYTE; MONOTHERAPY; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; THROMBOCYTE; THROMBOCYTE ADHESION; THROMBOSIS; UMBILICAL VEIN ENDOTHELIAL CELL; ANIMAL; CARDIOVASCULAR DISEASES; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECTS; GENETICS; METABOLISM; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RISK;

AMINOPYRIDINES; ANIMALS; BENZAMIDES; BLOOD PLATELETS; CARDIOVASCULAR DISEASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLOPROPANES; EXTRACELLULAR TRAPS; FIBRINOGEN; HUMANS; LEUKOCYTES; MACROPHAGE-1 ANTIGEN; MICE; MICROSCOPY, CONFOCAL; MONOCYTES; NEUTROPHILS; P-SELECTIN; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHODIESTERASE 4 INHIBITORS; PHOSPHORYLATION; PLATELET ADHESIVENESS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RISK; THROMBOPLASTIN; THROMBOSIS;

EID: 84955211811     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13173     Document Type: Article

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