Production of the polyketide 6-deoxyerythronolide B in the heterologous host Bacillus subtilis

Applied Microbiology and Biotechnology

Volumn 100, Issue 3, 2016, Pages 1209-1220

  Kumpfmüller, Jana ^a,c   Methling, Karen ^a   Fang, Lei ^b   Pfeifer, Blaine A ^b   Lalk, Michael ^a   Schweder, Thomas ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

^b the State University of New York   (United States)

^c HANS KNÖLL INSTITUTE   (Germany)

Author keywords

acoA promoter; Bacillus subtilis; Deoxyerythronolide B synthase; Heterologous expression; Metabolic engineering; Polyketide

Indexed keywords

ANTIBIOTICS; BACTERIA; BACTERIOLOGY; BINDING SITES; CLONING; ESCHERICHIA COLI; GENE EXPRESSION; GENES; METABOLIC ENGINEERING; METABOLITES; STRAIN; SYNTHESIS (CHEMICAL);

ACOA PROMOTER; BACILLUS SUBTILIS; HETEROLOGOUS EXPRESSION; POLYKETIDES; SYNTHASES;

KETONES;

6 DEOXYERYTHRONOLIDE B; BACILLAENE; BACTERIAL PROTEIN; ERYTHRONOLIDE B; PLIPASTATIN; POLYKETIDE; PROPIONYL COENZYME A; SURFACTIN; UNCLASSIFIED DRUG; 6-DEOXYERYTHRONOLIDE B; ERYTHROMYCIN;

ANTIBIOTICS; BACTERIUM; BIOLOGICAL ANALYSIS; ENZYME; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC ENGINEERING; SECONDARY METABOLITE; SECRETION;

ARTICLE; BACILLUS SUBTILIS; BINDING SITE; BIOSYNTHESIS; CONTROLLED STUDY; GENE CLUSTER; GENE EXPRESSION; MOLECULAR CLONING; NONHUMAN; OPERON; PROMOTER REGION; RIBOSOME; SACCHAROPOLYSPORA; SACCHAROPOLYSPORA ERYTHRAEA; ANALOGS AND DERIVATIVES; ENZYMOLOGY; GENETICS; METABOLIC ENGINEERING; METABOLISM;

BACILLUS SUBTILIS; ESCHERICHIA COLI; SACCHAROPOLYSPORA ERYTHRAEA;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; ERYTHROMYCIN; METABOLIC ENGINEERING; POLYKETIDES; SACCHAROPOLYSPORA;

EID: 84955206826     PISSN: 01757598     EISSN: 14320614     Source Type: Journal    
DOI: 10.1007/s00253-015-6990-6     Document Type: Article

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