Role of tentacles and protein loading on pore accessibility and mass transfer in cation exchange materials for proteins

Journal of Chromatography A

Volumn 1285, Issue , 2013, Pages 48-56

  Thomas, Helen ^a,b   Coquebert de Neuville, Bertrand ^b   Storti, Giuseppe ^b   Morbidelli, Massimo ^b   Joehnck, Matthias ^a   Schulte, Michael ^a  

^a MERCK KGAA   (Germany)

^b ETH ZURICH   (Switzerland)

Author keywords

Antibody; Ion exchange chromatography; Pore diffusion coefficient; Porosity; Protein adsorption

Indexed keywords

ADVANCED MATERIALS; CONFORMATIONAL CHANGE; EXPERIMENTAL VALUES; ION EXCHANGE CHROMATOGRAPHY; PORE DIFFUSION COEFFICIENTS; PROTEIN ADSORPTION; PROTEIN CHROMATOGRAPHY; PROTEIN PURIFICATION;

ANTIBODIES; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DIFFUSION; MATERIALS; POROSITY;

PROTEINS;

DEXTRAN; POLY(METHYL METHACRYLATE); PROTEIN; SODIUM CHLORIDE;

ADSORPTION; ARTICLE; CATION EXCHANGE; CONFORMATIONAL TRANSITION; DIFFUSION COEFFICIENT; GEL PERMEATION CHROMATOGRAPHY; HYDRODYNAMICS; INVERSE SIZE EXCLUSION CHROMATOGRAPHY; MATERIALS; MOLECULAR SIZE; POLYMERIZATION; POROSITY; PRIORITY JOURNAL; PROTEIN PURIFICATION; REPRODUCIBILITY;

ADSORPTION; ANTIBODIES; CATIONS; CHROMATOGRAPHY, ION EXCHANGE; DEXTRANS; DIFFUSION; MODELS, CHEMICAL; MOLECULAR WEIGHT; POLYMERS; POROSITY; POVIDONE; PROTEINS; SODIUM CHLORIDE;

EID: 84874961592     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.01.104     Document Type: Article

References (27)

1. Miyabe K., Guiochon G. J. Sep. Sci. 2003, 26:155.
2. Dziennik S.R., Lenhoff A.M. Proc. Natl. Acad. Sci. USA 2003, 100:420.
3. Guiochon G., Felinger A., Shirazi D.G., Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography 2006, Academic Press, Boston, MA, USA.
4. DePhillips P., Lenhoff A.M. J. Chromatogr. A 2000, 883:39.
5. DePhillips P., Lenhoff A.M. J. Chromatogr. A 2001, 933:57.
6. Yao Y., Lenhoff A.M. J. Chromatogr. A 2006, 1126:107.
7. Stone M.C., Carta G. J. Chromatogr. A 2007, 1146:202.
8. Franke A., Forrer N., Butté A., Cvijetic B., Morbidelli M. J. Chromatogr. A 2010, 1217:2216.
9. Chen W.-D., Dong X.-Y., Sun Y. J. Chromatogr. A 2002, 962:29.
10. Forrer N., Butté A., Storti G., Morbidelli M. Ind. Eng. Chem. Res. 2008, 47:9133.
11. Müller W. J. Chromatogr. 1990, 510:133.
12. To B.C.S., Lenhoff A.M. J. Chromatogr. A 2007, 1141:191.
13. Haynes H.W., Sarma P.N. AIChE J. 1973, 19:1043.
14. Einstein A. Ann. Phys. (Berlin) 1905, 17:549.
15. Yao Y., Lenhoff A.M. J. Chromatogr. A 2004, 1037:273.
16. Wernert V., Bouchet R., Denoyel R. Anal. Chem. 2010, 82:2668.
17. Groh R., Halász I. Anal. Chem. 1981, 53:1325.
18. Carta G., Ubiera A.R., Pabst T.M. Chem. Eng. Technol. 2005, 28:1252.
19. Kaczmarski K., Bellot J.-C. J. Chromatogr. A 2005, 1069:91.
20. Guan H., Guiochon G. J. Chromatogr. A 1996, 731:27.
21. Parmar A.S., Muschol M. Biophys. J. 2009, 97:590.
22. Encyclopedia of Surface and Colloid Science 1996, vol. 5. CRC, Press, Taylor and Francis Group LCC.
23. Armstong J.K., Wenby R.B., Meiselman H.J., Fisher T.C. J. Biophys. 2004, 87:4259.
24. Wandera D., Wickramasinghe S.R., Husson S.M. J. Membr. Sci. 2010, 357:6-35.
25. Schneider S.W., Laermer J., Henderson R.M., Oberleithner H. Eur. J. Physiol. 1998, 435:362.
26. Gunn D.J. Chem. Eng. Sci. 1987, 42:363.
27. Wilson E.J., Geankoplis C.J. Industr. Eng. Chem. Fundam. 1966, 5:9.