Design of high productivity antibody capture by protein A chromatography using an integrated experimental and modeling approach

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 899, Issue , 2012, Pages 116-126

  Ng, Candy K S ^a   Osuna Sanchez, Hector ^b,c   Valéry, Eric ^b   Sørensen, Eva ^a   Bracewell, Daniel G ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b Novasep Process   (France)

^c Processium CEI 3 62   (France)

Author keywords

Antibody capture; Batch chromatography; Integrated process experimentation and modeling; Productivity; Protein A chromatography

Indexed keywords

ANTIBODY CAPTURE; BATCH CHROMATOGRAPHY; BREAKTHROUGH EXPERIMENT; CHROMATOGRAPHIC PROCESS; DESIGN APPROACHES; HIGH PRODUCTIVITY; HUMAN IGG; INTEGRATED PROCESS; LUMPED PARAMETER MODELS; MODEL PARAMETER ESTIMATION; MODEL VALIDATION; MODELING APPROACH; PERFORMANCE PROTEINS; PROCESS DEVELOPMENT; PROCESS EXPERIMENTATION; PROCESS UNDERSTANDING; PROCESS VERIFICATIONS; PROTEIN A; PROTEIN A CHROMATOGRAPHY; PULSE INJECTION; WHOLE PROCESS;

ANTIBODIES; CHROMATOGRAPHY; DESIGN; EXPERIMENTS; PARAMETER ESTIMATION; SILICA;

PRODUCTIVITY;

IMMUNOGLOBULIN G; PROTEIN A; SILICON DIOXIDE;

ADSORPTION KINETICS; ARTICLE; BATCH PROCESS; CHROMATOGRAPHY; EXPERIMENTATION; MATERIALS; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PRODUCTIVITY;

ADSORPTION; CHROMATOGRAPHY, AFFINITY; HUMANS; IMMUNOGLOBULIN G; MODELS, THEORETICAL; STAPHYLOCOCCAL PROTEIN A;

EID: 84862123810     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.05.010     Document Type: Article

References (28)

1. Roque A.C.A., Silva C.S.O., Taipa M.A. J. Chromatogr. A 2007, 1160:44.
2. Shukla A., Hubbard B., Tressel T., Guhan S., Low D. J. Chromatogr. B 2007, 848:28.
3. Low D., O'Leary R., Pujar N.S. J. Chromatogr. B 2007, 848:48.
4. Walsh G. Nat. Biotechnol. 2010, 28:917.
5. Fahrner R.L., Whitney D.H., Vanderlaan M., Blank G.S. Biotechnol. Appl. Biochem. 1999, 30:121.
6. McCue J.T., Kemp G., Low D., Quiñones-García I. J. Chromatogr. A 2003, 989:139.
7. Hahn R., Schlegel R., Jungbauer A. J. Chromatogr. B 2003, 790:35.
8. Hahn R., Bauerhansl P., Shimahara K., Wizniewski C., Tscheliessnig A., Jungbauer A. J. Chromatogr. A 2005, 1093:98.
9. Bak H., Thomas O.R.T., Abildskov J. J. Chromatogr. B 2007, 848:131.
10. Perez-Almodovar E.X., Carta G. J. Chromatogr. A 2009, 1216:8339.
11. Perez-Almodovar E.X., Carta G. J. Chromatogr. A 2009, 1216:8348.
12. Karlsson D., Jakobsson N., Axelsson A., Nilsson B. J. Chromatogr. A 2004, 1055:29.
13. Orellana C.A., Shene C., Asenjo J.A. Biotechnol. Bioeng. 2009, 104:572.
14. Nfor B.K., Zuluaga D.S., Verheijen P.J.T., Verhaert P.D.E.M., van der Wielen L.A.M., Ottens M. Biotechnol. Prog. 2011, 27:1629.
15. Chan S., Titchener-Hooker N., Bracewell D.G., Sørensen E. AIChE J. 2008, 54:965.
16. Guiochon G., Felinger A., Shirazi D.G., Katti A.M. Fundamentals of Preparative and Nonlinear Chromatography 2006, Academic Press, San Diego. 2nd ed.
17. Teoh H.K., Sørensen E., Titchener-Hooker N. Chem. Eng. Sci. 2003, 58:4145.
18. Guiochon G., Lin B. Modeling for Preparative Chromatography 2003, Academic Press, New York.
19. Ströhlein G., Aumann L., Mazzotti M., Morbidelli M. J. Chromatogr. A 2006, 1126:338.
20. Finlayson B.A. Nonlinear Analysis in Chemical Engineering 1980, McGraw-Hill, Inc., New York.
21. Villadsen J.V., Michelsen M.L. Solution of Differential Equation Models by Polynomial Approximation 1978, Prentice-Hall, Inc., Englewood Cliffs, NJ.
22. Hindmarsh A.C., Brown P.N., Grant K.E., Lee S.L., Serban R., Shumaker D.E., Woodward C.S. ACM Trans. Maths. Softw. 2005, 31:363.
23. Powell M.J.D. Advances in Optimization and Numerical Analysis 1994, 51. Kluwer Academic, Dordrecht. S. Gomez, J.P. Hennart (Eds.).
24. Flatman S., Alam I., Gerard J., Mussa N. J. Chromatogr. B 2007, 848:79.
25. Usher K.M., Simmons C.R., Dorsey J.G. J. Chromatogr. A 2008, 1200:122.
26. Tran R., Joseph J.R., Sinclair A., Bracewell D., Zhou Y., Titchener-Hooker N.J. Biotechnol. Prog. 2007, 23:413.
27. Seidel-Morgenstern A. J. Chromatogr. A 2004, 1037:255.
28. Gritti F., Guiochon G. J. Chromatogr. A 2005, 1097:98.