Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages

Aging Cell

Volumn 15, Issue 1, 2016, Pages 77-88

  Aflaki, Elma ^a   Moaven, Nima ^a   Borger, Daniel K ^a   Lopez, Grisel ^a   Westbroek, Wendy ^a   Chae, Jae Jin ^a   Marugan, Juan ^b   Patnaik, Samarjit ^b   Maniwang, Emerson ^a   Gonzalez, Ashley N ^a   Sidransky, Ellen ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Autophagy; Gaucher disease; Glucocerebrosidase; Inflammasome; Interleukin 1 ; Lysosome; Macrophage

Indexed keywords

CHAPERONE; GLUCOSYLCERAMIDASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NCGC 758; UNCLASSIFIED DRUG; CARRIER PROTEIN;

AGING; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ERYTHROPHAGOCYTOSIS; GAUCHER DISEASE; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYSOSOME; LYSOSOME STORAGE DISEASE; MACROPHAGE; PRIORITY JOURNAL; ADULT; AGED; CYTOLOGY; INFLAMMATION; METABOLISM; MIDDLE AGED; MONOCYTE; PHYSIOLOGY;

ADULT; AGED; AUTOPHAGY; CARRIER PROTEINS; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LYSOSOMES; MACROPHAGES; MIDDLE AGED; MONOCYTES; NF-KAPPA B;

EID: 84955187445     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12409     Document Type: Article

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