Hollow-fiber flow field-flow fractionation with multi-angle laser scattering detection for aggregation studies of therapeutic proteins Field-Flow Fractionation

Analytical and Bioanalytical Chemistry

Volumn 406, Issue 6, 2014, Pages 1619-1627

  Reschiglian, P ^a,b   Roda, B ^a,b   Zattoni, A ^a,b   Tanase, M ^a   Marassi, V ^a   Serani, S ^c  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b ByFlow Srl   (Italy)

^c Sigma Tau SpA   (Italy)

Author keywords

Hollow fiber flow field flow fractionation (HF5); Multi angle light scattering for complex protein samples; Quality control of therapeutic proteins; Reversible and irreversible aggregates; Therapeutic proteins characterization

Indexed keywords

AGGREGATES; BIOCHEMISTRY; CONTROLLED DRUG DELIVERY; FLOW FIELDS; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; SIZE EXCLUSION CHROMATOGRAPHY;

FIELD FLOW FRACTIONATION; HOLLOW-FIBER FLOW FIELD-FLOW FRACTIONATION; IRREVERSIBLE AGGREGATES; MULTI-ANGLE LIGHT SCATTERINGS; PHARMACEUTICAL APPLICATIONS; PROTEIN SAMPLES; ROBUST ANALYTICAL METHODS; THERAPEUTIC PROTEIN;

QUALITY CONTROL;

AVIDIN; BOVINE SERUM ALBUMIN; PROTEIN;

ANIMAL; ARTICLE; CATTLE; CHEMISTRY; EVALUATION STUDY; FIELD FLOW FRACTIONATION; ISOLATION AND PURIFICATION; LASER; LIGHT; LIMIT OF DETECTION; METHODOLOGY; PARTICLE SIZE; PROTEIN DENATURATION; RADIATION SCATTERING; REPRODUCIBILITY;

ANIMALS; AVIDIN; CATTLE; FRACTIONATION, FIELD FLOW; LASERS; LIGHT; LIMIT OF DETECTION; PARTICLE SIZE; PROTEIN DENATURATION; PROTEINS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; SERUM ALBUMIN, BOVINE;

EID: 84898038756     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-013-7462-4     Document Type: Article

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