Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2

Toxicology and Applied Pharmacology

Volumn 271, Issue 2, 2013, Pages 184-195

  Kalayarasan, Srinivasan ^a,b   Sriram, Narayanan ^a,b   Soumyakrishnan, Syamala ^a   Sudhandiran, Ganapasam ^a  

^a UNIVERSITY OF MADRAS   (India)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Bleomycin; Diallylsulfide; PAR 2; Pulmonary fibrosis; Reactive oxygen species

Indexed keywords

ALLYL SULFIDE; ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; COLLAGEN; DNA; GELATINASE A; GELATINASE B; HEAT SHOCK PROTEIN 47; INTERLEUKIN 6; INTERLEUKIN 8 RECEPTOR; PROTEINASE ACTIVATED RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DNA FRAGMENTATION; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT;

Α-SMA; ALPHA SMOOTH MUSCLE ACTIN; APOPTOSIS; BLEOMYCIN; BOVINE SERUM ALBUMIN; BSA; DAS; DIALLYLSULFIDE; ECM; EXTRACELLULAR MATRIX; G-PROTEIN COUPLED RECEPTOR FAMILY; GPCR; HEAT SHOCK PROTEIN-47; HORSERADISH PEROXIDASE; HRP; HSP-47; IL-6; IL8RA; INTERLEUKIN 8 RECEPTOR ALPHA; INTERLEUKINS-6; MATRIX METALLOPROTEINASES 2 AND 9; MMP2/9; PAR-2; PF; PI; PROPIDIUM IODIDE; PROTEASE ACTIVATED RECEPTOR-2; PULMONARY FIBROSIS; REACTIVE OXYGEN SPECIES; ROS; TBST; TRIS BUFFERED SALINE-TWEEN-20;

ALLYL COMPOUNDS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; ANTIOXIDANTS; APOPTOSIS; BLEOMYCIN; BLOTTING, WESTERN; COLLAGEN; COLORING AGENTS; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; FREE RADICALS; IMMUNOHISTOCHEMISTRY; MALE; MAST CELLS; MATRIX METALLOPROTEINASE 9; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; PULMONARY ALVEOLI; PULMONARY FIBROSIS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, PAR-2; SULFIDES;

EID: 84880625696     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.04.021     Document Type: Article

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