Daidzein exhibits anti-fibrotic effect by reducing the expressions of Proteinase activated receptor 2 and TGFβ1/smad mediated inflammation and apoptosis in Bleomycin-induced experimental pulmonary fibrosis

Biochimie

Volumn 103, Issue 1, 2014, Pages 23-36

  Soumyakrishnan, Syamala ^a   Divya, Thomas ^a   Kalayarasan, Srinivasan ^a   Sriram, Narayanan ^a   Sudhandiran, Ganapasam ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Apoptosis; Bleomycin; Daidzein; Protease activated receptor 2; Pulmonary fibrosis; Transforming growth factor beta

Indexed keywords

BLEOMYCIN; CASPASE 3; COLLAGEN; CYCLOOXYGENASE 2; DAIDZEIN; GELATINASE A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEINASE ACTIVATED RECEPTOR 2; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA1; ISOFLAVONE DERIVATIVE; TGFB1 PROTEIN, HUMAN; TISSUE INHIBITOR OF METALLOPROTEINASE-1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE COURSE; EXPERIMENTAL PULMONARY FIBROSIS; HISTOPATHOLOGY; IMMUNOBLOTTING; INFLAMMATION; MAST CELL; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS;

RATTUS;

ANIMALS; APOPTOSIS; BLEOMYCIN; COLLAGEN; GENE EXPRESSION REGULATION; INFLAMMATION; ISOFLAVONES; MALE; MATRIX METALLOPROTEINASE 2; PULMONARY FIBROSIS; RATS; RECEPTOR, PAR-2; SMAD PROTEINS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84903745275     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2014.04.005     Document Type: Article

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