Structurally conserved erythrocyte-binding domain in Plasmodium provides a versatile scaffold for alternate receptor engagement

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 2, 2016, Pages E191-E200

  Gruszczyk, Jakub ^a   Lim, Nicholas T Y ^a   Arnott, Alicia ^a   He, Wen Qiang ^a,b   Nguitragool, Wang ^c   Roobsoong, Wanlapa ^d   Mok, Yee Foong ^e   Murphy, James M ^a,b   Smith, Katherine R ^a   Lee, Stuart ^a   Bahlo, Melanie ^a,b   Mueller, Ivo ^a,b   Barry, Alyssa E ^a,b   Tham, Wai Hong ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MAHIDOL UNIVERSITY   (Thailand)

^d MAHIDOL UNIVERSITY   (Thailand)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Malaria; Parasite invasion; Reticulocyte binding protein; SAXS; X ray crystallography

Indexed keywords

BINDING PROTEIN; CHYMOTRYPSIN; DUFFY BINDING PROTEIN; RETICULOCYTE BINDING PROTEIN; SIALIDASE; UNCLASSIFIED DRUG; PROTOZOAL PROTEIN;

ALPHA HELIX; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; ERYTHROCYTE; GENE STRUCTURE; MICROBIAL DIVERSITY; MOLECULAR RECOGNITION; MUTAGENESIS; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; RECEPTOR BINDING; RETICULOCYTE; SEQUENCE ALIGNMENT; AMINO ACID SEQUENCE; AREA UNDER THE CURVE; CHEMISTRY; CONSERVED SEQUENCE; GENE; GENE FREQUENCY; GENETICS; HAPLOTYPE; HUMAN; METABOLISM; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE; PROTEIN TERTIARY STRUCTURE; SINGLE NUCLEOTIDE POLYMORPHISM; SMALL ANGLE SCATTERING; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AREA UNDER CURVE; BASE SEQUENCE; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; ERYTHROCYTES; EVOLUTION, MOLECULAR; GENE FREQUENCY; GENES, PROTOZOAN; HAPLOTYPES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS; SCATTERING, SMALL ANGLE; SEQUENCE ALIGNMENT;

EID: 84954565296     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516512113     Document Type: Article

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