Growth factors and medium hyperglycemia induce Sox9+ ductal cell differentiation into β cells in mice with reversal of diabetes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 3, 2016, Pages 650-655

  Zhang, Mingfeng ^a   Lin, Qing ^a,b   Qi, Tong ^a   Wang, Tiankun ^a   Chen, Ching Cheng ^a   Riggs, Arthur D ^a   Zeng, Defu ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b Fujian Chinese Tradition Medicine University   (China)

Author keywords

Epidermal growth factor; Gastrin; Hyperglycemia; Sox9+ ductal cells; cell differentiation

Indexed keywords

ALLOXAN; ENHANCED GREEN FLUORESCENT PROTEIN; EPIDERMAL GROWTH FACTOR; GASTRIN; GLUCOSE; HEPATOCYTE NUCLEAR FACTOR 1BETA; INSULIN; TAMOXIFEN; TRANSCRIPTION FACTOR NKX6.1; TRANSCRIPTION FACTOR PDX 1; TRANSCRIPTION FACTOR SOX9; CULTURE MEDIUM; GLUCOSE BLOOD LEVEL;

ADULT; ALLOXAN-INDUCED DIABETES MELLITUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DIFFERENTIATION; CELL DIVISION; CONTROLLED STUDY; DRUG MEGADOSE; DRUG POTENTIATION; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HYPERGLYCEMIA; IMMUNOFLUORESCENCE TEST; INSULIN BLOOD LEVEL; INSULIN RELEASE; LOW DRUG DOSE; MOUSE; NONHUMAN; PANCREAS CELL; PANCREAS ISLET BETA CELL; PANCREATIC DUCTAL CELL; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CHEMISTRY; COMPLICATION; CULTURE MEDIUM; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; KINETICS; METABOLISM; PANCREATIC DUCT; PATHOLOGY;

ANIMALS; BLOOD GLUCOSE; CELL DIFFERENTIATION; CULTURE MEDIA; DIABETES MELLITUS, EXPERIMENTAL; EPIDERMAL GROWTH FACTOR; GASTRINS; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; KINETICS; MICE, INBRED C57BL; PANCREATIC DUCTS; SOX9 TRANSCRIPTION FACTOR;

EID: 84954520504     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524200113     Document Type: Article

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