Mixed chimerism and growth factors augment β cell regeneration and reverse late-stage type 1 diabetes

Science Translational Medicine

Volumn 4, Issue 133, 2012, Pages

  Wang, Miao ^a   Racine, Jeremy J ^a   Song, Xiaoping ^b   Li, Xiaofan ^a,c   Nair, Indu ^a   Liu, Hongjun ^a   Avakian Mansoorian, Alina ^a   Johnston, Heather F ^a   Liu, Can ^a,d   Shen, Christine ^a   Atkinson, Mark ^e   Todorov, Ivan ^a   Kandeel, Fouad ^a   Forman, Stephen ^a   Wilson, Brian ^b   Zeng, Defu ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c FUJIAN MEDICAL UNIVERSITY   (China)

^d SOUTHERN MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; EPIDERMAL GROWTH FACTOR; GASTRIN; GLUCAGON; GLUCOSE; INSULIN; INSULIN ANTIBODY; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL DIVISION; CELL REGENERATION; CELL SURVIVAL; CHIMERA; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SENSITIVITY; LATE STAGE TYPE 1 DIABETES; MIXED CHIMERISM; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; ANIMAL; C57BL MOUSE; HISTOCOMPATIBILITY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INSULIN RESISTANCE; MOUSE MUTANT; MULTIMODALITY CANCER THERAPY; NONOBESE DIABETIC MOUSE; PANCREAS ISLET TRANSPLANTATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; TRANSGENIC MOUSE; TRANSLATIONAL RESEARCH;

ANIMALS; COMBINED MODALITY THERAPY; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; EPIDERMAL GROWTH FACTOR; FEMALE; GASTRINS; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC; REGENERATION; TRANSLATIONAL MEDICAL RESEARCH; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING;

EID: 84860905305     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3003835     Document Type: Article

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