Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability

Journal of Biomolecular Screening

Volumn 21, Issue 2, 2016, Pages 156-164

  Gordon, Laurie J ^a   Allen, Morven ^a   Artursson, P E R ^b   Hann, Michael M ^a   Leavens, Bill J ^a   Mateus, André ^b   Readshaw, S I M O N ^a   Valko, Klara ^a   Wayne, Gareth J ^a   West, A N D Y ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

cell penetration; drug accumulation; intracellular drug concentrations; RapidFire MS

Indexed keywords

SULFADIMIDINE; DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYCLE TIME; DRUG PENETRATION; ELECTRONICS; FEMALE; HELA CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MASS SPECTROMETER; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCALE UP; TANDEM MASS SPECTROMETRY; TIME; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION STUDY; CHEMISTRY; DRUG DEVELOPMENT; LIQUID CHROMATOGRAPHY; METABOLISM; PERMEABILITY; PROCEDURES; TUMOR CELL LINE;

CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DRUG DISCOVERY; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; TANDEM MASS SPECTROMETRY;

EID: 84954503555     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057115604141     Document Type: Article

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