Methods to measure the intracellular concentration of unlabeled compounds within cultured cells using liquid chromatography/tandem mass spectrometry

Analytical Biochemistry

Volumn 383, Issue 2, 2008, Pages 186-193

  Colletti, Lynn M ^a   Liu, Yaya ^a   Koev, Gennadiy ^a   Richardson, Paul L ^a   Chen, Chih Ming ^a   Kati, Warren ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Confocal microscopy; HCV; Intracellular concentration; LC MS MS; Metabolic stability; Nonspecific binding; Protein binding; Replicon cells

Indexed keywords

BIOCHEMISTRY; CELL CULTURE; CONFOCAL MICROSCOPY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PROTEINS; VIRUSES;

INTRACELLULAR CONCENTRATION; LC/MS/MS; METABOLIC STABILITY; NON-SPECIFIC BINDING; PROTEIN BINDING;

CELLS;

EDETIC ACID; PROTEINASE INHIBITOR; TRYPSIN;

ARTICLE; CELL ASSAY; CELL CULTURE; CELL MEMBRANE; CONFOCAL MICROSCOPY; CYTOPLASM; HEPATITIS C VIRUS; LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TANDEM MASS SPECTROMETRY;

HEPATITIS C VIRUS;

EID: 54249084853     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.08.012     Document Type: Article

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