Developmentally regulated GTP-binding protein 2 coordinates Rab5 activity and transferrin recycling

Molecular Biology of the Cell

Volumn 27, Issue 2, 2016, Pages 334-348

  Mani, Muralidharan ^a   Lee, Unn Hwa ^a   Yoon, Nal Ae ^a   Kim, Hyo Jeong ^a   Ko, Myoung Seok ^b   Seol, Wongi ^c   Joe, Yeonsoo ^a   Chung, Hun Taeg ^a   Lee, Byung Ju ^a   Moon, Chang Hoon ^d   Cho, Wha Ja ^d   Park, Jeong Woo ^a  

^a University of Ulsan   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Wonkwang University   (South Korea)

^d University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN; DRG2 PROTEIN, HUMAN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; POLYPHOSPHOINOSITIDE; RAB PROTEIN; TRANSFERRIN; VESICULAR TRANSPORT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; ENDOCYTOSIS; ENDOSOME; FEMALE; GENETICS; HELA CELL LINE; HUMAN; INSTITUTE FOR CANCER RESEARCH MOUSE; KNOCKOUT MOUSE; MALE; MCF-7 CELL LINE; MEMBRANE FUSION; METABOLISM; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ENDOCYTOSIS; ENDOSOMES; FEMALE; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HELA CELLS; HUMANS; MALE; MCF-7 CELLS; MEMBRANE FUSION; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN STRUCTURE, TERTIARY; RAB5 GTP-BINDING PROTEINS; TRANSFERRIN; VESICULAR TRANSPORT PROTEINS;

EID: 84954485734     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E15-08-0558     Document Type: Article

References (44)

1. Aoki K, Matsuda M (2009). Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc 4, 1623-1631.
2. Bolte S, Cordelieres FP (2006). A guided tour into subcellular colocalization analysis in light microscopy. J Microsc 224, 213-232.
3. Bright NA, Lindsay MR, Stewart A, Luzio JP (2001). The relationship between lumenal and limiting membranes in swollen late endocytic compartments formed after wortmannin treatment or sucrose accumulation. Traffic 2, 631-642.
4. Bucci C, Thomsen P, Nicoziani P, McCarthy J, van Deurs B (2000). Rab7: a key to lysosome biogenesis. Mol Biol Cell 11, 467-480.
5. Chotard L, Mishra AK, Sylvain MA, Tuck S, Lambright DG, Rocheleau CE (2010). TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell 21, 2285-2296.
6. Christoforidis S, McBride HM, Burgoyne RD, Zerial M (1999a). The Rab5 effector EEA1 is a core component of endosome docking. Nature 397, 621-625.
7. Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao LY, Yip SC, Waterfield MD, Backer JM, Zerial M (1999b). Phosphatidylinositol-3-OH kinases are Rab5 effectors. Nat Cell Biol 1, 249-252.
8. Conner DA (2001). Mouse embryo fibroblast (MEF) feeder cell preparation. Curr Protoc Mol Biol Chapter 23, Unit 23.2.
9. Elangovan M, Wallrabe H, Chen Y, Day RN, Barroso M, Periasamy A (2003). Characterization of one-and two-photon excitation fluorescence resonance energy transfer microscopy. Methods 29, 58-73.
10. Grant BD, Donaldson JG (2009). Pathways and mechanisms of endocytic recycling. Nat Rev Mol Biol Cell 10, 597-608.
11. Haas AK, Fuchs E, Kopajtich R, Barr FA (2005). A GTPase-activating protein controls Rab5 function in endocytic trafficking. Nat Cell Biol 7, 887-893.
12. Hutagalung AH, Novick PJ (2011). Role of Rab GTPases in membrane traffic and cell physiology. Physiol Rev 91, 119-149.
13. Itoh RE, Kurokawa K, Ohba Y, Yoshizaki H, Mochizuki N, Matsuda M (2002). Activation of Rac and Cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol 22, 6582-6591.
14. Itoh T, Satoh M, Kanno E, Fukuda M (2006). Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Genes Cells 11, 1023-1037.
15. Kitano M, Nakaya M, Nakamura T, Nagata S, Matsuda M (2008). Imaging of Rab5 activity identifies essential regulators for phagosome maturation. Nature 453, U241-U215.
16. Ko MS, Kim HJ, Kim HK, Yoon NA, Lee UH, Lee SC, Chung DK, Lee BJ, Suh JH, Cho WJ, Park JW (2014). Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells. Clin Immunol 150, 225-235.
17. Ko MS, Lee UH, Kim SI, Kim HJ, Park JJ, Cha SJ, Kim SB, Song H, Chung DK, Han IS, et al. (2004). Overexpression of DRG2 suppresses the growth of Jurkat T cells but does not induce apoptosis. Arch Biochem Biophys 422, 137-144.
18. Krauss M, Haucke V (2007). Phosphoinositide-metabolizing enzymes at the interface between membrane traffic and cell signalling. EMBO Rep 8, 241-246.
19. Kutateladze TG (2010). Translation of the phosphoinositide code by PI effectors. Nat Chem Biol 6, 507-513.
20. Lanzetti L, Palamidessi A, Areces L, Scita G, Di Fiore PP (2004). Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases. Nature 429, 309-314.
21. Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP (2000). The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5. Nature 408, 374-377.
22. Li B, Trueb B (2000). DRG represents a family of two closely related GTPbinding proteins. Biochim Biophys Acta 1491, 196-204.
23. Lindmo K, Stenmark H (2006). Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci 119, 605-614.
24. Mahajan MA, Park ST, Sun XH (1996). Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins. Oncogene 12, 2343-2350.
25. Maxfield FR, McGraw TE (2004). Endocytic recycling. Nat Rev Mol Cell Biol 5, 121-132.
26. Mellman I (1996). Endocytosis and molecular sorting. Annu Rev Cell Dev Biol 12, 575-625.
27. Navaroli DM, Bellvé KD, Standley C, Lifshitz LM, Cardia J, Lambright D, Leonard D, Fogarty KE, Corvera S (2012). Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. Proc Natl Acad Sci USA 109, E471-E480.
28. Nazarewicz RR, Salazar G, Patrushev N, San Martin A, Hilenski L, Xiong S, Alexander RW (2011). Early endosomal antigen 1 (EEA1) is an obligate scaffold for angiotensin II-induced, PKC-alpha-dependent Akt activation in endosomes. J Biol Chem 286, 2886-2895.
29. Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M (2000). Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol 151, 601-612.
30. Nielsen E, Severin F, Backer JM, Hyman AA, Zerial M (1999). Rab5 regulates motility of early endosomes on microtubules. Nat Cell Biol 1, 376-382.
31. Palamidessi A, Frittoli E, Ducano N, Offenhauser N, Sigismund S, Kajiho H, Parazzoli D, Oldani A, Gobbi M, Serini G, et al. (2013). The GTPaseactivating protein RN-tre controls focal adhesion turnover and cell migration. Curr Biol 23, 2355-2364.
32. Palamidessi A, Frittoli E, Garre M, Faretta M, Mione M, Testa I, Diaspro A, Lanzetti L, Scita G, Di Fiore PP (2008). Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell 134, 135-147.
33. Patki V, Lawe DC, Corvera S, Virbasius JV, Chawla A (1998). A functional PtdIns(3)P-binding motif. Nature 394, 433-434.
34. Pfeffer SR (2001). Rab GTPases: specifying and deciphering organelle identity and function. Trends Cell Biol 11, 487-491.
35. Poteryaev D, Datta S, Ackema K, Zerial M, Spang A (2010). Identification of the switch in early-to-late endosome transition. Cell 141, 497-508.
36. Rink J, Ghigo E, Kalaidzidis Y, Zerial M (2005). Rab conversion as a mechanism of progression from early to late endosomes. Cell 122, 735-749.
37. Schenker T, Lach C, Kessler B, Calderara S, Trueb B (1994). A novel GTPbinding protein which is selectively repressed in SV40-transformed fibroblasts. J Biol Chem 269, 25447-25453.
38. Sheff D, Pelletier L, O'Connell CB, Warren G, Mellman I (2002). Transferrin receptor recycling in the absence of perinuclear recycling endosomes. J Cell Biol 156, 797-804.
39. Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H (1998). EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394, 494-498.
40. Stenmark H (2009). Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10, 513-525.
41. Sun L, Liu O, Desai J, Karbassi F, Sylvain MA, Shi A, Zhou Z, Rocheleau CE, Grant BD (2012). CED-10/Rac1 regulates endocytic recycling through the RAB-5 GAP TBC-2. PLoS Gene 8, e1002785.
42. Takahashi S, Kubo K, Waguri S, Yabashi A, Shin HW, Katoh Y, Nakayama K (2012). Rab11 regulates exocytosis of recycling vesicles at the plasma membrane. J Cell Sci 125, 4049-4057.
43. Tsutsumi K, Fujioka Y, Tsuda M, Kawaguchi H, Ohba Y (2009). Visualization of Ras-PI3K interaction in the endosome using BiFC. Cell Signal 21, 1672-1679.
44. Ullrich O, Reinsch S, Urbe S, Zerial M, Parton RG (1996). Rab11 regulates recycling through the pericentriolar recycling endosome. J Cell Biol 135, 913-924.