The relationship between lumenal and limiting membranes in swollen late endocytic compartments formed after worthmannin treatment or sucrose accumulation

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Volumn 2, Issue 9, 2001, Pages 631-642

  Bright, N A ^a   Lindsay, M R ^a   Stewart, A ^a   Luzio, J P ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Electron microscopy; Endocytosis; Endosomes; Lysobisphosphatidic acid; Multivesicular bodies; P13 kinase; Sucrosomes; Worthmannin

Indexed keywords

CATION; GLYCOPROTEIN; PHOSPHATIDIC ACID; SOMATOMEDIN B RECEPTOR; SUCROSE; TRANSFERRIN RECEPTOR; WORTMANNIN;

ANIMAL CELL; ARTICLE; BIOGENESIS; CELL ORGANELLE; CONTROLLED STUDY; CYTOPLASM VESICLE; DATA ANALYSIS; ELECTRON MICROSCOPY; ENDOSOME; FIBROBLAST; IMMUNOFLUORESCENCE; LYSOSOME; MEMBRANE; MEMBRANE TRANSPORT; MORPHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; TIME;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELL LINE; CELL MEMBRANE; ENDOCYTOSIS; ENZYME INHIBITORS; INTRACELLULAR MEMBRANES; LYSOPHOSPHOLIPIDS; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MICROSCOPY, FLUORESCENCE; MONOGLYCERIDES; RATS; RECEPTOR, IGF TYPE 2; RECEPTORS, TRANSFERRIN; SUCROSE; TIME FACTORS;

EID: 0034852440     PISSN: 13989219     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0854.2001.20906.x     Document Type: Article

References (35)

1. The mannose-6-phosphate receptor and the biogenesis of lysosomes
2. Characterization of the cation-independent mannose-6-phosphate receptor-enriched prelysosomal compartment in NRK cells
3. The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells
4. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
5. Multivesicular endosomes containing internalised EGF-EGF receptor complexes mature and then fuse directly with lysosomes
6. Characterisation of the early endosome and putative endocytic carrier vesicles in vivo and with an assay of vesicle fusion in vitro
7. Microtubule and motor dependent fusion in vitro between apical and basolateral endocytic vesicles from MDCK cells
8. Biogenesis of transport intermediates in the endocytic pathway
9. Lysosome-endosome fusion and lysosome biogenesis
10. Fab1p Ptdlns(3)P 5-kinase function essential for protein sorting in the multivesicular body
11. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking
12. A lipid associated with the antiphospholipid syndrome regulates endosome structure and function
13. Lipids, lipid domains and lipid-protein interactions in endocytic membrane traffic
14. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
15. Fab1p is essential for Ptdlns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis
16. Polar transmembrane domains target proteins to the interior of the yeast vacuole
17. Induction in vitro by autonomic drugs of cytoplasmic vacuoles in ascites tumour cells
18. The effect of lathyrogenic compounds on morphology and growth of cultured cells
19. The effect of wortmannin on the localisation of lysosomal type I integral membrane glycoproteins suggests a role for phosphoinositide 3-kinase activity in regulating membrane traffic late in the endocytic pathway
20. Wortmannin retards the movement of the mannose-6-phosphate / insulin-like growth factor II receptor and its ligand out of endosomes
21. Multivesicular body morphogenesis requires phosphatidylinositol 3-kinase activity
22. Dense core lysosomes can fuse with late endosomes and are reformed from the resultant hybrid organelles
23. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine 'fingers' and contains a calmodulin-binding IQ motif
24. Wortmannin alters the transferrin receptor endocytic pathway in vivo and in vitro
25. Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport
26. Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes
27. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation
28. The mouse SKD1, a homologue of yeast Vps4p, is required for normal endosomal trafficking and morphology in mammalian cells
29. Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependent
30. The endosomal concentration of a mannose-6-phosphate receptor is unchanged in the absence of ligand synthesis
31. Loss of cation-independent mannose 6-phosphate receptor expression promotes the accumulation of lysobisphosphatidic acid in multilamellar bodies
32. Improving structural integrity of cryosections for immunogold labelling
33. Stereological methods