SN50, a cell-permeable inhibitor of nuclear Factor-κB, attenuates ventilator-induced lung injury in an isolated and perfused rat lung model

Shock

Volumn 46, Issue 2, 2016, Pages 194-201

  Chian, Chih Feng ^a   Chiang, Chi Huei ^b,c   Chuang, Chiao Hui ^b   Liu, Shiou Ling ^b   Tsai, Chen Liang ^a  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; nuclear factor kB; SN50; ventilator induced lung injury

Indexed keywords

CASPASE 3; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; MYELOPEROXIDASE; PROTEIN SERINE THREONINE KINASE; SN 50; TUMOR NECROSIS FACTOR ALPHA; CXCL2 CHEMOKINE; PEPTIDE; PEROXIDASE; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTIFICIAL VENTILATION; BLOOD VESSEL PERMEABILITY; BRONCHOALVEOLAR LAVAGE FLUID; CELL ACTIVITY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INFLAMMATION; LUNG BLOOD VESSEL; LUNG CAPILLARY PRESSURE; LUNG HEMODYNAMICS; LUNG VENTILATION; LUNG WEIGHT; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TIDAL VOLUME; UPREGULATION; VENTILATOR INDUCED LUNG INJURY; ANIMAL; ANTAGONISTS AND INHIBITORS; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMODYNAMICS; MALE; METABOLISM; PHYSIOLOGY; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMODYNAMICS; INTERLEUKIN-1BETA; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PEPTIDES; PEROXIDASE; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA; VENTILATOR-INDUCED LUNG INJURY;

EID: 84954472637     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000563     Document Type: Article

References (35)

1. Slutsky AS, Ranieri VM. Ventilator-induced lung injury. N Engl J Med 369: 2126-2136, 2013
2. Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD. Incidence and outcomes of acute lung injury. N Engl J Med 353: 1685-1693, 2005
3. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 342: 1301-1308, 2000
4. Guérin C, Reignier J, Richard JC, Beuret P, Gacouin A, Boulain T, Mercier E, Badet M, Mercat A, Baudin O, et al. Prone positioning in severe acute respiratory distress syndrome. N Engl J Med 368: 2159-2168, 2013
5. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363: 1107-1116, 2010
6. Petrucci N, De Feo C. Lung protective ventilation strategy for the acute respiratory distress syndrome. Cochrane Database Syst Rev 2: CD003844, 2013
7. Rubenfeld GD, Cooper C, Carter G, Thompson BT, Hudson LD. Barriers to providing lung-protective ventilation to patients with acute lung injury. Crit Care Med 32: 1289-1293, 2004
8. Hussain N, Wu F, Zhu L, Thrall RS, Kresch MJ. Neutrophil apoptosis during the development and resolution of oleic acid-induced acute lung injury in the rat. Am J Respir Cell Mol Biol 19: 867-874, 1998
9. Kotecha S, Mildner RJ, Prince LR, Vyas JR, Currie AE, Lawson RA, Whyte MK. The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants. Thorax 58: 961-967, 2003
10. Syrkina O, Jafari B, Hales CA, Quinn DA. Oxidant stress mediates inflammation and apoptosis in ventilator-induced lung injury. Respirology 13: 333-340, 2008
11. Ghosh S, Hayden MS. Celebrating 25 years of NF-kB research. Immunol Rev 246: 5-13, 2012
12. Liu SF, Malik AB. NF-kappa B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290: L622-L645, 2006
13. Lin YZ, Yao SY, Veach RA, Torgerson TR, Hawiger J. Inhibition of nuclear translocation of transcription factor NF-kappa B by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequence. J Biol Chem 270: 14255-14258, 1995
14. Liu YY, Liao SK, Huang CC, Tsai YH, Quinn DA, Li LF. Role for nuclear factor-kappa B in augmented lung injury because of interaction between hyperoxia and high stretch ventilation. Transl Res 154: 228-240, 2009
15. Chiang CH, Pai HI, Liu SL. Ventilator-induced lung injury (VILI) promotes ischemia/reperfusion lung injury (I/R) and NF-kappa B antibody attenuates both injuries. Resuscitation 79: 147-154, 2008
16. Drake R, Gaar KA, Taylor AE. Estimation of the filtration coefficient of pulmonary exchange vessels. Am J Physiol 234: H266-H274, 1978
17. Phua J, Badia JR, Adhikari NK, Friedrich JO, Fowler RA, Singh JM, Scales DC, Stather DR, Li A, Jones A, et al. Has mortality from acute respiratory distress syndrome decreased over time? A systematic review. Am J Respir Crit CareMed 179: 220-227, 2009
18. Chian CF, Chiang CH, Chuang CH, Liu SL. Inhibitor of nuclear factor-kB, SN50, attenuates lipopolysaccharide-induced lung injury in an isolated and perfused rat lung model. Transl Res 163: 211-220, 2014
19. Gharib SA, Liles WC, Klaff LS, Altemeier WA. Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung. Physiol Genomics 37: 239-248, 2009
20. Moreno-Vinasco L, Quijada H, Sammani S, Siegler J, Letsiou E, Deaton R, Saadat L, Zaidi RS, Messana J, Gann PH, et al. Nicotinamide phosphoribosyltransferase inhibitor is a novel therapeutic candidate in murine models of inflammatory lung injury. Am J Respir Cell Mol Biol 51: 223-228, 2014
21. Welsh DA, Summer WR, Dobard EP, Nelson S, Mason CM. Keratinocyte growth factor prevents ventilator-induced lung injury in an ex vivo rat model. Am J Respir Crit Care Med 162: 1081-1086, 2000
22. Adir Y, Factor P, Dumasius V, Ridge KM, Sznajder JI. Na, K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury. Am J Respir Crit Care Med 168: 1445-1448, 2003
23. Vockeroth D, Gunasekara L, Amrein M, Possmayer F, Lewis JF, Veldhuizen RA. Role of cholesterol in the biophysical dysfunction of surfactant in ventilatorinduced lung injury. Am J Physiol Lung Cell Mol Physiol 298: L117-L125, 2010
24. Li LF, Chu PH, Hung CY, Kao WW, Lin MC, Liu YY, Yang CT. Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway. Chest 143: 1252-1260, 2013
25. Chiang CH, Chuang CH, Liu SL, Lee TS, Kou YR, Zhang H. Apocynin attenuates ventilator-induced lung injury in an isolated and perfused rat lung model. Intensive Care Med 37: 1360-1367, 2011
26. Jerng JS, Hsu YC, Wu HD, Pan HZ, Wang HC, Shun CT, Yu CJ, Yang PC. Role of the renin-angiotensin system in ventilator-induced lung injury: an in vivo study in a rat model. Thorax 62: 527-535, 2007
27. Torgerson TR, Colosia AD, Donahue JP, Lin YZ, Hawiger J. Regulation of NFkappa B, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NFkappa B p50. J Immunol 161: 6084-6092, 1998
28. Li LF, Ouyang B, Choukroun G, Matyal R, Mascarenhas M, Jafari B, Bonventre JV, Force T, Quinn DA. Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases. Am J Physiol Lung Cell Mol Physiol 285: L464-L475, 2003
29. Ko YA, Yang MC, Huang HT, Hsu CM, Chen LW. NF-kB activation in myeloid cells mediates ventilator-induced lung injury. Respir Res 14(69): 1-13, 2013
30. Shu YS, Tao W, Miao QB, Zhu YB, Yang YF. Improvement of ventilationinduced lung injury in a rodent model by inhibition of inhibitory kB kinase. J Trauma Acute Care Surg 76: 1417-1424, 2014
31. Hayes M, Curley GF, Masterson C, Contreras M, Ansari B, Devaney J, O'Toole D, Laffey JG. Pulmonary overexpression of inhibitor kBa decreases the severity of ventilator-induced lung injury in a rat model. Br J Anaesth 113: 1046-1054, 2014
32. Contreras M, Ansari B, Curley G, Higgins BD, Hassett P, O'Toole D, Laffey JG. Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kB-dependent mechanism. Crit Care Med 40: 2622-2630, 2012
33. Wang B, Wan JY, Zhang L, Min S. Synthetic RGDS peptide attenuates mechanical ventilation-induced lung injury in rats. Exp Lung Res 38: 204-210, 2012
34. Kim JH, Suk MH, Yoon DW, Kim HY, Jung KH, Kang EH, Lee SY, Lee SY, Suh IB, Shin C, et al. Inflammatory and transcriptional roles of poly (ADP-ribose) polymerase in ventilator-induced lung injury. Crit Care 12: R108, 2008
35. Huang CS, Kawamura T, Peng X, Tochigi N, Shigemura N, Billiar TR, Nakao A, Toyoda Y. Hydrogen inhalation reduced epithelial apoptosis in ventilatorinduced lung injury via a mechanism involving nuclear factor-kappa B activation. Biochem Biophys Res Commun 408: 253-258, 2011