Lumican regulates ventilation-induced epithelial-mesenchymal transition through extracelluar signal-regulated kinase pathway

Chest

Volumn 143, Issue 5, 2013, Pages 1252-1260

  Li, Fu ^a,b   Chu, Pao Hsien ^a,b   Hung, Cheng Yiu ^a,b   Kao, Winston W Y ^c   Lin, Meng Chih ^a,b   Liu, Yung Yang ^d,e   Yang, Cheng Ta ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ALPHA SMOOTH MUSCLE ACTIN; CALVASCULIN; COLLAGEN; CXCL3 CHEMOKINE; LUMICAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN;

AMBIENT AIR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL VENTILATION; BLOOD VESSEL PERMEABILITY; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; MALE; MICROVASCULATURE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; TIDAL VOLUME; VENTILATOR INDUCED LUNG INJURY; WILD TYPE;

EID: 84877595891     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.12-2058     Document Type: Article

References (33)

1. Held HD, Boettcher S, Hamann L, Uhlig S. Ventilation-induced chemokine and cytokine release is associated with activation of nuclear factor-kappaB and is blocked by steroids. Am J Respir Crit Care Med. 2001;163(3 pt1):711-716. (Pubitemid 32230834)
2. Cabrera-Benítez NE, Parotto M, Post M, et al. Mechanical stress induces lung fibrosis by epithelial-mesenchymal transition. Crit Care Med. 2012;40(2):510-517.
3. Ricard JD, Dreyfuss D, Saumon G. Ventilator-induced lung injury. Eur Respir J Suppl. 2003;22(suppl42):2s-9s. (Pubitemid 36975730)
4. Ludwig MS. Proteoglycans and pathophysiology. J Appl Physiol. 2007;103(3):735-736. (Pubitemid 47358850)
5. Li LF, Liao SK, Huang CC, Hung MJ, Quinn DA. Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibro sis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment. Crit Care. 2008; 12(4):R103.
6. Fahy RJ, Lichtenberger F, McKeegan CB, Nuovo GJ, Marsh CB, Wewers MD. The acute respiratory distress syn drome: a role for transforming growth factor-beta 1. Am J Respir Cell Mol Biol. 2003;28(4):499-503. (Pubitemid 36399372)
7. Keane MP, Belperio JA, Moore TA, et al. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. J Immunol. 1999;162(9):5511-5518. (Pubitemid 29307163)
8. Li LF, Chen BX, Tsai YH, Kao WW, Yang CT, Chu PH. Lumican expression in diaphragm induced by mechanical ventilation. PLoS ONE. 2011;6(9):e24692.
9. Park HS, Kim SR, Lee YC. Impact of oxidative stress on lung diseases. Respirology. 2009;14(1):27-38.
10. Moriondo A, Pelosi P, Passi A, et al. Proteoglycan fragmentation and respiratory mechanics in mechanically ventilated healthy rats. J Appl Physiol. 2007;103(3):747-756. (Pubitemid 47358854)
11. Dolhnikoff M, Morin J, Roughley PJ, Ludwig MS. Expression of lumican in human lungs. Am J Respir Cell Mol Biol. 1998; 19(4):582-587. (Pubitemid 128354239)
12. Nikitovic D, Katonis P, Tsatsakis A, Karamanos NK, Tzanakakis GN. Lumican, a small leucine-rich proteoglycan. IUBMB Life. 2008;60(12):818-823.
13. Kao WW, Funderburgh JL, Xia Y, Liu CY, Conrad GW. Focus on molecules: lumican. Exp Eye Res. 2006;82(1):3-4. (Pubitemid 43063391)
14. Kao WW-Y. Ocular surface tissue morphogenesis in normal and disease states revealed by genetically modified mice. Cornea. 2006;25(suppl): S7-S19.
15. Seomun Y, Joo CK. Lumican induces human corneal epithelial cell migration and integrin expression via ERK1/2 signaling. Biochem Biophys Res Commun. 2008;372(1):221-225.
16. Lawson WE, Polosukhin VV, Zoia O, et al. Characterization of fibroblast-specific protein 1 in pulmonary fibrosis. Am J Respir Crit Care Med. 2005;171(8):899-907. (Pubitemid 40562721)
17. Saika S, Miyamoto T, Tanaka S, et al. Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition. Invest Ophthalmol Vis Sci. 2003;44(5):2094-2102. (Pubitemid 36520304)
18. Pelosi P, Rocco PR. Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med. 2008;34(4):631-639. (Pubitemid 351660086)
19. Villar J, Cabrera NE, Valladares F, et al. Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS ONE. 2011;6(9):e23914.
20. Heise RL, Stober V, Cheluvaraju C, Hollingsworth JW, Garantziotis S. Mechanical stretch induces epithelialmesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. J Biol Chem. 2011;286(20): 17435-17444.
21. Saika S, Shiraishi A, Liu CY, et al. Role of lumican in the corneal epithelium during wound healing. J Biol Chem. 2000; 275(4):2607-2612. (Pubitemid 30082027)
22. Li LF, Yang CT, Huang CC, Liu YY, Kao KC, Lin HC. Low-molecular- weight heparin reduces hyperoxia-augmented ventilator-induced lung injury via serine/threonine kinaseprotein kinase B. Respir Res. 2011;12 :90.
23. Han B, Lodyga M, Liu M. Ventilator-induced lung injury: role of protein-protein interaction in mechanosensation. Proc Am Thorac Soc. 2005;2(3):181-187. (Pubitemid 41500843)
24. Bai KJ, Spicer AP, Mascarenhas MM, et al. The role of hyaluronan synthase 3 in ventilator-induced lung injury. Am J Respir Crit Care Med. 2005;172(1):92-98. (Pubitemid 40923319)
25. Agostini C, Gurrieri C. Chemokine/cytokine cocktail in idiopathic pulmonary fibrosis. Proc Am Thorac Soc. 2006;3(4): 357-363. (Pubitemid 43845413)
26. Strieter RM, Mehrad B. New mechanisms of pulmonary fibrosis. Chest. 2009;136(5):1364-1370.
27. Al-Jamal R, Ludwig MS. Changes in proteoglycans and lung tissue mechanics during excessive mechanical ventilation in rats. Am J Physiol Lung Cell Mol Physiol. 2001;281(5):L1078-L1087.
28. Svensson L, Närlid I, Oldberg Å. Fibromodulin and lumican bind to the same region on collagen type I fibrils. FEBS Lett. 2000;470(2):178-182. (Pubitemid 30151092)
29. Ying S, Shiraishi A, Kao CW, et al. Characterization and expression of the mouse lumican gene. J Biol Chem. 1997; 272(48):30306-30313. (Pubitemid 27512236)
30. Hayashi Y, Call MK, Chikama TI, et al. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci. 2010;123(pt17):2987-2995.
31. Lee S, Bowrin K, Hamad AR, Chakravarti S. Extracellular matrix lumican deposited on the surface of neutrophils promotes migration by binding to β2 integrin. J Biol Chem. 2009; 284(35):23662-23669.
32. Câmara J, Jarai G. Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-α. Fibrogenesis Tissue Repair. 2010;3(1):2.
33. Wilson MR, Patel BV, Takata M. Ventilation with "clinically relevant" high tidal volumes does not promote stretch-induced injury in the lungs of healthy mice. Crit Care Med. 2012;40(10): 2850-2857.