Factor H uptake regulates intracellular C3 activation during apoptosis and decreases the inflammatory potential of nucleosomes

Cell Death and Differentiation

Volumn 23, Issue 5, 2016, Pages 903-911

  Martin, M ^a   Leffler, J ^a   Smolag, K I ^a   Mytych, J ^a   Bjork A ^a   Chaves, L D ^b   Alexander, J J ^b   Quigg, R J ^b   Blom, A M ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; CATHEPSIN L; CD33 ANTIGEN; COMPLEMENT COMPONENT C3; COMPLEMENT FACTOR H; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIGLEC 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; NUCLEOSOME;

AGE RELATED MACULAR DEGENERATION; ANIMAL CELL; APOPTOSIS; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOGENICITY; IN VIVO STUDY; INFLAMMATION; INTERNALIZATION; MONOCYTE; MOUSE; NONHUMAN; NUCLEOSOME; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; C57BL MOUSE; COMPLEMENT ACTIVATION; DEFICIENCY; JURKAT CELL LINE; KNOCKOUT MOUSE; METABOLISM;

ANIMALS; APOPTOSIS; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT FACTOR H; HUMANS; INFLAMMATION; JURKAT CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NUCLEOSOMES;

EID: 84954409820     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2015.164     Document Type: Article

References (33)

1. Trouw LA, Bengtsson AA, Gelderman KA, Dahlback B, Sturfelt G, Blom AM. C4b-binding protein and factor H compensate for the loss of membrane-bound complement inhibitors to protect apoptotic cells against excessive complement attack. J Biol Chem 2007; 282: 28540-28548.
2. Botto M, Walport MJ. C1q, autoimmunity and apoptosis. Immunobiology 2002; 205: 395-406.
3. Sjoberg AP, Trouw LA, Blom AM. Complement activation and inhibition: a delicate balance. Trends Immunol 2009; 30: 83-90.
4. Kolev M, Friec GL, Kemper C. Complement -tapping into new sites and effector systems. Nat Rev Immunol 2014; 14: 811-820.
5. Leffler J, Herbert AP, Norstrom E, Schmidt CQ, Barlow PN, Blom AM, et al. Annexin-II, DNA, and histones serve as factor H ligands on the surface of apoptotic cells. J Biol Chem 2010; 285: 3766-3776.
6. Mevorach D, Mascarenhas JO, Gershov D, Elkon KB. Complement-dependent clearance of apoptotic cells by human macrophages. J Exp Med 1998; 188: 2313-2320.
7. Herrmann M, Voll RE, Zoller OM, Hagenhofer M, Ponner BB, Kalden JR. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998; 41: 1241-1250.
8. Radic M, Herrmann M, van der Vlag J, Rekvig OP. Regulatory and pathogenetic mechanisms of autoantibodies in SLE. Autoimmunity 2011; 44: 349-356.
9. Ao W, Zheng H, Chen XW, Shen Y, Yang CD. Anti-annexin II antibody is associated with thrombosis and/or pregnancy morbidity in antiphospholipid syndrome and systemic lupus erythematosus with thrombosis. Rheumatol Int 2011; 31: 865-869.
10. Lech M, Anders HJ. The pathogenesis of lupus nephritis. J Am Soc Nephrol 2013; 24: 1357-1366.
11. Jonsen A, Nilsson SC, Ahlqvist E, Svenungsson E, Gunnarsson I, Eriksson KG, et al. Mutations in genes encoding complement inhibitors CD46 and CFH affect the age at nephritis onset in patients with systemic lupus erythematosus. Arthritis Res Ther 2011; 13: R206.
12. Pickering MC, Cook HT, Warren J, Bygrave AE, Moss J, Walport MJ, et al. Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H. Nat Genet 2002; 31: 424-428.
13. Bao L, Haas M, Boackle SA, Kraus DM, Cunningham PN, Park P, et al. Transgenic expression of a soluble complement inhibitor protects against renal disease and promotes survival in MRL/lpr mice. J Immunol 2002; 168: 3601-3607.
14. Bao L, Haas M, Quigg RJ. Complement factor H deficiency accelerates development of lupus nephritis. J Am Soc Nephrol 2011; 22: 285-295.
15. Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 2005; 102: 7227-7232.
16. Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005; 308: 385-389.
17. Anderson DH, Mullins RF, Hageman GS, Johnson LV. A role for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002; 134: 411-431.
18. Dunaief JL, Dentchev T, Ying GS, Milam AH. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 2002; 120: 1435-1442.
19. Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, et al. Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity 2013; 39: 1143-1157.
20. Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC. Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2000; 2: 318-325.
21. Holers VM. Complement and its receptors: new insights into human disease. Annu Rev Immunol 2014; 32: 433-459.
22. Munoz LE, Lauber K, Schiller M, Manfredi AA, Herrmann M. The role of defective clearance of apoptotic cells in systemic autoimmunity. Nat Rev Rheumatol 2010; 6: 280-289.
23. Repnik U, Cesen MH, Turk B. The endolysosomal system in cell death and survival. Cold Spring Harb Perspect Biol 2013; 5: a008755.
24. DiScipio RG. Ultrastructures and interactions of complement factors H and I. J Immunol 1992; 149: 2592-2599.
25. Williams RC Jr, Malone CC, Meyers C, Decker P, Muller S. Detection of nucleosome particles in serum and plasma from patients with systemic lupus erythematosus using monoclonal antibody 4H7. J Rheumatol 2001; 28: 81-94.
26. Stephan F, Marsman G, Bakker LM, Bulder I, Stavenuiter F, Aarden LA, et al. Cooperation of factor VII-activating protease and serum DNase I in the release of nucleosomes from necrotic cells. Arthritis Rheumatol 2014; 66: 686-693.
27. Pillai S, Netravali IA, Cariappa A, Mattoo H. Siglecs and immune regulation. Annu Rev Immunol 2012; 30: 357-392.
28. Meri S, Pangburn MK. Discrimination between activators and nonactivators of the alternative pathway of complement: regulation via a sialic acid/polyanion binding site on factor H. Proc Natl Acad Sci USA 1990; 87: 3982-3986.
29. Xing C, Sivakumaran TA, Wang JJ, Rochtchina E, Joshi T, Smith W, et al. Complement factor H polymorphisms, renal phenotypes and age-related macular degeneration: the Blue Mountains Eye Study. Genes Immun 2008; 9: 231-239.
30. Klein R, Knudtson MD, Lee KE, Klein BE. Serum cystatin C level, kidney disease markers, and incidence of age-related macular degeneration: the Beaver Dam Eye Study. Arch Ophthalmol 2009; 127: 193-199.
31. Ding JD, Kelly U, Landowski M, Toomey CB, Groelle M, Miller C, et al. Expression of human complement factor h prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged cfh knockout mice. Am J Pathol 2015; 185: 29-42.
32. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.
33. Greenwood FC, Hunter WM, Glover JS. The preparation of I-131-labelled human growth hormone of high specific radioactivity. Biochem J 1963; 89: 114-123.