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Volumn 25, Issue 1, 2016, Pages 105-115

Trabectedin for the treatment of breast cancer

Author keywords

BRCA mutation; DNA repair; metastatic breast cancer; trabectedin

Indexed keywords

TRABECTEDIN; 1,3 DIOXOLANE DERIVATIVE; ALKYLATING AGENT; TETRAHYDROISOQUINOLINE DERIVATIVE;

EID: 84954386070     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2016.1124086     Document Type: Article
Times cited : (30)

References (74)
  • 1
    • 77955505177 scopus 로고    scopus 로고
    • A review of trabectedin (ET-743): A unique mechanism of action
    • Aug
    • D'Incalci M, Galmarini CM. A review of trabectedin (ET-743): A unique mechanism of action. Mol Cancer Ther. 2010 Aug;9 (8):2157-2163.
    • (2010) Mol Cancer Ther. , vol.9 , Issue.8 , pp. 2157-2163
    • D'Incalci, M.1    Galmarini, C.M.2
  • 2
    • 0035146702 scopus 로고    scopus 로고
    • Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action
    • Jan
    • Erba E, Bergamaschi D, Bassano L, et al. Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action. Eur J Cancer. 2001 Jan;37(1):97-105.
    • (2001) Eur J Cancer. , vol.37 , Issue.1 , pp. 97-105
    • Erba, E.1    Bergamaschi, D.2    Bassano, L.3
  • 3
    • 40249097419 scopus 로고    scopus 로고
    • Role of homologous recombination in trabectedin-induced DNA damage
    • Mar
    • Tavecchio M, Simone M, Erba E, et al. Role of homologous recombination in trabectedin-induced DNA damage. Eur J Cancer. 2008 Mar;44(4):609-618.
    • (2008) Eur J Cancer. , vol.44 , Issue.4 , pp. 609-618
    • Tavecchio, M.1    Simone, M.2    Erba, E.3
  • 4
    • 34548706418 scopus 로고    scopus 로고
    • Replication and homologous recombination repair regulate DNA doublestrand break formation by the antitumor alkylator ecteinascidin 743
    • Aug 7
    • Soares DG, Escargueil AE, Poindessous V, et al. Replication and homologous recombination repair regulate DNA doublestrand break formation by the antitumor alkylator ecteinascidin 743. Proc Natl Acad Sci U S A. 2007 Aug 7;104 (32):13062-13067.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.32 , pp. 13062-13067
    • Soares, D.G.1    Escargueil, A.E.2    Poindessous, V.3
  • 5
    • 0035874074 scopus 로고    scopus 로고
    • Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways
    • May 15
    • Damia G, Silvestri S, Carrassa L, et al. Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. Int J Cancer. 2001 May 15;92(4):583-588.
    • (2001) Int J Cancer. , vol.92 , Issue.4 , pp. 583-588
    • Damia, G.1    Silvestri, S.2    Carrassa, L.3
  • 6
    • 17944374027 scopus 로고    scopus 로고
    • Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
    • Aug
    • Takebayashi Y, Pourquier P, Zimonjic DB, et al. Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med. 2001 Aug;7(8):961-966.
    • (2001) Nat Med. , vol.7 , Issue.8 , pp. 961-966
    • Takebayashi, Y.1    Pourquier, P.2    Zimonjic, D.B.3
  • 7
    • 36248974108 scopus 로고    scopus 로고
    • Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NERproficient cells unravelled by a novel mathematical simulation approach
    • Dec
    • Tavecchio M, Natoli C, Ubezio P, et al. Dynamics of cell cycle phase perturbations by trabectedin (ET-743) in nucleotide excision repair (NER)-deficient and NERproficient cells, unravelled by a novel mathematical simulation approach. Cell Prolif. 2007 Dec;40(6):885-904.
    • (2007) Cell Prolif. , vol.40 , Issue.6 , pp. 885-904
    • Tavecchio, M.1    Natoli, C.2    Ubezio, P.3
  • 8
    • 84860220336 scopus 로고    scopus 로고
    • Characterization of a new trabectedinresistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents
    • Jul 1
    • Uboldi S, Bernasconi S, Romano M, et al. Characterization of a new trabectedinresistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents. Int J Cancer. 2012 Jul 1;131 (1):59-69.
    • (2012) Int J Cancer. , vol.131 , Issue.1 , pp. 59-69
    • Uboldi, S.1    Bernasconi, S.2    Romano, M.3
  • 10
    • 27544493942 scopus 로고    scopus 로고
    • Selective effects of the anticancer drug Yondelis (ET-743) on cell-cycle promoters
    • Nov
    • Minuzzo M, Ceribelli M, Pitarque-Marti M, et al. Selective effects of the anticancer drug Yondelis (ET-743) on cell-cycle promoters. Mol Pharmacol. 2005 Nov;68 (5):1496-1503.
    • (2005) Mol Pharmacol. , vol.68 , Issue.5 , pp. 1496-1503
    • Minuzzo, M.1    Ceribelli, M.2    Pitarque-Marti, M.3
  • 11
    • 0034612352 scopus 로고    scopus 로고
    • Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation
    • Jun 6
    • Jin S, Gorfajn B, Faircloth G, et al. Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6775-6779.
    • (2000) Proc Natl Acad Sci U S A. , vol.97 , Issue.12 , pp. 6775-6779
    • Jin, S.1    Gorfajn, B.2    Faircloth, G.3
  • 12
    • 60849129809 scopus 로고    scopus 로고
    • Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors
    • Feb
    • Forni C, Minuzzo M, Virdis E, et al. Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors. Mol Cancer Ther. 2009 Feb;8(2):449-457.
    • (2009) Mol Cancer Ther. , vol.8 , Issue.2 , pp. 449-457
    • Forni, C.1    Minuzzo, M.2    Virdis, E.3
  • 13
    • 84887111590 scopus 로고    scopus 로고
    • Mode of action of trabectedin in myxoid liposarcomas
    • Oct 30
    • Di Giandomenico S, Frapolli R, Bello E, et al. Mode of action of trabectedin in myxoid liposarcomas. Oncogene. 2014 Oct 30;33(44):5201-5210.
    • (2014) Oncogene. , vol.33 , Issue.44 , pp. 5201-5210
    • Di Giandomenico, S.1    Frapolli, R.2    Bello, E.3
  • 14
    • 58149200507 scopus 로고    scopus 로고
    • Von Hippel-Lindau-coupled and transcriptioncoupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin
    • Oct 15
    • Aune GJ, Takagi K, Sordet O, et al. Von Hippel-Lindau-coupled and transcriptioncoupled nucleotide excision repair-dependent degradation of RNA polymerase II in response to trabectedin. Clin Cancer Res. 2008 Oct 15;14(20):6449-6455.
    • (2008) Clin Cancer Res. , vol.14 , Issue.20 , pp. 6449-6455
    • Aune, G.J.1    Takagi, K.2    Sordet, O.3
  • 15
    • 80052167125 scopus 로고    scopus 로고
    • XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinkingmimetic alkaloids
    • Aug 26
    • Feuerhahn S, Giraudon C, Martinez-Diez M, et al. XPF-dependent DNA breaks and RNA polymerase II arrest induced by antitumor DNA interstrand crosslinkingmimetic alkaloids. Chem Biol. 2011 Aug 26;18(8):988-999.
    • (2011) Chem Biol. , vol.18 , Issue.8 , pp. 988-999
    • Feuerhahn, S.1    Giraudon, C.2    Martinez-Diez, M.3
  • 16
    • 84873597334 scopus 로고    scopus 로고
    • Role of macrophage targeting in the antitumor activity of trabectedin
    • Feb 11
    • Germano G, Frapolli R, Belgiovine C, et al. Role of macrophage targeting in the antitumor activity of trabectedin. Cancer Cell. 2013 Feb 11;23(2):249-262.
    • (2013) Cancer Cell. , vol.23 , Issue.2 , pp. 249-262
    • Germano, G.1    Frapolli, R.2    Belgiovine, C.3
  • 17
    • 77950231708 scopus 로고    scopus 로고
    • Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells
    • Mar 15
    • Germano G, Frapolli R, Simone M, et al. Antitumor and anti-inflammatory effects of trabectedin on human myxoid liposarcoma cells. Cancer Res. 2010 Mar 15;70 (6):2235-2244.
    • (2010) Cancer Res. , vol.70 , Issue.6 , pp. 2235-2244
    • Germano, G.1    Frapolli, R.2    Simone, M.3
  • 18
    • 84906092874 scopus 로고    scopus 로고
    • Trabectedin, a drug acting on both cancer cells and the tumour microenvironment
    • D'Incalci M, Badri N, Galmarini CM, et al. Trabectedin, a drug acting on both cancer cells and the tumour microenvironment. Br J Cancer. 2014;111(4):646-650.
    • (2014) Br J Cancer. , vol.111 , Issue.4 , pp. 646-650
    • D'Incalci, M.1    Badri, N.2    Galmarini, C.M.3
  • 19
    • 84879179814 scopus 로고    scopus 로고
    • New activities for the anti-tumor agent trabectedin: Taking two birds with one stone
    • Apr
    • D'Incalci M, Frapolli R, Germano G, et al. New activities for the anti-tumor agent trabectedin: Taking two birds with one stone. Oncotarget. 2013 Apr;4 (4):496-497.
    • (2013) Oncotarget. , vol.4 , Issue.4 , pp. 496-497
    • D'Incalci, M.1    Frapolli, R.2    Germano, G.3
  • 20
    • 84911007522 scopus 로고    scopus 로고
    • Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1
    • Feb 1
    • Dossi R, Frapolli R, Di Giandomenico S, et al. Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1. Int J Cancer. 2015 Feb 1;136(3):721-729.
    • (2015) Int J Cancer. , vol.136 , Issue.3 , pp. 721-729
    • Dossi, R.1    Frapolli, R.2    Di Giandomenico, S.3
  • 21
    • 84904467233 scopus 로고    scopus 로고
    • Anti-angiogenic effects of trabectedin (Yondelis; ET-743) on human breast cancer cells
    • Mar 1
    • Atmaca H, Uzunoglu S. Anti-angiogenic effects of trabectedin (Yondelis; ET-743) on human breast cancer cells. Eur Cytokine Netw. 2014 Mar 1;25(1):1-7.
    • (2014) Eur Cytokine Netw. , vol.25 , Issue.1 , pp. 1-7
    • Atmaca, H.1    Uzunoglu, S.2
  • 22
    • 0030453986 scopus 로고    scopus 로고
    • Progress in the acquisition of new marine-derived anticancer compounds: Development of ecteinascidin-743 (et-743)
    • Jimeno J, Faircloth G, Cameron L. Progress in the acquisition of new marine-derived anticancer compounds: Development of ecteinascidin-743 (et-743). Drugs Future. 1996;21:1155-1165.
    • (1996) Drugs Future. , vol.21 , pp. 1155-1165
    • Jimeno, J.1    Faircloth, G.2    Cameron, L.3
  • 23
    • 0031766324 scopus 로고    scopus 로고
    • In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients
    • Sep
    • Izbicka E, Lawrence R, Raymond E, et al. In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients. Ann Oncol. 1998 Sep;9(9):981-987.
    • (1998) Ann Oncol. , vol.9 , Issue.9 , pp. 981-987
    • Izbicka, E.1    Lawrence, R.2    Raymond, E.3
  • 24
    • 0036830244 scopus 로고    scopus 로고
    • Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis
    • Nov 1
    • Gajate C, An F, Mollinedo F. Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis. J Biol Chem. 2002 Nov 1;277(44):41580-41589.
    • (2002) J Biol Chem. , vol.277 , Issue.44 , pp. 41580-41589
    • Gajate, C.1    An, F.2    Mollinedo, F.3
  • 25
    • 1542357606 scopus 로고    scopus 로고
    • Apoptosis pathways in cancer and cancer therapy
    • Mar
    • Debatin KM. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother. 2004 Mar;53(3):153-159.
    • (2004) Cancer Immunol Immunother. , vol.53 , Issue.3 , pp. 153-159
    • Debatin, K.M.1
  • 26
    • 34247345833 scopus 로고    scopus 로고
    • The apoptosome: Signalling platform of cell death
    • May
    • Riedl SJ, Salvesen GS. The apoptosome: Signalling platform of cell death. Nat Rev Mol Cell Biol. 2007 May;8(5):405-413.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , Issue.5 , pp. 405-413
    • Riedl, S.J.1    Salvesen, G.S.2
  • 27
    • 84880370496 scopus 로고    scopus 로고
    • A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells
    • Aug 14
    • Atmaca H, Bozkurt E, Uzunoglu S, et al. A diverse induction of apoptosis by trabectedin in MCF-7 (HER2-/ER+) and MDA-MB-453 (HER2+/ER-) breast cancer cells. Toxicol Lett. 2013 Aug 14;221 (2):128-136.
    • (2013) Toxicol Lett. , vol.221 , Issue.2 , pp. 128-136
    • Atmaca, H.1    Bozkurt, E.2    Uzunoglu, S.3
  • 28
    • 0033516265 scopus 로고    scopus 로고
    • Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer
    • Jun 2
    • Peto J, Collins N, Barfoot R, et al. Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst. 1999 Jun 2;91(11):943-949.
    • (1999) J Natl Cancer Inst. , vol.91 , Issue.11 , pp. 943-949
    • Peto, J.1    Collins, N.2    Barfoot, R.3
  • 29
    • 4944229642 scopus 로고    scopus 로고
    • Hallmarks of 'BRCAness' sporadic cancers
    • Oct
    • Turner N, Tutt A, Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat Rev Cancer. 2004 Oct;4(10):814-819.
    • (2004) Nat Rev Cancer. , vol.4 , Issue.10 , pp. 814-819
    • Turner, N.1    Tutt, A.2    Ashworth, A.3
  • 30
    • 84876462970 scopus 로고    scopus 로고
    • Analysis of DNA repairrelated genes in breast cancer reveals CUL4A ubiquitin ligase as a novel biomarker of trabectedin response
    • Apr
    • Garcia MJ, Saucedo-Cuevas LP, Munoz-Repeto I, et al. Analysis of DNA repairrelated genes in breast cancer reveals CUL4A ubiquitin ligase as a novel biomarker of trabectedin response. Mol Cancer Ther. 2013 Apr;12(4):530-541.
    • (2013) Mol Cancer Ther. , vol.12 , Issue.4 , pp. 530-541
    • Garcia, M.J.1    Saucedo-Cuevas, L.P.2    Munoz-Repeto, I.3
  • 31
    • 84954384490 scopus 로고    scopus 로고
    • Synergistic combination of trabectedin and olaparib in breast cancer tumor cell lines
    • Apr 5- 9; San Diego, CA
    • Avila S, Martinez M, Moneo V, et al. Synergistic combination of trabectedin and olaparib in breast cancer tumor cell lines. American Association for Cancer Research, 105th Annual meeting; 2014 Apr 5-9; San Diego, CA; p. 1686.
    • (2014) American Association for Cancer Research 105th Annual Meeting , pp. 1686
    • Avila, S.1    Martinez, M.2    Moneo, V.3
  • 32
    • 0036894384 scopus 로고    scopus 로고
    • Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo
    • Dec 1
    • Takahashi N, Li W, Banerjee D, et al. Sequence-dependent synergistic cytotoxicity of ecteinascidin-743 and paclitaxel in human breast cancer cell lines in vitro and in vivo. Cancer Res. 2002 Dec 1;62 (23):6909-6915.
    • (2002) Cancer Res. , vol.62 , Issue.23 , pp. 6909-6915
    • Takahashi, N.1    Li, W.2    Banerjee, D.3
  • 33
    • 0035281641 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
    • Mar 1
    • Taamma A, Misset JL, Riofrio M, et al. Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol. 2001 Mar 1;19 (5):1256-1265.
    • (2001) J Clin Oncol. , vol.19 , Issue.5 , pp. 1256-1265
    • Taamma, A.1    Misset, J.L.2    Riofrio, M.3
  • 34
    • 67651089735 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours
    • Sessa C, Cresta S, Noberasco C, et al. Phase I clinical and pharmacokinetic study of trabectedin and cisplatin in solid tumours. Eur J Cancer. 2009;45 (12):2116-2122.
    • (2009) Eur J Cancer. , vol.45 , Issue.12 , pp. 2116-2122
    • Sessa, C.1    Cresta, S.2    Noberasco, C.3
  • 35
    • 77951738158 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors
    • May 1
    • Chu Q, Mita A, Forouzesh B, et al. Phase I and pharmacokinetic study of sequential paclitaxel and trabectedin every 2 weeks in patients with advanced solid tumors. Clin Cancer Res. 2010 May 1;16(9):2656-2665.
    • (2010) Clin Cancer Res. , vol.16 , Issue.9 , pp. 2656-2665
    • Chu, Q.1    Mita, A.2    Forouzesh, B.3
  • 36
    • 66149170084 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of trabectedin as a 1-or 3-hour infusion weekly in patients with advanced solid malignancies
    • May 15
    • Forouzesh B, Hidalgo M, Chu Q, et al. Phase I and pharmacokinetic study of trabectedin as a 1-or 3-hour infusion weekly in patients with advanced solid malignancies. Clin Cancer Res. 2009 May 15;15 (10):3591-3599.
    • (2009) Clin Cancer Res. , vol.15 , Issue.10 , pp. 3591-3599
    • Forouzesh, B.1    Hidalgo, M.2    Chu, Q.3
  • 37
    • 84867775658 scopus 로고    scopus 로고
    • Phase i combination study of trabectedin and capecitabine in patients with advanced malignancies
    • Gore L, Rivera E, Basche M, et al. Phase I combination study of trabectedin and capecitabine in patients with advanced malignancies. Invest New Drugs. 2012;30 (5):1942-1949.
    • (2012) Invest New Drugs. , vol.30 , Issue.5 , pp. 1942-1949
    • Gore, L.1    Rivera, E.2    Basche, M.3
  • 38
    • 53149133906 scopus 로고    scopus 로고
    • Phase i trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors
    • Messersmith WA, Jimeno A, Ettinger D, et al. Phase I trial of weekly trabectedin (ET-743) and gemcitabine in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2008;63(1):181-188.
    • (2008) Cancer Chemother Pharmacol. , vol.63 , Issue.1 , pp. 181-188
    • Messersmith, W.A.1    Jimeno, A.2    Ettinger, D.3
  • 39
    • 0035127175 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies
    • Ryan DP, Supko JG, Eder JP, et al. Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res. 2001;7 (2):231-242.
    • (2001) Clin Cancer Res. , vol.7 , Issue.2 , pp. 231-242
    • Ryan, D.P.1    Supko, J.G.2    Eder, J.P.3
  • 40
    • 64449085620 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer
    • May
    • Sessa C, Perotti A, Noberasco C, et al. Phase I clinical and pharmacokinetic study of trabectedin and doxorubicin in advanced soft tissue sarcoma and breast cancer. Eur J Cancer. 2009 May;45 (7):1153-1161.
    • (2009) Eur J Cancer. , vol.45 , Issue.7 , pp. 1153-1161
    • Sessa, C.1    Perotti, A.2    Noberasco, C.3
  • 41
    • 0142121506 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours
    • Twelves C, Hoekman K, Bowman A, et al. Phase I and pharmacokinetic study of Yondelis (Ecteinascidin-743; ET-743) administered as an infusion over 1 h or 3 h every 21 days in patients with solid tumours. Eur J Cancer. 2003;39 (13):1842-1851.
    • (2003) Eur J Cancer. , vol.39 , Issue.13 , pp. 1842-1851
    • Twelves, C.1    Hoekman, K.2    Bowman, A.3
  • 42
    • 0034490073 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase i dose-finding study
    • van Kesteren C, Cvitkovic E, Taamma A, et al. Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study. Clin Cancer Res. 2000;6(12):4725-4732.
    • (2000) Clin Cancer Res. , vol.6 , Issue.12 , pp. 4725-4732
    • Van Kesteren, C.1    Cvitkovic, E.2    Taamma, A.3
  • 43
    • 84862250901 scopus 로고    scopus 로고
    • Phase i clinical and pharmacokinetic study of trabectedin and carboplatin in patients with advanced solid tumors
    • Vidal L, Magem M, Barlow C, et al. Phase I clinical and pharmacokinetic study of trabectedin and carboplatin in patients with advanced solid tumors. Invest New Drugs. 2012;30(2):616-628.
    • (2012) Invest New Drugs. , vol.30 , Issue.2 , pp. 616-628
    • Vidal, L.1    Magem, M.2    Barlow, C.3
  • 44
    • 0036154945 scopus 로고    scopus 로고
    • A phase i and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies
    • Villalona-Calero MA, Eckhardt SG, Weiss G, et al. A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies. Clin Cancer Res. 2002;8(1):75-85.
    • (2002) Clin Cancer Res. , vol.8 , Issue.1 , pp. 75-85
    • Villalona-Calero, M.A.1    Eckhardt, S.G.2    Weiss, G.3
  • 45
    • 84938677932 scopus 로고    scopus 로고
    • Phase i study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies
    • von Mehren M, Bookman M, Meropol NJ, et al. Phase I study of the safety and pharmacokinetics of trabectedin with docetaxel in patients with advanced malignancies. Cancer Chemother Pharmacol. 2015;75(5):1047-1055.
    • (2015) Cancer Chemother Pharmacol. , vol.75 , Issue.5 , pp. 1047-1055
    • Von Mehren, M.1    Bookman, M.2    Meropol, N.J.3
  • 46
    • 53049092830 scopus 로고    scopus 로고
    • A phase i study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies
    • von Mehren M, Schilder RJ, Cheng JD, et al. A phase I study of the safety and pharmacokinetics of trabectedin in combination with pegylated liposomal doxorubicin in patients with advanced malignancies. Ann Oncol. 2008;19(10):1802-1809.
    • (2008) Ann Oncol. , vol.19 , Issue.10 , pp. 1802-1809
    • Von Mehren, M.1    Schilder, R.J.2    Cheng, J.D.3
  • 47
    • 84864348875 scopus 로고    scopus 로고
    • A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in phase II clinical trials
    • Le Cesne A, Yovine A, Blay JY, et al. A retrospective pooled analysis of trabectedin safety in 1,132 patients with solid tumors treated in phase II clinical trials. Invest New Drugs. 2012;30(3):1193-1202.
    • (2012) Invest New Drugs. , vol.30 , Issue.3 , pp. 1193-1202
    • Le Cesne, A.1    Yovine, A.2    Blay, J.Y.3
  • 48
    • 84910646290 scopus 로고    scopus 로고
    • Trabectedin as a single-agent treatment of advanced breast cancer after anthracycline and taxane treatment: A multicenter, randomized, phase II study comparing 2 administration regimens
    • Goldstein LJ, Gurtler J, Del Prete SA, et al. Trabectedin as a single-agent treatment of advanced breast cancer after anthracycline and taxane treatment: A multicenter, randomized, phase II study comparing 2 administration regimens. Clin Breast Cancer. 2014;14(6):396-404.
    • (2014) Clin Breast Cancer. , vol.14 , Issue.6 , pp. 396-404
    • Goldstein, L.J.1    Gurtler, J.2    Del Prete, S.A.3
  • 49
    • 84903900546 scopus 로고    scopus 로고
    • Activity of trabectedin in germline BRCA1/2-mutated metastatic breast cancer: Results of an international first-in-class phase II study
    • Jun
    • Delaloge S, Wolp-Diniz R, Byrski T, et al. Activity of trabectedin in germline BRCA1/2-mutated metastatic breast cancer: Results of an international first-in-class phase II study. Ann Oncol. 2014 Jun;25 (6):1152-1158.
    • (2014) Ann Oncol. , vol.25 , Issue.6 , pp. 1152-1158
    • Delaloge, S.1    Wolp-Diniz, R.2    Byrski, T.3
  • 50
    • 84954386460 scopus 로고    scopus 로고
    • Final results of a phase II trial of trabectedin (T) in patients with hormone receptor-positive, HER2-negative advanced breast cancer, according to xeroderma pigmentosum gene (XPG) expression. American Society of Clinical Oncology, 49th Annual Meeting 2013
    • May 31-Jun 4; Chicago, IL
    • Awada A, Cortes J, Martin M, et al. Final results of a phase II trial of trabectedin (T) in patients with hormone receptor-positive, HER2-negative advanced breast cancer, according to xeroderma pigmentosum gene (XPG) expression. American Society of Clinical Oncology, 49th Annual Meeting; 2013 May 31-Jun 4; Chicago, IL. J Clin Oncol. 31(Supl 15):547.
    • J Clin Oncol. , vol.31 , pp. 547
    • Awada, A.1    Cortes, J.2    Martin, M.3
  • 51
    • 84930678267 scopus 로고    scopus 로고
    • A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: The TRUSTS trial
    • Bui-Nguyen B, Butrynski JE, Penel N, et al. A phase IIb multicentre study comparing the efficacy of trabectedin to doxorubicin in patients with advanced or metastatic untreated soft tissue sarcoma: The TRUSTS trial. Eur J Cancer. 2015;51 (10):1312-1320.
    • (2015) Eur J Cancer. , vol.51 , Issue.10 , pp. 1312-1320
    • Bui-Nguyen, B.1    Butrynski, J.E.2    Penel, N.3
  • 52
    • 84930588472 scopus 로고    scopus 로고
    • Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocationrelated sarcoma: A randomised, open-label, phase 2 study
    • Kawai A, Araki N, Sugiura H, et al. Trabectedin monotherapy after standard chemotherapy versus best supportive care in patients with advanced, translocationrelated sarcoma: A randomised, open-label, phase 2 study. Lancet Oncol. 2015;16 (4):406-416.
    • (2015) Lancet Oncol. , vol.16 , Issue.4 , pp. 406-416
    • Kawai, A.1    Araki, N.2    Sugiura, H.3
  • 53
    • 84933503980 scopus 로고    scopus 로고
    • Trabectedin in combination with doxorubicin for first-line treatment of advanced uterine or soft-tissue leiomyosarcoma (LMS-02): A non-randomised, multicentre, phase 2 trial
    • Pautier P, Floquet A, Chevreau C, et al. Trabectedin in combination with doxorubicin for first-line treatment of advanced uterine or soft-tissue leiomyosarcoma (LMS-02): A non-randomised, multicentre, phase 2 trial. Lancet Oncol. 2015;16 (4):457-464.
    • (2015) Lancet Oncol. , vol.16 , Issue.4 , pp. 457-464
    • Pautier, P.1    Floquet, A.2    Chevreau, C.3
  • 54
    • 84924912711 scopus 로고    scopus 로고
    • Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): A randomised phase 2 trial
    • Le Cesne A, Blay JY, Domont J, et al. Interruption versus continuation of trabectedin in patients with soft-tissue sarcoma (T-DIS): A randomised phase 2 trial. Lancet Oncol. 2015;16(3):312-319.
    • (2015) Lancet Oncol. , vol.16 , Issue.3 , pp. 312-319
    • Le Cesne, A.1    Blay, J.Y.2    Domont, J.3
  • 55
    • 84860516956 scopus 로고    scopus 로고
    • Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum
    • Massuti B, Cobo M, Camps C, et al. Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum. Lung Cancer. 2012;76 (3):354-361.
    • (2012) Lung Cancer. , vol.76 , Issue.3 , pp. 354-361
    • Massuti, B.1    Cobo, M.2    Camps, C.3
  • 56
    • 83055194284 scopus 로고    scopus 로고
    • A phase II evaluation of trabectedin in the treatment of advanced, persistent, or recurrent uterine leiomyosarcoma: A gynecologic oncology group study
    • Jan
    • Monk BJ, Blessing JA, Street DG, et al. A phase II evaluation of trabectedin in the treatment of advanced, persistent, or recurrent uterine leiomyosarcoma: A gynecologic oncology group study. Gynecol Oncol. 2012 Jan;124(1):48-52.
    • (2012) Gynecol Oncol. , vol.124 , Issue.1 , pp. 48-52
    • Monk, B.J.1    Blessing, J.A.2    Street, D.G.3
  • 57
    • 81055124701 scopus 로고    scopus 로고
    • Multicenter phase II study of trabectedin in patients with metastatic castration-resistant prostate cancer
    • Michaelson MD, Bellmunt J, Hudes GR, et al. Multicenter phase II study of trabectedin in patients with metastatic castration-resistant prostate cancer. Ann Oncol. 2012;23(5):1234-1240.
    • (2012) Ann Oncol. , vol.23 , Issue.5 , pp. 1234-1240
    • Michaelson, M.D.1    Bellmunt, J.2    Hudes, G.R.3
  • 58
    • 84857530639 scopus 로고    scopus 로고
    • Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma
    • Gronchi A, Bui BN, Bonvalot S, et al. Phase II clinical trial of neoadjuvant trabectedin in patients with advanced localized myxoid liposarcoma. Ann Oncol. 2012;23(3):771-776.
    • (2012) Ann Oncol. , vol.23 , Issue.3 , pp. 771-776
    • Gronchi, A.1    Bui, B.N.2    Bonvalot, S.3
  • 59
    • 79951576840 scopus 로고    scopus 로고
    • Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: A phase II study of the Gynecologic Oncology Group
    • Monk BJ, Sill MW, Hanjani P, et al. Docetaxel plus trabectedin appears active in recurrent or persistent ovarian and primary peritoneal cancer after up to three prior regimens: A phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 2011;120(3):459-463.
    • (2011) Gynecol Oncol. , vol.120 , Issue.3 , pp. 459-463
    • Monk, B.J.1    Sill, M.W.2    Hanjani, P.3
  • 60
    • 84862266455 scopus 로고    scopus 로고
    • Trabectedin in pre-treated patients with advanced or metastatic soft tissue sarcoma: A phase II study evaluating cotreatment with dexamethasone
    • Paz-Ares L, Lopez-Pousa A, Poveda A, et al. Trabectedin in pre-treated patients with advanced or metastatic soft tissue sarcoma: A phase II study evaluating cotreatment with dexamethasone. Invest New Drugs. 2012;30(2):729-740.
    • (2012) Invest New Drugs. , vol.30 , Issue.2 , pp. 729-740
    • Paz-Ares, L.1    Lopez-Pousa, A.2    Poveda, A.3
  • 61
    • 70249101414 scopus 로고    scopus 로고
    • Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules
    • Sep 1
    • Demetri GD, Chawla SP, von Mehren M, et al. Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules. J Clin Oncol. 2009 Sep 1;27(25):4188-4196.
    • (2009) J Clin Oncol. , vol.27 , Issue.25 , pp. 4188-4196
    • Demetri, G.D.1    Chawla, S.P.2    Von Mehren, M.3
  • 62
    • 71049192700 scopus 로고    scopus 로고
    • Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m2 24 h or 1.3 mg/m2 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer
    • Del Campo JM, Roszak A, Bidzinski M, et al. Phase II randomized study of trabectedin given as two different every 3 weeks dose schedules (1.5 mg/m2 24 h or 1.3 mg/m2 3 h) to patients with relapsed, platinum-sensitive, advanced ovarian cancer. Ann Oncol. 2009;20(11):1794-1802.
    • (2009) Ann Oncol. , vol.20 , Issue.11 , pp. 1794-1802
    • Del Campo, J.M.1    Roszak, A.2    Bidzinski, M.3
  • 63
    • 67549084350 scopus 로고    scopus 로고
    • Single-agent trabectedin as second-line therapy of persistent or recurrent endometrial cancer: Results of a multicenter phase II study
    • McMeekin DS, Lisyanskaya A, Crispens M, et al. Single-agent trabectedin as second-line therapy of persistent or recurrent endometrial cancer: Results of a multicenter phase II study. Gynecol Oncol. 2009;114(2):288-292.
    • (2009) Gynecol Oncol. , vol.114 , Issue.2 , pp. 288-292
    • McMeekin, D.S.1    Lisyanskaya, A.2    Crispens, M.3
  • 64
    • 84954405336 scopus 로고    scopus 로고
    • Trabectedin and indole-3-carbinol combination in heavily pretreated metastatic breast cancer: Results of a pilot clinical study
    • Abstract e12015
    • Zambelli A, Tancredi R, Negri S, et al. Trabectedin and indole-3-carbinol combination in heavily pretreated metastatic breast cancer: Results of a pilot clinical study. J Clin Oncol 2014;32(Suppl). Abstract e12015.
    • (2014) J Clin Oncol , vol.32
    • Zambelli, A.1    Tancredi, R.2    Negri, S.3
  • 65
    • 33745259879 scopus 로고    scopus 로고
    • A phase II study of Yondelis (trabectedin, ET-743) as a 24-h continuous intravenous infusion in pretreated advanced breast cancer
    • Jun 5
    • Zelek L, Yovine A, Brain E, et al. A phase II study of Yondelis (trabectedin, ET-743) as a 24-h continuous intravenous infusion in pretreated advanced breast cancer. Br J Cancer. 2006 Jun 5;94(11):1610-1614.
    • (2006) Br J Cancer. , vol.94 , Issue.11 , pp. 1610-1614
    • Zelek, L.1    Yovine, A.2    Brain, E.3
  • 66
    • 4143073806 scopus 로고    scopus 로고
    • Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma
    • Oct 10
    • Donald S, Verschoyle RD, Greaves P, et al. Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma. Int J Cancer. 2004 Oct 10;111(6):961-967.
    • (2004) Int J Cancer. , vol.111 , Issue.6 , pp. 961-967
    • Donald, S.1    Verschoyle, R.D.2    Greaves, P.3
  • 67
    • 84929073473 scopus 로고    scopus 로고
    • Effect of BRCA1 and XPG mutations on treatment response to trabectedin and pegylated liposomal doxorubicin in patients with advanced ovarian cancer: Exploratory analysis of the phase 3 OVA-301 study
    • Monk BJ, Ghatage P, Parekh T, et al. Effect of BRCA1 and XPG mutations on treatment response to trabectedin and pegylated liposomal doxorubicin in patients with advanced ovarian cancer: Exploratory analysis of the phase 3 OVA-301 study. Ann Oncol. 2015;26(5):914-920.
    • (2015) Ann Oncol. , vol.26 , Issue.5 , pp. 914-920
    • Monk, B.J.1    Ghatage, P.2    Parekh, T.3
  • 68
    • 84929992639 scopus 로고    scopus 로고
    • Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients
    • Byrski T, Huzarski T, Dent R, et al. Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res Treat. 2014;147(2):401-405.
    • (2014) Breast Cancer Res Treat. , vol.147 , Issue.2 , pp. 401-405
    • Byrski, T.1    Huzarski, T.2    Dent, R.3
  • 69
    • 84921771510 scopus 로고    scopus 로고
    • Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation
    • Jan 20
    • Kaufman B, Shapira-Frommer R, Schmutzler RK, et al. Olaparib monotherapy in patients with advanced cancer and a germline BRCA1/2 mutation. J Clin Oncol. 2015 Jan 20;33(3):244-250.
    • (2015) J Clin Oncol. , vol.33 , Issue.3 , pp. 244-250
    • Kaufman, B.1    Shapira-Frommer, R.2    Schmutzler, R.K.3
  • 70
    • 84907198355 scopus 로고    scopus 로고
    • Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199
    • Sep 20
    • Adams S, Gray RJ, Demaria S, et al. Prognostic value of tumor-infiltrating lymphocytes in triple-negative breast cancers from two phase III randomized adjuvant breast cancer trials: ECOG 2197 and ECOG 1199. J Clin Oncol. 2014 Sep 20;32(27):2959-2966.
    • (2014) J Clin Oncol. , vol.32 , Issue.27 , pp. 2959-2966
    • Adams, S.1    Gray, R.J.2    Demaria, S.3
  • 71
    • 84905178989 scopus 로고    scopus 로고
    • Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: Results from the FinHER trial
    • Aug
    • Loi S, Michiels S, Salgado R, et al. Tumor infiltrating lymphocytes are prognostic in triple negative breast cancer and predictive for trastuzumab benefit in early breast cancer: Results from the FinHER trial. Ann Oncol. 2014 Aug;25 (8):1544-1550.
    • (2014) Ann Oncol. , vol.25 , Issue.8 , pp. 1544-1550
    • Loi, S.1    Michiels, S.2    Salgado, R.3
  • 72
    • 84912011347 scopus 로고    scopus 로고
    • The prognostic value of tumorinfiltrating lymphocytes in triple-negative breast cancer: A meta-analysis
    • Dec
    • Ibrahim EM, Al-Foheidi ME, Al-Mansour MM, et al. The prognostic value of tumorinfiltrating lymphocytes in triple-negative breast cancer: A meta-analysis. Breast Cancer Res Treat. 2014 Dec;148(3):467-476.
    • (2014) Breast Cancer Res Treat. , vol.148 , Issue.3 , pp. 467-476
    • Ibrahim, E.M.1    Al-Foheidi, M.E.2    Al-Mansour, M.M.3
  • 73
    • 84928760665 scopus 로고    scopus 로고
    • Anti-programmed cell death protein-1/ligand-1 therapy in different cancers
    • Apr 28
    • Homet Moreno B, Ribas A. Anti-programmed cell death protein-1/ligand-1 therapy in different cancers. Br J Cancer. 2015Apr 28;112(9):1421-1427.
    • (2015) Br J Cancer. , vol.112 , Issue.9 , pp. 1421-1427
    • Homet Moreno, B.1    Ribas, A.2


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